A Possible Role for the Striatum in the Pathogenesis of the Cognitive Symptoms of Schizophrenia
Open accessAbstract
The cognitive symptoms of schizophrenia are largely resistant to current treatment and are thus a life-long burden of the illness. Studies of cognitive symptoms have commonly focused on prefrontal cortex because of its demonstrated importance for executive function and working memory--key components of the deficit. The role of striatal-cortical circuitry and therefore the striatum itself has received much less attention. Here we review longstanding evidence that the striatum and its cortical connections are critical for complex cognition and discuss emerging evidence of the striatum's potential involvement in cognitive symptoms. Finally, we suggest how mouse models might test ideas about the contribution of early striatal dysfunction to the cognitive symptoms of schizophrenia.
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In morphometric MRI studies, decreased gray matter in the dorsolateral anterior cingulate cortex and striatum is suggestive of impairment in uncertainty adaptation and decision-making processes.
“In morphometric MRI studies, decreased gray matter in the dorsolateral anterior cingulate cortex and striatum is suggestive of impairment in uncertainty adaptation and decision-making processes (Baiano et al., 2007; McCutcheon et al., 2019; Simpson et al., 2010).”
From Predictive coding in neuropsychiatric disorders: a systematic transdiagnostic review. (2025) · cites this paper as Simpson et al., 2010
The sections on mouse models and altered subcortical dopamine report reduced frontal gray-matter volume in people at risk for schizophrenia and smaller caudate nuclei in never-medicated patients. “The Striatum Has an Important Role in Cognition” links the striatum to decision-making. The paper does not identify decreased gray matter in the dorsolateral anterior cingulate cortex or link those MRI findings to impaired uncertainty adaptation; page numbers were not available in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThe striatum has been highlighted as playing an important role in the pathogenesis of the cognitive symptoms of schizophrenia.
“Moreover, the striatum has been highlighted as playing an important role in the pathogenesis of the cognitive symptoms of schizophrenia [63].”
This mouse model may provide a link explaining how altered mesostriatal and mesolimbic DA receptors and DA transmission can alter cognitive processes in the frontal cortex, possibly by dysregulating circuit pathways linking the striatum and prefrontal cortex.
“this mouse model may provide a link explaining how altered mesostriatal and mesolimbic DA receptors and DA transmission can alter cognitive processes in the frontal cortex, possibly by dysregulating circuit pathways that link connectivity between the striatum and pre-frontal cortex [381].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [381]
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Cites
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527 · see citing works
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724 · see citing works
What are the functional consequences of neurocognitive deficits in schizophrenia?
(1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.3.321 · Cited by 3,516 · see citing works
Dementia Praecox and Paraphrenia.
(1972) · Annals of Internal Medicine · doi:10.7326/0003-4819-76-6-1058_8 · Cited by 2,906 · see citing works
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,374 · see citing works
A review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346 · see citing works
Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs
Creese, I., Burt, D. R., & Snyder, S. H. (1976) · Science · doi:10.1126/science.3854 · Cited by 2,220 · see citing works
Dopamine in schizophrenia: a review and reconceptualization
Davis, K. L., Kahn, R. S., Ko, G., & Davidson, M. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.11.1474 · Cited by 2,021 · see citing works
Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia
Weinberger, D. R. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800020020004 · Cited by 2,019 · see citing works
Habits, Rituals, and the Evaluative Brain
Graybiel, A. M. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112851 · Cited by 1,697 · see citing works
Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
Williams, G. V., & Goldman-Rakic, P. S. (1995) · Nature · doi:10.1038/376572a0 · Cited by 1,593 · see citing works
Control of memory formation through regulated expression of a CaMKII transgene
