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Cited by 603

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Physiological Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia: III. A New Cohort and Evidence for a Monoaminergic Mechanism

Weinberger, Daniel R.·1988·Archives of General Psychiatry
DOI 10.1001/archpsyc.1988.01800310013001
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Abstract

We previously reported that compared with normals, patients with chronic schizophrenia have reduced regional cerebral blood flow (rCBF) in dorsolateral prefrontal cortex (DLPFC) during performance of the Wisconsin Card Sort Test (WCS), a DLPFC-related cognitive task, but not during nonprefrontal tasks, such as a simple number-matching (NM) test. We also found that unlike normals, patients failed to activate DLPFC during the WCS over their own baseline (NM) level. To explore the reproducibility of these findings, a new cohort of 16 medication-free patients underwent a series of xenon 133 inhalation rCBF studies under the following conditions: at rest, while performing the WCS, and while performing NM. The results confirmed our earlier findings. In addition, the concentrations in cerebrospinal fluid of homovanillic acid and 5-hydroxyindoleacetic acid correlated with prefrontal rCBF during the WCS but not during the NM test or at rest. The results show that behavior-specific hypofunction of DLPFC in schizophrenia is reproducible, and they implicate a monoaminergic mechanism.

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Metadata

Authors
Weinberger, D. R.
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1988-07-01
Volume
45
Issue
7
Pages
609
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.1988.01800310013001
OpenAlex
W2095878413
Cited by
603
References
1
FWCI
29.46
Type
journal article
Language
en
Open access
closed

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