The DOI matches its Crossref record; 222 of the 225 references it cites were found in a registry or an index.
Liver regeneration
Open accessAbstract
Liver regeneration after partial hepatectomy is a very complex and well-orchestrated phenomenon. It is carried out by the participation of all mature liver cell types. The process is associated with signaling cascades involving growth factors, cytokines, matrix remodeling, and several feedbacks of stimulation and inhibition of growth related signals. Liver manages to restore any lost mass and adjust its size to that of the organism, while at the same time providing full support for body homeostasis during the entire regenerative process. In situations when hepatocytes or biliary cells are blocked from regeneration, these cell types can function as facultative stem cells for each other.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These ligands activate epidermal growth factor receptor (EGFR) signaling in hepatocytes driving their proliferation, especially in liver zones 1 and 2[4,20].”
From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [20]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Additionally, IL-6 plays a central role in restoring normal hepatic function following liver injury [1], [2].”
From Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli (2014) · cites this paper as [1]
Experimental — accuracy not yet measuredIn the citing paper
“The ability of the gut microbiome to remodel and persist in the face of insults such as antibiotic use is probably only matched in the host by the regenerative capacity of the liver (Michalopoulos, 2007) (Fig. 1, A and B).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Michalopoulos, 2007
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Michalopoulos, G. K., & DeFrances, M. C. (1997) · Science · doi:10.1126/science.276.5309.60 · Cited by 2,828
Self-citationBone Marrow as a Potential Source of Hepatic Oval Cells
Petersen, B. E., Bowen, W. C., Patrene, K. D., Mars, W. M., Sullivan, A. K., Murase, N., Boggs, S. S., Greenberger, J. S., & Goff, J. P. (1999) · Science · doi:10.1126/science.284.5417.1168 · Cited by 2,377
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
Lagasse, E., Connors, H., Al-Dhalimy, M., Reitsma, M., Dohse, M., Osborne, L., Wang, X., Finegold, M., Weissman, I. L., & Grompe, M. (2000) · Nature Medicine · doi:10.1038/81326 · Cited by 2,314
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
Terada, N., Hamazaki, T., Oka, M., Hoki, M., Mastalerz, D. M., Nakano, Y., Meyer, E. M., Morel, L. M., Petersen, B. E., & Scott, E. W. (2002) · Nature · doi:10.1038/nature730 · Cited by 2,000
Cell fusion is the principal source of bone-marrow-derived hepatocytes
Wang, X., Willenbring, H., Akkari, Y. M. N., Torimaru, Y., Foster, M., Al-Dhalimy, M., Lagasse, E., Finegold, M. J., Olson, S. B., & Grompe, M. (2003) · Nature · doi:10.1038/nature01531 · Cited by 1,569
Liver regeneration: from myth to mechanism
Taub, R. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1489 · Cited by 1,567
Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice
Cressman, D. E., Greenbaum, L. E., DeAngelis, R. A., Ciliberto, G., Furth, E. E., Poli, V., & Taub, R. (1996) · Science · doi:10.1126/science.274.5291.1379 · Cited by 1,538
Scatter factor/hepatocyte growth factor is essential for liver development
Schmidt, C. S., Bladt, F., Gödecke, S., Brinkmann, V., Zschiesche, W., Sharpe, M. J., Gherardi, E., & Birchmeler, C. (1995) · Nature · doi:10.1038/373699a0 · Cited by 1,395
Fausto, N., Campbell, J. S., & Riehle, K. J. (2006) · Hepatology · doi:10.1002/hep.20969 · Cited by 1,378