Mayford, M., Bach, M. E., Huang, Y.-Y., Wang, L., Hawkins, R. D., & Kandel, E. R. (1996) · Science · doi:10.1126/science.274.5293.1678 · Cited by 1,550 · see citing works
Self-citationCognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey
Brozoski, T. J., Brown, R. M., Rosvold, H. E., & Goldman, P. S. (1979) · Science · doi:10.1126/science.112679 · Cited by 1,500 · see citing works
Laruelle, M., Abi-Dargham, A., van Dyck, C. H., Gil, R., D'Souza, C. D., Erdos, J., McCance, E., Rosenblatt, W., Fingado, C., Zoghbi, S. S., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9235 · Cited by 1,291 · see citing works
Surmeier, D. J., Ding, J., Day, M., Wang, Z., & Shen, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.008 · Cited by 1,203 · see citing works
Putting a spin on the dorsal-ventral divide of the striatum
Voorn, P., Vanderschuren, L. J. M. J., Groenewegen, H. J., Robbins, T. W., & Pennartz, C. M. A. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.06.006 · Cited by 1,188 · see citing works
Breier, A., Su, T.-P., Saunders, R., Carson, R. E., Kolachana, B. S., de Bartolomeis, A., Weinberger, D. R., Weisenfeld, N., Malhotra, A. K., Eckelman, W. C., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2569 · Cited by 1,154 · see citing works
Keefe, R. S. E. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.6.633 · Cited by 1,072 · see citing works
Working memory dysfunction in schizophrenia
(1994) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.6.4.348 · Cited by 1,068 · see citing works
Allen, N. C., Bagade, S., McQueen, M. B., Ioannidis, J. P. A., Kavvoura, F. K., Khoury, M. J., Tanzi, R. E., & Bertram, L. (2008) · Nature Genetics · doi:10.1038/ng.171 · Cited by 1,054 · see citing works
The Basal Ganglia and Chunking of Action Repertoires
Graybiel, A. M. (1998) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1998.3843 · Cited by 1,042 · see citing works
Increased baseline occupancy of D <sub>2</sub> receptors by dopamine in schizophrenia
Abi-Dargham, A., Rodenhiser, J., Printz, D., Zea-Ponce, Y., Gil, R., Kegeles, L. S., Weiss, R., Cooper, T. B., Mann, J. J., Van Heertum, R. L., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.14.8104 · Cited by 1,020 · see citing works
Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
Vijayraghavan, S., Wang, M., Birnbaum, S. G., Williams, G. V., & Arnsten, A. F. T. (2007) · Nature Neuroscience · doi:10.1038/nn1846 · Cited by 1,013 · see citing works
Fuster, J. M. (1973) · Journal of Neurophysiology · doi:10.1152/jn.1973.36.1.61 · Cited by 995 · see citing works
Central Catecholamine Neuron Systems: Anatomy and Physiology of the Dopamine Systems
Moore, R. Y., & Bloom, F. E. (1978) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.01.030178.001021 · Cited by 931 · see citing works
Positron Emission Tomography Reveals Elevated D 2 Dopamine Receptors in Drug-Naive Schizophrenics
Wong, D. F., Wagner, H. N., Tune, L. E., Dannals, R. F., Pearlson, G. D., Links, J. M., Tamminga, C. A., Broussolle, E., Ravert, H. T., Wilson, A. A., et al. (1986) · Science · doi:10.1126/science.2878495 · Cited by 928 · see citing works
Duan, J. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg055 · Cited by 916 · see citing works
Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort.
Abi-Dargham, A., Gil, R. B., Krystal, J., Baldwin, R., Seibyl, J., Bowers, M., van Dyck, C., Charney, D., Innis, R., & Laruelle, M. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.6.761 · Cited by 860 · see citing works
Building neural representations of habits.
Jog, M. S., Kubota, Y., Connolly, C. I., Hillegaart, V., & Graybiel, A. M. (1999) · Science · doi:10.1126/science.286.5445.1745 · Cited by 834 · see citing works
Elevated Striatal Dopamine Function Linked to Prodromal Signs of Schizophrenia
Howes, O. D., Montgomery, A. J., Asselin, M.-C., Murray, R. M., Valli, I., Tabraham, P., Bramon-Bosch, E., Valmaggia, L., Johns, L., Broome, M., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.514 · Cited by 744 · see citing works
Prefrontal Dopamine D<sub>1</sub>Receptors and Working Memory in Schizophrenia
Abi-Dargham, A., Mawlawi, O., Lombardo, I., Gil, R., Martinez, D., Huang, Y., Hwang, D.-R., Keilp, J., Kochan, L., Van Heertum, R., et al. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03708.2002 · Cited by 724 · see citing works
Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET
Okubo, Y., Suhara, T., Suzuki, K., Kobayashi, K., Inoue, O., Terasaki, O., Someya, Y., Sassa, T., Sudo, Y., Matsushima, E., et al. (1997) · Nature · doi:10.1038/385634a0 · Cited by 710 · see citing works
Brain receptors for antipsychotic drugs and dopamine: direct binding assays.
