Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men.
Open accessAbstract
Background The effects of docosahexaenoic acid (DHA) on the mean size and concentrations of VLDL, LDL, and HDL subclasses have not been previously studied.Objective We determined the effects of DHA supplementation on the concentrations of apoproteins; large, medium, and small VLDL, LDL, and HDL particles; and the mean diameters of these particles in fasting and postprandial plasma.Design Hypertriglyceridemic men aged 39-66 y (n = 34) participated in a double-blind, randomized, placebo-controlled parallel study. They received no supplements for the first 8 d and received either 7.5 g DHA oil/d (3 g DHA/d) or olive oil (placebo) for the last 90 d. Lipoprotein particle diameters and concentrations were measured by nuclear magnetic resonance spectroscopy.Results DHA supplementation for 45 d significantly (P < 0.05) decreased concentrations of fasting triacylglycerol (24%), large VLDL (92%), and intermediate-density lipoproteins (53%) and the mean diameter of VLDL particles (11.1 nm). It elevated concentrations of LDL cholesterol (12.6%), small VLDL particles (133%), and large LDL particles (120%) and the mean diameter of LDL particles (0.6 nm) in fasting plasma. Similar changes were observed for area under the curve for postprandial samples (0-6 h); however, the number of small dense LDL particles decreased significantly (21%), and the change in LDL cholesterol was not significant. Continued supplementation with DHA beyond 45 d caused no further changes; placebo treatment altered none of the responses tested.Conclusion DHA supplementation may improve cardiovascular health by lowering concentrations of triacylglycerols and small, dense LDL particles.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the one study that gave 3 g/d of algal oil DHA, there was a further reduction in TG concentration.
“In the one study that gave 3 g/d of algal oil DHA, there was a further reduction in TG concentration (23).”
The greatest decrease in TG and greatest increase in LDL-C appeared in the two studies that included participants with elevated serum lipid concentrations at baseline.
“The greatest decrease in TG and greatest increase in LDL-C appeared in the two studies that included participants with elevated serum lipid concentrations at baseline (23,29).”
Dietary marine-derived omega-3 PUFA intake is very low, at <0.2 g of the ~1.4 g of total omega-3 PUFA consumed daily in the United States.
“Dietary marine-derived omega-3 PUFA intake is very low, at Ͻ0.2 g of the Ϸ1.4 g of total omega-3 PUFA consumed daily in the United States.464,465”
From Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association (2011) · cites this paper as [464]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423 · see citing works
Littell, R. C. (1996) · Medical Entomology and Zoology · Cited by 10,345 · see citing works
Enzymatic determination of total serum cholesterol.
Allain, C. C., Poon, L. S., Chan, C. S. G., Richmond, W., & Fu, P. C. (1974) · Clinical Chemistry · doi:10.1093/clinchem/20.4.470 · Cited by 9,845 · see citing works
Statistics for experimenters. An introduction to design, data analysis, and model building.
Box, G. E. P., Hunter, W. G., & Hunter, J. S. (1978) · Cited by 4,021 · see citing works
Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease
Kris-Etherton, P. M., Harris, W. S., & Appel, L. J. (2002) · Circulation · doi:10.1161/01.cir.0000038493.65177.94 · Cited by 3,707 · see citing works
Warnick, G. R., Benderson, J., & Albers, J. J. (1982) · Clinical Chemistry · doi:10.1093/clinchem/28.6.1379 · Cited by 2,171 · see citing works
A peroxidase-coupled method for the colorimetric determination of serum triglycerides.
McGowan, M. W., Artiss, J. D., Strandbergh, D. R., & Zak, B. (1983) · Clinical Chemistry · doi:10.1093/clinchem/29.3.538 · Cited by 1,298 · see citing works
Metabolic origins and clinical significance of LDL heterogeneity
Berneis, K. K., & Krauss, R. M. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r200004-jlr200 · Cited by 896 · see citing works
Lipoprotein Particle Analysis by Nuclear Magnetic Resonance Spectroscopy
Jeyarajah, E. J., Cromwell, W. C., & Otvos, J. D. (2006) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2006.07.006 · Cited by 735 · see citing works
Statistics for Experimenters: An Introduction to Design, Data Analysis, and Model Building
Parameswaran, R., Box, G. E. P., Hunter, W. G., & Hunter, J. S. (1979) · Journal of Marketing Research · doi:10.2307/3150696 · Cited by 685 · see citing works
Mori, T. A., Burke, V., Puddey, I. B., Watts, G. F., O’Neal, D. N., Best, J. D., & Beilin, L. J. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.5.1085 · Cited by 588 · see citing works
n–3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored
Calder, P. C. (2004) · Clinical Science · doi:10.1042/cs20040119 · Cited by 561 · see citing works
Otvos, J. D., Collins, D. E., Freedman, D. S., SHALAUROVA, I. Y., Schaefer, E. J., McNamara, J. R., Bloomfield, H. E., & Robins, S. J. (2006) · Circulation · doi:10.1161/circulationaha.105.565135 · Cited by 542 · see citing works
Role of apoCs in lipoprotein metabolism: functional differences between apoC1, apoC2, and apoC3
Jong, M. C., Hofker, M. H., & Havekes, L. M. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.3.472 · Cited by 539 · see citing works
Lipoproteins, nutrition, and heart disease.
