Adult hippocampal neurogenesis and its role in cognition.
Open accessAbstract
UNLABELLED: Adult hippocampal neurogenesis (AHN) has intrigued neuroscientists for decades. Several lines of evidence show that adult-born neurons in the hippocampus are functionally integrated and contribute to cognitive function, in particular learning and memory processes. Biological properties of immature hippocampal neurons indicate that these cells are more easily excitable compared with mature neurons, and demonstrate enhanced structural plasticity. The structure in which adult-born hippocampal neurons are situated-the dentate gyrus-is thought to contribute to hippocampus function by disambiguating similar input patterns, a process referred to as pattern separation. Several ideas about AHN function have been put forward; currently there is good evidence in favor of a role for AHN in pattern separation. This function of AHN may be understood within a 'representational-hierarchical' view of brain organization. WIREs Cogn Sci 2014, 5:573-587. doi: 10.1002/wcs.1304 For further resources related to this article, please visit the WIREs website. CONFLICT OF INTEREST: The authors have declared no conflicts of interest for this article.
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The hippocampus, and particularly the dentate gyrus, is crucial in selecting and separating similar events in space and time.
“Also, the hippocampus, and particularly the DG, is crucial in selecting and separating similar events in space and time, and hence pattern separation is a main function attributed to the hippocampus (Yassa and Stark, 2011; Oomen et al., 2013, 2014).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Oomen et al., 2014
The proliferation of adult-born granule cells is thought to play an important role in hippocampal functioning.
“The proliferation of adult-born granule cells is thought to play an important role in hippocampal functioning (Deng et al., 2010; Oomen et al., 2014).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Oomen et al., 2014
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- Authors
- Oomen, C. A., Bekinschtein, P., Kent, B. A., Saksida, L. M., & Bussey, T. J.
- Affiliations
- University of Cambridge (GB)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Oomen, Charlotte A.
- Venue
- WIREs Cognitive Science
- Publisher
- Wiley
- Published
- 2014-08-12
- Volume
- 5
- Issue
- 5
- Pages
- 573-587
- ISSN
- 1939-5078 (ISSN-L)
- 1939-5086
- PMC
- PMC4568304
- OpenAlex
- W1956964467
- Cited by
- 93
- References
- 192
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 12 · 2016: 23 · 2015: 7 · 2014: 2
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- Locations
- Wiley Interdisciplinary Reviews Cognitive Science (publishedVersion)
- PubMed (publishedVersion)
- Apollo (University of Cambridge) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Wellcome Trust (089703/Z/09/Z)
- Biotechnology and Biological Sciences Research Council (BB/G019002/1)
- Innovative Medicine Initiative Joint Undertaking of which resources are composed of a European Federation of Pharmaceutical Industries and Associations in-kind contribution and financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) (115008)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult hippocampal neurogenesis, dentate gyrus, pattern separation, learning and memory, hippocampal neurons, neuronal excitability, structural plasticity, hippocampal function
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