The third international consensus definitions for sepsis and septic shock (Sepsis-3).

Singer, Mervyn, Deutschman, Clifford S., Seymour, Christopher Warren, Shankar-Hari, Manu, Annane, Djillali, Bauer, Michael, Bellomo, Rinaldo, Bernard, Gordon R. +11 more·2016·JAMA
DOI 10.1001/jama.2016.0287

Cited by (264)

Items 101–200 of 264

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  2. Fisetin ameliorates cognitive impairment by activating mitophagy and suppressing neuroinflammation in rats with sepsis-associated encephalopathy
    Ding, Hongguang, Li, Ya, Chen, Shenglong, Wen, Yin, Zhang, Shiying, Luo, Ensi, Li, Xusheng, Zhong, Wenhong, Zeng, Hongke · 2022 · CNS Neuroscience & Therapeutics
  3. Factors driving provider adoption of the TREWS machine learning-based early warning system and its effects on sepsis treatment timing
    Henry, Katharine E., Adams, Roy, Parent, Cassandra, Soleimani, Hossein, Sridharan, Anirudh, Johnson, Lauren, Hager, David N., Cosgrove, Sara E., Markowski, Andrew, Klein, Eili Y. et al. · 2022 · Nature Medicine
  4. Identifying Patients With Sepsis on the Hospital Wards
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  5. Sepsis prediction, early detection, and identification using clinical text for machine learning: a systematic review
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  6. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
    Evans, Laura, Rhodes, Andrew, Alhazzani, Waleed, Antonelli, Massimo, Coopersmith, Craig M., French, Craig, Machado, Flávia R., Mcintyre, Lauralyn, Ostermann, Marlies, Prescott, Hallie C. et al. · 2021 · Intensive Care Medicine
  7. Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment
    Gasparotto, Juciano, Girardi, Carolina S., Somensi, Nauana, Ribeiro, Camila T., Moreira, José C.F., Michels, Monique, Sonai, Beatriz, Rocha, Mariane, Steckert, Amanda V., Barichello, Tatiana et al. · 2018 · Journal of Biological Chemistry
  8. Evaluation of the neonatal sequential organ failure assessment and mortality risk in preterm infants with late-onset infection
    Fleiss, Noa, Coggins, Sarah A., Lewis, Angela N., Zeigler, Angela, Cooksey, Krista E., Walker, L. Anne, Husain, Ameena N., de Jong, Brenda S., Wallman-Stokes, Aaron, Alrifai, Mhd Wael et al. · 2021 · JAMA Network Open
  9. Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages
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  10. Short-course adjunctive gentamicin as empirical therapy in patients with severe sepsis and septic shock: A prospective observational cohort study.
    Ong, David S. Y., Frencken, Jos F., Klein Klouwenberg, Peter M. C., Juffermans, Nicole, van der Poll, Tom, Bonten, Marc J. M., Cremer, Olaf L. · 2017 · Clinical Infectious Diseases
  11. A lactate-targeted resuscitation strategy may be associated with higher mortality in patients with septic shock and normal capillary refill time: A post hoc analysis of the ANDROMEDA-SHOCK study
    Kattan, Eduardo, Hernández, Glenn, Ospina-Tascón, Gustavo, Valenzuela, Emilio Daniel, Bakker, Jan, Castro, Ricardo · 2020 · Annals of Intensive Care
  12. Machine learning for early detection of sepsis: an internal and temporal validation study
    Bedoya, Armando D, Futoma, Joseph, Clement, Meredith E, Corey, Kristin, Brajer, Nathan, Lin, Anthony, Simons, Morgan G, Gao, Michael, Nichols, Marshall, Balu, Suresh et al. · 2020 · JAMIA Open