Seeman, P. M., Chau-Wong, M., Tedesco, J., & Wong, K. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.11.4376 · Cited by 702 · see citing works
Harrison, P. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1761-y · Cited by 693 · see citing works
Haber, S. N., Kim, K.-S., Mailly, P., & Calzavara, R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0271-06.2006 · Cited by 686 · see citing works
ABNORMALITIES OF CEREBRAL BLOOD FLOW DISTRIBUTION IN PATIENTS WITH CHRONIC SCHIZOPHRENIA
Ingvar, D. H., & FRANZÉN, G. (1974) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1974.tb09707.x · Cited by 663 · see citing works
Glahn, D. C., Ragland, J., Abramoff, A., Barrett, J., Laird, A. R., Bearden, C., & Velligan, D. (2005) · Human Brain Mapping · doi:10.1002/hbm.20138 · Cited by 660 · see citing works
Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia
Meyer-Lindenberg, A., Miletich, R. S., Kohn, P. D., Esposito, G., Carson, R. E., Quarantelli, M., Weinberger, D. R., & Berman, K. F. (2002) · Nature Neuroscience · doi:10.1038/nn804 · Cited by 652 · see citing works
The basal ganglia: learning new tricks and loving it
Graybiel, A. M. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.10.006 · Cited by 650 · see citing works
Physiological Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia
Weinberger, D. R. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800310013001 · Cited by 605 · see citing works
DEMENTIA PRAECOX AND PARAPHRENIA
Kraepelin, E. (1921) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-192110000-00104 · Cited by 605 · see citing works
Activity of striatal neurons reflects dynamic encoding and recoding of procedural memories
Barnes, T. D., Kubota, Y., Hu, D., Jin, D. Z., & Graybiel, A. M. (2005) · Nature · doi:10.1038/nature04053 · Cited by 595 · see citing works
Hikosaka, O., Sakamoto, M., & Usui, S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.4.814 · Cited by 579 · see citing works
Behavioral effects of selective ablation of the caudate nucleus.
Divac, I., Rosvold, H. E., & Szwarcbart, M. K. (1967) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0024348 · Cited by 568 · see citing works
Chakos, M., Lieberman, J. A., Bilder, R. M., Borenstein, M., Lerner, G., Bogerts, B., Wu, H., Kinon, B. J., & Ashtari, M. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.10.1430 · Cited by 557 · see citing works
Cerebral Glucography With Positron Tomography
Buchsbaum, M. S. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290030001001 · Cited by 535 · see citing works
Kellendonk, C., Simpson, E. H., Polan, H. J., Malleret, G., Vronskaya, S., Winiger, V., Moore, H., & Kandel, E. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.023 · Cited by 520 · see citing works
Self-citationChudasama, Y., & Robbins, T. W. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.01.005 · Cited by 484 · see citing works
Kolb, B. E., & Whishaw, I. Q. (1983) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198307000-00008 · Cited by 464 · see citing works
Rogers, R. D., Andrews, T. C., Grasby, P. M., Brooks, D. J., & Robbins, T. W. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/089892900561931 · Cited by 458 · see citing works
Neuromotor Precursors of Schizophrenia
Walker, E. F., Savoie, T. M., & Davis, D. (1994) · Schizophrenia Bulletin · doi:10.1093/schbul/20.3.441 · Cited by 445 · see citing works
The cognitive neuroscience of schizophrenia.
