Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories.
Open accessAbstract
Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. The computational process for making representations of similar input patterns more distinct from each other has been referred to as "pattern separation." Although adult-born immature neurons have been implicated in this memory feature, the precise role of these neurons and associated molecules in the processing of overlapping memories is unknown. Recently, we found that brain-derived neurotrophic factor (BDNF) in the dentate gyrus is required for the encoding/consolidation of overlapping memories. In this study, we provide evidence that consolidation of these "pattern-separated" memories requires the action of BDNF on immature neurons specifically.
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Brain-derived neurotrophic factor is required for pattern separation to occur in memory encoding and consolidation.
“Recent studies have shown that BDNF is required for the pattern separation to occur in memory encoding and consolidation, and specifically that BDNF acts on adult-born granule cells within the DG to facilitate pattern separation (Bekinschtein et al., 2013, 2014).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Bekinschtein et al., 2014
Brain-derived neurotrophic factor acts on adult-born granule cells within the dentate gyrus to facilitate pattern separation.
“Recent studies have shown that BDNF is required for the pattern separation to occur in memory encoding and consolidation, and specifically that BDNF acts on adult-born granule cells within the DG to facilitate pattern separation (Bekinschtein et al., 2013, 2014).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Bekinschtein et al., 2014
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- Authors
- Bekinschtein, P., Kent, B. A., Oomen, C. A., Clemenson, G. D., Gage, F. H., Saksida, L. M., & Bussey, T. J.
- Affiliations
- University of Cambridge (GB)
- Salk Institute for Biological Studies (US)
- Corresponding author
- Bekinschtein, Pedro
- ORCID
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2014-05-23
- Volume
- 24
- Issue
- 8
- Pages
- 905-911
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- PMC
- PMC4312906
- OpenAlex
- W1934269805
- Cited by
- 94
- References
- 32
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 7 · 2018: 14 · 2017: 11 · 2016: 11 · 2015: 12 · 2014: 3
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Hippocampus (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (publishedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- Americanae (AECID Library) (submittedVersion, cc-by)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/G019002/1)
- Innovative Medicine Initiative Joint Undertaking (115008)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- brain-derived neurotrophic factor, adult neurogenesis, dentate gyrus, immature neurons, pattern separation, memory consolidation, memory encoding
- MeSH terms
- Animals, Humans, Immunohistochemistry, Male, Memory, Neurons, Neuropsychological Tests, Recombinant Proteins, Dentate Gyrus, Brain-Derived Neurotrophic Factor, Rats, Long-Evans, Neurogenesis
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