  13. Life after sepsis: An international survey of survivors to understand the post-sepsis syndrome.
    Huang, Cynthia Y, Daniels, Ron, Lembo, Angie, Hartog, Christiane, O’Brien, Jim, Heymann, Thomas, Reinhart, Konrad, Nguyen, H Bryant, Sepsis Survivors Engagement Project (SSEP) · 2019 · International Journal for Quality in Health Care
  14. Enteric dysbiosis is associated with sepsis in patients
    Liu, Zhanguo, Li, Na, Fang, Heng, Chen, Xiaojiao, Guo, Yuexun, Gong, Shenhai, Niu, Mengwei, Zhou, Hongwei, Jiang, Yong, Chang, Ping et al. · 2019 · The FASEB Journal
  15. Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial
    Dark, Paul, Hossain, Anower, McAuley, Daniel F., Brealey, David, Carlson, Gordon, Clayton, Jonathan C., Felton, Timothy W., Ghuman, Belinder K., Gordon, Anthony C., Hellyer, Thomas P. et al. · 2025 · JAMA
  16. Artificial intelligence should genuinely support clinical reasoning and decision making to bridge the translational gap
    Sokol, Kacper, Fackler, James, Vogt, Julia E. · 2025 · npj Digital Medicine
  17. Evaluation of domain generalization and adaptation on improving model robustness to temporal dataset shift in clinical medicine
    Guo, Lin Lawrence, Pfohl, Stephen R., Fries, Jason, Johnson, Alistair E. W., Posada, Jose, Aftandilian, Catherine, Shah, Nigam, Sung, Lillian · 2022 · Scientific Reports
  18. Equitably Allocating Resources during Crises: Racial Differences in Mortality Prediction Models
    Ashana, Deepshikha Charan, Anesi, George L., Liu, Vincent X., Escobar, Gabriel J., Chesley, Christopher, Eneanya, Nwamaka D., Weissman, Gary E., Miller, William Dwight, Harhay, Michael O., Halpern, Scott D. · 2021 · American Journal of Respiratory and Critical Care Medicine
  19. Characterization of Sepsis and Sepsis-Associated Encephalopathy
    Feng, Qing, Ai, Yu-Hang, Gong, Hua, Wu, Long, Ai, Mei-Lin, Deng, Song-Yun, Huang, Li, Peng, Qian-Yi, Zhang, Li-Na · 2019 · Journal of Intensive Care Medicine
  20. Source control in emergency general surgery: WSES, GAIS, SIS-E, SIS-A guidelines
    Coccolini, Federico, Sartelli, Massimo, Sawyer, Robert, Rasa, Kemal, Viaggi, Bruno, Abu-Zidan, Fikri, Soreide, Kjetil, Hardcastle, Timothy, Gupta, Deepak, Bendinelli, Cino et al. · 2023 · World Journal of Emergency Surgery
  21. Rethinking Human-AI Collaboration in Complex Medical Decision Making: A Case Study in Sepsis Diagnosis
    Zhang, Shao, Yu, Jianing, Xu, Xuhai, Yin, Changchang, Lu, Yuxuan, Yao, Bingsheng, Tory, Melanie, Padilla, Lace M., Caterino, Jeffrey, Zhang, Ping et al. · 2024 · Proceedings of the CHI Conference on Human Factors in Computing Systems
  22. Prevention of adrenal crisis: cortisol responses to major stress compared to stress dose hydrocortisone delivery
    Prete, Alessandro, Taylor, Angela E, Bancos, Irina, Smith, David J, Foster, Mark A, Kohler, Sibylle, Fazal-Sanderson, Violet, Komninos, John, O’Neil, Donna M, Vassiliadi, Dimitra A et al. · 2020 · The Journal of Clinical Endocrinology & Metabolism
  23. Comparing the validity of different ICD coding abstraction strategies for sepsis case identification in German claims data
    Fleischmann-Struzek, Carolin, Thomas-Rüddel, Daniel O., Schettler, Anna, Schwarzkopf, Daniel, Stacke, Angelika, Seymour, Christopher W., Haas, Christoph, Dennler, Ulf, Reinhart, Konrad · 2018 · PLOS ONE
  24. Fecal microbiota transplantation and short-chain fatty acids reduce sepsis mortality by remodeling antibiotic-induced gut microbiota disturbances
    Lou, Xiran, Xue, Jinfang, Shao, Ruifei, Yang, Yan, Ning, Deyuan, Mo, Chunyan, Wang, Fuping, Chen, Guobing · 2023 · Frontiers in Immunology
