Cited by 1,384Liver physiology and pathologyOrgan Transplantation Techniques and OutcomesTissue Engineering and Regenerative Medicine

The DOI matches its Crossref record; 222 of the 225 references it cites were found in a registry or an index.

Liver regeneration

Open access

Michalopoulos, George K.·2007·Journal of Cellular Physiology

DOI 10.1002/jcp.21172PMC PMC2701258

Open this paper in CoChat — free account Open PDF

Abstract

Liver regeneration after partial hepatectomy is a very complex and well-orchestrated phenomenon. It is carried out by the participation of all mature liver cell types. The process is associated with signaling cascades involving growth factors, cytokines, matrix remodeling, and several feedbacks of stimulation and inhibition of growth related signals. Liver manages to restore any lost mass and adjust its size to that of the organism, while at the same time providing full support for body homeostasis during the entire regenerative process. In situations when hepatocytes or biliary cells are blocked from regeneration, these cell types can function as facultative stem cells for each other.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/jcp.21172

Cites

222 of 222 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Liver Regeneration
Michalopoulos, G. K., & DeFrances, M. C. (1997) · Science · doi:10.1126/science.276.5309.60 · Cited by 2,828
Self-citation
Bone Marrow as a Potential Source of Hepatic Oval Cells
Petersen, B. E., Bowen, W. C., Patrene, K. D., Mars, W. M., Sullivan, A. K., Murase, N., Boggs, S. S., Greenberger, J. S., & Goff, J. P. (1999) · Science · doi:10.1126/science.284.5417.1168 · Cited by 2,377
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
Lagasse, E., Connors, H., Al-Dhalimy, M., Reitsma, M., Dohse, M., Osborne, L., Wang, X., Finegold, M., Weissman, I. L., & Grompe, M. (2000) · Nature Medicine · doi:10.1038/81326 · Cited by 2,314
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
Terada, N., Hamazaki, T., Oka, M., Hoki, M., Mastalerz, D. M., Nakano, Y., Meyer, E. M., Morel, L. M., Petersen, B. E., & Scott, E. W. (2002) · Nature · doi:10.1038/nature730 · Cited by 2,000
Cell fusion is the principal source of bone-marrow-derived hepatocytes
Wang, X., Willenbring, H., Akkari, Y. M. N., Torimaru, Y., Foster, M., Al-Dhalimy, M., Lagasse, E., Finegold, M. J., Olson, S. B., & Grompe, M. (2003) · Nature · doi:10.1038/nature01531 · Cited by 1,569
Liver regeneration: from myth to mechanism
Taub, R. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1489 · Cited by 1,567
Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice
Cressman, D. E., Greenbaum, L. E., DeAngelis, R. A., Ciliberto, G., Furth, E. E., Poli, V., & Taub, R. (1996) · Science · doi:10.1126/science.274.5291.1379 · Cited by 1,538
Scatter factor/hepatocyte growth factor is essential for liver development
Schmidt, C. S., Bladt, F., Gödecke, S., Brinkmann, V., Zschiesche, W., Sharpe, M. J., Gherardi, E., & Birchmeler, C. (1995) · Nature · doi:10.1038/373699a0 · Cited by 1,395
Liver regeneration
Fausto, N., Campbell, J. S., & Riehle, K. J. (2006) · Hepatology · doi:10.1002/hep.20969 · Cited by 1,378
The IKK NF-κB system: a treasure trove for drug development
Karin, M., Yamamoto, Y., & Wang, Q. M. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1279 · Cited by 1,364
Liver regeneration
Fausto, N. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80412-2 · Cited by 1,022
Notch Signaling: From the Outside In
Mumm, J. S., & Kopan, R. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9960 · Cited by 964
Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor
Yamada, Y., Kirillova, I., Peschon, J. J., & Fausto, N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1441 · Cited by 944
IKK/NF- B signaling: balancing life and death - a new approach to cancer therapy
Luo, J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26322 · Cited by 898
Platelet-Derived Serotonin Mediates Liver Regeneration
Lesurtel, M., Graf, R., Aleil, B., Walther, D. J., Tian, Y., Jochum, W., Gachet, C., Bäder, M., & Clavien, P. (2006) · Science · doi:10.1126/science.1123842 · Cited by 800
Hepatocyte growth factor/ c-met signaling pathway is required for efficient liver regeneration and repair
Huh, C.-G., Factor, V. M., Sánchez, A., Uchida, K., Conner, E. A., & Thorgeirsson, S. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306068101 · Cited by 750
Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells
Fausto, N. (2004) · Hepatology · doi:10.1002/hep.20214 · Cited by 720
Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET.
Naldini, L., Vigna, E., Narsimhan, R. P., Gaudino, G., Zarnegar, R., Michalopoulos, G. K., & Comoglio, P. M. (1991) · PubMed · Cited by 698
Self-citation
Angiogenesis-Independent Endothelial Protection of Liver: Role of VEGFR-1
LeCouter, J. E., Moritz, D. R., Li, B., Phillips, G. D. L., Liang, X. H., Gerber, H., Hillan, K. J., & Ferrara, N. (2003) · Science · doi:10.1126/science.1079562 · Cited by 677
Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.
Sanderson, N., Factor, V., Nagy, P., Kopp, J. B., Kondaiah, P., Wakefield, L. M., Roberts, A. B., Sporn, M. B., & Thorgeirsson, S. S. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.2572 · Cited by 671
Emerging Multipotent Aspects of Hepatocyte Growth Factor
Matsumoto, K., & Nakamura, T. (1996) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021283 · Cited by 666
Nuclear Receptor-Dependent Bile Acid Signaling Is Required for Normal Liver Regeneration
Huang, W., Ma, K., Zhang, J., Qatanani, M., Cuvillier, J., Liu, J., Dong, B., Huang, X., & Moore, D. D. (2006) · Science · doi:10.1126/science.1121435 · Cited by 645
Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes.
Overturf, K., Al-Dhalimy, M., Ou, C. N., Finegold, M. J., & Grompe, M. (1997) · Europe PMC (PubMed Central) · Cited by 599
The initiation of liver development is dependent on Foxa transcription factors
Lee, C. S., Friedman, J. R., Fulmer, J. T., & Kaestner, K. H. (2005) · Nature · doi:10.1038/nature03649 · Cited by 581
Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism.
Mead, J. E., & Fausto, N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.5.1558 · Cited by 535
Met provides essential signals for liver regeneration
Borowiak, M., Garratt, A. N., Wüstefeld, T., Strehle, M., Trautwein, C., & Birchmeier, C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403412101 · Cited by 497
TGF-β: Regulation of extracellular matrix
Roberts, A. B., McCune, B. K., & Sporn, M. B. (1992) · Kidney International · doi:10.1038/ki.1992.81 · Cited by 492
Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium.
Block, G. D., Locker, J. D., Bowen, W. C., Petersen, B. E., Katyal, S. L., Strom, S. C., Riley, T., Howard, T. A., & Michalopoulos, G. K. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.132.6.1133 · Cited by 485
Self-citation
