The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Single‐Atom Pd Nanozyme for Ferroptosis‐Boosted Mild‐Temperature Photothermal Therapy
Abstract
Photothermal therapy (PTT) is an extremely promising tumor therapeutic modality. However, excessive heat inevitably injures normal tissues near tumors, and the damage to cancer cells caused by mild hyperthermia is easily repaired by stress‐induced heat shock proteins (HSPs). Thus, maximizing the PTT efficiency and minimizing the damage to healthy tissues simultaneously by adopting appropriate therapeutic temperatures is imperative. Herein, an innovative strategy is reported: ferroptosis‐boosted mild PTT based on a single‐atom nanozyme (SAzyme). The Pd SAzyme with atom‐economical utilization of catalytic centers exhibits peroxidase (POD) and glutathione oxidase (GSHOx) mimicking activities, and photothermal conversion performance, which can result in ferroptosis featuring the up‐regulation of lipid peroxides (LPO) and reactive oxygen species (ROS). The accumulation of LPO and ROS provides a powerful approach for cleaving HSPs, which enables Pd SAzyme‐mediated mild‐temperature PTT.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Intrinsic peroxidase-like activity of ferromagnetic nanoparticles
Gao, L., Zhuang, J., Nie, L., Zhang, J., Zhang, Y., Gu, N., Wang, T., Feng, J., Yang, D., Perrett, S., et al. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.260 · Cited by 7,483
Research works printed but not linked: 45
- 10.1016/j.nantod.2019.100795 · DOI · Paper page
- 10.1073/pnas.1906929116 · DOI · Paper page
- 10.1002/anie.201911477 · DOI · Paper page
- 10.1002/ange.201911477 · DOI
- 10.1002/anie.201811273 · DOI · Paper page
- 10.1002/ange.201811273 · DOI
- 10.1039/C7CS00522A · DOI · Paper page
- 10.1016/j.biomaterials.2020.120459 · DOI · Paper page
- 10.1038/s41467-020-16513-0 · DOI · Paper page
- 10.1021/jacs.9b12929 · DOI
- 10.1021/acsnano.8b00309 · DOI · Paper page
- 10.1126/sciadv.abb1311 · doi:10.1126/sciadv.abb1311
- 10.1002/advs.201600327 · DOI · Paper page
- 10.1038/s41467-019-12771-9 · DOI · Paper page
- 10.1002/adfm.201702834 · DOI
- 10.1002/adfm.201909745 · DOI
- 10.1002/smll.202003398 · DOI
- 10.1002/adma.201703588 · DOI · Paper page
- 10.1016/j.nantod.2020.100910 · DOI
- 10.1021/acsnano.0c00910 · DOI · Paper page
- 10.1016/j.bbrc.2016.10.086 · DOI · Paper page
- 10.1016/j.foodchem.2014.11.154 · DOI
- 10.1016/0891-5849(91)90192-6 · DOI · Paper page
- 10.1021/tx970112c · DOI
- 10.1038/s41467-018-03903-8 · DOI · Paper page
- 10.1126/sciadv.aav5490 · DOI · Paper page
- 10.1007/s11427-019-9518-0 · doi:10.1007/s11427-019-9518-0
- 10.1039/C8CS00457A · DOI · Paper page
- 10.1038/s41467-019-14199-7 · DOI · Paper page
- 10.1002/adma.202005423 · DOI · Paper page
- 10.1002/anie.201909729 · DOI · Paper page
- 10.1002/ange.201909729 · DOI
- 10.1002/adma.202002246 · DOI · Paper page
- 10.1021/acs.chemrev.0c00576 · DOI · Paper page
- 10.1126/science.1085721 · DOI · Paper page
- 10.1038/nchem.1095 · DOI · Paper page
- 10.1002/smll.202004129 · DOI
- 10.1016/j.nantod.2020.100971 · DOI · Paper page
- 10.1038/s41565-019-0373-6 · DOI · Paper page
- 10.1002/anie.202017152 · DOI · Paper page
- 10.1002/ange.202017152 · DOI
- 10.1021/acsnano.0c00764 · DOI · Paper page
- 10.1002/anie.202003004 · DOI · Paper page
- 10.1002/ange.202003004 · DOI
- 10.1038/s41565-018-0197-9 · DOI · Paper page
Cited by
Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry
Cao, C., Wang, X., Yang, N., Song, X., & Dong, X. (2022) · Chemical Science · doi:10.1039/d1sc05482a · Cited by 298
Strategies for enhancing cancer chemodynamic therapy performance
Jana, D., & Zhao, Y. (2022) · Exploration · doi:10.1002/exp.20210238 · Cited by 284
Defect engineering in nanozymes
Wu, Y., Xu, W., Jiao, L., Tang, Y., Chen, Y., Gu, W., & Zhu, C. (2022) · Materials Today · doi:10.1016/j.mattod.2021.10.032 · Cited by 269
Xu, W., Qian, J., Hou, G., Wang, T., Wang, J., Wang, Y., Yang, L., Cui, X., & Suo, A. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202205013 · Cited by 267
Dong, S., Dong, Y., Zhao, Z., Liu, J., Liu, S., Feng, L., He, F., Gai, S., Xie, Y., & Yang, P. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.2c09608 · Cited by 267
Metadata
- Authors
- Chang, M., Hou, Z., Wang, M., Yang, C., Wang, R., Li, F., Liu, D., Peng, T., Li, C., & Lin, J.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2021-04-28
- Volume
- 60
- Issue
- 23
- Pages
- 12971-12979
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3143176399
- Cited by
- 682
- References
- 1
- FWCI
- 34.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Funders
- National Natural Science Foundation of China (51929201, 51720105015, 52072082, 51972138, 51872263, 51828202)
- CAS-Croucher Funding Scheme for Joint Laboratories (CAS18204)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Single‐Atom Pd Nanozyme for Ferroptosis‐Boosted Mild‐Temperature Photothermal Therapy. https://app.cochat.ai/papers/10.1002/anie.202101924
- The paper
- Chang, M., Hou, Z., Wang, M., Yang, C., Wang, R., Li, F., Liu, D., Peng, T., Li, C., & Lin, J. (2021). Single‐Atom Pd Nanozyme for Ferroptosis‐Boosted Mild‐Temperature Photothermal Therapy. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.202101924
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