  25. Infectious diseases team for the early management of severe sepsis and septic shock in the emergency department.
    Viale, Pierluigi, Tedeschi, Sara, Scudeller, Luigia, Attard, Luciano, Badia, Lorenzo, Bartoletti, Michele, Cascavilla, Alessandra, Cristini, Francesco, Dentale, Nicola, Fasulo, Giovanni et al. · 2017 · Clinical Infectious Diseases
  26. Blood culture-free ultra-rapid antimicrobial susceptibility testing
    Kim, Tae Hyun, Kang, Junwon, Jang, Haewook, Joo, Hyelyn, Lee, Gi Yoon, Kim, Hamin, Cho, Untack, Bang, Hyeeun, Jang, Jisung, Han, Sangkwon et al. · 2024 · Nature
  27. Surviving Sepsis campaign: international guidelines for Management of Sepsis and Septic Shock 2026
    Prescott, Hallie C., Antonelli, Massimo, Alhazzani, Waleed, Møller, Morten Hylander, Alshamsi, Fayez, Azevedo, Luciano C. P., Belley-Cote, Emilie, De Waele, Jan, Derde, Lennie, Dionne, Joanna C. et al. · 2026 · Critical Care Medicine
  28. Circulating biomarkers may be unable to detect infection at the early phase of sepsis in ICU patients: the CAPTAIN prospective multicenter cohort study
    The Captain Study Group, Parlato, Marianna, Philippart, François, Rouquette, Alexandra, Moucadel, Virginie, Puchois, Virginie, Blein, Sophie, Bedos, Jean-Pierre, Diehl, Jean-Luc, Hamzaoui, Olfa et al. · 2018 · Intensive Care Medicine
  29. Vitamin C in sepsis
    Kuhn, Sven-Olaf, Meissner, Konrad, Mayes, Lena M., Bartels, Karsten · 2018 · Current Opinion in Anaesthesiology
  30. Translational evidence for two distinct patterns of neuroaxonal injury in sepsis: a longitudinal, prospective translational study
    Ehler, Johannes, Barrett, Lucinda K., Taylor, Valerie, Groves, Michael, Scaravilli, Francesco, Wittstock, Matthias, Kolbaske, Stephan, Grossmann, Annette, Henschel, Jörg, Gloger, Martin et al. · 2017 · Critical Care
  31. The initial resuscitation of septic shock
    Cinel, Ismail, Kasapoglu, Umut S., Gul, Fethi, Dellinger, R. Phillip · 2020 · Journal of Critical Care
  32. An Fgr kinase inhibitor attenuates sepsis-associated encephalopathy by ameliorating mitochondrial dysfunction, oxidative stress, and neuroinflammation via the SIRT1/PGC-1α signaling pathway
    Liu, Yuqiang, Yang, Han, Luo, Nanbo, Fu, Yifei, Qiu, Fang, Pan, Zhenglong, Li, Xiongjuan, Jian, Wenling, Yang, Xinping, Xue, Qingsheng et al. · 2023 · Journal of Translational Medicine
  33. Sepsis prediction model for determining sepsis vs SIRS, qSOFA, and SOFA
    Schertz, Adam R., Lenoir, Kristin M., Bertoni, Alain G., Levine, Beverly J., Mongraw-Chaffin, Morgana, Thomas, Karl W. · 2023 · JAMA Network Open
  34. Infiltrated regulatory T cells and Th2 cells in the brain contribute to attenuation of sepsis-associated encephalopathy and alleviation of mental impairments in mice with polymicrobial sepsis
    Saito, Masafumi, Fujinami, Yoshihisa, Ono, Yuko, Ohyama, Shohei, Fujioka, Kazumichi, Yamashita, Kimihiro, Inoue, Shigeaki, Kotani, Joji · 2021 · Brain, Behavior, and Immunity
  35. Evaluation of sepsis prediction models before onset of treatment
    Kamran, Fahad, Tjandra, Donna, Heiler, Andrew, Virzi, Jessica, Singh, Karandeep, King, Jessie E., Valley, Thomas S., Wiens, Jenna · 2024 · NEJM AI