Baboon-to-human liver transplantation
Starzl, T. E., Fung, J., Tzakis, A., Todo, S., Demetris, A. J., Marino, I. R., Doyle, H., Zeevi, A., Warty, V, Kusne, S., et al. (1993) · The Lancet · doi:10.1016/0140-6736(93)92553-6 · Cited by 471
Diverse Roles of the Nuclear Orphan Receptor CAR in Regulating Hepatic Genes in Response to Phenobarbital
Ueda, A., Hamadeh, H. K., Webb, H. K., Yamamoto, Y., Sueyoshi, T., Afshari, C. A., Lehmann, J. M., & Negishi, M. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.1.1 · Cited by 465
NFkappaB prevents apoptosis and liver dysfunction during liver regeneration.
Iimuro, Y., Nishiura, T., Hellerbrand, C., Behrns, K. E., Schoonhoven, R., Grisham, J. W., & Brenner, D. A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci483 · Cited by 447
The proinflammatory mediators C3a and C5a are essential for liver regeneration
Strey, C. W., Markiewski, M., Mastellos, D., Tudoran, R., Spruce, L. A., Greenbaum, L. E., & Lambris, J. D. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030374 · Cited by 436
Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat.
Russell, W. E., Coffey, R. J., Ouellette, A. J., & Moses, H. L. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5126 · Cited by 427
Induction of Cyclin D1 Transcription and CDK2 Activity by Notch ic : Implication for Cell Cycle Disruption in Transformation by Notch ic
Ronchini, C., & Capobianco, A. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.5925-5934.2001 · Cited by 418
Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy
Akerman, P., Cote, P., Yang, S. Q., McClain, C., Nelson, S., Bagby, G. J., & Diehl, A. M. (1992) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1992.263.4.g579 · Cited by 401
Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver
Stanger, B. Z., Tanaka, A., & Melton, D. A. (2007) · Nature · doi:10.1038/nature05537 · Cited by 396
Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration
Lindroos, P. M., Zarnegar, R., & Michalopoulos, G. K. (1991) · Hepatology · doi:10.1002/hep.1840130422 · Cited by 385
Self-citation
Long-Term, Near-Total Liver Replacement by Transplantation of Isolated Hepatocytes in Rats Treated with Retrorsine
Laconi, E., Oren, R., Mukhopadhyay, D. K., Hurston, E., Laconi, S., Pani, P., Dabeva, M. D., & Shafritz, D. A. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65574-5 · Cited by 381
Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA.
Mars, W. M., Zarnegar, R., & Michalopoulos, G. K. (1993) · PubMed · Cited by 377
Self-citation
Transcriptional control of liver regeneration
Taub, R. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.4.8647340 · Cited by 353
Cross-talk between Epidermal Growth Factor Receptor and c-Met Signal Pathways in Transformed Cells*
Jo, M., Stolz, D. B., Esplen, J. E., Dorko, K., Michalopoulos, G. K., & Strom, S. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8806 · Cited by 347
Self-citation
Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas†
Luo, J., Ren, B., Keryanov, S., Tseng, G. C., Rao, U. N. M., Monga, S. P., Strom, S. C., Demetris, A. J., Nalesnik, M. A., Yu, Y. P., et al. (2006) · Hepatology · doi:10.1002/hep.21328 · Cited by 339
Self-citation
c-Met is essential for wound healing in the skin
Chmielowiec, J., Borowiak, M., Morkel, M., Stradal, T. E. B., Munz, B., Werner, S., Wehland, J., Birchmeier, C., & Birchmeier, W. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200701086 · Cited by 335
Biphasic Effect of Transforming Growth Factor-β1 on in Vitro Angiogenesis
Pepper, M. S., Vassalli, J. D., Orci, L., & Montesano, R. (1993) · Experimental Cell Research · doi:10.1006/excr.1993.1043 · Cited by 329
The role of SF/HGF and c-Met in the development of skeletal muscle
Dietrich, S., Abou‐Rebyeh, F., Brohmann, H., Bladt, F., Sonnenberg-Riethmacher, E., Yamaai, T., Lumsden, A., Brand‐Saberi, B., & Birchmeier, C. (1999) · Development · doi:10.1242/dev.126.8.1621 · Cited by 328
Signaling Pathways and Genes that Inhibit Pathogen-Induced Macrophage Apoptosis— CREB and NF-κB as Key Regulators
Park, J. M., Greten, F. R., Wong, A. W., Westrick, R. J., Arthur, J. S. C., Otsu, K., Hoffmann, A., Montminy, M., & Karin, M. (2005) · Immunity · doi:10.1016/j.immuni.2005.08.010 · Cited by 324
In vivo differentiation of rat liver oval cells into hepatocytes.
Evarts, R. P., Nagy, P., Nakatsukasa, H., Marsden, E. R., & Thorgeirsson, S. S. (1989) · PubMed · Cited by 321
Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury†
Michalopoulos, G. K., Barua, L., & Bowen, W. C. (2005) · Hepatology · doi:10.1002/hep.20600 · Cited by 319
Self-citation
Rapid activation of the stat3 transcription complex in liver regeneration
Cressman, D. E., Diamond, R. H., & Taub, R. (1995) · Hepatology · doi:10.1002/hep.1840210531 · Cited by 314
STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration
Li, W., Liang, X., Kellendonk, C., Poli, V., & Taub, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202807200 · Cited by 307
An overview of the Notch signalling pathway
Baron, M. (2003) · Seminars in Cell and Developmental Biology · doi:10.1016/s1084-9521(02)00179-9 · Cited by 306
Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes.
Monga, S. P., Mars, W. M., Pediaditakis, P., Bell, A. W., Mulé, K., Bowen, W. C., Wang, X., Zarnegar, R., & Michalopoulos, G. K. (2002) · PubMed · Cited by 298
Self-citation
Control of hepatocyte replication by two serum factors.
Michalopoulos, G. K., Houck, K. A., Dolan, M. L., & Leutteke, N. C. (1984) · PubMed · Cited by 297
Self-citation
Changes in Wnt/β–Catenin Pathway During Regulated Growth in Rat Liver Regeneration
Monga, S. P. S., Pediaditakis, P., Mule, K., Stolz, D. B., & Michalopoulos, G. K. (2001) · Hepatology · doi:10.1053/jhep.2001.23786 · Cited by 292
Self-citation
Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat.
Fujio, K., Evarts, R. P., Hu, Z., Marsden, E. R., & Thorgeirsson, S. S. (1994) · PubMed · Cited by 286
Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor
Swindle, C. S., Tran, K. T., Johnson, T. D., Banerjee, P., Mayes, A. M., Griffith, L., & Wells, A. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200103103 · Cited by 286
Tumor Necrosis Factor Primes Hepatocytes for Dna Replication in the Rat
Webber, E. M., Bruix, J., Pierce, R. H., & Fausto, N. (1998) · Hepatology · doi:10.1002/hep.510280509 · Cited by 280
Caveolin-1 Is Essential for Liver Regeneration
Fernandez-Rojo, M. A., Albor, C. V., Ingelmo‐Torres, M., Nixon, S. J., Ferguson, C., Kurzchalia, T. V., Tebar, F., Enrich, C., Parton, R. G., & Pol, A. (2006) · Science · doi:10.1126/science.1130773 · Cited by 279
Regeneration of Rat Liver: Transfer of Humoral Agent by Cross Circulation
Moolten, F. L., & Bucher, N. L. R. (1967) · Science · doi:10.1126/science.158.3798.272 · Cited by 277
Mitosis and Apoptosis in the Liver of Interleukin–6-Deficient Mice After Partial Hepatectomy
