Cited by 112Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disordersNeuroscience and Neuropharmacology Research

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In vivo dynamics of innate immune sentinels in the CNS

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Nayak, Debasis, Zinselmeyer, Bernd H., Corps, Kara N., McGavern, Dorian B.·2012·IntraVital

DOI 10.4161/intv.22823PMC PMC3784260

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Abstract

The innate immune system is comprised of cellular sentinels that often serve as the first responders to injury and invading pathogens. Our basic understanding of innate immunity is derived from research conducted in peripheral lymphoid tissues. However, it is now recognized that most non-lymphoid tissues throughout the body are equipped with specialized innate immune cells that are uniquely adapted to the niches in which they reside. The central nervous system (CNS) is a particularly interesting compartment because it contains a population of post-mitotic cells (neurons) that are intolerant of robust, cytopathic inflammatory responses observed in many peripheral tissues. Thus, evolutionary adaptations have fitted the CNS with a unique array of innate immune sentinels that facilitate the development of local inflammatory responses but attempt to do so in a manner that preserves the integrity of its post-mitotic residents. Interestingly, studies have even suggested that CNS resident innate immune cells contribute to the homeostasis of this compartment and promote neural activity. In this review we discuss recent advances in our understanding of CNS innate immune sentinels and how novel imaging approaches such as intravital two-photon laser scanning microscopy (TPLSM) have shed light on these cells during states of health and disease.

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Authors: Nayak, D., Zinselmeyer, B. H., Corps, K. N., & McGavern, D. B.
Affiliations: National Institutes of Health (US)
Corresponding author: McGavern, Dorian B.
ORCID: Nayak, Debasis
Zinselmeyer, Bernd H.
Corps, Kara N.
McGavern, Dorian B.
Venue: IntraVital
Publisher: Informa UK Limited
Published: 2012-10
Volume: 1
Issue: 2
Pages: 95-106
ISSN: 2165-9079 (ISSN-L)
2165-9087
DOI: 10.4161/intv.22823
PMC: PMC3784260
OpenAlex: W1965769215
Cited by: 109
References: 104
Citations by year: 2026: 1 · 2025: 4 · 2024: 8 · 2023: 10 · 2022: 16 · 2021: 8 · 2020: 7 · 2019: 10 · 2018: 10 · 2017: 6 · 2016: 6 · 2015: 14 · 2014: 6 · 2013: 3
FWCI: 3.71
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: IntraVital (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Neurological Disorders and Stroke (ZIANS003112)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: innate immunity, central nervous system, neuroinflammation, intravital imaging, two-photon microscopy, CNS homeostasis, neuroimmune interactions, postmitotic neurons, neuroinflammation imaging

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In vivo dynamics of innate immune sentinels in the CNS

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