  36. Explainable Machine-Learning Model for Prediction of In-Hospital Mortality in Septic Patients Requiring Intensive Care Unit Readmission
    Hu, Chang, Li, Lu, Li, Yiming, Wang, Fengyun, Hu, Bo, Peng, Zhiyong · 2022 · Infectious Diseases and Therapy
  37. Initiation of vasopressor infusions via peripheral <i>versus</i> central access in patients with early septic shock: A retrospective cohort study
    Delaney, Anthony, Finnis, Mark, Bellomo, Rinaldo, Udy, Andrew, Jones, Daryl, Keijzers, Gerben, MacDonald, Stephen, Peake, Sandra · 2020 · Emergency Medicine Australasia
  38. Use of continuous glucose monitor in critically ill COVID-19 patients requiring insulin infusion: an observational study
    Faulds, Eileen R, Boutsicaris, Andrew, Sumner, Lyndsey, Jones, Laureen, McNett, Molly, Smetana, Keaton S, May, Casey C, Buschur, Elizabeth, Exline, Matthew C, Ringel, Matthew D et al. · 2021 · The Journal of Clinical Endocrinology &amp; Metabolism
  39. Improving timeliness of antibiotic administration using a provider and pharmacist facing sepsis early warning system in the emergency department setting: a randomized controlled quality improvement initiative
    Tarabichi, Yasir, Cheng, Aurelia, Bar-Shain, David, McCrate, Brian M., Reese, Lewis H., Emerman, Charles, Siff, Jonathan, Wang, Christine, Kaelber, David C., Watts, Brook et al. · 2022 · Critical Care Medicine
  40. Treatment patterns and clinical outcomes after the introduction of the Medicare Sepsis Performance measure (SEP-1).
    Barbash, Ian J., Davis, Billie S., Yabes, Jonathan G., Seymour, Chris W., Angus, Derek C., Kahn, Jeremy M. · 2021 · Annals of Internal Medicine
  41. Machine learning algorithms for early sepsis detection in the emergency department: a retrospective study
    Kijpaisalratana, Norawit, Sanglertsinlapachai, Daecha, Techaratsami, Siwapol, Musikatavorn, Khrongwong, Saoraya, Jutamas · 2022 · International Journal of Medical Informatics
  42. Alteration of sphingolipid metabolism as a putative mechanism underlying <scp>LPS</scp>‐induced <scp>BBB</scp> disruption
    Vutukuri, Rajkumar, Brunkhorst, Robert, Kestner, Roxane‐Isabelle, Hansen, Lena, Bouzas, Nerea Ferreiros, Pfeilschifter, Josef, Devraj, Kavi, Pfeilschifter, Waltraud · 2018 · Journal of Neurochemistry
  43. Integrated diagnostics: the future of laboratory medicine?
    Lippi, Giuseppe, Plebani, Mario · 2020 · Biochemia medica
  44. Non-occlusive mesenteric ischemia: Diagnostic challenges and perspectives in the era of artificial intelligence
    Bourcier, Simon, Klug, Julian, Nguyen, Lee S · 2021 · World Journal of Gastroenterology
  45. P2X7 Receptor Signaling Contributes to Sepsis-Associated Brain Dysfunction
    Savio, Luiz Eduardo Baggio, Andrade, Mariana G. Juste, de Andrade Mello, Paola, Santana, Patrícia Teixeira, Moreira-Souza, Aline Cristina Abreu, Kolling, Janaína, Longoni, Aline, Feldbrügge, Linda, Wu, Yan, Wyse, Angela T. S. et al. · 2017 · Molecular Neurobiology
  46. Functions and regulation of lipocalin-2 in gut-origin sepsis: a narrative review
    Lu, Fanglin, Inoue, Kei, Kato, Jungo, Minamishima, Shizuka, Morisaki, Hiroshi · 2019 · Critical Care
  47. Outcome of immediate versus early antibiotics in severe sepsis and septic shock: A systematic review and meta-analysis.
