Cited by 123Luminescence and Fluorescent MaterialsNanoplatforms for cancer theranosticsPhotochemistry and Electron Transfer Studies

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Increasing Molecular Planarity through Donor/Side‐Chain Engineering for Improved NIR‐IIa Fluorescence Imaging and NIR‐II Photothermal Therapy under 1064 nm

Chen, Shangyu, Pan, Yonghui, Chen, Kai, Chen, Pengfei, Shen, Qingming, Sun, Pengfei, Hu, Wenbo, Fan, Quli·2023·Angewandte Chemie International Edition

DOI 10.1002/anie.202215372

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Abstract

Developing conjugated small molecules (CSM) with intense NIR‐II (1000–1700 nm) absorption for phototheranostic is highly desirable but remains a tremendous challenge due to a lack of reliable design guidelines. This study reports a high‐performance NIR‐II CSM for phototheranostic by tailoring molecular planarity. A series of CSM show bathochromic absorption extended to the NIR‐II region upon the increasing thiophene number, but an excessive number of thiophene results in decreased NIR‐IIa (1300–1400 nm) brightness and photothermal effects. Further introduction of terminal nonconjugated alkyl chain can enhance NIR‐II absorption coefficient, NIR‐IIa brightness, and photothermal effects. Mechanism studies ascribe this overall enhancement to molecular planarity stemming from the collective contribution of donor/side‐chain engineering. This finding directs the design of NIR‐II CSM by rational manipulating molecular planarity to perform 1064 nm mediated phototheranostic at high efficiency.

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Authors: Chen, S., Pan, Y., Chen, K., Chen, P., Shen, Q., Sun, P., Hu, W., & Fan, Q.
Affiliations: Nanjing University of Posts and Telecommunications (CN)
Northwestern Polytechnical University (CN)
Corresponding author: Sun, Pengfei
Hu, Wenbo
Fan, Quli
ORCID: Chen, Shangyu
Pan, Yonghui
Chen, Kai
Chen, Pengfei
Shen, Qingming
Sun, Pengfei
Hu, Wenbo
Fan, Quli
Venue: Angewandte Chemie International Edition
Publisher: Wiley
Published: 2022-12-29
Volume: 62
Issue: 6
Pages: e202215372-e202215372
ISSN: 1433-7851 (ISSN-L)
1521-3773
DOI: 10.1002/anie.202215372
OpenAlex: W4310957594
Cited by: 122
References: 66
Citations by year: 2026: 21 · 2025: 43 · 2024: 41 · 2023: 17
FWCI: 7.09
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Angewandte Chemie International Edition (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (21604042, 62175201)
Natural Science Foundation of Jiangsu Province (BK20201380, BK20221326)
Fundamental Research Funds for the Central Universities
Topics: Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Photochemistry and Electron Transfer Studies
Keywords: NIR-II photothermal therapy, conjugated small molecules, molecular planarity, 1064 nm excitation, phototheranostics, molecular design

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Increasing Molecular Planarity through Donor/Side‐Chain Engineering for Improved NIR‐IIa Fluorescence Imaging and NIR‐II Photothermal Therapy under 1064 nm

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