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Cited by 303

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Near-Infrared-II (NIR-II) Bioimaging via Off-Peak NIR-I Fluorescence Emission

Open access
Zhu, Shoujun, Yung, Bryant C., Chandra, Swati, Niu, Gang, Antaris, Alexander L., Chen, Xiaoyuan·2018·Theranostics

Abstract

biological imaging compared to tradition NIR fluorophores (~700-900 nm). However, the existing palette of NIR-II fluorescent agents including semiconducting inorganic nanomaterials and recently introduced small-molecule organic dyes face significant technical and regulatory hurdles prior to clinical translation. Fortunately, recent spectroscopic characterization of NIR-I dyes (e.g., indocyanine green (ICG), IRDye800CW and IR-12N3) revealed long non-negligible emission tails reaching past 1500 nm. Repurposing the most widely used NIR dye in medicine, in addition to those in the midst of clinical trials creates an accelerated pathway for NIR-II clinical translation. This review focuses on the significant advantage of imaging past 1000 nm with NIR-I fluorophores from both a basic and clinical viewpoint. We further discuss optimizing NIR-I dyes around their NIR-II/shortwave infrared (SWIR) emission, NIR-II emission tail characteristics and prospects of NIR-II imaging with clinically available and commercially available dyes.

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Metadata

Authors
Zhu, S., Yung, B. C., Chandra, S., Niu, G., Antaris, A. L., & Chen, X.
Venue
Theranostics
Published
2018
Volume
8
Issue
15
Pages
4141-4151
ISSN
1838-7640 (ISSN-L)
OpenAlex
W2886949120
Cited by
303
References
13
FWCI
19.37
Type
journal article
Language
en
Open access
gold

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Zhu, S., Yung, B. C., Chandra, S., Niu, G., Antaris, A. L., & Chen, X. (2018). Near-Infrared-II (NIR-II) Bioimaging via Off-Peak NIR-I Fluorescence Emission. Theranostics. https://doi.org/10.7150/thno.27995

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