    Rothrock, Steven G., Cassidy, David D., Barneck, Mitchell, Schinkel, Michiel, Guetschow, Brian, Myburgh, Christiaan, Nguyen, Linh, Earwood, Ryan, Nanayakkara, Prabath W.B., Nannan Panday, Rishi S. et al. · 2020 · Annals of Emergency Medicine
  48. Liberal versus restrictive red blood cell transfusion strategy in sepsis or septic shock: A systematic review and meta-analysis of randomized trials.
    Hirano, Yohei, Miyoshi, Yukari, Kondo, Yutaka, Okamoto, Ken, Tanaka, Hiroshi · 2019 · Critical Care
  49. Increased glucocorticoid receptor expression in sepsis is related to heat shock proteins, cytokines, and cortisol and is associated with increased mortality
    Vardas, Konstantinos, Ilia, Stavroula, Sertedaki, Amalia, Charmandari, Evangelia, Briassouli, Efrossini, Goukos, Dimitris, Apostolou, Kleovoulos, Psarra, Katerina, Botoula, Efthimia, Tsagarakis, Stylianos et al. · 2017 · Intensive Care Medicine Experimental
  50. A Machine Learning Sepsis Prediction Algorithm for Intended Intensive Care Unit Use (NAVOY Sepsis): Proof-of-Concept Study
    Persson, Inger, Östling, Andreas, Arlbrandt, Martin, Söderberg, Joakim, Becedas, David · 2021 · JMIR Formative Research
  51. Association of neighborhood socioeconomic status with risk of infection and sepsis.
    Donnelly, John P, Lakkur, Sindhu, Judd, Suzanne E, Levitan, Emily B, Griffin, Russell, Howard, George, Safford, Monika M, Wang, Henry E · 2018 · Clinical Infectious Diseases
  52. Septic shock with no diagnosis at 24 hours: A pragmatic multicenter prospective cohort study.
    Contou, Damien, Roux, Damien, Jochmans, Sébastien, Coudroy, Rémi, Guérot, Emmanuel, Grimaldi, David, Ricome, Sylvie, Maury, Eric, Plantefève, Gaëtan, Mayaux, Julien et al. · 2016 · Critical Care
  53. External validation of AI-based scoring systems in the ICU: a systematic review and meta-analysis
    Rockenschaub, Patrick, Akay, Ela Marie, Carlisle, Benjamin Gregory, Hilbert, Adam, Wendland, Joshua, Meyer-Eschenbach, Falk, Näher, Anatol-Fiete, Frey, Dietmar, Madai, Vince Istvan · 2025 · BMC Medical Informatics and Decision Making
  54. Accuracy of Quick Sequential Organ Failure Assessment Score to Predict Sepsis Mortality in 121 Studies Including 1,716,017 Individuals: A Systematic Review and Meta-Analysis
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  55. Machine learning methods to improve bedside fluid responsiveness prediction in severe sepsis or septic shock: An observational study
    Bataille, Benoît, de Selle, Jade, Moussot, Pierre-Etienne, Marty, Philippe, Silva, Stein, Cocquet, Pierre · 2021 · British Journal of Anaesthesia
  56. Prognostic factors of acute mesenteric ischemia in ICU patients
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  57. Screening for sepsis in general hospitalized patients: a systematic review
    Alberto, L., Marshall, A.P., Walker, R., Aitken, L.M. · 2017 · Journal of Hospital Infection
  58. Real-time surveillance system for patient deterioration: a pragmatic cluster-randomized controlled trial
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  59. Factors Disrupting Melatonin Secretion Rhythms During Critical Illness
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  60. Point-of-care lactate testing for sepsis at presentation to health care: A systematic review of patient outcomes.
    Morris, Elizabeth, McCartney, David, Lasserson, Daniel, Van den Bruel, Ann, Fisher, Rebecca, Hayward, Gail · 2017 · British Journal of General Practice
  61. The implementation of a pathway and care bundle for the management of acute occlusive arterial mesenteric ischemia reduced mortality
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  62. Effectiveness of Fludrocortisone Plus Hydrocortisone versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
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  63. Ineffectiveness of procalcitonin-guided antibiotic therapy in severely critically ill patients: A meta-analysis.
