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Induction of apoptosis by diallyl disulfide through activation of caspase-3 in human leukemia HL-60 cells11Abbreviations: Ac-DEVD-CHO, N-acetyl-Asp-Glu-Val-Asp-CHO (aldehyde); Ac-DEVD-AFC, N-acetyl-Asp-Glu-Val-Asp-AFC (7-amino-4-trifluoromethyl-coumaine); Ac-YVAD-CHO, N-acetyl-Tyr-Val-Ala-Asp-CHO (aldehyde); CAD, caspase-activated deoxyribonuclease; CM-H2DCFDA, 5-(and -6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate; DADS, diallyl disulfide; FACS, fluorescence-activated cell sorter; FITC, fluorescein isothiocyanate; ICAD, inhibitor of caspase-activated deoxyribonuclease; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NAC, N-acetylcysteine; PARP, poly(ADP-ribose) polymerase; PI, propidium iodide; and ROI, reactive oxygen intermediate.

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