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Cited by 487

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Low Serum Testosterone and Mortality in Male Veterans

Shores, Molly M., Matsumoto, Alvin M., Sloan, Kevin L., Kivlahan, Daniel R.·2006·Archives of Internal Medicine
DOI 10.1001/archinte.166.15.1660
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Abstract

BACKGROUND: Low serum testosterone is a common condition in aging associated with decreased muscle mass and insulin resistance. This study evaluated whether low testosterone levels are a risk factor for mortality in male veterans. METHODS: We used a clinical database to identify men older than 40 years with repeated testosterone levels obtained from October 1, 1994, to December 31, 1999, and without diagnosed prostate cancer. A low testosterone level was a total testosterone level of less than 250 ng/dL (<8.7 nmol/L) or a free testosterone level of less than 0.75 ng/dL (<0.03 nmol/L). Men were classified as having a low testosterone level (166 [19.3%]), an equivocal testosterone level (equal number of low and normal levels) (240 [28.0%]), or a normal testosterone level (452 [52.7%]). The risk for all-cause mortality was estimated using Cox proportional hazards regression models, adjusting for demographic and clinical covariates over a follow-up of up to 8 years. RESULTS: Mortality in men with normal testosterone levels was 20.1% (95% confidence interval [CI], 16.2%-24.1%) vs 24.6% (95% CI, 19.2%-30.0%) in men with equivocal testosterone levels and 34.9% (95% CI, 28.5%-41.4%) in men with low testosterone levels. After adjusting for age, medical morbidity, and other clinical covariates, low testosterone levels continued to be associated with increased mortality (hazard ratio, 1.88; 95% CI, 1.34-2.63; P<.001) while equivocal testosterone levels were not significantly different from normal testosterone levels (hazard ratio, 1.38; 95% CI, 0.99%-1.92%; P=.06). In a sensitivity analysis, men who died within the first year (50 [5.8%]) were excluded to minimize the effect of acute illness, and low testosterone levels continued to be associated with elevated mortality. CONCLUSIONS: Low testosterone levels were associated with increased mortality in male veterans. Further prospective studies are needed to examine the association between low testosterone levels and mortality.

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Metadata

Authors
Shores, M. M., Matsumoto, A. M., Sloan, K. L., & Kivlahan, D. R.
Venue
Archives of Internal Medicine
Publisher
American Medical Association (AMA)
Published
2006-08-14
Volume
166
Issue
15
Pages
1660
ISSN
0003-9926 (ISSN-L)
DOI
10.1001/archinte.166.15.1660
OpenAlex
W2096861659
Cited by
487
References
9
FWCI
19.36
Type
journal article
Language
en
Open access
closed

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