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  64. Low-density lipoprotein cholesterol levels are associated with poor clinical outcomes in COVID-19
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  65. Impact of timing to source control in patients with septic shock: A prospective multi-center observational study.
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  68. COVID-19 e Estado de Hipercoagulabilidade: Uma Nova Perspectiva Terapêutica
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  69. Use of explicit ICD9-CM codes to identify adult severe sepsis: impacts on epidemiological estimates
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  70. The early recognition and management of sepsis in sub-saharan african adults: A systematic review and meta-analysis.
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  71. The modified radical peripartum cesarean hysterectomy (Soleymani-Alazzam-Collins technique): a systematic, safe procedure for the management of severe placenta accreta spectrum
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  72. Puerarin protects against sepsis-associated encephalopathy by inhibiting NLRP3/Caspase-1/GSDMD pyroptosis pathway and reducing blood-brain barrier damage
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  73. Intestinal Epithelial Cell Exosome Launches IL-1β-Mediated Neuron Injury in Sepsis-Associated Encephalopathy
    Xi, Shaosong, Wang, Yunguang, Wu, Chenghao, Peng, Weihua, Zhu, Ying, Hu, Wei · 2022 · Frontiers in Cellular and Infection Microbiology
  74. Preventing sepsis; how can artificial intelligence inform the clinical decision-making process? A systematic review
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  75. Culture-negative sepsis.
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  76. The modulatory effects of gut microbes and metabolites on blood-brain barrier integrity and brain function in sepsis-associated encephalopathy
    Li, Zhaoying, Zhang, Fangxiang, Sun, Meisha, Liu, Jia, Zhao, Li, Liu, Shuchun, Li, Shanshan, Wang, Bin · 2023 · PeerJ
  77. Malvidin alleviates mitochondrial dysfunction and ROS accumulation through activating AMPK-α/UCP2 axis, thereby resisting inflammation and apoptosis in SAE mice
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  78. Incidence, risk factors, and outcomes for sepsis-associated delirium in patients with mechanical ventilation: a sub-analysis of a multicenter randomized controlled trial
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  79. Ethyl pyruvate protects against sepsis-associated encephalopathy through inhibiting the NLRP3 inflammasome
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  80. Immune response in bacterial and Candida sepsis
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  81. Transatlantic transferability of a new reinforcement learning model for optimizing haemodynamic treatment for critically ill patients with sepsis
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  83. Improving sepsis outcomes in the era of pay-for-performance and electronic quality measures: a joint IDSA/ACEP/PIDS/SHEA/SHM/SIDP position paper.
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  84. PD-L1 promotes GSDMD-mediated NET release by maintaining the transcriptional activity of Stat3 in sepsis-associated encephalopathy
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  85. Postbiotics as potential new therapeutic agents for sepsis
    Lou, Xiran, Xue, Jinfang, Shao, Ruifei, Mo, Chunyan, Wang, Fuping, Chen, Guobing · 2023 · Burns &amp; Trauma
  86. Citrulline, intestinal fatty acid-binding protein and the acute gastrointestinal injury score as predictors of gastrointestinal failure in patients with sepsis and septic shock
    Tyszko, Maciej, Lemańska-Perek, Anna, Śmiechowicz, Jakub, Tomaszewska, Paulina, Biecek, Przemyslaw, Gozdzik, Waldemar, Adamik, Barbara · 2023 · Nutrients
  87. Conservative Fluid Management After Sepsis Resuscitation: A Pilot Randomized Trial
    Semler, Matthew W., Janz, David R., Casey, Jonathan D., Self, Wesley H., Rice, Todd W. · 2020 · Journal of Intensive Care Medicine
  88. Iron metabolism in critically ill patients developing anemia of inflammation: a case control study
    Boshuizen, Margit, Binnekade, Jan M., Nota, Benjamin, van de Groep, Kirsten, Cremer, Olaf L., Tuinman, Pieter R., Horn, Janneke, Schultz, Marcus J., van Bruggen, Robin, Juffermans, Nicole P. et al. · 2018 · Annals of Intensive Care
  89. Selective activation of cholinergic neurotransmission from the medial septal nucleus to hippocampal pyramidal neurones improves sepsis-induced cognitive deficits in mice
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