The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies
Abstract
Reviews20 April 2004Alzheimer Disease: Mechanistic Understanding Predicts Novel TherapiesDennis J. Selkoe, MDDennis J. Selkoe, MDFrom Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-8-200404200-00047 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Clinical PrinciplesAlzheimer disease usually begins with gradual failure of recent memory with preserved alertness and motor function.The syndrome of minimal cognitive impairment (mild cognitive impairment)—a subtle decrease in short-term declarative memory with otherwise normal cognition—is often a harbinger of Alzheimer disease.Alzheimer disease progresses slowly to involve many cognitive spheres and shortens life expectancy, with most patients ultimately dying of secondary respiratory complications (for example, aspiration and pneumonia).Treatment with acetylcholinesterase inhibitors can temporarily alleviate some symptoms but does not modify disease progression.A noncompetitive N-methyl-d-aspartate–receptor antagonist (memantine) has recently been approved as a noncholinergic symptomatic treatment.Epidemiologic data suggest that long-term use of ...References1. Glenner GG, Wong CW. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem…
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Metadata
- Authors
- Selkoe, D. J.
- Affiliations
- From Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 2004-04-20
- Volume
- 140
- Issue
- 8
- Pages
- 627-638
- ISSN
- 0003-4819
- 1539-3704
- Cited by
- 208
- References
- 32
- Language
- en
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