Testosterone use in men with sexual dysfunction: a systematic review and meta-analysis of randomized placebo-controlled trials
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Testosterone replacement increases libido, sexual motivation and sexual function, mood, sense of well-being, concentration, self-reported sense of energy, muscle mass and strength, and recovery of anemia related to testosterone deficiency.
“T replacement increases libido, sexual motivation and sexual function (134,135,138-143), mood (144), sense of well being, concentration (135,139,143,145-147), self-reported sense of energy (134,135), muscle mass and strength (132,148,149), and the recovery of anemia related to T deficiency (134).”
From Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [144]
Cites
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763 · see citing works
Impotence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study
Feldman, H. A., Goldstein, I., Hatzichristou, D. G., Krane, R. J., & McKinlay, J. B. (1994) · Journal of Urology · doi:10.1016/s0022-5347(17)34871-1 · Cited by 5,074 · see citing works
Moher, D., Cook, D. J., Eastwood, S., Olkin, I., Rennie, D., & Stroup, D. F. (1999) · The Lancet · doi:10.1016/s0140-6736(99)04149-5 · Cited by 4,826 · see citing works
Interaction revisited: the difference between two estimates.
Altman, D. G., & Bland, J. M. (2003) · BMJ · doi:10.1136/bmj.326.7382.219 · Cited by 3,203 · see citing works
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., & Blackman, M. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7219 · Cited by 2,760 · see citing works
Measuring Health-Related Quality of Life
Guyatt, G., Feeny, D., & Patrick, D. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-118-8-199304150-00009 · Cited by 2,168 · see citing works
The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications
Kaufman, J. M., & Vermeulen, A. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0013 · Cited by 1,079 · see citing works
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2847 · Cited by 965 · see citing works
Self-citationBacon, C. G., Mittleman, M. A., Kawachi, I., Giovannucci, E., Glasser, D. B., & Rimm, E. B. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-3-200308050-00005 · Cited by 832 · see citing works
Calof, O. M., Singh, A. B., Lee, M. L., Kenny, A. M., Urban, R. J., Tenover, J. L., & Bhasin, S. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.11.1451 · Cited by 728 · see citing works
Isidori, A. M., Giannetta, E., Greco, E. A., Gianfrilli, D., Bonifacio, V., Isidori, A., Lenzi, A., & Fabbri, A. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02339.x · Cited by 695 · see citing works
Decision aids for people facing health treatment or screening decisions
O'Connor, A. M. C., Bennett, C. L., Stacey, D., Barry, M. J., Col, N. F., Eden, K., Entwistle, V. A., Fiset, V., Holmes-Rovner, M. M., Khangura, S. D., et al. (2003) · doi:10.1002/14651858.cd001431 · Cited by 662 · see citing works
Effect of Testosterone Treatment on Bone Mineral Density in Men Over 65 Years of Age
Snyder, P. J. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.6.1966 · Cited by 460 · see citing works
SHABSIGH, R., KAUFMAN, J. M., STEIDLE, C., & PADMA-NATHAN, H. (2004) · Journal of Urology · doi:10.1097/01.ju.0000132389.97804.d7 · Cited by 406 · see citing works
Steidle, C. P., Schwartz, S. L., Jacoby, K., Sebree, T. B., Smith, T. P. L., & Bachand, R. T. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021058 · Cited by 406 · see citing works
Boyanov, M. A., Boneva, Z., & Christov, V. G. (2003) · The Aging Male · doi:10.1080/tam.6.1.1.7 · Cited by 381 · see citing works
Aversa, A., Isidori, A. M., Spera, G., Lenzi, A., & Fabbri, A. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01764.x · Cited by 343 · see citing works
KWAN, M., GREENLEAF, W. J., MANN, J., CRAPO, L., & DAVIDSON, J. M. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-3-557 · Cited by 339 · see citing works
Skakkebæk, N. E., Bancroft, J., DAVIDSON, D. W., & Warner, P. (1981) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1981.tb00364.x · Cited by 335 · see citing works
The n-of-1 Randomized Controlled Trial: Clinical Usefulness
Guyatt, G., Keller, J. L., Jaeschke, R., Rosenbloom, D., Adachi, J. D., & Newhouse, M. T. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-4-293 · Cited by 320 · see citing works
Changes in erectile responsiveness during androgen replacement therapy
Bancroft, J., & Wu, F. C. W. (1983) · Archives of Sexual Behavior · doi:10.1007/bf01542116 · Cited by 288 · see citing works