Sakamoto, T., Liu, Z., Murase, N., Ezure, T., Yokomuro, S., Poli, V., & Demetris, A. J. (1999) · Hepatology · doi:10.1002/hep.510290244 · Cited by 276
Amnion-Derived Pluripotent/Multipotent Stem Cells
Miki, T., & Strom, S. C. (2006) · Stem Cell Reviews and Reports · doi:10.1007/s12015-006-0020-0 · Cited by 275
Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: Requirement for type 1 but not type 2 receptor
Yamada, Y., Webber, E. M., Kirillova, I., Peschon, J. J., & Fausto, N. (1998) · Hepatology · doi:10.1002/hep.510280410 · Cited by 260
Induction of DNA Synthesis in Cultured Rat Hepatocytes Through Stimulation of α 1 Adrenoreceptor by Norepinephrine
Cruise, J. L., Houck, K. A., & Michalopoulos, G. K. (1985) · Science · doi:10.1126/science.2982212 · Cited by 259
Self-citation
The Physiology Of Transforming Growth Factor-α
Derynck, R. (1992) · Advances in cancer research · doi:10.1016/s0065-230x(08)60289-4 · Cited by 256
Human and Rat Hepatic Stellate Cells Express Neurotrophins and Neurotrophin Receptors
Cassiman, D. M., Denef, C., Desmet, V. J., & Roskams, T. (2001) · Hepatology · doi:10.1053/jhep.2001.20793 · Cited by 250
Hepatocyte nuclear factor 4α orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver
Battle, M. A., Konopka, G., Parviz, F., Gaggl, A. L., Yang, C., Sladek, F. M., & Duncan, S. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600246103 · Cited by 246
Impaired liver regeneration in inducible nitric oxide synthasedeficient mice
Rai, R. M., Lee, F.-Y. J., Rosen, A., Yang, S. Q., Lin, H. Z., Koteish, A. A., Liew, F. Y., Zaragoza, C., Lowenstein, C. J., & Diehl, A. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13829 · Cited by 242
PDGF and signal transduction in hepatic stellate cells
Pinzani, M. (2002) · Frontiers in bioscience · doi:10.2741/a875 · Cited by 239
Disruption of Hepatic Adipogenesis Is Associated With Impaired Liver Regeneration in Mice
Shteyer, E., Liao, Y., Muglia, L. J., Hruz, P. W., & Rudnick, D. A. (2004) · Hepatology · doi:10.1002/hep.20462 · Cited by 234
Experimental pathology of the liver. Restoration of the liver of the white rat following partial surgical removal
Higgins, G. (1931) · Medical Entomology and Zoology · Cited by 234
Expression of hepatic transcription factors during liver development and oval cell differentiation.
Nagy, P., Bisgaard, H. C., & Thorgeirsson, S. S. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.1.223 · Cited by 230
A Mechanism of Cell Survival
Wang, X., DeFrances, M. C., Dai, Y., Pediaditakis, P., Johnson, C., Bell, A., Michalopoulos, G. K., & Zarnegar, R. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00439-2 · Cited by 225
Self-citation
Expression of Hepatocyte Growth Factor mRNA in regenerating rat liver after partial hepatectomy
Zarnegar, R., DeFrances, M. C., Kost, D. P., Lindroos, P. M., & Michalopoulos, G. K. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)92020-k · Cited by 222
Self-citation
Lung may have an endocrine function producing hepatocyte growth factor in response to injury of distal organs
Yanagita, K., Nagaike, M., Ishibashi, H., Niho, Y., Matsumoto, K., & Nakamura, T. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91803-x · Cited by 214
Rapid DNA binding by nuclear factor kappa B in hepatocytes at the start of liver regeneration.
Fitzgerald, M. J., Webber, E. M., Donovan, J. R., & Fausto, N. (1995) · PubMed · Cited by 213
Deficient liver regeneration after carbon tetrachloride injury in mice lacking type 1 but not type 2 tumor necrosis factor receptor.
Yamada, Y., & Fausto, N. (1998) · Europe PMC (PubMed Central) · Cited by 208
Amphiregulin: An early trigger of liver regeneration in mice
Berasain, C., García–Trevijano, E. R., Castillo, J., Erroba, E., Lee, D. C., Prìeto, J., & Avila, M. A. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.006 · Cited by 207
Extracellular matrix remodeling at the early stages of liver regeneration in the rat
Kim, T., Mars, W. M., Stolz, D. B., Petersen, B. E., & Michalopoulos, G. K. (1997) · Hepatology · doi:10.1002/hep.510260415 · Cited by 196
Self-citation
Cell-Extracellular Matrix Interactions Can Regulate the Switch between Growth and Differentiation in Rat Hepatocytes: Reciprocal Expression of C/ΕΒΡα and Immediate-Early Growth Response Transcription Factors
Rana, B., Mischoulon, D., Xie, Y., Bucher, N. L. R., & Farmer, S. R. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5858 · Cited by 196
Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration
Köhler, C. N., Bell, A. W., Bowen, W. C., Monga, S. P., Fleig, W. E., & Michalopoulos, G. K. (2004) · Hepatology · doi:10.1002/hep.20156 · Cited by 195
Self-citation
α1-Adrenergic effects and liver regeneration
Cruise, J. L., Knechtle, S. J., Bollinger, R. R., Kuhn, C. M., & Michalopoulos, G. K. (1987) · Hepatology · doi:10.1002/hep.1840070604 · Cited by 192
Self-citation
Transcriptional Control of Wound Repair
Schäfer, M., & Werner, S. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123609 · Cited by 190
Liver regeneration versus direct hyperplasia
Columbano, A., & Shinozuka, H. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.10.8751714 · Cited by 186
TACE/ADAM17 Processing of EGFR Ligands Indicates a Role as a Physiological Convertase
Lee, D. C., Sunnarborg, S. W., Hinkle, C. L., MYERS, T. J., STEVENSON, M., Russell, W. E., Castner, B. J., GERHART, M. J., Paxton, R. J., Black, R. A., et al. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03207.x · Cited by 184
Regulation of Hepatic Stellate Cell Differentiation by the Neurotrophin Receptor p75 NTR
Passino, M. A., Adams, R. A., Sikorski, S. L., & Akassoglou, K. (2007) · Science · doi:10.1126/science.1137603 · Cited by 181
Glial fibrillary acidic protein - a cell type specific marker for Ito cells in vivo and in vitro
Neubauer, K., Knittel, T. E., Aurisch, S., Fellmer, P., & Ramadori, G. P. (1996) · Journal of Hepatology · doi:10.1016/s0168-8278(96)80269-8 · Cited by 175
Expression and activation of pro-MMP-2 and pro-MMP-9 during rat liver regeneration
Kim, T., Mars, W. M., Stolz, D. B., & Michalopoulos, G. K. (2000) · Hepatology · doi:10.1002/hep.510310114 · Cited by 170
Self-citation
Interleukin 6/Gp130–Dependent Pathways Are Protective During Chronic Liver Diseases
Streetz, K. L., Tacke, F., Leifeld, L., Wüstefeld, T., Graw, A., Klein, C., Kamino, K., Spengler, U., Kreipe, H. H., Kubicka, S., et al. (2003) · Hepatology · doi:10.1053/jhep.2003.50268 · Cited by 168
Immediate early detection of urokinase receptor after partial hepatectomy and its implications for initiation of liver regeneration
Mars, W. M., Liu, M.-L., Kitson, R. P., Goldfarb, R. H., Gabauer, M. K., & Michalopoulos, G. K. (1995) · Hepatology · doi:10.1002/hep.1840210631 · Cited by 168
Self-citation
Role of fibroblast growth factor type 1 and 2 in carbon tetrachloride-induced hepatic injury and fibrogenesis