Barch, D. M. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143959 · Cited by 437 · see citing works
Roberts, A., De Salvia, M., Wilkinson, L., Collins, P., Muir, J., Everitt, B., & Robbins, T. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-05-02531.1994 · Cited by 415 · see citing works
Akil, M., Pierri, J. N., Whitehead, R. E., Edgar, C. L., Mohila, C., Sampson, A. R., & Lewis, D. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.10.1580 · Cited by 393 · see citing works
Highly restricted origin of prefrontal cortical inputs to striosomes in the macaque monkey
Eblen, F., & Graybiel, A. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-09-05999.1995 · Cited by 391 · see citing works
Heterosynaptic Dopamine Neurotransmission Selects Sets of Corticostriatal Terminals
Bamford, N. S., Zhang, H., Schmitz, Y., Wu, N.-P., Cepeda, C., Levine, M. S., Schmauss, C., Zakharenko, S. S., Zablow, L., & Sulzer, D. (2004) · Neuron · doi:10.1016/s0896-6273(04)00265-x · Cited by 373 · see citing works
The basal ganglia and cognitive pattern generators
Graybiel, A. M. (1997) · Schizophrenia Bulletin · doi:10.1093/schbul/23.3.459 · Cited by 351 · see citing works
Sanders, A. R., Duan, J., Levinson, D. F., Shi, J., He, D., Hou, C., Burrell, G. J., Rice, J. P., Nertney, D. A., Olincy, A., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07101573 · Cited by 349 · see citing works
Cirillo, M. A., & Seidman, L. J. (2003) · Neuropsychology Review · doi:10.1023/a:1023870821631 · Cited by 345 · see citing works
Elevated dopa decarboxylase activity in living brain of patients with psychosis
Reith, J., Benkelfat, C., Sherwin, A., Yasuhara, Y., Kuwabara, H., Andermann, F., Bachneff, S., Cumming, P., Diksic, M., & Dyve, S. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11651 · Cited by 342 · see citing works
Lindström, L., Gefvert, O., Hagberg, G., Lundberg, T., Bergström, M., Hartvig, P., & Långström, B. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00109-2 · Cited by 332 · see citing works
Psychosis pathways converge via D2High dopamine receptors
Seeman, P. M., Schwarz, J., Chen, J., Szechtman, H., Perreault, M. L., McKnight, G. S., Roder, J., Quirion, R., Boksa, P., Srivastava, L. K., et al. (2006) · Synapse · doi:10.1002/syn.20303 · Cited by 328 · see citing works
Presynaptic dopamine function in striatum of neuroleptic-naive schizophrenic patients
Hietala, J. A., Syvälahti, E. K. G., Kuoppamäki, M., Hietala, J., Syvälahti, E. K. G., Haaparanta‐Solin, M., Kuoppamäki, M., Ruotsalainen, U., Vuorio, K. A., Räkköläinen, V., et al. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91801-9 · Cited by 321 · see citing works
Regional Gray Matter Volume Abnormalities in the At Risk Mental State
Borgwardt, S., Riecher‐Rössler, A., Dazzan, P., Chitnis, X. A., Aston, J., Drewe, M., Gschwandtner, U., Haller, S., Pflueger, M. O., Rechsteiner, E., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.009 · Cited by 310 · see citing works
DISTRIBUTION OF CEREBRAL ACTIVITY IN CHRONIC SCHIZOPHRENIA
Ingvar, D. H., & FRANZÉN, G. (1974) · The Lancet · doi:10.1016/s0140-6736(74)90221-9 · Cited by 293 · see citing works
Changes in caudate volume with neuroleptic treatment
Keshavan, M. S. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90599-1 · Cited by 291 · see citing works
Imaging dopamine transmission in schizophrenia. A review and meta-analysis.
