Cited by 93Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Adult hippocampal neurogenesis and its role in cognition.

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Oomen, Charlotte A., Bekinschtein, Pedro, Kent, Brianne A., Saksida, Lisa M., Bussey, Timothy J.·2014·WIREs Cognitive Science

Abstract

UNLABELLED: Adult hippocampal neurogenesis (AHN) has intrigued neuroscientists for decades. Several lines of evidence show that adult-born neurons in the hippocampus are functionally integrated and contribute to cognitive function, in particular learning and memory processes. Biological properties of immature hippocampal neurons indicate that these cells are more easily excitable compared with mature neurons, and demonstrate enhanced structural plasticity. The structure in which adult-born hippocampal neurons are situated-the dentate gyrus-is thought to contribute to hippocampus function by disambiguating similar input patterns, a process referred to as pattern separation. Several ideas about AHN function have been put forward; currently there is good evidence in favor of a role for AHN in pattern separation. This function of AHN may be understood within a 'representational-hierarchical' view of brain organization. WIREs Cogn Sci 2014, 5:573-587. doi: 10.1002/wcs.1304 For further resources related to this article, please visit the WIREs website. CONFLICT OF INTEREST: The authors have declared no conflicts of interest for this article.

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  1. [167]Ungerleider L Mishkin M Ingle D Goodale M Mansfield R Analysis of Behavior 1983 549 586 MIT Press Cambridge, MA

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Authors
Oomen, C. A., Bekinschtein, P., Kent, B. A., Saksida, L. M., & Bussey, T. J.
Affiliations
  • University of Cambridge (GB)
  • Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
Corresponding author
Oomen, Charlotte A.
Venue
WIREs Cognitive Science
Publisher
Wiley
Published
2014-08-12
Volume
5
Issue
5
Pages
573-587
ISSN
  • 1939-5078 (ISSN-L)
  • 1939-5086
OpenAlex
W1956964467
Cited by
93
References
192
Citations by year
2026: 8 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 12 · 2016: 23 · 2015: 7 · 2014: 2
FWCI
5.10
Type
journal article
Language
en
Open access
Locations
  • Wiley Interdisciplinary Reviews Cognitive Science (publishedVersion)
  • PubMed (publishedVersion)
  • Apollo (University of Cambridge) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Funders
  • Wellcome Trust (089703/Z/09/Z)
  • Biotechnology and Biological Sciences Research Council (BB/G019002/1)
  • Innovative Medicine Initiative Joint Undertaking of which resources are composed of a European Federation of Pharmaceutical Industries and Associations in-kind contribution and financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) (115008)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
adult hippocampal neurogenesis, dentate gyrus, pattern separation, learning and memory, hippocampal neurons, neuronal excitability, structural plasticity, hippocampal function

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