Yu, C., Wang, F., Jin, C., Huang, X., Miller, D. L., Basilico, C., & McKeehan, W. L. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63522-5 · Cited by 167
Structural and functional characterization of the mouse hepatocyte growth factor gene promoter.
Liu, Y., Michalopoulos, G. K., & Zarnegar, R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41756-x · Cited by 162
Self-citation
Heparin-binding Epidermal Growth Factor-like Growth Factor Links Hepatocyte Priming with Cell Cycle Progression during Liver Regeneration
Mitchell, C., Nivison, M. P., Jackson, L. F., Fox, R., Lee, D. C., Campbell, J. S., & Fausto, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412372200 · Cited by 160
Untitled work
(1999) · PubMed · Cited by 158
Self-citation
Metalloproteinase inhibitor TIMP‐1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration†
Mohammed, F. F., Pennington, C. J., Kassiri, Z., Rubin, J. S., Soloway, P. D., Rüther, U., Edwards, D. R., & Khokha, R. (2005) · Hepatology · doi:10.1002/hep.20618 · Cited by 156
Spatiotemporal expression of angiogenesis growth factor receptors during the revascularization of regenerating rat liver
Ross, M. A., Sander, C. M., Kleeb, T. B., Watkins, S. C., & Stolz, D. B. (2001) · Hepatology · doi:10.1053/jhep.2001.29624 · Cited by 156
Lessons from animal models of NASH
Diehl, A. M. (2005) · Hepatology Research · doi:10.1016/j.hepres.2005.09.022 · Cited by 152
Influence of epidermal growth factor on liver regeneration after partial hepatectomy in rats
Olsen, P. S., Boesby, S., Kirkegaard, P. O., Therkelsen, K., Almdal, T., Poulsen, S. S., & Nexø, E. (1988) · Hepatology · doi:10.1002/hep.1840080503 · Cited by 151
HGF: a multifunctional growth factor controlling cell scattering
Stella, M. C. (1999) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(99)00089-8 · Cited by 151
Transforming growth factor-beta (TGF-beta) isoforms in rat liver regeneration: messenger RNA expression and activation of latent TGF-beta.
Jakowlew, S. B., Mead, J. E., Danielpour, D., Wu, J., Roberts, A. B., & Fausto, N. (1991) · Cell Regulation · doi:10.1091/mbc.2.7.535 · Cited by 147
Bone Marrow–Derived Hepatic Oval Cells Differentiate Into Hepatocytes in 2-Acetylaminofluorene/Partial Hepatectomy–Induced Liver Regeneration
Oh, S., Witek, R. P., Bae, S., Zheng, D., Jung, Y., Piscaglia, A. C., & Petersen, B. E. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.01.001 · Cited by 147
The processing and utilization of hepatocyte growth factor/scatter factor following partial hepatectomy in the rat
Pediaditakis, P., López-Talavera, J. C., Petersen, B. E., Monga, S. P., & Michalopoulos, G. K. (2001) · Hepatology · doi:10.1053/jhep.2001.27811 · Cited by 143
Self-citation
Cytotoxicity of TNFα is regulated by integrin‐mediated matrix signaling
Chen, C., Young, J. L., Monzon, R. I., Chen, N., Todorović, V., & Lau, L. F. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601596 · Cited by 143
Tumor necrosis factor induces DNA replication in hepatic cells through nuclear factor kappaB activation.
Kirillova, I., Chaisson, M. L., & Fausto, N. (1999) · PubMed · Cited by 143
Transcriptional Regulatory Signals Define Cytokine-Dependent and -Independent Pathways in Liver Regeneration
Taub, R., Greenbaum, L., & Peng, Y. (1999) · Seminars in Liver Disease · doi:10.1055/s-2007-1007104 · Cited by 139
Evidence That Cyclin D1 Mediates Both Growth and Proliferation Downstream of TOR in Hepatocytes
Nelsen, C. J., Rickheim, D. G., Tucker, M. M., Hansen, L. K., & Albrecht, J. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209374200 · Cited by 138
An alpha 2-macroglobulin receptor-dependent mechanism for the plasma clearance of transforming growth factor-beta 1 in mice.
LaMarre, J., Hayes, M. A., Wollenberg, G. K., Hussaini, I. M., Hall, S. W., & Gonias, S. L. (1991) · Journal of Clinical Investigation · doi:10.1172/jci114998 · Cited by 137
Immunolocalization of putative human liver progenitor cells in livers from patients with end-stage primary biliary cirrhosis and sclerosing cholangitis using the monoclonal antibody OV-6.
Crosby, H. A., Hübscher, S. G., Fabris, L., Joplin, R., Sell, S., Kelly, D. A., & Strain, A. J. (1998) · Europe PMC (PubMed Central) · Cited by 136
Collagenase pretreatment and the mitogenic effects of hepatocyte growth factor and transforming growth factor-α in adult rat liver
Liu, M.-L., Mars, W. M., Zarnegar, R., & Michalopoulos, G. K. (1994) · Hepatology · doi:10.1002/hep.1840190630 · Cited by 134
Self-citation
Hepatocellular expression of glutamine synthetase: An indicator of morphogen actions as master regulators of zonation in adult liver
Gebhardt, R., Baldysiak-Figiel, A., Krügel, V., Ueberham, E., & Gaunitz, F. (2007) · Progress in Histochemistry and Cytochemistry · doi:10.1016/j.proghi.2006.12.001 · Cited by 131
Histological organization in hepatocyte organoid cultures.
Michalopoulos, G., Bowen, W., Mulé, K., & Stolz, D. B. (2001) · American Journal of Pathology · doi:10.1016/s0002-9440(10)63034-9 · Cited by 129
Self-citation
Coexpression of IL‐6 and soluble IL‐6R causes nodular regenerative hyperplasia and adenomas of the liver
Maione, D., Carlo, E. D., Li, W., Musiani, P., Modesti, A., Peters, M., Rose‐John, S., Rocca, C. D., Tripodi, M., Lazzaro, D., et al. (1998) · The EMBO Journal · doi:10.1093/emboj/17.19.5588 · Cited by 128
Morphogenetic Events in Mixed Cultures of Rat Hepatocytes and Nonparenchymal Cells Maintained in Biological Matrices in the Presence of Hepatocyte Growth Factor and Epidermal Growth Factor
Michalopoulos, G. K., Bowen, W. C., Zajac, V. F., Beer–Stolz, D., Watkins, S. C., Kostrubsky, V. E., & Strom, S. C. (1999) · Hepatology · doi:10.1002/hep.510290149 · Cited by 126
Self-citation
Liver regeneration, growth factors, and amphiregulin
Michalopoulos, G. K., & Khan, Z. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.12.039 · Cited by 125
Self-citation
Intact signaling by transforming growth factor β is not required for termination of liver regeneration in mice
Oe, S., Lemmer, E. R., Conner, E. A., Factor, V. M., Levéen, P., Larsson, J. T., Karlsson, S., & Thorgeirsson, S. S. (2004) · Hepatology · doi:10.1002/hep.20426 · Cited by 125
Overexpression of transforming growth factor-alpha causes liver enlargement and increased hepatocyte proliferation in transgenic mice.
Webber, E. M., Wu, J. C., Wang, L., Merlino, G. T., & Fausto, N. (1994) · PubMed Central · Cited by 123
Sinusoidal endothelial cell proliferation and expression of angiopoietin/Tie family in regenerating rat liver
Sato, T., El-Assal, O. N., Ono, T., Yamanoi, A., Dhar, D. K., & Nagasue, N. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(00)00109-4 · Cited by 123
Activation of hepatic stem cell compartment in the rat: role of transforming growth factor alpha, hepatocyte growth factor, and acidic fibroblast growth factor in early proliferation.
Evarts, R. P., Hu, Z., Fujio, K., Marsden, E. R., & Thorgeirsson, S. S. (1993) · PubMed · Cited by 121