Laruelle, M. (1998) · PubMed · Cited by 280 · see citing works
Levy, R., Friedman, H. R., Davachi, L., & Goldman-Rakic, P. S. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03870.1997 · Cited by 279 · see citing works
Schizophrenia: More dopamine, more D <sub>2</sub> receptors
Seeman, P., & Kapur, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.14.7673 · Cited by 279 · see citing works
Barnett, J. H., Jones, P. B., Robbins, T. W., & Müller, U. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001973 · Cited by 274 · see citing works
Grauer, S. M., Pulito, V. L., Navarra, R. L., Kelly, M. P., Kelley, C., Graf, R., Langen, B., Logue, S. F., Brennan, J. A., Jiang, L., et al. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.155994 · Cited by 270 · see citing works
Bruder, G. E., Keilp, J. G., Xu, H., Shikhman, M., Schori, E., Gorman, J. M., & Gilliam, T. C. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.010 · Cited by 260 · see citing works
PYCOCK, C., Carter, C. J., & Kerwin, R. W. (1980) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1980.tb04625.x · Cited by 247 · see citing works
Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia
Hietala, J. A., Syvälahti, E. K. G., Vilkman, H., Vuorio, K. A., Räkköläinen, V., Bergman, J. R., Haaparanta‐Solin, M., Solin, O. H., Kuoppamäki, M., Eronen, E., et al. (1999) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00113-3 · Cited by 243 · see citing works
Bättig, K., Rosvold, H. E., & Mishkin, M. (1960) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0047392 · Cited by 236 · see citing works
Regional Brain Glucose Metabolism in Chronic Schizophrenia
Farkas, T. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1984.01790140083010 · Cited by 233 · see citing works
Positron Emission Tomography Studies of Abnormal Glucose Metabolism in Schizophrenia
Buchsbaum, M. S., & Hazlett, E. A. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033331 · Cited by 210 · see citing works
Berman, K. F., Illowsky, B. P., & Weinberger, D. R. (1988) · PubMed · doi:10.1001/archpsyc.1988.01800310020002 · Cited by 204 · see citing works
Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase
Zhi, X., Adamowicz, W. O., Eldred, W. D., et al. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.12.042 · Cited by 198 · see citing works
Decreased Caudate Volume in Neuroleptic-Naive Psychotic Patients
Keshavan, M. S., Rosenberg, D., Sweeney, J. A., & Pettegrew, J. W. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.6.774 · Cited by 196 · see citing works
COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PET
Slifstein, M., Kolachana, B. S., Simpson, E. H., Tabares, P., Cheng, B., Duvall, M., Frankle, W. G., Weinberger, D. R., Laruelle, M. A., & Abi‐Dargham, A. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.19 · Cited by 195 · see citing works
Self-citationStriatal Metabolic Rate and Clinical Response to Neuroleptics in Schizophrenia
Buchsbaum, M. S. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120054008 · Cited by 182 · see citing works
Calzavara, R., Mailly, P., & Haber, S. N. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05825.x · Cited by 170 · see citing works
Cross, A. J., Crow, T. J., & Owen, F. (1981) · Psychopharmacology · doi:10.1007/bf00432676 · Cited by 164 · see citing works
Increased Caudate Dopamine D2 Receptor Availability as a Genetic Marker for Schizophrenia
Hirvonen, J., van Erp, T. G. M., Huttunen, J., Aalto, S., Någren, K., HUTTUNEN, M. O., Lönnqvist, J. K., Kaprio, J. A., Hietala, J. A., & Cannon, T. D. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.4.371 · Cited by 161 · see citing works
A network of dopaminergic gene variations implicated as risk factors for schizophrenia.
Talkowski, M. E., Kirov, G., Bamne, M., Georgieva, L., Torres, G. E., Mansour, H. A., Chowdari, K., Milanova, V., Wood, J., McClain, L., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddm347 · Cited by 154 · see citing works
Shihabuddin, L., Buchsbaum, M. S., Hazlett, E. A., Haznedar, M. M., Harvey, P. D., Newman, A. C., Schnur, D. B., Spiegel-Cohen, J., Wei, T.-C., Macháč, J., et al. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.3.235 · Cited by 152 · see citing works
Neuroimaging of cognitive disability in schizophrenia: Search for a pathophysiological mechanism
Ragland, J. D., Yoon, J. H., Minzenberg, M., & Carter, C. S. (2007) · International Review of Psychiatry · doi:10.1080/09540260701486365 · Cited by 146 · see citing works
Prefrontal Cortical Projections to the Midbrain in Primates: Evidence for a Sparse Connection
