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Cited by 296

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Topographic organization of suprachiasmatic nucleus projection neurons

Leak, Rehana K., Moore, Robert Y.·2001·Journal of Comparative Neurology
DOI 10.1002/cne.1142
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Abstract

The mammalian circadian pacemaker, the hypothalamic suprachiasmatic nucleus (SCN), has two subdivisions. The core is located above the optic chiasm, receives primary and secondary visual afferents, and contains neurons producing vasoactive intestinal polypeptide and gastrin‐releasing peptide. The shell largely surrounds the core, receives input from nonvisual sources and contains neurons producing arginine vasopressin and calretinin. In this study, we tested the hypothesis that SCN efferent projections are topographically organized with respect to the subdivision of origin. Injections of retrograde tracers were placed in major sites of efferent termination, described from prior studies that used anterograde tracers (Watts and Swanson, [1987] J. Comp. Neurol. 258:230–252; Watts et al. [1987] J. Comp. Neurol. 258:204–229). After retrograde tracer injections in the medial preoptic area, dorsomedial and paraventricular hypothalamic nuclei, bed nucleus of stria terminalis, paraventricular thalamic nucleus, zona incerta, and medial subparaventricular zone, retrogradely labeled SCN cells are clustered in the shell with few labeled neurons in the core. After injections centered in the lateral subparaventricular zone, peri‐suprachiasmatic region, lateral septum, or ventral tuberal area, the majority of neuronal label is in the core with moderate to sparse neuronal label in the shell. Both subdivisions are labeled after injections in the paratenial thalamic nucleus. The same pattern of retrograde labeling is found with four tracers, cholera toxin‐β subunit, Fluoro‐Gold, the Bartha strain of pseudorabies virus, and biotinylated dextran amine. These data extend our understanding of the significance of the division of the SCN into shell and core by demonstrating that the subdivisions differ in the pattern of projections. Together with prior observations that the subdivisions differ with respect to afferents, local connections, and neuroactive substances, the present study provides an anatomic basis for discrete control of circadian function by the SCN core and shell. In this novel view, the nature of the signal conveyed to areas receiving core or shell projections varies as a function of the subdivision from which innervation is derived. J. Comp. Neurol. 433:312–334, 2001. © 2001 Wiley‐Liss, Inc.

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Metadata

Authors
Leak, R. K., & Moore, R. Y.
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
2001-04-04
Volume
433
Issue
3
Pages
312-334
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.1142
OpenAlex
W2003023920
Cited by
296
References
5
FWCI
5.33
Type
journal article
Language
en
Open access
closed

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