Identification of Transcriptional Networks during Liver Regeneration
White, P., Brestelli, J. E., Kaestner, K. H., & Greenbaum, L. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410844200 · Cited by 120
Disruption of Redox Homeostasis in Tumor Necrosis Factor-Induced Apoptosis in a Murine Hepatocyte Cell Line
Pierce, R. H., Campbell, J. S., Stephenson, A. B., Franklin, C. C., Chaisson, M. L., Poot, M., Kavanagh, T. J., Rabinovitch, P. S., & Fausto, N. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64533-6 · Cited by 119
Modulation of insulin-like growth factor-II/mannose 6-phosphate receptors and transforming growth factor-beta 1 during liver regeneration.
Jirtle, R. L., Carr, B. I., & Scott, C. D. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54592-0 · Cited by 115
Liver stem cells.
Sell, S. (1994) · PubMed · Cited by 115
Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1
Benigni, F., Fantuzzi, G., Sacco, S., Sironi, M., Pozzi, P., Dinarello, C. A., Sipe, J. D., Poli, V., Cappelletti, M., Paonessa, G., et al. (1996) · Blood · doi:10.1182/blood.v87.5.1851.1851 · Cited by 112
Hepatocyte growth factor induces hepatocyte proliferation in vivo and allows for efficient retroviral-mediated gene transfer in mice
Patijn, G. A., Lieber, A., Schowalter, D. B., SCHWALL, R. H., & Kay, M. A. (1998) · Hepatology · doi:10.1002/hep.510280317 · Cited by 111
Peroxisome Proliferator–induced Pleiotropic Responses: Pursuit of a Phenomenona
Reddy, J. K., & Chu, R. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb18616.x · Cited by 110
Hormonal Factors Concerned with Liver Regeneration
Bucher, N. L. R., Patel, U., & Cohen, S. (1978) · Novartis Foundation symposium · doi:10.1002/9780470720363.ch5 · Cited by 108
Impaired Hepatocyte DNA Synthetic Response Posthepatectomy in Insulin-Like Growth Factor Binding Protein 1-Deficient Mice with Defects in C/EBPβ and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Regulation
Leu, J. I.-J., Crissey, M. A. S., Craig, L. E., & Taub, R. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1251-1259.2003 · Cited by 108
Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice†‡
Croquelois, A., Blindenbacher, A., Terracciano, L., Wang, X., Langer, I., Radtke, F., & Heim, M. H. (2005) · Hepatology · doi:10.1002/hep.20571 · Cited by 106
Sequestration of a hepatocyte growth factor in extracellular matrix in normal adult rat liver
Masumoto, A., & Yamamoto, N. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)90489-t · Cited by 105
Multiple levels of Notch signal regulation (Review)
Baron, M., Aslam, H., Flasza, M., Fostier, M., Higgs, J. E., Mazaleyrat, S., & Wilkin, M. B. (2002) · Molecular Membrane Biology · doi:10.1080/09687680110112929 · Cited by 105
Norepinephrine and neuropeptide Y promote proliferation and collagen gene expression of hepatic myofibroblastic stellate cells
Oben, J. A., Yang, S., Lin, H., Ono, M., & Diehl, A. M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00232-8 · Cited by 104
Epidermal Growth Factor Receptor Transactivation Mediates Tumor Necrosis Factor-induced Hepatocyte Replication
Argast, G. M., Campbell, J. S., Brooling, J. T., & Fausto, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405703200 · Cited by 104
Role of heparin-binding epidermal growth factor-like growth factor as a hepatotrophic factor in rat liver regeneration after partial hepatectomy
Kiso, S., Kawata, S., Tamura, S., Higashiyama, S., Ito, N., Tsushima, H., Taniguchi, N., & Matsuzawa, Y. (1995) · Hepatology · doi:10.1002/hep.1840220535 · Cited by 103
Interleukin–6, Hepatocyte Growth Factor, and Their Receptors in Biliary Epithelial Cells During A Type I Ductular Reaction in Mice: Interactions Between the Periductal Inflammatory and Stromal Cells and the Biliary Epithelium
Liu, Z., Sakamoto, T., Ezure, T., Yokomuro, S., Murase, N., Michalopoulos, G. K., & Demetris, A. J. (1998) · Hepatology · doi:10.1002/hep.510280514 · Cited by 103
Self-citation
Effects of partial hepatectomy on transplanted hepatocytes.
Jirtle, R. L., & Michalopoulos, G. K. (1982) · PubMed · Cited by 100
Self-citation
Cell cycle effects resulting from inhibition of hepatocyte growth factor and its receptor c-Met in regenerating rat livers by RNA interference
Paranjpe, S., Bowen, W. C., Bell, A. W., Nejak-Bowen, K., Luo, J.-H., & Michalopoulos, G. K. (2007) · Hepatology · doi:10.1002/hep.21570 · Cited by 100
Self-citation
STAT-3 Overexpression and p21 Up-Regulation Accompany Impaired Regeneration of Fatty Livers
Torbenson, M. S., Yang, S. Q., Liu, H. Z., Huang, J., Gage, W. R., & Diehl, A. M. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64167-3 · Cited by 97
Thinking outside the cell: proteases regulate hepatocyte division
Mohammed, F. F., & Khokha, R. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.08.009 · Cited by 95
EFFECT OF PARTIAL HEPATECTOMY ON DNA SYNTHESIS AND MITOSIS IN HETEROTOPIC PARTIAL AUTOGRAFTS OF RAT LIVER.
Leong, G. F., Grisham, J. W., Hole, B. V., & Albright, M. L. (1964) · PubMed · Cited by 93
Gadd45β Is Induced Through a CAR-Dependent, TNF-Independent Pathway in Murine Liver Hyperplasia * #
Columbano, A., Ledda‐Columbano, G. M., Pibiri, M., Cossu, C., Menegazzi, M., Moore, D. D., Huang, W., Tian, J., & Locker, J. D. (2005) · Hepatology · doi:10.1002/hep.20883 · Cited by 91
Effect of portal hemodynamics on liver regeneration studied in a novel portohepatic shunt rat model
Marubashi, S., Sakon, M., Nagano, H., Gotoh, K., Hashimoto, K., Kubota, M., Kobayashi, S., Yamamoto, S., Miyamoto, A., Dono, K., et al. (2004) · Surgery · doi:10.1016/j.surg.2004.03.012 · Cited by 91
Liver Regeneration
Michalopoulos, G. K., & DeFrances, M. C. (2005) · Advances in biochemical engineering, biotechnology · doi:10.1007/b99968 · Cited by 91
Self-citation
Epidermal growth factor secreted from the salivary gland is necessary for liver regeneration
Jones, D. E., Tran-Paterson, R., Cui, D., Davin, D., Estell, K., & Miller, D. M. (1995) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1995.268.5.g872 · Cited by 90
Bile ductular damage induced by methylene dianiline inhibits oval cell activation.
Petersen, B. E., Zajac, V. F., & Michalopoulos, G. K. (1997) · PubMed · Cited by 89
Self-citation
Transforming growth factor β and activin tonically inhibit DNA synthesis in the rat liver
Ichikawa, T., Zhang, Y.-Q., Kogure, K., Hasegawa, Y., Takagi, H., Mori, M., & Kojima, I. (2001) · Hepatology · doi:10.1053/jhep.2001.29132 · Cited by 89
Altered responses of regenerating hepatocytes to norepinephrine and transforming growth factor type β
Houck, K. A., & Michalopoulos, G. K. (1989) · Journal of Cellular Physiology · doi:10.1002/jcp.1041410308 · Cited by 89
Self-citation
Differential regulation of extracellular matrix synthesis during liver regeneration after partial hepatectomy in rats