Frankle, W., Laruelle, M., & Haber, S. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300990 · Cited by 141 · see citing works
Seidman, L. J., Pantelis, C., Keshavan, M. S., Faraone, S. V., Goldstein, J. M., Horton, N. J., Makris, N., Falkai, P., Caviness, V. S., & Tsuang, M. T. (2003) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007048 · Cited by 137 · see citing works
Cerebral Blood Flow and Mental Processes in Schizophrenia
Liddle, P. F., Friston, K. J., Frith, C., & Frackowiak, R. S. J. (1992) · Journal of the Royal Society of Medicine · doi:10.1177/014107689208500415 · Cited by 136 · see citing works
Modeling cognitive endophenotypes of schizophrenia in mice
Kellendonk, C., Simpson, E. H., & Kandel, E. R. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.02.003 · Cited by 134 · see citing works
Self-citationMittal, V. A., Neumann, C. S., Saczawa, M. E., & Walker, E. F. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.23 · Cited by 132 · see citing works
The associative striatum: Organization of cortical projections to the dorsocentral striatum in rats
Reep, R. L., Cheatwood, J. L., & Corwin, J. V. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10868 · Cited by 125 · see citing works
Betcheva‐Krajcir, E., Mushiroda, T., Takahashi, A., Kubo, M., Karachanak-Yankova, S., Zaharieva, I. T., Vazharova, R., Dimova, I. I., Milanova, V. K., Tolev, T., et al. (2009) · Journal of Human Genetics · doi:10.1038/jhg.2008.14 · Cited by 115 · see citing works
Historical Development of the Dopamine Hypothesis of Schizophrenia
Baumeister, A. A., & Francis, J. (2002) · Journal of the History of the Neurosciences · doi:10.1076/jhin.11.3.265.10391 · Cited by 106 · see citing works
Xu, H., Kellendonk, C., Simpson, E. H., Keilp, J. G., Bruder, G. E., Polan, H. J., Kandel, E. R., & Gilliam, T. C. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.10.001 · Cited by 100 · see citing works
Self-citationElsworth, J. D., Leahy, D. J., Roth, R. H., & Redmond, D. E. (1987) · Journal of Neural Transmission · doi:10.1007/bf01244639 · Cited by 91 · see citing works
Lawford, B. R., Young, R. M., Swagell, C. D., Barnes, M., Burton, S. C., Ward, W. K., Heslop, K., Shadforth, S., van Daal, A., & Morris, C. P. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.08.020 · Cited by 85 · see citing works
Ultrastructural correlates of haloperidol‐induced oral dyskinesias in rat striatum
Roberts, R. C., Gaither, L. A., Gao, X., Kashyap, S. M., & Tamminga, C. A. (1995) · Synapse · doi:10.1002/syn.890200307 · Cited by 82 · see citing works
Monakhov, M. V., Голимбет, В. Е., Abramova, L. I., Каледа, В. Г., & Карпов, В. Л. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.01.007 · Cited by 82 · see citing works
Impaired implicit learning in schizophrenia.
Horan, W. P., Green, M. F., Knowlton, B. J., Wynn, J. K., Mintz, J., & Nuechterlein, K. H. (2008) · Neuropsychology · doi:10.1037/a0012602 · Cited by 79 · see citing works
Caudate Nucleus Lesions: Behavioral Effects in the Rat
Chorover, S. L., & Gross, C. G. (1963) · Science · doi:10.1126/science.141.3583.826 · Cited by 69 · see citing works
Kahn, R. S., Harvey, P. D., Davidson, M., Keefe, R. S. E., APTER, S., Neale, J. M., Mohs, R. C., & Davis, K. L. (1994) · Schizophrenia Research · doi:10.1016/0920-9964(94)90015-9 · Cited by 65 · see citing works
Bach, M. E., Simpson, E. H., Kahn, L. W., Marshall, J. J., Kandel, E. R., & Kellendonk, C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807746105 · Cited by 64 · see citing works
Self-citationIs implicit sequence learning impaired in schizophrenia? A meta-analysis
Siegert, R. J., Weatherall, M., & Bell, E. M. (2008) · Brain and Cognition · doi:10.1016/j.bandc.2008.02.005 · Cited by 61 · see citing works
Mair, R. G., Koch, J., Newman, J. B., Howard, J. R., & Burk, J. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06756.2002 · Cited by 55 · see citing works
Rodríguez–Jiménez, R., Hoenicka, J., Jiménez‐Arriero, M. Á., Ponce, G., Bagney, A., Aragüés, M., & Palomo, T. (2006) · Neuropsychobiology · doi:10.1159/000098652 · Cited by 54 · see citing works
Genetic Susceptibility to Schizophrenia: Role of Dopaminergic Pathway Gene Polymorphisms
Gupta, M., Chauhan, C. R., Bhatnagar, P., Gupta, S., Grover, S., Singh, P. K., Purushottam, M., Mukherjee, O., Jain, S., Brahmachari, S. K., et al. (2009) · Pharmacogenomics · doi:10.2217/14622416.10.2.277 · Cited by 54 · see citing works
PDE10A inhibitors: an assessment of the current CNS drug discovery landscape.