The IKK NF-κB system: a treasure trove for drug development
Karin, M., Yamamoto, Y., & Wang, Q. M. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1279 · Cited by 1,364
Flagged first, then by citations
3 of the 225 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- 10.1210/en.133.4.1731 · DOI
Cited by
Sorted by citations
Items 101–200 of 1,000
Organ repair and regeneration: An overview
Baddour, J., Sousounis, K., & Tsonis, P. A. (2012) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.21006 · Cited by 137
Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics
Ma, X., Huang, T., Chen, X., Li, Q., Liao, M., Fu, L., Huang, J., Yuan, K., Wang, Z., & Zeng, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02104-8 · Cited by 133
Understanding the marvels behind liver regeneration
Rmilah, A. A. A., Zhou, W., Nelson, E., Li, L., Amiot, B. P., & Nyberg, S. L. (2019) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.340 · Cited by 133
Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli
Norris, C. A., He, M., Kang, L.-I., Ding, M. Q., Radder, J. E., Haynes, M. M., Yang, Y., Paranjpe, S., Bowen, W. C., Orr, A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096053 · Cited by 132
Self-citationThe Epidermal Growth Factor Receptor: A Link Between Inflammation and Liver Cancer
Berasain, C., Perugorria, M. J., Latasa, M. U., Castillo, J., Goñi, S., Santamaría, M., Prìeto, J., & Avila, M. A. (2009) · Experimental Biology and Medicine · doi:10.3181/0901-mr-12 · Cited by 134
Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action
Elufioye, T. O., & Habtemariam, S. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108600 · Cited by 134
YAP oncogene overexpression supercharges colon cancer proliferation
Avruch, J., Zhou, D., & Bardeesy, N. M. (2012) · Cell Cycle · doi:10.4161/cc.11.6.19453 · Cited by 136
Role of platelets on liver regeneration after 90% hepatectomy in mice
Myronovych, A., Murata, S., Chiba, M., Matsuo, R., Ikeda, O., Watanabe, M., Hisakura, K., Nakano, Y., Kohno, K., Kawasaki, T., et al. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.04.019 · Cited by 131
The types of hepatic myofibroblasts contributing to liver fibrosis of different etiologies
Xu, J., Liu, X., Koyama, Y., Wang, P., Lan, T., Kim, I., Kim, I. H., Ma, H., & Kisseleva, T. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00167 · Cited by 130
Raftery, R. M., Walsh, D. P., Castaño, I. M., Heise, A., Duffy, G. P., Cryan, S., & O’Brien, F. J. (2016) · Advanced Materials · doi:10.1002/adma.201505088 · Cited by 123
Functional Relationships between Lipid Metabolism and Liver Regeneration
Rudnick, D. A., & Davidson, N. O. (2012) · International Journal of Hepatology · doi:10.1155/2012/549241 · Cited by 123
Toxicomicrobiomics: The Human Microbiome vs. Pharmaceutical, Dietary, and Environmental Xenobiotics
Abdelsalam, N. A., Ramadan, A. T., ElRakaiby, M. T., & Aziz, R. K. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00390 · Cited by 125
Beneficial Paracrine Effects of Cannabinoid Receptor 2 on Liver Injury and Regeneration†
Teixeira-Clerc, F., Belot, M., Manin, S., Deveaux, V., Cadoudal, T., Chobert, M.-N., Louvet, A., Zimmer, A., Tordjmann, T., Mallat, A., et al. (2010) · Hepatology · doi:10.1002/hep.23779 · Cited by 124
The generation of hepatocytes from mesenchymal stem cells and engraftment into murine liver
Stock, P., Brückner, S., Ebensing, S., Hempel, M., Dollinger, M. M., & Christ, B. (2010) · Nature Protocols · doi:10.1038/nprot.2010.7 · Cited by 121
Strategies for immortalization of primary hepatocytes
