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In vivo dynamics of innate immune sentinels in the CNS
Open accessAbstract
The innate immune system is comprised of cellular sentinels that often serve as the first responders to injury and invading pathogens. Our basic understanding of innate immunity is derived from research conducted in peripheral lymphoid tissues. However, it is now recognized that most non-lymphoid tissues throughout the body are equipped with specialized innate immune cells that are uniquely adapted to the niches in which they reside. The central nervous system (CNS) is a particularly interesting compartment because it contains a population of post-mitotic cells (neurons) that are intolerant of robust, cytopathic inflammatory responses observed in many peripheral tissues. Thus, evolutionary adaptations have fitted the CNS with a unique array of innate immune sentinels that facilitate the development of local inflammatory responses but attempt to do so in a manner that preserves the integrity of its post-mitotic residents. Interestingly, studies have even suggested that CNS resident innate immune cells contribute to the homeostasis of this compartment and promote neural activity. In this review we discuss recent advances in our understanding of CNS innate immune sentinels and how novel imaging approaches such as intravital two-photon laser scanning microscopy (TPLSM) have shed light on these cells during states of health and disease.
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“Immune surveillance and the initiation of CNS immune responses is dependent on antigen-presenting cells (APCs) that reside alongside important barriers such as perivascular spaces, leptomeningeal vessels, the choroid plexus, and the subarachnoid space (65-68).”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [68]
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Cites
Two-photon laser scanning fluorescence microscopy
Denk, W., Strickler, J. H., & Webb, W. W. (1990) · Science · doi:10.1126/science.2321027 · Cited by 9,488
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
ATP mediates rapid microglial response to local brain injury in vivo
Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913
Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504
A guide to choosing fluorescent proteins
Shaner, N. C., Steinbach, P. A., & Tsien, R. Y. (2005) · Nature Methods · doi:10.1038/nmeth819 · Cited by 2,823
Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632
Water-Soluble Quantum Dots for Multiphoton Fluorescence Imaging in Vivo
Larson, D. R., Zipfel, W. R., Williams, R. M., Clark, S. W., Bruchez, M. P., Wise, F. W., & Webb, W. W. (2003) · Science · doi:10.1126/science.1083780 · Cited by 2,290
Research works printed but not linked: 2
- 10.1073/pnas.95.26.15741 · DOI · Paper page
- Claudio L, 1994, Lab Invest, 70, 850
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Nayak, D., Roth, T. L., & McGavern, D. B. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120240 · Cited by 1,154
Self-citationInflammation and neuroprotection in traumatic brain injury.
Corps, K. N., Roth, T. L., & McGavern, D. B. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2014.3558 · Cited by 853
Self-citationNeuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift
Jassam, Y. N., Izzy, S., Whalen, M., McGavern, D. B., & El Khoury, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.010 · Cited by 799
Self-citationThe Gut–Brain Axis and the Microbiome: Mechanisms and Clinical Implications
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Rea, K., Dinan, T. G., & Cryan, J. F. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.03.001 · Cited by 508
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Kierdorf, K., Masuda, T., Jordão, M. J. C., & Prinz, M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0201-x · Cited by 416
González, H., Elgueta, D., Montoya, A., & Pacheco, R. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.07.012 · Cited by 352
Myeloid Cells in the Central Nervous System
Herz, J., Filiano, A. J., Wiltbank, A. T., Yogev, N., & Kipnis, J. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.007 · Cited by 345
The anatomy and immunology of vasculature in the central nervous system
Mastorakos, P., & McGavern, D. (2019) · Science Immunology · doi:10.1126/sciimmunol.aav0492 · Cited by 333
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Rua, R., & McGavern, D. B. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.04.003 · Cited by 326
Self-citationMatt, S. M., & Gaskill, P. J. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09851-4 · Cited by 293
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Umpierre, A. D., & Wu, L. (2021) · Glia · doi:10.1002/glia.23961 · Cited by 237
Leukocyte migration in the interstitial space of non-lymphoid organs
Weninger, W., Biro, M., & Jain, R. (2014) · Nature reviews. Immunology · doi:10.1038/nri3641 · Cited by 226
Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone
Filosa, J. A., Morrison, H. W., Iddings, J. A., Du, W., & Kim, K. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.064 · Cited by 222
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Jacob, L., Brito, J. M., Lenck, S., Corcy, C., Benbelkacem, F., Geraldo, L. H., Xu, Y., Thomas, J.-M., Kamouh, M.-R. E., Spajer, M., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220035 · Cited by 206
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“These cells provide critical surveillance of the CNS under steady-state conditions and are the first cells to detect foreign pathogens or tissue damage and initiate an immunological intervention [6].”
