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Association of Dietary Patterns With Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue
Open accessAbstract
IMPORTANCE: Fusobacterium nucleatum appears to play a role in colorectal carcinogenesis through suppression of the hosts' immune response to tumor. Evidence also suggests that diet influences intestinal F nucleatum. However, the role of F nucleatum in mediating the relationship between diet and the risk of colorectal cancer is unknown. OBJECTIVE: To test the hypothesis that the associations of prudent diets (rich in whole grains and dietary fiber) and Western diets (rich in red and processed meat, refined grains, and desserts) with colorectal cancer risk may differ according to the presence of F nucleatum in tumor tissue. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study was conducted using data from the Nurses' Health Study (June 1, 1980, to June 1, 2012) and the Health Professionals Follow-up Study (June 1, 1986, to June 1, 2012) on a total of 121 700 US female nurses and 51 529 US male health professionals aged 30 to 55 years and 40 to 75 years, respectively (both predominantly white individuals), at enrollment. Data analysis was performed from March 15, 2015, to August 10, 2016. EXPOSURES: Prudent and Western diets. MAIN OUTCOMES AND MEASURES: Incidence of colorectal carcinoma subclassified by F nucleatum status in tumor tissue, determined by quantitative polymerase chain reaction. RESULTS: Of the 173 229 individuals considered for the study, 137 217 were included in the analysis, 47 449 were male (34.6%), and mean (SD) baseline age for men was 54.0 (9.8) years and for women, 46.3 (7.2) years. A total of 1019 incident colon and rectal cancer cases with available F nucleatum data were documented over 26 to 32 years of follow-up, encompassing 3 643 562 person-years. The association of prudent diet with colorectal cancer significantly differed by tissue F nucleatum status (P = .01 for heterogeneity); prudent diet score was associated with a lower risk of F nucleatum-positive cancers (P = .003 for trend; multivariable hazard ratio of 0.43; 95% CI, 0.25-0.72, for the highest vs the lowest prudent score quartile) but not with F nucleatum-negative cancers (P = .47 for trend, the corresponding multivariable hazard ratio of 0.95; 95% CI, 0.77-1.17). There was no significant heterogeneity between the subgroups in relation to Western dietary pattern scores. CONCLUSIONS AND RELEVANCE: Prudent diets rich in whole grains and dietary fiber are associated with a lower risk for F nucleatum-positive colorectal cancer but not F nucleatum-negative cancer, supporting a potential role for intestinal microbiota in mediating the association between diet and colorectal neoplasms.
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“A large prospective study found that the association of dietary fiber with reduced risk of CRC had a larger effect on tumors with detectable F nucleatum than those without F nucleatum.140”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [140]
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Metadata
- Authors
- Mehta, R. S., Nishihara, R., Cao, Y., Song, M., Mima, K., Qian, Z. R., Nowak, J. A., Kosumi, K., Hamada, T., Masugi, Y., Bullman, S., Drew, D. A., Kostic, A. D., Fung, T. T., Garrett, W. S., Huttenhower, C., Wu, K., Meyerhardt, J. A., Zhang, X., Willett, W. C., Giovannucci, E. L., Fuchs, C. S., Chan, A. T., & Ogino, S.
- Affiliations
- Harvard University (US)
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Simmons University (US)
- Corresponding author
- Ogino, Shuji
- ORCID
- Nishihara, Reiko
- Cao, Yin
- Song, Mingyang
- Mima, Kosuke
- Qian, Zhi Rong
- Nowak, Jonathan A.
- Kosumi, Keisuke
- Hamada, Tsuyoshi
- Masugi, Yohei
- Bullman, Susan
- Drew, David A.
- Kostic, Aleksandar D.
- Fung, Teresa T.
- Garrett, Wendy S.
- Huttenhower, Curtis
- Wu, Kana
- Meyerhardt, Jeffrey A.
- Zhang, Xuehong
- Willett, Walter C.
- Giovannucci, Edward L.
- Fuchs, Charles S.
- Chan, Andrew T.
- Ogino, Shuji
- Venue
- JAMA Oncology
- Publisher
- American Medical Association (AMA)
- Published
- 2017-07-01
- Volume
- 3
- Issue
- 7
- Pages
- 921
- ISSN
- 2374-2437 (ISSN-L)
- PMC
- PMC5502000
- OpenAlex
- W2584619074
- Cited by
- 325
- References
- 51
- Citations by year
- 2026: 20 · 2025: 34 · 2024: 28 · 2023: 28 · 2022: 43 · 2021: 44 · 2020: 39 · 2019: 33 · 2018: 42 · 2017: 12
- FWCI
- 32.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Oncology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Entertainment Industry Foundation
- Gary Bennett Family Fund
- National Institutes of Health (CA-167552, CA 87969, CA55075, UL1TR001863)
- National Cancer Institute (P50CA127003, K07CA188126, R01CA202704, R01CA151993, R01CA118553, R01CA137178, R35CA197735, P01CA087969, R01CA169141, P01CA055075, UM1CA186107, UM1CA167552, K07CA190673, R01CA154426)
- National Institute of Diabetes and Digestive and Kidney Diseases (K24DK098311, P30DK036836, P30DK043351)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Keywords
- Fusobacterium nucleatum, colorectal cancer, prudent diet, Western diet, dietary habits, colorectal cancer subtypes, tumor tissue, whole grains, dietary fiber, red and processed meat, colorectal carcinogenesis, antitumor immunity, Nurses' Health Study, Health Professionals Follow-up Study, colon cancer, rectal cancer, cancer risk factors, gut microbiota
- MeSH terms
- Whole Grains, Gastrointestinal Microbiome, Diet, Healthy, Adult, Aged, Carcinoma, Diet, Dietary Fiber, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, United States, Viral Proteins, Colorectal Neoplasms, Cohort Studies, Incidence, Proportional Hazards Models, Fusobacterium nucleatum, Diet, Western
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