Ramboer, E., Craene, B. D., Kock, J. D., Vanhaecke, T., Berx, G., Rogiers, V., & Vinken, M. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.05.046 · Cited by 127
Regulation of hepatocyte fate by interferon-γ
Horras, C. J., Lamb, C. L., & Mitchell, K. A. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.01.001 · Cited by 120
Limaye, P. B., Bowen, W. C., Orr, A. V., Luo, J., Tseng, G. C., & Michalopoulos, G. K. (2008) · Hepatology · doi:10.1002/hep.22221 · Cited by 120
Self-citationExtracellular vesicle therapeutics for liver disease
Borrelli, D. A., Yankson, K., Shukla, N., Vilanilam, G. K., Ticer, T. D., & Wolfram, J. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.01.022 · Cited by 120
Takeishi, K., Collin de l’Hortet, A., Wang, Y., Handa, K., Guzman-Lepe, J., Matsubara, K., Morita, K., Jang, S., Haep, N., Florentino, R. M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107711 · Cited by 118
In vivo and ex vivo methods of growing a liver bud through tissue connection
Yanagi, Y., Nakayama, K., Taguchi, T., Enosawa, S., Tamura, T., Yoshimaru, K., Matsuura, T., Hayashida, M., Kohashi, K., Oda, Y., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-14542-2 · Cited by 119
Fibroblast Growth Factor Signaling Controls Liver Size in Mice With Humanized Livers
Naugler, W. E., Tarlow, B., Fedorov, L. M., Taylor, M. J., Pelz, C., Li, B., Darnell, J. C., & Grompe, M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.05.043 · Cited by 120
Lauschke, V. M., Vorrink, S. U., Moro, S. M. L., Rezayee, F., Nordling, Å., Hendriks, D. F. G., Bell, C. C., Sison‐Young, R., Park, B. K., Goldring, C. E., et al. (2016) · Hepatology · doi:10.1002/hep.28780 · Cited by 121
Barash, H., Gross, E. R., Edrei, Y., Ella, E., Israel, A., Cohen, I., Corchia, N., Ben-Moshe, T., Pappo, O., Pikarsky, E., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908867107 · Cited by 117
Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development
Avruch, J., Zhou, D., Fitamant, J., & Bardeesy, N. M. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6606011 · Cited by 115
Post hepatectomy liver failure – A comprehensive review of current concepts and controversies
Ray, S., Mehta, N. N., Golhar, A., & Nundy, S. (2018) · Annals of Medicine and Surgery · doi:10.1016/j.amsu.2018.08.012 · Cited by 122
Defining Post Hepatectomy Liver Insufficiency: Where do We stand?
Lafaro, K. J., Buettner, S., Maqsood, H., Wagner, D., Bagante, F., Spolverato, G., Xu, L., Kamel, I. R., & Pawlik, T. M. (2015) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-015-2872-6 · Cited by 116
Pregnane X receptor is essential for normal progression of liver regeneration†
Dai, G., He, L., Bu, P., & Wan, Y. Y. (2008) · Hepatology · doi:10.1002/hep.22129 · Cited by 114
Rozenblum, N., Zeira, E., Bulvik, B. E., Gourevitch, S., Yotvat, H., Galun, E., & Goldberg, S. N. (2015) · Radiology · doi:10.1148/radiol.15141918 · Cited by 113
Hydrogels for Liver Tissue Engineering
Ye, S., Boeter, J. W. B., Penning, L. C., Spee, B., & Schneeberger, K. (2019) · Bioengineering · doi:10.3390/bioengineering6030059 · Cited by 112
p53 on the crossroad between regeneration and cancer
Charni‐Natan, M., Aloni-Grinstein, R., Molchadsky, A., & Rotter, V. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.117 · Cited by 115
Plant-Derived Exosome-like Nanoparticles for Biomedical Applications and Regenerative Therapy
Sarasati, A., Syahruddin, M. H., Nuryanti, A., Ana, I. D., Barlian, A., Wijaya, C. H., Ratnadewi, D., Wungu, T. D. K., & Takemori, H. (2023) · Biomedicines · doi:10.3390/biomedicines11041053 · Cited by 118
Yu, J., Yin, S., Zhang, W., Gao, F., Liu, Y., Chen, Z., Zhang, M., He, J., & Zheng, S. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt234 · Cited by 110
Liver stem cells: experimental findings and implications for human liver disease
Michalopoulos, G. K., & Khan, Z. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.08.004 · Cited by 109
Self-citationNicotinamide adenine dinucleotide biosynthesis promotes liver regeneration
Mukherjee, S., Chellappa, K., Moffitt, A. B., Ndungu, J., Dellinger, R. W., Davis, J. G., Agarwal, B., & Baur, J. A. (2016) · Hepatology · doi:10.1002/hep.28912 · Cited by 108
Jin, J., Iakova, P. A., Jiang, Y., Medrano, E. E., & Timchenko, N. A. (2011) · Hepatology · doi:10.1002/hep.24471 · Cited by 107
Lin, W., Wu, J., Dong, H., Bouck, D. C., Zeng, F.-Y., & Chen, T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806132200 · Cited by 107
Ritschka, B., Knauer-Meyer, T., Gonçalves, D. S., Mas, A., Plassat, J.-L., Durik, M., Jacobs, H., Pedone, E., Di Vicino, U., Cosma, M. P., et al. (2020) · Genes & Development · doi:10.1101/gad.332643.119 · Cited by 105
Viral manipulation of STAT3: Evade, exploit, and injure
Suarez, A. A. R., Renne, N. V., Baumert, T. F., & Lupberger, J. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006839 · Cited by 112
Rich dynamics of a hepatitis B viral infection model with logistic hepatocyte growth
Hews, S., Eikenberry, S. E., Nagy, J. D., & Kuang, Y. (2009) · Journal of Mathematical Biology · doi:10.1007/s00285-009-0278-3 · Cited by 105
Kan, N. G., Junghans, D., & Belmonte, J. C. I. (2009) · The FASEB Journal · doi:10.1096/fj.09-131730 · Cited by 102
Immune cells in liver regeneration
Li, N., & Hua, J. (2017) · Oncotarget · doi:10.18632/oncotarget.12275 · Cited by 104
Luo, Z., Zhu, W. M., Guo, Q., Luo, W., Zhang, J., Xu, W., & Xu, J. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/4768541 · Cited by 104
Evidence for Serotonin as a Relevant Inducer of Liver Regeneration After Liver Resection in Humans
Starlinger, P. P., Assinger, A., Haegele, S., Wanek, D., Zikeli, S., Schauer, D., Birner, P., Fleischmann, E., Gruenberger, B., Brostjan, C., et al. (2013) · Hepatology · doi:10.1002/hep.26950 · Cited by 103
Functional compensation precedes recovery of tissue mass following acute liver injury
Walesky, C. M., Kolb, K. E., Winston, C. L., Henderson, J., Kruft, B., Fleming, I., Ko, S., Monga, S. P., Mueller, F., Apte, U., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19558-3 · Cited by 103
Protective effect of wedelolactone against CCl 4 -induced acute liver injury in mice
Yang, L., Hu, D., Ma, S., Zhao, X., Wang, S., Wei, G., Wang, X., Wen, A., & Wang, J. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.02.003 · Cited by 103
Cellular plasticity balances the metabolic and proliferation dynamics of a regenerating liver
Chembazhi, U. V., Bangru, S., Hernaez, M., & Kalsotra, A. (2021) · Genome Research · doi:10.1101/gr.267013.120 · Cited by 102
Gebhardt, R., & Hovhannisyan, A. (2009) · Developmental Dynamics · doi:10.1002/dvdy.22041 · Cited by 104
de l’Hortet, A. C., Takeishi, K., Guzman‐Lepe, J., Morita, K., Achreja, A., Popovic, B., Wang, Y., Handa, K., Mittal, A., Meurs, N., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.017 · Cited by 106
Valdecantos, M. P., Pardo, V., Ruiz, L., Castro‐Sánchez, L., Lanzón, B., Fernández‐Millán, E., García‐Monzón, C., Arroba, A. I., González‐Rodríguez, Á., Escrivá, F., et al. (2017) · Hepatology · doi:10.1002/hep.28962 · Cited by 100
Liver-Derived Exosomes and Their Implications in Liver Pathobiology
Sung, S., Kim, J., & Jung, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123715 · Cited by 101
New Paradigms in Post-hepatectomy Liver Failure
Golse, N., Bucur, P. O., Adam, R., Castaing, D., Sa Cunha, A., & Vibert, E. (2013) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-012-2048-6 · Cited by 100
Borude, P. C., Edwards, G., Walesky, C. M., Li, F., Ma, X., Kong, B., Guo, G. L., & Apte, U. M. (2012) · Hepatology · doi:10.1002/hep.25918 · Cited by 99
Vesicle-Mediated Control of Cell Function: The Role of Extracellular Matrix and Microenvironment
Rackov, G., Garcia‐Romero, N., Esteban-Rubio, S., Carrión-Navarro, J., Belda-Iniesta, C., & Ayuso‐Sacido, Á. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00651 · Cited by 102
Microenvironmental sensing by fibroblasts controls macrophage population size
Zhou, X., Franklin, R. A., Adler, M., Carter, T. S., Condiff, E., Adams, T. S., Pope, S. D., Philip, N. H., Meizlish, M. L., Kaminski, N., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2205360119 · Cited by 99
Gkretsi, V., Apte, U. M., Mars, W. M., Bowen, W. C., Luo, J., Yang, Y. H. C., Yu, Y. P., Orr, A., St.-Arnaud, R., Dedhar, S., et al. (2008) · Hepatology · doi:10.1002/hep.22537 · Cited by 98
Self-citationAbalymov, A. A., Parakhonskiy, B. V., & Skirtach, A. G. (2020) · Polymers · doi:10.3390/polym12030620 · Cited by 100
Padrissa‐Altés, S., Bachofner, M., Bogorad, R. L., Pohlmeier, L. M., Rossolini, T., Böhm, F., Liebisch, G., Hellerbrand, C., Koteliansky, V., Speicher, T., et al. (2014) · Gut · doi:10.1136/gutjnl-2014-307874 · Cited by 98
The Roles of Neutrophils in the Pathogenesis of Liver Diseases
Tang, J., Yan, Z.-J., Feng, Q., Yu, L., & Wang, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.625472 · Cited by 101
Zellmer, S., Schmidt‐Heck, W., Godoy, P., Weng, H., Meyer, C., Lehmann, T. J., Sparna, T., Schormann, W., Hammad, S., Kreutz, C., et al. (2010) · Hepatology · doi:10.1002/hep.23930 · Cited by 100
p21 is required for dextrose-mediated inhibition of mouse liver regeneration #
Weymann, A., Hartman, E., Gazit, V. A., Wang, C., Glauber, M., Turmelle, Y. P., & Rudnick, D. A. (2009) · Hepatology · doi:10.1002/hep.22979 · Cited by 94
Markers of liver regeneration—the role of growth factors and cytokines: a systematic review
Hoffmann, K., Nagel, A. J., Tanabe, K., Fuchs, J., Dehlke, K., Ghamarnejad, O., Lemekhova, A., & Mehrabi, A. (2020) · BMC Surgery · doi:10.1186/s12893-019-0664-8 · Cited by 94
Rahnemai‐Azar, A. A., Cloyd, J. M., Weber, S. M., Dillhoff, M., Schmidt, C. R., Winslow, E. R., & Pawlik, T. M. (2017) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2017.00060 · Cited by 94
Limaye, P. B., Alarcón, G., Walls, A. L., Nalesnik, M. A., Michalopoulos, G. K., Demetris, A. J., & Ochoa, E. R. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.56 · Cited by 94
Self-citationLiver Regeneration is Impaired in Lipodystrophic Fatty Liver Dystrophy Mice
Gazit, V. A., Weymann, A., Hartman, E., Finck, B. N., Hruz, P. W., Tzekov, A., & Rudnick, D. A. (2010) · Hepatology · doi:10.1002/hep.23920 · Cited by 93
Walesky, C. M., Gunewardena, S., Terwilliger, E. F., Edwards, G., Borude, P. C., & Apte, U. M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00064.2012 · Cited by 93
Jakobsen, J. S., Waage, J., Rapin, N., Bisgaard, H. C., Larsen, F. S., & Porse, B. T. (2013) · Genome Research · doi:10.1101/gr.146399.112 · Cited by 90
Soto–Gutiérrez, A., Gough, A., Vernetti, L. A., Taylor, D. L., & Monga, S. P. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217707731 · Cited by 94
Zhang, L., Ma, X.-J.-N., Fei, Y.-Y., Han, H., Xu, J., Cheng, L., & Li, X. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108004 · Cited by 95
Engelmann, C., Habtesion, A., Hassan, M., Kerbert, A. J. C., Hammerich, L., Novelli, S., Fidaleo, M., Philips, A., Davies, N. A., Ferreira-González, S., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.07.006 · Cited by 92
Reference gene selection for real-time RT-PCR in regenerating mouse livers
Tatsumi, K., Ohashi, K., Taminishi, S., Okano, T., Yoshioka, A., & Shima, M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.103 · Cited by 92
The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations
Bisteau, X., Caldez, M. J., & Kaldis, P. (2014) · Cancers · doi:10.3390/cancers6010079 · Cited by 93
Regenerative medicine and cell-based approaches to restore pancreatic function
Ellis, C. E., Ramzy, A., & Kieffer, T. J. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.93 · Cited by 92
Self-healing, injectable chitosan-based hydrogels: structure, properties and biological applications
Jinugu, M. E., Solanki, R., Dhanka, M., Thareja, P., & Bhatia, D. D. (2024) · Materials Advances · doi:10.1039/d4ma00131a · Cited by 90
T cell-derived lymphotoxin regulates liver regeneration
Tumanov, A. V., Koroleva, E. P., Christiansen, P. A., Khan, M. A., Ruddy, M. J., Burnette, B., Papa, S., Franzoso, G., Nedospasov, S. A., Fu, Y., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.09.015 · Cited by 89
Control of Growth During Regeneration
Sun, G., & Irvine, K. D. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-391498-9.00003-6 · Cited by 93
Current evidence on posthepatectomy liver failure: Comprehensive review
Sparrelid, E., Olthof, P. B., Dasari, B. V. M., Erdmann, J. I., Santol, J., Starlinger, P., & Gilg, S. (2022) · BJS Open · doi:10.1093/bjsopen/zrac142 · Cited by 88
Activation of fetal-like molecular programs during regeneration in the intestine and beyond
Viragova, S., Li, D., & Klein, O. D. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.05.009 · Cited by 89
Lgr5 + liver stem cells, hepatic organoids and regenerative medicine
Huch, M., Boj, S. F., & Clevers, H. C. (2013) · Regenerative Medicine · doi:10.2217/rme.13.39 · Cited by 90
Matsuzaki, K. (2011) · Cell and Tissue Research · doi:10.1007/s00441-011-1178-6 · Cited by 90
Senescence and immortality in hepatocellular carcinoma
Öztürk, M., Arslan-Ergül, A., Baǧışlar, S., Şentürk, Ş., & Yuzugullu, H. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.10.048 · Cited by 89
Verboven, E., Moya, I. M., Sansores-Garcia, L., Xie, J., Hillen, H., Kowalczyk, W., Vella, G., Verhulst, S., Castaldo, S. A., Algueró-Nadal, A., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.10.035 · Cited by 87
Kowalik, M. A., Saliba, C., Pibiri, M., Perra, A., Ledda-Columbano, G. M., Sarotto, I., Ghiso, E., Giordano, S., & Columbano, A. (2011) · Hepatology · doi:10.1002/hep.24289 · Cited by 86
Update on the Mechanisms of Liver Regeneration
Preziosi, M., & Monga, S. P. (2017) · Seminars in Liver Disease · doi:10.1055/s-0037-1601351 · Cited by 89
Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration
Bangru, S., Arif, W., Seimetz, J., Bhate, A., Chen, J., Rashan, E. H., Carstens, R. P., Anakk, S., & Kalsotra, A. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-018-0129-2 · Cited by 85
Role of HDAC1 in senescence, aging, and cancer
Willis-Martinez, D., Richards, H. W., Timchenko, N. A., & Medrano, E. E. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.10.001 · Cited by 85
Köhler, U. A., Kurinna, S. M., Schwitter, D., Marti, A. T., Schäfer, M., Hellerbrand, C., Speicher, T., & Werner, S. (2013) · Hepatology · doi:10.1002/hep.26964 · Cited by 85
Speicher, T., Siegenthaler, B., Bogorad, R. L., Ruppert, R., Petzold, T., Padrissa-Altes, S., Bachofner, M., Anderson, D. G., Koteliansky, V., Fässler, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms4862 · Cited by 85
Souza, P. R., de Oliveira, A. C., Vilsinski, B. H., Kipper, M. J., & Martins, A. F. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13050621 · Cited by 84
Melgar‐Lesmes, P., & Edelman, E. R. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.05.011 · Cited by 84
Hayashi, H., Sakai, K., Baba, H., & Sakai, T. (2011) · Hepatology · doi:10.1002/hep.24800 · Cited by 84
Hypoxia of the growing liver accelerates regeneration
Schadde, E., Tsatsaris, C., Swiderska‐Syn, M., Breitenstein, S., Urner, M., Schimmer, R. R., Booy, C., Z’graggen, B. R., Wenger, R. H., Spahn, D. R., et al. (2016) · Surgery · doi:10.1016/j.surg.2016.05.018 · Cited by 83
Gene Deletions and Amplifications in Human Hepatocellular Carcinomas
Nalesnik, M. A., Tseng, G. C., Ding, Y., Xiang, G., Zheng, Z., Yu, Y., Marsh, J. W., Michalopoulos, G. K., & Luo, J. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.12.021 · Cited by 80
Self-citationQuaglia, A., Portmann, B. C., Knisely, A. S., Srinivasan, P., Muiesan, P., Wendon, J. A., Heneghan, M. A., O'Grady, J. G., Samyn, M., Hadžić, N., et al. (2008) · Liver Transplantation · doi:10.1002/lt.21568 · Cited by 81
Pei, W., Tanaka, K., Huang, S. C., Xu, L., Liu, B., Sinclair, J. W., Idol, J., Varshney, G. K., Huang, H., Lin, S., et al. (2016) · npj Regenerative Medicine · doi:10.1038/npjregenmed.2016.13 · Cited by 81
Zeng, Z., Ouyang, J., Sun, L., Zeng, C., Zeng, F., & Wu, S. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c01596 · Cited by 80
Aydemir, T. B., Sitren, H. S., & Cousins, R. J. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.02.046 · Cited by 79
Laliena, A., San‐Miguel, B., Crespo, I., Alvarez, M., González‐Gallego, J., & Tuñón, M. J. (2012) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2012.00995.x · Cited by 80
RetractedOxidative Stress and Hepatic Stellate Cells: A PARADOXICAL RELATIONSHIP.
Gandhi, C. R. (2012) · PubMed · Cited by 80
Shu, J., Kren, B. T., Xia, Z., Wong, P. Y.-P., Li, L., Hanse, E. A., Min, M. X., Li, B., Albrecht, J. H., Zeng, Y., et al. (2011) · Hepatology · doi:10.1002/hep.24421 · Cited by 79
Borel, F., Tang, Q., Gernoux, G., Greer, C., Wang, Z., Barzel, A., Kay, M. A., Shultz, L. D., Greiner, D. L., Flotte, T. R., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.09.020 · Cited by 79
Metadata
- Authors
- Michalopoulos, G. K.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Michalopoulos, George K.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2007-06-08
- Volume
- 213
- Issue
- 2
- Pages
- 286-300
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- PMC
- PMC2701258
- OpenAlex
- W4210995852
- Cited by
- 1,384
- References
- 225
- Citations by year
- 2026: 32 · 2025: 60 · 2024: 78 · 2023: 58 · 2022: 74 · 2021: 81 · 2020: 81 · 2019: 82 · 2018: 88 · 2017: 77 · 2016: 89 · 2015: 90 · 2014: 84 · 2013: 84 · 2012: 72
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (2r01ca103958-06a1, UL1TR000005, CA 103958)
- National Cancer Institute (R01CA035373, CA035373, R01-CA103958, CA103958)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- liver regeneration, partial hepatectomy, hepatocytes, growth factors, cytokines, extracellular matrix remodeling, signaling pathways, liver homeostasis
- MeSH terms
- Animals, Epithelial Cells, Hemodynamics, Hepatectomy, Humans, Liver, Liver Regeneration, Mitosis, Stem Cells, Signal Transduction, Interleukin-6, Hepatocytes, Transforming Growth Factor beta1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
