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Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury
Open accessAbstract
MSC-exos exhibit preferential tropism to injured kidney and localize to proximal tubules in ischemic AKI. We demonstrate that MSC-exos ameliorate ischemic AKI and promote tubular repair by targeting the cell cycle arrest and apoptosis of TECs through miR-125b-5p/p53 pathway. This study provides a novel insight into the role of MSC-exos in renal tubule repair and highlights the potential of MSC-exos as a promising therapeutic strategy for AKI.
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Metadata
- Authors
- Cao, J.-Y., Wang, B., Tang, T.-T., Wen, Y., Li, Z.-L., Feng, S.-T., Wu, M., Liu, D., Yin, D., Ma, K.-L., Tang, R.-N., Wu, Q.-L., Lan, H.-Y., Lv, L.-L., & Liu, B.-C.
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2021
- Volume
- 11
- Issue
- 11
- Pages
- 5248-5266
- ISSN
- 1838-7640 (ISSN-L)
- OpenAlex
- W3139526136
- Cited by
- 303
- References
- 54
- FWCI
- 12.41
- Type
- journal article
- Language
- en
- Open access
- gold
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