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New life in an old idea: The synaptic plasticity and memory hypothesis revisited
Abstract
The notion that changes in synaptic efficacy underlie learning and memory processes is now widely accepted, although definitive proof of the synaptic plasticity and memory hypothesis is still lacking. This article reviews recent evidence relevant to the hypothesis, with particular emphasis on studies of experience‐dependent plasticity in the neocortex and hippocampus. In our view, there is now compelling evidence that changes in synaptic strength occur as a consequence of certain forms of learning. A major challenge will be to determine whether such changes constitute the memory trace itself or play a less specific supporting role in the information processing that accompanies memory formation. Hippocampus 2002;12:609–636. © 2002 Wiley‐Liss, Inc.
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Cites
Receptive fields, binocular interaction and functional architecture in the cat’s visual cortex
Hubel, D. H., & Wiesel, T. N. (1962) · The Journal of Physiology · doi:10.1113/jphysiol.1962.sp006837 · Cited by 13,680
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
McClelland, J. L., McNaughton, B. L., & O'Reilly, R. C. (1995) · Psychological Review · doi:10.1037/0033-295x.102.3.419 · Cited by 5,256
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640
Self-citationSynaptic Plasticity and Memory: An Evaluation of the Hypothesis
Martin, S. J., Grimwood, P. D., & Morris, R. G. M. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.649 · Cited by 2,794
Self-citationFear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588
CORTICAL PLASTICITY: From Synapses to Maps
Buonomano, D. V., & Merzenich, M. M. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.149 · Cited by 2,083
Cited by
Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior
Phelps, E. A., & LeDoux, J. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.025 · Cited by 3,203
The cortisol awakening response (CAR): Facts and future directions
Fries, E., Dettenborn, L., & Kirschbaum, C. (2009) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2008.03.014 · Cited by 1,188
Memory engrams: Recalling the past and imagining the future
Josselyn, S. A., & Tonegawa, S. (2020) · Science · doi:10.1126/science.aaw4325 · Cited by 1,087
Engineering a memory with LTD and LTP
Nabavi, S., Fox, R., Proulx, C. D., Lin, J. Y., Tsien, R. Y., & Malinow, R. (2014) · Nature · doi:10.1038/nature13294 · Cited by 980
A disinhibitory microcircuit for associative fear learning in the auditory cortex
Letzkus, J. J., Wolff, S. B. E., Meyer, E. M. M., Tovote, P., Courtin, J., Herry, C., & Lüthi, A. (2011) · Nature · doi:10.1038/nature10674 · Cited by 840
A role for adult neurogenesis in spatial long-term memory
Snyder, J. S., Hong, N. S., McDonald, R. J., & Wojtowicz, J. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.009 · Cited by 854
Are spatial memories strengthened in the human hippocampus during slow wave sleep?
Peigneux, P., Laureys, S., Fuchs, S., Collette, F., Perrin, F., Reggers, J., Phillips, C., Degueldre, C., Del Fiore, G., Aerts, J., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.007 · Cited by 766
NMDA receptors, place cells and hippocampal spatial memory
Nakazawa, K., McHugh, T. J., Wilson, M. A., & Tonegawa, S. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1385 · Cited by 619
Real-time fMRI neurofeedback: Progress and challenges
Sulzer, J., Haller, S., Scharnowski, F., Weiskopf, N., Birbaumer, N., Blefari, M. L., Bruehl, A. B., Cohen, L. G., deCharms, R. C., Gassert, R., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.03.033 · Cited by 453
Izquierdo, I., Furini, C. R. G., & Myskiw, J. C. (2016) · Physiological Reviews · doi:10.1152/physrev.00018.2015 · Cited by 453
Morris, R. G. M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04888.x · Cited by 398
Self-citationA clustered plasticity model of long-term memory engrams.