Schaefer, E. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.2.191 · Cited by 448 · see citing works
Blake, G. J., Otvos, J. D., Rifai, N., & Ridker, P. M. (2002) · Circulation · doi:10.1161/01.cir.0000033222.75187.b9 · Cited by 409 · see citing works
Why do omega-3 fatty acids lower serum triglycerides?
Harris, W. S., & Bulchandani, D. (2006) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000236363.63840.16 · Cited by 398 · see citing works
Mora, S., Szklo, M., Otvos, J. D., Greenland, P., Psaty, B. M., Goff, D. C., O’Leary, D. H., Saad, M. F., Tsai, M. Y., & Sharrett, A. R. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.05.007 · Cited by 380 · see citing works
Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance
Park, Y., & Harris, W. S. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200282-jlr200 · Cited by 348 · see citing works
Freedman, D. S., Otvos, J. D., Jeyarajah, E. J., Barboriak, J. J., Anderson, A. J., & Walker, J. A. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.7.1046 · Cited by 345 · see citing works
Kuller, L. H., Arnold, A. M., Tracy, R. P., Otvos, J. D., Burke, G. L., Psaty, B. M., Siscovick, D. S., Freedman, D. S., & Kronmal, R. A. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000022015.97341.3a · Cited by 310 · see citing works
Grimsgaard, S., Bonaa, K., Hansen, J., & Nordøy, A. (1997) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.3.649 · Cited by 300 · see citing works
Rosenson, R. S., Otvos, J. D., & Freedman, D. S. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02427-x · Cited by 293 · see citing works
n‐3 fatty acids and lipoproteins: Comparison of results from human and animal studies
Harris, W. S. (1996) · Lipids · doi:10.1007/bf02529870 · Cited by 264 · see citing works
Nestel, P., Shige, H., Pomeroy, S., Cehun, M., Abbey, M., & Raederstorff, D. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.2.326 · Cited by 263 · see citing works
Festa, A., Williams, K., Hanley, A. J., Otvos, J. D., Goff, D. C., Wagenknecht, L. E., & Haffner, S. M. (2005) · Circulation · doi:10.1161/circulationaha.104.512079 · Cited by 259 · see citing works
Low-density lipoprotein size and cardiovascular risk assessment
Rizzo, M., & Berneis, K. K. (2005) · QJM · doi:10.1093/qjmed/hci154 · Cited by 257 · see citing works
Low-Density Lipoprotein Size and Cardiovascular Disease: A Reappraisal
Sacks, F. M., & Campos, H. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030636 · Cited by 241 · see citing works
Roche, H. M., & Gibney, M. J. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.232s · Cited by 195 · see citing works
Chan, D. C., Watts, G. F., Mori, T. A., Barrett, P. H. R., Redgrave, T. G., & Beilin, L. J. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.2.300 · Cited by 185 · see citing works
Lipoprotein atherogenicity: an overview of current mechanisms
Griffin, B. A. (1999) · Proceedings of The Nutrition Society · doi:10.1079/pns19990022 · Cited by 182 · see citing works
Conquer, J. A., & Holub, B. J. (1996) · The Journal of Nutrition · doi:10.1093/jn/126.12.3032 · Cited by 181 · see citing works
Stark, K. D., & Holub, B. J. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.765 · Cited by 177 · see citing works
Buckley, R., Shewring, B., Turner, R., Yaqoob, P., & Minihane, A. M. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041235 · Cited by 118 · see citing works
Ågren, J. J., Hänninen, O., Julkunen, A., Fogelholm, L., Vidgren, H. M., Schwab, U., Pynnönen, O., & Uusitupa, M. I. J. (1996) · PubMed · Cited by 117 · see citing works
Sanders, T. A. B., Gleason, K. L. T., Griffin, B. A., & Miller, G. J. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20051658 · Cited by 112 · see citing works
Triglyceride-lowering effect of omega-3 LC-polyunsaturated fatty acids--a review.