Testosterone supplementation therapy for older men: potential benefits and risks
Gruenewald, D. A., & Matsumoto, A. M. (2003) · Journal of the American Geriatrics Society · doi:10.1034/j.1601-5215.2002.51018.x · Cited by 279 · see citing works
TESTOSTERONE SUPPLEMENTATION FOR ERECTILE DYSFUNCTION: RESULTS OF A META-ANALYSIS
Jain, P., RADEMAKER, A. W., & McVary, K. T. (2000) · The Journal of Urology · doi:10.1016/s0022-5347(05)67363-6 · Cited by 200 · see citing works
Testosterone Therapy for Low Sexual Interest and Erectile Dysfunction in Men: a Controlled Study
O'Carroll, R., & Bancroft, J. (1984) · British Journal of Psychiatry · doi:10.1192/bjp.145.2.146 · Cited by 188 · see citing works
Publication Bias: A Brief Review for Clinicians
Montori, V. M., Smieja, M., & Guyatt, G. H. (2000) · Mayo Clinic Proceedings · doi:10.4065/75.12.1284 · Cited by 169 · see citing works
Self-citationMethodologic Issues in Systematic Reviews and Meta-Analyses
Montori, V. M., Swiontkowski, M. F., & Cook, D. J. (2003) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000079322.41006.5b · Cited by 146 · see citing works
Self-citationPatients at the center: In our practice, and in our use of language
Gordon Guyatt, M., Montori, V. M., Devereaux, P. J., Schünemann, H. J., & Bhandari, M. (2004) · ACP Journal Club · doi:10.7326/acpjc-2004-140-1-a11 · Cited by 143 · see citing works
Self-citationRelationship of Serum Testosterone to Sexual Activity in Healthy Elderly Men
Tsitouras, P. D., Martin, C. E., & Harman, S. M. (1982) · Journal of Gerontology · doi:10.1093/geronj/37.3.288 · Cited by 134 · see citing works
Holmäng, S., Mårin, P., Lindstedt, G., & Hedelin, H. H. (1993) · The Prostate · doi:10.1002/pros.2990230203 · Cited by 133 · see citing works
Effect of Testosterone Administration on Sexual Behavior and Mood in Men with Erectile Dysfunction
Schiavi, R. C., White, D., Mandeli, J., & Levine, A. C. (1997) · Archives of Sexual Behavior · doi:10.1023/a:1024518730222 · Cited by 122 · see citing works
Cavallini, G., Caracciolo, S., Vitali, G., Modenini, F., & Biagiotti, G. (2004) · Urology · doi:10.1016/j.urology.2003.11.009 · Cited by 120 · see citing works
Seftel, A. D., Mack, R. J., Secrest, A. R., & Smith, T. M. (2004) · Journal of Andrology · doi:10.1002/j.1939-4640.2004.tb03169.x · Cited by 108 · see citing works
Effects of androgen treatment in impotent men with normal and low levels of free testosterone
Carani, C., Zini, D., Augusto, B., Casa, L. D., Ghizzani, A., & Marrama, P. (1990) · Archives of Sexual Behavior · doi:10.1007/bf01541548 · Cited by 98 · see citing works
Dobs, A. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.1.33 · Cited by 79 · see citing works
Benkert, O., Witt, W. D., Adam, W., & Leitz, A. (1979) · Archives of Sexual Behavior · doi:10.1007/bf01541414 · Cited by 70 · see citing works
THERAPEUTIC EFFECTIVENESS OF ORAL TESTOSTERONE
Johnsen, S., Bennett, E. P., & Jensen, V. G. (1974) · The Lancet · doi:10.1016/s0140-6736(74)90216-5 · Cited by 67 · see citing works
Aydın, S., Odabaş, Ö., Ercan, M., Kara, H., & Ağargün, M. (1996) · British Journal of Urology · doi:10.1046/j.1464-410x.1996.86316.x · Cited by 50 · see citing works
Chronic testosterone cypionate therapy in men with secondary impotence
Nankin, H. R., Lin, T., & Osterman, J. (1986) · Fertility and Sterility · doi:10.1016/s0015-0282(16)49529-4 · Cited by 46 · see citing works
A simple method for converting an odds ratio to effect size for use in meta-analysis
Chinn, S. (2000) · Statistics in Medicine · doi:10.1002/1097-0258(20001130)19:22
Flagged first, then by citations
Cited by
Sorted by citations
GRADE guidelines: 4. Rating the quality of evidence—study limitations (risk of bias)
Guyatt, G. H., Oxman, A. D., Vist, G., Kunz, R., Brozek, J., Alonso-Coello, P., Montori, V., Akl, E. A., Djulbegovic, B., & Falck-Ytter, Y. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.07.017 · Cited by 2,798 · see citing works
Self-citationBhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2354 · Cited by 1,954 · see citing works
Self-citationVigen, R. (2013) · JAMA · doi:10.1001/jama.2013.280386 · Cited by 1,003 · see citing works
Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline
Fleseriu, M., Hashim, I. A., Karavitaki, N., Melmed, S., Murad, M. H., Salvatori, R., & Samuels, M. H. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2118 · Cited by 945 · see citing works
Erectile dysfunction: AUA guideline