Govindarajan, A., Kelleher, R. J., & Tonegawa, S. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1937 · Cited by 355
Hayashi, M. L., Choi, S.-Y., Rao, B. S. S., Jung, H.-Y., Lee, H.-K., Zhang, D., Chattarji, S., Kirkwood, A., & Tonegawa, S. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.003 · Cited by 280
Induction of sharp wave–ripple complexes in vitro and reorganization of hippocampal networks
Behrens, C. J., van den Boom, L. P., de Hoz, L., Friedman, A., & Heinemann, U. (2005) · Nature Neuroscience · doi:10.1038/nn1571 · Cited by 262
Wistar rats show episodic-like memory for unique experiences
KARTTEKE, E., DESOUZASILVA, M., HUSTON, J., & DERE, E. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.10.002 · Cited by 250
Romberg, C., Yang, S., Melani, R., Andrews, M. R., Horner, A. E., Spillantini, M. G., Bussey, T. J., Fawcett, J. W., Pizzorusso, T., & Saksida, L. M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.6267-11.2013 · Cited by 231
Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP
Wang, H., Ferguson, G. D., Pineda, V. V., Cundiff, P. E., & Storm, D. R. (2004) · Nature Neuroscience · doi:10.1038/nn1248 · Cited by 244
Modulation of Hippocampus-Dependent Learning and Synaptic Plasticity by Nicotine
Kenney, J. W., & Gould, T. J. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8037-9 · Cited by 242
Long-term potentiation and memory
Morris, R. G. M. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1230 · Cited by 232
Self-citationHippocampal Function in Cognition
Sweatt, J. D. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1795-9 · Cited by 217
Stewart, M. G., Davies, H. A., Sandi, C., Kraev, I. V., Rogachevsky, V. V., Peddie, C. J., Rodriguez, J. J., Cordero, M. I., Donohue, H. S., Gabbott, P. L. A., et al. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.031 · Cited by 197
The neuroscience of memory: implications for the courtroom
Lacy, J. W., & Stark, C. E. L. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3563 · Cited by 155
Ma, Y., Hu, H., & Agmon, A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5007-11.2012 · Cited by 102
Diamond, D. M., Park, C. R., & Woodson, J. C. (2004) · Hippocampus · doi:10.1002/hipo.10186 · Cited by 95
Dynamically changing effects of corticosteroids on human hippocampal and prefrontal processing
Henckens, M. J. A. G., Pu, Z., Hermans, E. J., van Wingen, G. A., Joëls, M., & Fernández, G. (2012) · Human Brain Mapping · doi:10.1002/hbm.21409 · Cited by 80
Enhanced synaptic plasticity in mice with phosphomimetic mutation of the GluA1 AMPA receptor
Makino, Y., Johnson, R. C., Yu, Y., Takamiya, K., & Huganir, R. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105261108 · Cited by 77
Esslinger, C., Schüler, N., Sauer, C., Gass, D., Mier, D., Braun, U., Ochs, E., Schulze, T. G., Rietschel, M., Kirsch, P., et al. (2014) · Human Brain Mapping · doi:10.1002/hbm.22165 · Cited by 70
Pettigrew, D. B., Smolen, P., Baxter, D. A., & Byrne, J. H. (2005) · Journal of Computational Neuroscience · doi:10.1007/s10827-005-6557-0 · Cited by 48
The Role of Serotonin in Orbitofrontal Function and Obsessive-Compulsive Disorder
Maia, T. V., & Cano-Colino, M. (2015) · Clinical Psychological Science · doi:10.1177/2167702614566809 · Cited by 42
Neuroimaging and plasticity in schizophrenia
Meyer-Lindenberg, A., & Tost, H. (2014) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-139014 · Cited by 33
Hager, A. M., & Dringenberg, H. C. (2010) · Brain Research · doi:10.1016/j.brainres.2009.12.063 · Cited by 13
Metadata
- Authors
- Martin, S. J., & Morris, R. G. M.
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2002-01
- Volume
- 12
- Issue
- 5
- Pages
- 609-636
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W1996860397
- Cited by
- 437
- References
- 34
- FWCI
- 11.46
- Type
- journal article
- Language
- en
- Open access
- closed
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