Weber, P., & Raederstorff, D. (2000) · PubMed · Cited by 106 · see citing works
LDL cholesterol-raising effect of low-dose docosahexaenoic acid in middle-aged men and women.
Theobald, H. E., Chowienczyk, P. J., Whittall, R., Humphries, S. E., & Sanders, T. A. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.4.558 · Cited by 101 · see citing works
Geppert, J., Kraft, V., Demmelmair, H., & Koletzko, B. (2006) · British Journal of Nutrition · doi:10.1079/bjn20051720 · Cited by 96 · see citing works
Nelson, G. J., Schmidt, P. C., Bartolini, G. L., Kelley, D. S., & Kyle, D. J. (1997) · Lipids · doi:10.1007/s11745-997-0146-5 · Cited by 92 · see citing works
Self-citationHansen, J., Grimsgaard, S., Nilsen, H., Nordøy, A., & Bønaa, K. H. (1998) · Lipids · doi:10.1007/s11745-998-0188-8 · Cited by 91 · see citing works
Sørensen, N. S., Marckmann, P., Høy, C., van Duyvenvoorde, W., & Princen, H. M. G. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.2.235 · Cited by 78 · see citing works
Wu, W. H., Lu, S. C., Wang, T. F., Jou, H. J., & Wang, T. A. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602328 · Cited by 70 · see citing works
Maki, K. C., Elswyk, M. E. V., McCarthy, D., Hess, S. P., Veith, P. E., Bell, M., Subbaiah, P. V., & Davidson, M. H. (2005) · Journal of the American College of Nutrition · doi:10.1080/07315724.2005.10719465 · Cited by 67 · see citing works
Thomas, T. R., SMITH, B. K., Donahue, O. M., Altena, T. S., James-Kracke, M., & Sun, G. Y. (2004) · Metabolism · doi:10.1016/j.metabol.2003.12.019 · Cited by 55 · see citing works
Woodman, R. J., Mori, T. A., Burke, V., Puddey, I. B., Watts, G. F., Best, J. D., & Beilin, L. J. (2003) · Diabetes Care · doi:10.2337/diacare.26.1.253 · Cited by 48 · see citing works
Postprandial triacylglycerolaemia—Nutritional implications
Roche, H. M., & Gibney, M. J. (1995) · Progress in Lipid Research · doi:10.1016/0163-7827(95)00012-o · Cited by 44 · see citing works
Hamazaki, T., Sawazaki, S., Asaoka, E., Itomura, M., Mizushima, Y., Yazawa, K., Kuwamori, T., & Kobayashi, M. (1996) · Journal of Nutrition · doi:10.1093/jn/126.11.2784 · Cited by 17 · see citing works
(1997) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(97)90133-2 · Cited by 11 · see citing works
Flagged first, then by citations
1 of the 50 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Calder PC. nҀ3 Fatty acids and cardiovascular disease: evidence ex- plained and mechanisms explored. Clin Sci (Lond) 2004;107:1-11.
- Sanders TA, Gleason K, Griffin B, Miller GJ. Influence of an algal triacylglycerol containing docosahexaenoic acid (22:6nҀ3) and doco- sapentaenoic acid (22:5nҀ6) on cardiovascular risk factors in healthy men and women. Br J Nutr 2006;95:525-31.
Cited by
Sorted by citations
Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association
Miller, M., Stone, N. J., Ballantyne, C., Bittner, V., Criqui, M. H., Ginsberg, H. N., Goldberg, A. C., Howard, W. J., Jacobson, M. S., Kris-Etherton, P. M., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182160726 · Cited by 1,871 · see citing works
A Systemic Review of the Roles of n-3 Fatty Acids in Health and Disease
Riediger, N. D., Othman, R. A., Suh, M., & Moghadasian, M. H. (2009) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.12.022 · Cited by 694 · see citing works
Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids
Adkins, Y. C., & Kelley, D. S. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.12.004 · Cited by 557 · see citing works
Self-citationLorente‐Cebrián, S., Costa, A. G. V., Navas‐Carretero, S., Zabala, M., Martínez, J. A., & Moreno-Aliaga, M. J. (2013) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-013-0265-4 · Cited by 416 · see citing works
(n-3) Fatty Acids and Cardiovascular Health: Are Effects of EPA and DHA Shared or Complementary?
Mozaffarian, D., & Wu, J. H. Y. (2012) · The Journal of Nutrition · doi:10.3945/jn.111.149633 · Cited by 368 · see citing works
Miller, P. E., Elswyk, M. E. V., & Alexander, D. D. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu024 · Cited by 341 · see citing works
Omega-3 fatty acids: a comprehensive review of their role in health and disease
Yashodhara, B. M., Umakanth, S., Pappachan, J. M., Bhat, S. K., Kamath, R., & Choo, B. H. (2009) · Postgraduate Medical Journal · doi:10.1136/pgmj.2008.073338 · Cited by 334 · see citing works
Oppedisano, F., Macrì, R., Gliozzi, M., Musolino, V., Carresi, C., Maiuolo, J., Bosco, F., Nucera, S., Zito, M. C., Guarnieri, L., et al. (2020) · Biomedicines · doi:10.3390/biomedicines8090306 · Cited by 326 · see citing works
Fish, docosahexaenoic acid and Alzheimer’s disease
Cunnane, S. C., Plourde, M., Pifferi, F., Bégin, M. E., Féart, C., & Barberger‐Gateau, P. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.04.001 · Cited by 316 · see citing works
Wei, M. Y., & Jacobson, T. A. (2011) · Current Atherosclerosis Reports · doi:10.1007/s11883-011-0210-3 · Cited by 284 · see citing works
Jacobson, T. A., Glickstein, S. B., Rowe, J. D., & Soni, P. N. (2012) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2011.10.018 · Cited by 263 · see citing works
The differential effects of EPA and DHA on cardiovascular risk factors
Cottin, S. C., Sanders, T. A., & Hall, W. L. (2011) · Proceedings of the Nutrition Society · doi:10.1017/s0029665111000061 · Cited by 247 · see citing works
Omega-3 fatty acid supplementation and cardiovascular disease
Jump, D. Β., Depner, C. M., & Tripathy, S. (2012) · Journal of Lipid Research · doi:10.1194/jlr.r027904 · Cited by 243 · see citing works
Cussons, A. J., Watts, G. F., Mori, T. A., & Stuckey, B. G. A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0870 · Cited by 181 · see citing works
Bernstein, A. M., Ding, E. L., Willett, W. C., & Rimm, E. B. (2012) · The Journal of Nutrition · doi:10.3945/jn.111.148973 · Cited by 148 · see citing works
Depner, C. M., Philbrick, K. A., & Jump, D. Β. (2013) · Journal of Nutrition · doi:10.3945/jn.112.171322 · Cited by 145 · see citing works
Kelley, D. S., Siegel, D., Fedor, D. M., Adkins, Y. C., & Mackey, B. E. (2009) · Journal of Nutrition · doi:10.3945/jn.108.100354 · Cited by 139 · see citing works
Self-citationEffects of dietary fats on blood lipids: a review of direct comparison trials
DiNicolantonio, J. J., & O’Keefe, J. H. (2018) · Open Heart · doi:10.1136/openhrt-2018-000871 · Cited by 136 · see citing works
AbuMweis, S., Jew, S., Tayyem, R., & Agraib, L. (2018) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12493 · Cited by 122 · see citing works
Zhang, X., Ritonja, J. A., Zhou, N., Chen, B. E., & Li, X. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.025071 · Cited by 122 · see citing works
Neff, L. M., Culiner, J., Cunningham-Rundles, S., Seidman, C., Meehan, D., Maturi, J., Wittkowski, K. M., Levine, B., & Breslow, J. L. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.130021 · Cited by 121 · see citing works
Cytochrome P450-derived eicosanoids and heart function
Jamieson, K. L., Endo, T. H., Darwesh, A. M., Samokhvalov, V., & Seubert, J. M. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.05.005 · Cited by 119 · see citing works
Role of ω3 Longchain Polyunsaturated Fatty Acids in Reducing Cardio- Metabolic Risk Factors
Abeywardena, M. Y., & Patten, G. S. (2011) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153011796429817 · Cited by 104 · see citing works
Correia, M., Michel, V., Matos, A., Carvalho, P. A., Oliveira, M. J., Ferreira, R. M., Dillies, M., Huerre, M., Seruca, R., Figueiredo, C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035072 · Cited by 104 · see citing works
Docosahexaenoic acid (DHA) and cardiovascular disease risk factors
Holub, B. J. (2009) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.05.016 · Cited by 100 · see citing works
Klop, B., Proctor, S. D., Mamo, J. C. L., Botham, K. M., & Cabezas, M. C. (2011) · International Journal of Vascular Medicine · doi:10.1155/2012/947417 · Cited by 93 · see citing works
Reference levels of blood mercury and association with metabolic syndrome in Korean adults
Eom, S., Choi, S., Ahn, S.-J., Kim, D.-K., Kim, D., Lim, J.-A., Choi, B., Shin, H.-J., Yun, S.-W., Yoon, H., et al. (2013) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-013-0891-8 · Cited by 94 · see citing works
Omega-3 fatty acid concentrates in the treatment of moderate hypertriglyceridemia
Skulas-Ray, A. C., West, S. G., Davidson, M. H., & Kris-Etherton, P. M. (2008) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.9.7.1237 · Cited by 91 · see citing works
Guillot, N., Caillet, E., Laville, M., Calzada, C., Lagarde, M., & Véricel, E. (2009) · The FASEB Journal · doi:10.1096/fj.09-133421 · Cited by 90 · see citing works
Dittrich, M., Jahreis, G., Bothor, K., Drechsel, C., Kiehntopf, M., Blüher, M., & Dawczynski, C. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0764-2 · Cited by 81 · see citing works
Lien, E. L. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.05.004 · Cited by 78 · see citing works
Guo, X., Li, K., Li, J., & Li, D. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1492901 · Cited by 77 · see citing works
Ryan, A. S., Keske, M. A., Hoffman, J. P., & Nelson, E. B. (2009) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e31817fe2be · Cited by 72 · see citing works
Childhood Obesity: Immune Response and Nutritional Approaches
Magrone, T., & Jirillo, E. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00076 · Cited by 67 · see citing works
“n-3 PUFAs and their derivatives, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are able to reduce plasma triglyceride levels and body weight (156, 157).”
BackgroundMakhoul, Z., Kristal, A. R., Gulati, R., Luick, B. R., Bersamin, A., O’Brien, D. M., Hopkins, S. E., Stephensen, C. B., Stanhope, K. L., Havel, P. J., et al. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.39 · Cited by 68 · see citing works
Kelley, D. S., & Adkins, Y. C. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000080 · Cited by 62 · see citing works
Self-citationThota, R. N., Ferguson, J. J. A., Abbott, K. A., Dias, C. B., & Garg, M. L. (2018) · Food & Function · doi:10.1039/c8fo00348c · Cited by 60 · see citing works
Milte, C. M., Coates, A. M., Buckley, J. D., Hill, A. M., & Howe, P. R. C. (2007) · British Journal Of Nutrition · doi:10.1017/s000711450785344x · Cited by 61 · see citing works
Fat and Fatty Acid Intake and Metabolic Effects in the Human Body
Sanders, T. A. B. (2009) · Annals of Nutrition and Metabolism · doi:10.1159/000229001 · Cited by 58 · see citing works
Polyunsaturated fatty acids and cardiovascular disease
Richard, D., Bausero, P., Schneider, C., & Visioli, F. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0085-4 · Cited by 57 · see citing works
Gidding, S. S., Prospero, C., Hossain, J., Zappalla, F., Balagopal, P. (., Falkner, B., & Kwiterovich, P. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.05.039 · Cited by 56 · see citing works
The role of marine n-3 fatty acids in improving cardiovascular health: a review
Nicholson, T., Khademi, H., & Moghadasian, M. H. (2013) · Food & Function · doi:10.1039/c2fo30235g · Cited by 56 · see citing works
Talebi, S., Bagherniya, M., Atkin, S. L., Askari, G., Orafai, H. M., & Sahebkar, A. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01250-6 · Cited by 54 · see citing works
Berge, R. K., Ramsvik, M. S., Bohov, P., Svardal, A., Nordrehaug, J. E., Rostrup, E., Bruheim, I., & Bjørndal, B. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0162-7 · Cited by 51 · see citing works
Kelley, D. S., Siegel, D., Vemuri, M., Chung, G. H., & Mackey, B. E. (2008) · Journal of Nutrition · doi:10.1093/jn/138.1.30 · Cited by 52 · see citing works
Self-citationEnkhmaa, B., Surampudi, P. N., Anuurad, E., & Berglund, L. (2015) · Europe PMC (PubMed Central) · Cited by 50 · see citing works
Smith, K., Barraj, L. M., Kantor, M., & Sahyoun, N. R. (2008) · Public Health Nutrition · doi:10.1017/s1368980008003844 · Cited by 50 · see citing works
Ritz, P. P., Rogers, M. B., Zabinsky, J. S., Hedrick, V. E., Rockwell, J., Rimer, E. G., Kostelnik, S. B., Hulver, M. W., & Rockwell, M. S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228834 · Cited by 50 · see citing works
Makhoul, Z., Kristal, A. R., Gulati, R., Luick, B. R., Bersamin, A., Boyer, B. B., & Mohatt, G. V. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28820 · Cited by 48 · see citing works
Maki, K. C., Yurko‐Mauro, K., Dicklin, M. R., Schild, A. L., & Geohas, J. G. (2014) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2014.07.012 · Cited by 49 · see citing works
Safety Evaluation of Single Cell Oils and the Regulatory Requirements for Use as Food Ingredients
Ryan, A. S., Zeller, S., & NELSON, E. B. (2010) · Elsevier eBooks · doi:10.1016/b978-1-893997-73-8.50019-0 · Cited by 45 · see citing works
Zhang, H., Gao, X., Guo, X., Li, K., Li, S., Sinclair, A. J., & Li, D. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.05.025 · Cited by 42 · see citing works
Mejía-Barradas, C. M., Del-Rio-Navarro, B. E., Domínguez‐López, A., Campos‐Rodríguez, R., Martínez–Godínez, M. D. L. Á., Rojas-Hernández, S., Lara‐Padilla, E., Abarca‐Rojano, E., & Miliar-García, Á. (2013) · Endocrine · doi:10.1007/s12020-013-9941-y · Cited by 41 · see citing works
Omega-3 polyunsaturated fatty acids and oxygenated metabolism in atherothrombosis
Guichardant, M., Calzada, C., Bernoud‐Hubac, N., Lagarde, M., & Véricel, E. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.09.013 · Cited by 41 · see citing works
Oelrich, B., Dewell, A., & Gardner, C. D. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.06.003 · Cited by 41 · see citing works
Erkkilä, A. T., Schwab, U., Lehto, S., de Mello, V. D., Kangas, A. J., Soininen, P., Ala‐Korpela, M., & Uusitupa, M. I. J. (2013) · Journal of clinical lipidology · doi:10.1016/j.jacl.2013.09.007 · Cited by 38 · see citing works
Li, D., & Hu, X. (2009) · PubMed · Cited by 38 · see citing works
Neuroprotection for the Warrior: Dietary Supplementation With Omega-3 Fatty Acids
Lewis, M. D., & Bailes, J. E. (2011) · Military Medicine · doi:10.7205/milmed-d-10-00446 · Cited by 38 · see citing works
Dietary polyunsaturated fatty acids (C18:2 ω6 and C18:3 ω3) do not suppress hepatic lipogenesis
Sealls, W., González-Lopez, M., Brosnan, M. J., Black, P. N., & Dirusso, C. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.06.010 · Cited by 38 · see citing works
Fish oil in the treatment of dyslipidemia
Goldberg, R. B., & Sabharwal, A. K. (2008) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282f76728 · Cited by 37 · see citing works
Hanwell, H., Kay, C. D., Lampe, J. W., Holub, B. J., & Duncan, A. M. (2009) · Journal of Nutrition · doi:10.3945/jn.109.105171 · Cited by 36 · see citing works
Omega-3 fatty acids (ῳ-3 fatty acids) in epilepsy: animal models and human clinical trials
DeGiorgio, C. M., & Taha, A. Y. (2016) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2016.1226135 · Cited by 35 · see citing works
Kelley, D. S., Adkins, Y. C., Woodhouse, L. R., Swislocki, A., Mackey, B. E., & Siegel, D. (2011) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2011.0081 · Cited by 33 · see citing works
Self-citationExercise and Dietary-Mediated Reductions in Postprandial Lipemia
Plaisance, E. P., & Fisher, G. (2014) · Journal of Nutrition and Metabolism · doi:10.1155/2014/902065 · Cited by 33 · see citing works
Michaeloudes, C., Christodoulides, S., Christodoulou, P., Kyriakou, T.-C., Patrikios, I. S., & Stephanou, A. (2023) · Nutrients · doi:10.3390/nu15224830 · Cited by 32 · see citing works
Kelley, D. S., Adkins, Y. C., Zunino, S. J., Woodhouse, L. R., Bonnel, E. L., Breksa, A. P., Manners, G. D., & Mackey, B. E. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.11.026 · Cited by 33 · see citing works
Self-citationTalon, L. D. C., de Oliveira, E. P., Moreto, F., Portero‐McLellan, K. C., & Burini, R. C. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.01.022 · Cited by 30 · see citing works
Current level of fish and omega-3 fatty acid intakes and risk of Type 2 diabetes in China
Zhang, Y., Zhuang, P., Mao, L., Chen, X., Wang, J., Cheng, L., Ding, G., & Jiao, J. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.108249 · Cited by 30 · see citing works
Falkenhain, K., Roach, L. A., McCreary, S., McArthur, E., Weiss, E. J., François, M. E., & Little, J. P. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab212 · Cited by 34 · see citing works
Impact of DHA on Metabolic Diseases from Womb to Tomb
Arnoldussen, I. A. C., & Kiliaan, A. J. (2014) · Marine Drugs · doi:10.3390/md12126190 · Cited by 29 · see citing works
Allaire, J., Vors, C., Tremblay, A. J., Marin, J., Charest, A., Tchernof, A., Couture, P., & Lamarche, B. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02745 · Cited by 29 · see citing works
Adkins, Y. C., Soulika, A. M., Mackey, B. E., & Kelley, D. S. (2019) · Lipids · doi:10.1002/lipd.12130 · Cited by 28 · see citing works
Self-citationSanders, T. A. B. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.071555 · Cited by 26 · see citing works
Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men
Dawson, K., Zhao, L., Adkins, Y., Vemuri, M., Rodriguez, R. L., Gregg, J. P., Kelley, D. S., & Hwang, D. H. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.03.004 · Cited by 24 · see citing works
Self-citationArmstrong, P., Kelley, D. S., Newman, J. W. I., Staggers, F. E., Hartiala, J., Allayee, H., & Stephensen, C. B. (2012) · Journal of Nutrition · doi:10.3945/jn.112.159814 · Cited by 24 · see citing works
Self-citationBravo, E., Napolitano, M., & Botham, K. M. (2010) · The Open Translational Medicine Journal · doi:10.2174/1876399501002010001 · Cited by 25 · see citing works
Mebarek, S., Ermak, N., Benzaria, A., Vicca, S., Dubois, M., Némoz, G., Laville, M., Lacour, B., Véricel, E., Lagarde, M., et al. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508051520 · Cited by 24 · see citing works
Marinangeli, C. P. F., & Jones, P. J. H. (2010) · Annals of Medicine · doi:10.3109/07853890.2010.484026 · Cited by 23 · see citing works
Eicosapentaenoic acid improves glycemic control in elderly bedridden patients with type 2 diabetes
Ogawa, S., Abe, T., Nako, K., Okamura, M., Senda, M., Sakamoto, T., Ito, S., & the DIMS study group (2013) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.231.63 · Cited by 22 · see citing works
Lei, D., Yu, Y., Kuang, Y., Liu, J., Krauss, R. M., & Ren, G. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.12.004 · Cited by 22 · see citing works
Maki, K. C., Lawless, A. L., Kelley, K., Dicklin, M. R., Schild, A. L., & Rains, T. M. (2011) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2011.06.005 · Cited by 21 · see citing works
Raatz, S. K., Johnson, L. K., Rosenberger, T. A., & Picklo, M. J. (2016) · Nutrition Research · doi:10.1016/j.nutres.2016.06.011 · Cited by 21 · see citing works
Acute consumption of fish oil improves postprandial VLDL profiles in healthy men aged 50–65 years
Burdge, G. C., Powell, J. R., Dadd, T., Talbot, D., Civil, J., & Calder, P. C. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114508143550 · Cited by 21 · see citing works
Dietary, Physiological, and Genetic Impacts on Postprandial Lipid Metabolism
López‐Miranda, J., & Marı́n, C. (2009) · Frontiers in neuroscience · doi:10.1201/9781420067767-c17 · Cited by 21 · see citing works
EFSA Panel on Dietetic Products, N. A. A. (. (2010) · EFSA Journal · doi:10.2903/j.efsa.2010.1734 · Cited by 21 · see citing works
Weekday variation in triglyceride concentrations in 1.8 million blood samples
Jaskolowski, J., Ritz, C., Sjödin, A., Astrup, A., Szecsi, P. B., Stender, S., & Hjorth, M. F. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m074062 · Cited by 20 · see citing works
Ouellette, C., Rudkowska, I., Lemieux, S., Lamarche, B., Couture, P., & Vohl, M. (2014) · Lipids in Health and Disease · doi:10.1186/1476-511x-13-86 · Cited by 20 · see citing works
Fedor, D. M., Adkins, Y. C., Mackey, B. E., & Kelley, D. S. (2012) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2011.0113 · Cited by 19 · see citing works
Self-citationYang, Y., Deng, W., Wang, Y., Li, T., Chen, Y., Long, C., Wen, Q., Wu, Y., & Chen, Q. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1039056 · Cited by 18 · see citing works
Balogun, K. A., Randunu, R. S., & Cheema, S. K. (2014) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2014.05.002 · Cited by 18 · see citing works
Sørensen, G. V. B., Svensson, M. H. S., Strandhave, C., Schmidt, E. B., Jørgensen, K. A., & Christensen, J. H. (2015) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2015.01.021 · Cited by 18 · see citing works
Hartwich, J., Malczewska-Malec, M., Partyka, Ł., Pérez‐Martínez, P., Marı́n, C., López‐Miranda, J., Tierney, A. C., Monagle, J. M., Roche, H. M., Defoort, C., et al. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.04.016 · Cited by 18 · see citing works
Dyslipidemia Induced by Drugs Used for the Prevention and Treatment of Vascular Diseases
Τζιόμαλος, Κ., Athyros, V. G., Karagiannis, A. I., & Mikhailidis, D. P. (2011) · The Open Cardiovascular Medicine Journal · doi:10.2174/1874192401105010085 · Cited by 18 · see citing works
Dias, C. B., Amigó, N., Wood, L. G., Correig, X., & Garg, M. L. (2017) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2017.56 · Cited by 18 · see citing works
Richter, M., Baumgartner, J., Wentzel‐Viljoen, E., & Smuts, C. M. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.01.023 · Cited by 16 · see citing works
Vekić, J., Zeljković, A., Stefanović, A., Bogavac‐Stanojević, N., Ilias, Ι., Silva‐Nunes, J., Stoian, A. P., Janež, A., & Rizzo, M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14040825 · Cited by 16 · see citing works
Natale, C. D., Minerva, V., Patti, L., Mazzarella, R., Ciano, O., Maione, S., Luongo, D., Naviglio, D., Marotta, G., Turco, S., et al. (2012) · Journal of the American College of Nutrition · doi:10.1080/07315724.2012.10720427 · Cited by 15 · see citing works
Pishva, H., Mahboob, S., Mehdipour, P., Eshraghian, M. R., Asl, J. M., Hosseini, S., & Karimi, F. (2010) · Nutrition · doi:10.1016/j.nut.2009.09.028 · Cited by 15 · see citing works
Omega-3 fatty acids: How can they be used in secondary prevention?
Τζιόμαλος, Κ., Athyros, V. G., Karagiannis, A. I., & Mikhailidis, D. P. (2008) · Current Atherosclerosis Reports · doi:10.1007/s11883-008-0079-y · Cited by 15 · see citing works
McCann, J. C., Shigenaga, M. K., Mietus‐Snyder, M., Lal, A., Suh, J. H., Krauss, R. M., Gildengorin, G. L., Goldrich, A., Block, D. S., Shenvi, S. V., et al. (2015) · The FASEB Journal · doi:10.1096/fj.15-271833 · Cited by 14 · see citing works
- Authors
- Kelley, D. S., Siegel, D., Vemuri, M., & Mackey, B. E.
- Affiliations
- Agricultural Research Service (US)
- Corresponding author
- Kelley, Darshan S
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 86
- Issue
- 2
- Pages
- 324-333
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W1937978193
- Cited by
- 179
- References
- 50
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 8 · 2019: 5 · 2018: 9 · 2017: 6 · 2016: 8 · 2015: 17 · 2014: 16 · 2013: 15 · 2012: 12
- FWCI
- 13.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture (UL1 RR024146)
- National Institutes of Health (RR024146)
- Agricultural Research Service
- National Center for Research Resources (RR-024146, UL1RR024146)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- docosahexaenoic acid, omega-3 supplementation, hypertriglyceridemia, lipoprotein particle size, VLDL particles, LDL cholesterol, HDL cholesterol, small dense LDL, postprandial lipemia, triglycerides, apolipoproteins, olive oil placebo, cardiovascular health
- MeSH terms
- Adult, Aged, Docosahexaenoic Acids, Double-Blind Method, Fasting, Humans, Lipids, Lipoproteins, Lipoproteins, HDL, Lipoproteins, LDL, Cholesterol, LDL, Lipoproteins, VLDL, Male, Middle Aged, Placebos, Triglycerides, Hypertriglyceridemia, Patient Selection, Postprandial Period, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review