Burnett, A. L., Nehra, A., Breau, R. H., Culkin, D. J., Faraday, M. M., Hakim, L. S., Heidelbaugh, J., Khera, M., McVary, K. T., Miner, M. M., et al. (2018) · Journal of Urology · doi:10.1016/j.juro.2018.05.004 · Cited by 949 · see citing works
Wang, C., Jackson, G., Jones, T. H., Matsumoto, A. M., Nehra, A., Perelman, M. A., Swerdloff, R. S., Traish, A., Zitzmann, M., & Cunningham, G. (2011) · Diabetes Care · doi:10.2337/dc10-2339 · Cited by 366 · see citing works
Basaria, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61126-5 · Cited by 328 · see citing works
Testosterone supplementation and sexual function: A meta-analysis study
Corona, G., Isidori, A. M., Buvat, J., Aversa, A., Rastrelli, G., Hackett, G., Rochira, V., Sforza, A., Lenzi, A., Mannucci, E., et al. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12536 · Cited by 263 · see citing works
Endocrine Aspects of Male Sexual Dysfunctions
Buvat, J., Maggi, M., Gooren, L., Guay, A. T., Kaufman, J., Morgentaler, A., Schulman, C., Tan, H. M., Torres, L. O., Yassin, A., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01780.x · Cited by 221 · see citing works
Testosterone Treatment and Sexual Function in Older Men With Low Testosterone Levels
Cunningham, G. R., Stephens-Shields, A. J., Rosen, R. C., Wang, C., Bhasin, S., Matsumoto, A. M., Parsons, J. K., Gill, T. M., Molitch, M. E., Farrar, J. T., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1645 · Cited by 162 · see citing works
Risks and benefits of testosterone therapy in older men
Spitzer, M., Huang, G., Basaria, S., Travison, T. G., & Bhasin, S. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.73 · Cited by 154 · see citing works
Ponce, O. J., Spencer-Bonilla, G., Alvarez-Villalobos, N., Serrano, V., Singh-Ospina, N., Rodriguez-Gutierrez, R., Salcido-Montenegro, A., Benkhadra, R., Prokop, L. J., Bhasin, S., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00404 · Cited by 148 · see citing works
Giltay, E. J., Tishova, Y. A., Mskhalaya, G. J., Gooren, L. J. G., Saad, F., & Kalinchenko, S. Y. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01859.x · Cited by 140 · see citing works
Traish, A. M., Haider, A., Haider, K. S., Doros, G., & Saad, F. (2017) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248417691136 · Cited by 130 · see citing works
Sexual function of the ageing male
Corona, G., Rastrelli, G., Maseroli, E., Forti, G., & Maggi, M. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.05.007 · Cited by 121 · see citing works
Why Is Androgen Replacement in Males Controversial?
Cunningham, G. R., & Toma, S. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0266 · Cited by 111 · see citing works
Testosterone replacement therapy: for whom, when and how?
Tsametis, C. P., & Isidori, A. M. (2018) · Metabolism · doi:10.1016/j.metabol.2018.03.007 · Cited by 96 · see citing works
Male late-onset hypogonadism: pathogenesis, diagnosis and treatment
Huhtaniemi, I., & Forti, G. (2011) · Nature Reviews Urology · doi:10.1038/nrurol.2011.47 · Cited by 88 · see citing works
Veldhuis, J. D., Liu, P. Y., Keenan, D. M., & Takahashi, P. Y. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00450.2011 · Cited by 48 · see citing works
Testosterone administration in older men
Matsumoto, A. M. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.02.011 · Cited by 32 · see citing works
Melehan, K. L., Hoyos, C. M., Yee, B. J., Wong, K. K., Buchanan, P. R., Grunstein, R. R., & Liu, P. Y. (2016) · Andrology · doi:10.1111/andr.12132 · Cited by 26 · see citing works
Testosterone therapy in older men with late-onset hypogonadism: a counter-rationale
Basaria, S. (2013) · Endocrine Practice · doi:10.4158/ep13318.ra · Cited by 18 · see citing works
- Authors
- Boloña, E. R., Uraga, M. V., Haddad, R. M., Tracz, M. J., Sideras, K., Kennedy, C. C., Caples, S. M., Erwin, P. J., & Montori, V. M.
- Affiliations
- Mayo Clinic (US)
- Venue
- Mayo Clinic Proceedings
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 82
- Issue
- 1
- Pages
- 20-28
- ISSN
- 0025-6196 (ISSN-L)
- OpenAlex
- W4240786588
- Cited by
- 184
- References
- 39
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 9 · 2021: 2 · 2020: 6 · 2019: 11 · 2018: 10 · 2017: 13 · 2016: 13 · 2015: 9 · 2014: 17 · 2013: 23 · 2012: 9
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mayo Clinic Proceedings (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- testosterone replacement therapy, male sexual dysfunction, erectile function, sexual desire, sexual satisfaction, androgen deficiency
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review