Rudolph, K. L., Trautwein, C., Kubicka, S., Rakemann, T., Bahr, M. J., Sedlaczek, N., Schuppan, D., & Manns, M. P. (1999) · Hepatology · doi:10.1002/hep.510300502 · Cited by 88
Liver regeneration in heparin-binding EGF-like growth factor transgenic mice after partial hepatectomy
Kiso, S., Kawata, S., Tamura, S., Inui, Y., Yoshida, Y., Sawai, Y., Umeki, S., Ito, N., Yamada, A., Miyagawa, J., et al. (2003) · Gastroenterology · doi:10.1053/gast.2003.50097 · Cited by 87
Presence of urokinase in serum-free primary rat hepatocyte cultures and its role in activating hepatocyte growth factor.
Mars, W. M., Kim, T., Stolz, D. B., Liu, M.-L., & Michalopoulos, G. K. (1996) · PubMed · Cited by 87
Self-citation
Matrix metalloproteinase-9 is an important factor in hepatic regeneration after partial hepatectomy in mice
Olle, E. W., Ren, X., McClintock, S. D., Warner, R. L., Deogracias, M. P., Johnson, K. J., & Colletti, L. M. (2006) · Hepatology · doi:10.1002/hep.21314 · Cited by 87
Senescence, Wound Healing, and Cancer: the PAI-1 Connection
Kortlever, R. M., & Bernards, R. (2006) · Cell Cycle · doi:10.4161/cc.5.23.3510 · Cited by 84
Hepatocyte growth factor, blood clearance, organ uptake, and biliary excretion in normal and partially hepatectomized rats.
Appasamy, R., Tanabe, M., Murase, N., Zarnegar, R., Venkataramanan, R., Thiel, D. H. V., & Michalopoulos, G. K. (1993) · PubMed · Cited by 83
Self-citation
Adrenergic effects on secretion of epidermal growth factor from Brunner's glands.
Olsen, P. S., Poulsen, S. S., & Kirkegaard, P. O. (1985) · Gut · doi:10.1136/gut.26.9.920 · Cited by 81
Update on hepatic stem cells
Alison, M. R., Poulsom, R., & Forbes, S. J. (2001) · Liver International · doi:10.1034/j.1600-0676.2001.210601.x · Cited by 80
Regulation and Significance of Hepatocyte-Derived Matrix Metalloproteinases in Liver Remodeling
Haruyama, T., Ajioka, I., Akaike, T., & Watanabe, Y. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2837 · Cited by 80
Cell proliferation induced by triiodothyronine in rat liver is associated with nodule regression and reduction of hepatocellular carcinomas.
Ledda‐Columbano, G. M., Perra, A., Loi, R., Shinozuka, H., & Columbano, A. (2000) · PubMed · Cited by 79
Insulin, glucagon, liver regeneration, and DNA synthesis
Bucher, N. L. R., & Weir, G. C. (1976) · Metabolism · doi:10.1016/s0026-0495(76)80156-4 · Cited by 78
Precursor-product relationship between oval cells and hepatocytes: comparison between tritiated thymidine and bromodeoxyuridine as tracers
Evarts, R. P., Hu, Z., Omori, N., Omori, M., Marsden, E. R., & Thorgeirsson, S. S. (1996) · Carcinogenesis · doi:10.1093/carcin/17.10.2143 · Cited by 78
TGF-β is a potent inhibitor of hepatocyte growth factor secretion by human fibroblasts
Gohda, E., Matsunaga, T., Kataoka, H., & YAMAMOTO, I. (1992) · Cell Biology International Reports · doi:10.1016/s0309-1651(06)80171-2 · Cited by 77
Norepinephrine modulates the growth‐inhibitory effect of transforming growth factor‐beta in primary rat hepatocyte cultures
Houck, K. A., Cruise, J. L., & Michalopoulos, G. K. (1988) · Journal of Cellular Physiology · doi:10.1002/jcp.1041350327 · Cited by 76
Self-citation
Further characterization and comparison of inducible nitric oxide synthase in mouse, rat, and human hepatocytes
Nussler, A. K., Silvio, M. D., Liu, Z.-Z., Geller, D. A., Freeswick, P. D., Dorko, K., Bartoli, F., & Billiar, T. R. (1995) · Hepatology · doi:10.1002/hep.1840210613 · Cited by 75
Transforming growth factor-alpha (TGF alpha) concentrations increase in regenerating rat liver: evidence for a delayed accumulation of mature TGF alpha
Russell, W. E., Dempsey, P. J., Sitaric, S., Peck, A. J., & Coffey, R. J. (1993) · Endocrinology · doi:10.1210/endo.133.4.8404616 · Cited by 72
Liver Cell Proliferation Induced by Nafenopin and Cyproterone Acetate Is Not Associated With Increases in Activation of Transcription Factors Nf–κB and Ap–1 or With Expression of Tumor Necrosis Factor α
Menegazzi, M., de Prati, A. C., Suzuki, H., Shinozuka, H., Pibiri, M., Piga, R., Columbano, A., & Ledda-Columbano, G. M. (1997) · Hepatology · doi:10.1002/hep.510250316 · Cited by 68
Role of Connective Tissue Growth Factor in Oval Cell Response During Liver Regeneration After 2-AAF/PHx in Rats
Pi, L., Oh, S., Shupe, T. D., & Petersen, B. E. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.081 · Cited by 68
Kinetics of Hepatocellular Proliferation as a Function of the Microvascular Structure and Functional State of the Liver
Rabes, H. M. (1978) · Novartis Foundation symposium · doi:10.1002/9780470720363.ch3 · Cited by 66
The role of activin and transforming growth factor-β in the regulation of organ mass in the rat liver
Kogure, K., Zhang, Y.-Q., Maeshima, A., Suzuki, K., Kuwano, H., & Kojima, I. (2000) · Hepatology · doi:10.1053/he.2000.6100 · Cited by 66
Normal Liver Regeneration in P50/Nuclear Factor κB1 Knockout Mice
DeAngelis, R. A., Kovalovich, K. K., Cressman, D. E., & Taub, R. A. (2001) · Hepatology · doi:10.1053/jhep.2001.23192 · Cited by 66
Down-regulation of transforming growth factor beta receptor type I, II, and III during liver regeneration
Chart, R. S., Price, D. T., Sue, S. R., Meyers, W. C., & Jirtle, R. L. (1995) · The American Journal of Surgery · doi:10.1016/s0002-9610(99)80120-2 · Cited by 62
Differential regulation of urokinase-type plasminogen activator expression by fluid shear stress in human coronary artery endothelial cells
Sokabe, T., Yamamoto, K., Ohura, N., Nakatsuka, H., Qin, K., Obi, S., Kamiya, A., & Ando, J. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00260.2004 · Cited by 62
Liver regeneration is transiently impaired in urokinase-deficient mice
Roselli, H. T., Su, M., Washington, K. M., Kerins, D. M., Vaughan, D. E., & Russell, W. E. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.6.g1472 · Cited by 62
A subtractive gene expression screen suggests a role for vanin1 in testis development in mice
Bowles, J., Bullejos, M., & Koopman, P. A. (2000) · genesis · doi:10.1002/1526-968x(200007)27:3 · Cited by 60
Regulation of IL-6 and the hepatic IL-6 receptor in acute inflammation in vivo
Geisterfer, M., Richards, C. D., Baumann, M., Fey, G. H., Gywnne, D., & Gauldie, J. (1993) · Cytokine · doi:10.1016/1043-4666(93)90017-y · Cited by 60
Growth stimulation followed by growth inhibition in livers of female rats treated with ethinyl estradiol
Yager, J. D., Zurlo, J., Sewall, C. H., Lucier, G. W., & He, H. (1994) · Carcinogenesis · doi:10.1093/carcin/15.10.2117 · Cited by 59
Hepatic transdifferentiation in the pancreas
Rao, S. M., & Reddy, J. K. (1995) · Seminars in Cell Biology · doi:10.1006/scel.1995.0021 · Cited by 59
Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis†
Gkretsi, V., Mars, W. M., Bowen, W. C., Barua, L., Yang, Y. H. C., Guo, L., St.‐Arnaud, R., Dedhar, S., Wu, C., & Michalopoulos, G. K. (2007) · Hepatology · doi:10.1002/hep.21540 · Cited by 58
Self-citation