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Bosco, A., Romero, C. O., Breen, K., Chagovetz, A. A., Steele, M. R., Ambati, B. K., & Vetter, M. L. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.018788 · Cited by 160
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Imaging cell biology in live animals: Ready for prime time
Weigert, R., Porat‐Shliom, N., & Amornphimoltham, P. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201212130 · Cited by 124
McMenamin, P. G., Saban, D. R., & Dando, S. J. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.12.002 · Cited by 115
Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects
Cardoso, F. L., Herz, J., Fernandes, A., Rocha, J., Sepodes, B., Brito, M. A., McGavern, D. B., & Brites, D. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0299-3 · Cited by 103
Self-citationActivation of pial and dural macrophages and dendritic cells by cortical spreading depression
Schain, A. J., Melo‐Carrillo, A., Borsook, D., Grutzendler, J., Strassman, A. M., & Burstein, R. (2018) · Annals of Neurology · doi:10.1002/ana.25169 · Cited by 108
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Sun, R., & Jiang, H. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03059-x · Cited by 120
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Buckley, M. W., & McGavern, D. B. (2022) · Immunological Reviews · doi:10.1111/imr.13066 · Cited by 107
Self-citationDorand, R. D., Barkauskas, D. S., Evans, T. A., Petrošiūtė, A., & Huang, A. Y.-C. (2014) · IntraVital · doi:10.4161/intv.29728 · Cited by 88
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Self-citationThe meningeal lymphatic vasculature in neuroinflammation
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Self-citationTritz, Z. P., Orozco, R. C., Malo, C. S., Ayasoufi, K., Fain, C. E., Khadka, R. H., Goddery, E. N., Yokanovich, L. T., Settell, M. L., Hansen, M. J., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000340 · Cited by 16
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McGavern, P. A. S. I. A. D. B. (2015) · CRC Press eBooks · doi:10.1201/b19299-5 · Cited by 13
Luo, Y., Chen, X., Wei, C., Zhang, H., Zhang, L., Han, L., Sun, K., Li, B., & Wen, S. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.926572 · Cited by 13
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Metadata
- Authors
- Nayak, D., Zinselmeyer, B. H., Corps, K. N., & McGavern, D. B.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- McGavern, Dorian B.
- Venue
- IntraVital
- Publisher
- Informa UK Limited
- Published
- 2012-10
- Volume
- 1
- Issue
- 2
- Pages
- 95-106
- ISSN
- 2165-9079 (ISSN-L)
- 2165-9087
- PMC
- PMC3784260
- OpenAlex
- W1965769215
- Cited by
- 109
- References
- 104
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 8 · 2023: 10 · 2022: 16 · 2021: 8 · 2020: 7 · 2019: 10 · 2018: 10 · 2017: 6 · 2016: 6 · 2015: 14 · 2014: 6 · 2013: 3
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- IntraVital (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (ZIANS003112)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- innate immunity, central nervous system, neuroinflammation, intravital imaging, two-photon microscopy, CNS homeostasis, neuroimmune interactions, postmitotic neurons, neuroinflammation imaging
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