Chappie, T., Humphrey, J. M., Menniti, F. S., et al. (2009) · PubMed · Cited by 49 · see citing works
Isohanni, M. K., Lauronen, E., Moilanen, K., Isohanni, I., Kemppainen, L., Koponen, H., Miettunen, J., Mäki, P. H., Räsänen, S., Veijola, J. M., et al. (2005) · The British Journal of Psychiatry · doi:10.1192/bjp.187.48.s4 · Cited by 47 · see citing works
Caudate volume in offspring of patients with schizophrenia
Rajarethinam, R., Upadhyaya, A. R., Tsou, P., et al. (2007) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.029017 · Cited by 44 · see citing works
C957T DRD2 polymorphism is associated with schizophrenia in Spanish patients
Hoenicka, J., Aragüés, M., Rodríguez–Jiménez, R., Ponce, G., Martínez, I., Rubio, G., Jiménez‐Arriero, M. Á., & Palomo, T. (2006) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2006.00874.x · Cited by 42 · see citing works
Association between the C957T polymorphism of the dopamine D2 receptor gene and schizophrenia
Hänninen, K., Katila, H., Kampman, O., Anttila, S. A. K., Illi, A., Rontu, R., Mattila, K. M., Hietala, J. A., Hurme, M., Leinonen, E. V. J., et al. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.08.041 · Cited by 41 · see citing works
Andreassen, O. A., Meshul, C. K., Moore, C., et al. (2001) · Psychopharmacology · doi:10.1007/s002130100767 · Cited by 30 · see citing works
Neuroreceptor Imaging Studies in Schizophrenia
Frankle, G. (2007) · Harvard Review of Psychiatry · doi:10.1080/10673220701679812 · Cited by 27 · see citing works
Kegeles, L. S., Frankle, W. G., Gil, R. B., Narendran, R., Slifstein, M., Hwang, D.-R., Cangiano, C., Haber, S. N., Abi‐Dargham, A., & Laruelle, M. A. (2006) · Journal of Nuclear Medicine · Cited by 20 · see citing works
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Animal models of neuropsychiatric disorders
Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023 · see citing works
Interneuron dysfunction in psychiatric disorders
Marín, O. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3155 · Cited by 1,190 · see citing works
Moghaddam, B., & Javitt, D. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.181 · Cited by 1,035 · see citing works
The Computational Anatomy of Psychosis
Adams, R. A., Stephan, K. E., Brown, H. R., Frith, C. D., & Friston, K. J. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00047 · Cited by 850 · see citing works
“Stephan et al. (2009), Morrison (2012), Carlsson et al. (1999), Lisman et al. (2008), Simpson et al. (2010). other in numerous ways (Cepeda and Levine, 2006).”
BackgroundSchizophrenia: an integrated sociodevelopmental-cognitive model
Howes, O. D., & Murray, R. M. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62036-x · Cited by 864 · see citing works
Schizophrenia, dopamine and the striatum: From biology to symptoms
McCutcheon, R. A., Abi-Dargham, A., & Howes, O. D. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2018.12.004 · Cited by 763 · see citing works
Glutamate and dopamine in schizophrenia: An update for the 21 <sup>st</sup> century
Howes, O., McCutcheon, R., & Stone, J. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114563634 · Cited by 702 · see citing works
Inhibition of mediodorsal thalamus disrupts thalamofrontal connectivity and cognition
Parnaudeau, S., O’Neill, P.-K., Bolkan, S. S., Ward, R. D., Abbas, A. I., Roth, B. L., Balsam, P. D., Gordon, J. A., & Kellendonk, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.038 · Cited by 387 · see citing works
Self-citationA direct GABAergic output from the basal ganglia to frontal cortex
Saunders, A., Oldenburg, I. A., Berezovskii, V. K., Johnson, C. A., Kingery, N. D., Elliott, H. L., Xie, T., Gerfen, C. R., & Sabatini, B. L. (2015) · Nature · doi:10.1038/nature14179 · Cited by 293 · see citing works
Bussey, T. J., Holmes, A., Lyon, L., Mar, A. C., McAllister, K. A. L., Nithianantharajah, J., Oomen, C. A., & Saksida, L. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.04.011 · Cited by 299 · see citing works
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Functional Dysconnectivity of Corticostriatal Circuitry as a Risk Phenotype for Psychosis