Impaired liver regeneration after partial hepatectomy in db/db mice
Yamauchi, H., Uetsuka, K., Okada, T., Nakayama, H., & Doi, K. (2003) · Experimental and Toxicologic Pathology · doi:10.1078/0940-2993-00265 · Cited by 57
Adrenergic Stimulation of Hepatocyte Growth Factor Expression
Broten, J., Michalopoulos, G. K., Petersen, B. E., & Cruise, J. L. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1183 · Cited by 56
Self-citation
Defective hepatic regeneration after partial hepatectomy in leptin-deficient mice is not rescued by exogenous leptin
Leclercq, I. A., Vansteenberghe, M., Lebrun, V., VanHul, N. K., Abarca‐Quinones, J., Sempoux, C. L., Picard, C., Stärkel, P., & Horsmans, Y. (2006) · Laboratory Investigation · doi:10.1038/labinvest.3700474 · Cited by 54
Growth Factor-regulated Pathways in Epithelial Cell Proliferation
Aaronson, S. A., Rubin, J. S., Finch, P. W., Wong, J., Marchese, C., Falco, J., Taylor, W. G., & Kraus, M. H. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/142.6_pt_2.s7 · Cited by 54
Biliary wound healing, ductular reactions, and IL-6/gp130 signaling in the development of liver disease
Demetris, A. J. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i22.3512 · Cited by 52
Peroxisomal Localization of Hypoxia-Inducible Factors and Hypoxia-Inducible Factor Regulatory Hydroxylases in Primary Rat Hepatocytes Exposed to Hypoxia-Reoxygenation
Khan, Z., Michalopoulos, G. K., & Stolz, D. B. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060360 · Cited by 52
Self-citation
Small proline-rich proteins 2 are noncoordinately upregulated by IL-6/STAT3 signaling after bile duct ligation
Nozaki, I., Lunz, J. G., Specht, S. M., Stolz, D. B., Taguchi, K., Subbotin, V. M., Murase, N., & Demetris, A. J. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700213 · Cited by 51
The Mitogenic Activity of Hepatocyte Growth Factor on Rat Hepatocytes Is Dependent upon Endogenous Transforming Growth Factor-α
Tomiya, T., Ogata, I., Yamaoka, M., Yanase, M., Inoue, Y., & Fujiwara, K. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64806-7 · Cited by 51
Activated hepatic stellate cells overexpress p75NTR after partial hepatectomy and undergo apoptosis on nerve growth factor stimulation
Asai, K., Tamakawa, S., Yamamoto, M., Yoshie, M., Tokusashi, Y., Yaginuma, Y., Kasai, S., & Ogawa, K. (2006) · Liver International · doi:10.1111/j.1478-3231.2006.01267.x · Cited by 49
Orthogonal analysis of C/EBPβ targets in vivo during liver proliferation
Friedman, J. R., Larris, B., Le, P. P., Peiris, T. H., Arsenlis, A., Schug, J., Tobias, J. W., Kaestner, K. H., & Greenbaum, L. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402875101 · Cited by 49
Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase inhibitor p15INK4B and Sp1
Ho, J., de Guise, C., Kim, C., Lemay, S., Wang, X., & Lebrun, J. J. (2003) · Cellular Signalling · doi:10.1016/j.cellsig.2003.11.002 · Cited by 48
Multiple Sites of Proteolytic Cleavage to Release Soluble Forms of Hepatocyte Growth Factor Activator Inhibitor Type 1 from a Transmembrane Form
Shimomura, T., Denda, K., Kawaguchi, T., Matsumoto, K., Miyazawa, K., & Kitamura, N. (1999) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022522 · Cited by 47
Increased expression of c-fos, c-jun and LRF-1 is not required for in vivo priming of hepatocytes by the mitogen TCPOBOP
Columbano, A., Ledda‐Columbano, G. M., Pibiri, M., Piga, R., Shinozuka, H., Luca, V. D., Cerignoli, F., & Tripodi, M. (1997) · Oncogene · doi:10.1038/sj.onc.1200891 · Cited by 46
Distribution and activity of glutamine synthase and carbamoylphosphate synthase upon enlargement of the liver lobule by repeated partial hepatectomies
Wagenaar, G. T. M., Chamuleau, R. A. F. M., Pool, C. W., de Haan, J. G., Maas, M. A. W., Korfage, H. A. M., & Lamers, W. H. (1993) · Journal of Hepatology · doi:10.1016/s0168-8278(05)80224-7 · Cited by 45
Loss of cyclin D1 does not inhibit the proliferative response of mouse liver to mitogenic stimuli
Ledda-Columbano, G. M., Pibiri, M., Concas, D., Cossu, C., Tripodi, M., & Columbano, A. (2002) · Hepatology · doi:10.1053/jhep.2002.36159 · Cited by 45
Integrin-linked kinase is involved in matrix-induced hepatocyte differentiation
Gkretsi, V., Bowen, W. C., Yang, Y. H. C., Wu, C., & Michalopoulos, G. K. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.091 · Cited by 43
Self-citation
Acidic fibroblast growth factor (HBGF‐1) stimulates DNA synthesis in primary rat hepatocyte cultures
Houck, K. A., Zarnegar, R., Muga, S. J., & Michalopoulos, G. K. (1990) · Journal of Cellular Physiology · doi:10.1002/jcp.1041430117 · Cited by 43
Self-citation
Comitogenic effects of estrogens on DNA synthesis induced by various growth factors in cultured female rat hepatocytes
Ni, N., & Yager, J. D. (1994) · Hepatology · doi:10.1002/hep.1840190128 · Cited by 42
Involvement of Growth Factors in the Regulation of Pubertal Mammary Growth in Cattle
Purup, S., Vestergaard, M., & Sejrsen, K. (2005) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-46832-8_4 · Cited by 39
Phenobarbital regulates nuclear expression of HNF-4α in mouse and rat hepatocytes independent of CAR and PXR
Bell, A. W., & Michalopoulos, G. K. (2006) · Hepatology · doi:10.1002/hep.21234 · Cited by 38
Self-citation
[Capacity of regeneration in liver epithelia of juvenile, repeated partially hepatectomized rats. Autoradiographic studies after continous infusion of 3H-thymidine (author's transl)].
Stöcker, E., Wullstein, H. K., & Bräu, G. (1973) · PubMed · Cited by 38
Activated Rat Stellate Cells Express c-metand Respond to Hepatocyte Growth Factor to Enhance Transforming Growth Factor β1 Expression and DNA Synthesis
Ikeda, H., Nagoshi, S., Ohno, A., Yanase, M., Maekawa, H., & Fujiwara, K. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9387 · Cited by 36
VEGF isoforms and receptors expression throughout acute acetaminophen-induced liver injury and regeneration
Papastefanou, V. P., Bozas, E., Mykoniatis, M. G., Grypioti, A. D., Garyfallidis, S., Bartsocas, C. S., & Nicolopoulou‐Stamati, P. (2007) · Archives of Toxicology · doi:10.1007/s00204-007-0201-x · Cited by 36
Vascular endothelial growth factor and angiopoietins regulate sinusoidal regeneration and remodeling after partial hepatectomy in rats
Shimizu, H. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i46.7254 · Cited by 34
The role of Ito cells in the biosynthesis of HGF-SF in the liver.
Schirmacher, P., Geerts, A. E., Jung, W., Pietrangelo, A., Rogler, C. E., & Dienes, H. (1993) · PubMed · Cited by 34
Cell-Extracellular Matrix Interactions Can Regulate the Switch between Growth and Differentiation in Rat Hepatocytes: Reciprocal Expression of C/ΕΒΡα and Immediate-Early Growth Response Transcription Factors
Rana, B., Mischoulon, D., Xie, Y., Bucher, N. L. R., & Farmer, S. R. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5858-5869.1994 · Cited by 34

