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Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies

Selkoe, Dennis J.·2004·Annals of Internal Medicine

DOI 10.7326/0003-4819-140-8-200404200-00047

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Reviews20 April 2004Alzheimer Disease: Mechanistic Understanding Predicts Novel TherapiesDennis J. Selkoe, MDDennis J. Selkoe, MDFrom Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-8-200404200-00047 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Clinical PrinciplesAlzheimer disease usually begins with gradual failure of recent memory with preserved alertness and motor function.The syndrome of minimal cognitive impairment (mild cognitive impairment)—a subtle decrease in short-term declarative memory with otherwise normal cognition—is often a harbinger of Alzheimer disease.Alzheimer disease progresses slowly to involve many cognitive spheres and shortens life expectancy, with most patients ultimately dying of secondary respiratory complications (for example, aspiration and pneumonia).Treatment with acetylcholinesterase inhibitors can temporarily alleviate some symptoms but does not modify disease progression.A noncompetitive N-methyl-d-aspartate–receptor antagonist (memantine) has recently been approved as a noncholinergic symptomatic treatment.Epidemiologic data suggest that long-term use of ...References1. Glenner GG, Wong CW. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem…

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Authors: Selkoe, D. J.
Affiliations: From Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.
Venue: Annals of Internal Medicine
Publisher: American College of Physicians
Published: 2004-04-20
Volume: 140
Issue: 8
Pages: 627-638
ISSN: 0003-4819
1539-3704
DOI: 10.7326/0003-4819-140-8-200404200-00047
Cited by: 208
References: 32
Language: en
Licence: www.acpjournals.org/journal/aim/text-and-data-mining (tdm)

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Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies

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