Fornito, A., Harrison, B. J., Goodby, E., Dean, A., Ooi, C., Nathan, P. J., Lennox, B. R., Jones, P. B., Suckling, J., & Bullmore, E. T. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1976 · Cited by 279 · see citing works
Dopamine D2 receptors regulate the anatomical and functional balance of basal ganglia circuitry
Cazorla, M., de Carvalho, F. D., Chohan, M. O., Shegda, M., Chuhma, N., Rayport, S., Ahmari, S. E., Moore, H., & Kellendonk, C. (2014) · Neuron · doi:10.1016/j.neuron.2013.10.041 · Cited by 226 · see citing works
Self-citationDevelopmental origins of brain disorders: roles for dopamine
Money, K. M., & Stanwood, G. D. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00260 · Cited by 221 · see citing works
Griffiths, K. R., Morris, R. W., & Balleine, B. W. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00101 · Cited by 118 · see citing works
Abraham, A., Beudt, S., Ott, D. V. M., & Yves von Cramon, D. (2012) · Brain Research · doi:10.1016/j.brainres.2012.09.007 · Cited by 111 · see citing works
Hill, R. A., Wu, Y. W. C., Kwek, P., & Buuse, M. V. D. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02277.x · Cited by 96 · see citing works
Quan, M., Lee, S.-H., Kubicki, M., Kikinis, Z., Rathi, Y., Seidman, L. J., Mesholam-Gately, R. I., Goldstein, J. M., McCarley, R. W., Shenton, M. E., et al. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2012.11.028 · Cited by 97 · see citing works
Li, Y.-C., Kellendonk, C., Simpson, E. H., Kandel, E. R., & Gao, W.-J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109718108 · Cited by 78 · see citing works
Self-citationThe role of opioid processes in reward and decision-making
Laurent, V., Morse, A. K., & Balleine, B. W. (2015) · British Journal of Pharmacology · doi:10.1111/bph.12818 · Cited by 64 · see citing works
Steullet, P., Cabungcal, J.-H., Cuénod, M., & Do, K. Q. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00244 · Cited by 49 · see citing works
Predictive coding in neuropsychiatric disorders: a systematic transdiagnostic review.
Qela, B., Damiani, S., De Santis, S., Groppi, F., Pichiecchio, A., Asteggiano, C., Brondino, N., Monteleone, A. M., Grassi, L., Politi, P., et al. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106020 · Cited by 26 · see citing works
“In morphometric MRI studies, decreased gray matter in the dorsolateral anterior cingulate cortex and striatum is suggestive of impairment in uncertainty adaptation and decision-making processes (Baiano et al., 2007; McCutcheon et al., 2019; Simpson et al., 2010).”
Haddon, J. E., Titherage, D., Heckenast, J. R., Carter, J., Owen, M. J., Hall, J., Wilkinson, L. S., & Jones, M. W. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02969-x · Cited by 6 · see citing works
“Moreover, the striatum has been highlighted as playing an important role in the pathogenesis of the cognitive symptoms of schizophrenia [63].”
Background
- Authors
- Simpson, E. H., Kellendonk, C., & Kandel, E.
- Affiliations
- New York State Psychiatric Institute (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Simpson, Eleanor H.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 65
- Issue
- 5
- Pages
- 585-596
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4929859
- OpenAlex
- W2034457280
- Cited by
- 478
- References
- 117
- Citations by year
- 2026: 15 · 2025: 14 · 2024: 28 · 2023: 29 · 2022: 35 · 2021: 18 · 2020: 24 · 2019: 32 · 2018: 31 · 2017: 32 · 2016: 30 · 2015: 37 · 2014: 32 · 2013: 32 · 2012: 42
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1234 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- National Institute of Mental Health (P50MH086404)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- schizophrenia, cognitive symptoms, striatum, executive function, working memory, complex cognition, mouse model, pathogenesis
- MeSH terms
- Animals, Cerebral Cortex, Cognition Disorders, Corpus Striatum, Disease Models, Animal, Dopamine, Humans, Models, Biological, Neural Pathways, Schizophrenia, Schizophrenic Psychology, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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