Research works printed but not linked: 1

10.1210/en.133.4.1731 · DOI

Sorted by citations

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets
Gao, B., & Bataller, R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.09.002 · Cited by 1,963
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280
Liver immunology and its role in inflammation and homeostasis
Robinson, M. W., Harmon, C., & O’Farrelly, C. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2016.3 · Cited by 1,151
Liver regeneration: biological and pathological mechanisms and implications
Michalopoulos, G. K., & Bhushan, B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0342-4 · Cited by 998
Self-citation
Notch Signaling in Development, Tissue Homeostasis, and Disease
Siebel, C., & Lendahl, U. (2017) · Physiological Reviews · doi:10.1152/physrev.00005.2017 · Cited by 1,001

See all 1,384

Authors: Michalopoulos, G. K.
Affiliations: University of Pittsburgh (US)
Corresponding author: Michalopoulos, George K.
ORCID: Michalopoulos, George K.
Venue: Journal of Cellular Physiology
Publisher: Wiley
Published: 2007-06-08
Volume: 213
Issue: 2
Pages: 286-300
ISSN: 0021-9541 (ISSN-L)
1097-4652
DOI: 10.1002/jcp.21172
PMC: PMC2701258
OpenAlex: W4210995852
Cited by: 1,384
References: 225
Citations by year: 2026: 32 · 2025: 60 · 2024: 78 · 2023: 58 · 2022: 74 · 2021: 81 · 2020: 81 · 2019: 82 · 2018: 88 · 2017: 77 · 2016: 89 · 2015: 90 · 2014: 84 · 2013: 84 · 2012: 72
FWCI: 7.81
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Cellular Physiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (2r01ca103958-06a1, UL1TR000005, CA 103958)
National Cancer Institute (R01CA035373, CA035373, R01-CA103958, CA103958)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords: liver regeneration, partial hepatectomy, hepatocytes, growth factors, cytokines, extracellular matrix remodeling, signaling pathways, liver homeostasis
MeSH terms: Animals, Epithelial Cells, Hemodynamics, Hepatectomy, Humans, Liver, Liver Regeneration, Mitosis, Stem Cells, Signal Transduction, Interleukin-6, Hepatocytes, Transforming Growth Factor beta1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Liver regeneration

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks