The DOI matches its Crossref record; 222 of the 225 references it cites were found in a registry or an index.
Liver regeneration
Open accessAbstract
Liver regeneration after partial hepatectomy is a very complex and well-orchestrated phenomenon. It is carried out by the participation of all mature liver cell types. The process is associated with signaling cascades involving growth factors, cytokines, matrix remodeling, and several feedbacks of stimulation and inhibition of growth related signals. Liver manages to restore any lost mass and adjust its size to that of the organism, while at the same time providing full support for body homeostasis during the entire regenerative process. In situations when hepatocytes or biliary cells are blocked from regeneration, these cell types can function as facultative stem cells for each other.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These ligands activate epidermal growth factor receptor (EGFR) signaling in hepatocytes driving their proliferation, especially in liver zones 1 and 2[4,20].”
From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [20]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Additionally, IL-6 plays a central role in restoring normal hepatic function following liver injury [1], [2].”
From Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli (2014) · cites this paper as [1]
Experimental — accuracy not yet measuredIn the citing paper
“The ability of the gut microbiome to remodel and persist in the face of insults such as antibiotic use is probably only matched in the host by the regenerative capacity of the liver (Michalopoulos, 2007) (Fig. 1, A and B).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Michalopoulos, 2007
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Michalopoulos, G. K., & DeFrances, M. C. (1997) · Science · doi:10.1126/science.276.5309.60 · Cited by 2,828
Self-citationBone Marrow as a Potential Source of Hepatic Oval Cells
Petersen, B. E., Bowen, W. C., Patrene, K. D., Mars, W. M., Sullivan, A. K., Murase, N., Boggs, S. S., Greenberger, J. S., & Goff, J. P. (1999) · Science · doi:10.1126/science.284.5417.1168 · Cited by 2,377
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
Lagasse, E., Connors, H., Al-Dhalimy, M., Reitsma, M., Dohse, M., Osborne, L., Wang, X., Finegold, M., Weissman, I. L., & Grompe, M. (2000) · Nature Medicine · doi:10.1038/81326 · Cited by 2,314
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
Terada, N., Hamazaki, T., Oka, M., Hoki, M., Mastalerz, D. M., Nakano, Y., Meyer, E. M., Morel, L. M., Petersen, B. E., & Scott, E. W. (2002) · Nature · doi:10.1038/nature730 · Cited by 2,000
Cell fusion is the principal source of bone-marrow-derived hepatocytes
Wang, X., Willenbring, H., Akkari, Y. M. N., Torimaru, Y., Foster, M., Al-Dhalimy, M., Lagasse, E., Finegold, M. J., Olson, S. B., & Grompe, M. (2003) · Nature · doi:10.1038/nature01531 · Cited by 1,569
Liver regeneration: from myth to mechanism
Taub, R. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1489 · Cited by 1,567
Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice
Cressman, D. E., Greenbaum, L. E., DeAngelis, R. A., Ciliberto, G., Furth, E. E., Poli, V., & Taub, R. (1996) · Science · doi:10.1126/science.274.5291.1379 · Cited by 1,538
Scatter factor/hepatocyte growth factor is essential for liver development
Schmidt, C. S., Bladt, F., Gödecke, S., Brinkmann, V., Zschiesche, W., Sharpe, M. J., Gherardi, E., & Birchmeler, C. (1995) · Nature · doi:10.1038/373699a0 · Cited by 1,395
Fausto, N., Campbell, J. S., & Riehle, K. J. (2006) · Hepatology · doi:10.1002/hep.20969 · Cited by 1,378
The IKK NF-κB system: a treasure trove for drug development
Karin, M., Yamamoto, Y., & Wang, Q. M. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1279 · Cited by 1,364
Flagged first, then by citations
3 of the 225 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- 10.1210/en.133.4.1731 · DOI
Cited by
Sorted by citations
Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets
Gao, B., & Bataller, R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.09.002 · Cited by 1,963
Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280
Liver immunology and its role in inflammation and homeostasis
Robinson, M. W., Harmon, C., & O’Farrelly, C. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2016.3 · Cited by 1,151
Liver regeneration: biological and pathological mechanisms and implications
Michalopoulos, G. K., & Bhushan, B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0342-4 · Cited by 998
Self-citationNotch Signaling in Development, Tissue Homeostasis, and Disease
Siebel, C., & Lendahl, U. (2017) · Physiological Reviews · doi:10.1152/physrev.00005.2017 · Cited by 1,001
TGF-β in progression of liver disease
Dooley, S., & ten Dijke, P. (2012) · Cell and Tissue Research · doi:10.1007/s00441-011-1246-y · Cited by 718
Liver Regeneration after Partial Hepatectomy
Michalopoulos, G. K. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090675 · Cited by 713
Self-citationMechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions
Yan, M., Huo, Y., Yin, S., & Hu, H. (2018) · Redox Biology · doi:10.1016/j.redox.2018.04.019 · Cited by 687
The Hippo signaling pathway in stem cell biology and cancer
Mo, J., Park, H. W., & Guan, K. (2014) · EMBO Reports · doi:10.15252/embr.201438638 · Cited by 701
Fernández, M., Semela, D., Bruix, J., Colle, I. O., Pinzani, M., & Bosch, J. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2008.12.011 · Cited by 606
Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming
Miyajima, A., Tanaka, M., & Itoh, T. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.04.010 · Cited by 570
Stem Cells and Liver Regeneration
Duncan, A. W., Dorrell, C., & Grompe, M. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.05.044 · Cited by 560
Cancer stem cells in the development of liver cancer
Yamashita, T., & Wang, X. W. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66024 · Cited by 530
The role of long noncoding RNAs in hepatocellular carcinoma
Huang, Z., Zhou, J., Peng, Y., He, W., & Huang, C. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01188-4 · Cited by 506
Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer
Font-Burgada, J., Shalapour, S., Ramaswamy, S., Hsueh, B., Rossell, D., Umemura, A., Taniguchi, K., Nakagawa, H., Valasek, M. A., Ye, L., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.026 · Cited by 486
Cancer across the tree of life: cooperation and cheating in multicellularity
Aktipis, C. A., Boddy, A. M., Jansen, G., Hibner, U., Hochberg, M. E., Maley, C. C., & Wilkinson, G. S. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0219 · Cited by 466
Hypertrophy and Unconventional Cell Division of Hepatocytes Underlie Liver Regeneration
Miyaoka, Y., Ebato, K., Kato, H., Arakawa, S., Shimizu, S., & Miyajima, A. (2012) · Current Biology · doi:10.1016/j.cub.2012.05.016 · Cited by 461
Hepatostat: Liver regeneration and normal liver tissue maintenance
Michalopoulos, G. K. (2017) · Hepatology · doi:10.1002/hep.28988 · Cited by 444
Self-citationFate tracing of mature hepatocytes in mouse liver homeostasis and regeneration
Malato, Y., Naqvi, S., Schürmann, N., Ng, R., Wang, B., Zape, J., Kay, M. A., Grimm, D., & Willenbring, H. (2011) · Journal of Clinical Investigation · doi:10.1172/jci59261 · Cited by 434
Liver regeneration — mechanisms and models to clinical application
Forbes, S. J., & Newsome, P. N. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.97 · Cited by 415
Bioprinting: From Tissue and Organ Development to in Vitro Models
Mota, C., Camarero‐Espinosa, S., Baker, M. B., Wieringa, P. A., & Moroni, L. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00789 · Cited by 359
Omenetti, A., Porrello, A., Jung, Y., Yang, L., Popov, Y. V., Choi, S. S., Witek, R. P., Alpini, G. D., Venter, J., VanDongen, H. M. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35875 · Cited by 346
Hepatic stellate cells in physiology and pathology
Kamm, D. R., & McCommis, K. S. (2022) · The Journal of Physiology · doi:10.1113/jp281061 · Cited by 374
Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture
Peng, W. C., Logan, C. Y., Fish, M., Anbarchian, T., Aguisanda, F., Álvarez-Varela, A., Wu, P., Jin, Y., Zhu, J., Li, B., et al. (2018) · Cell · doi:10.1016/j.cell.2018.11.012 · Cited by 331
The three R’s of lung health and disease: repair, remodeling, and regeneration
Beers, M. F., & Morrisey, E. E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45961 · Cited by 329
Gut reactions: Breaking down xenobiotic–microbiome interactions
Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., & Hyland, N. P. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015768 · Cited by 319
Endothelial Cell-Derived Angiopoietin-2 Controls Liver Regeneration as a Spatiotemporal Rheostat
Hu, J., Srivastava, K., Wieland, M. J., Runge, A., Mogler, C., Besemfelder, E., Terhardt, D., Vogel, M. J., Cao, L., Korn, C., et al. (2014) · Science · doi:10.1126/science.1244880 · Cited by 328
Human liver stem cell‐derived microvesicles accelerate hepatic regeneration in hepatectomized rats
Herrera, M. B., Fonsato, V., Gatti, S., Deregibus, M. C., Sordi, A., Cantarella, D., Calogero, R., Bussolati, B., Tetta, C., & Camussi, G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00860.x · Cited by 325
Liver regeneration and inflammation: from fundamental science to clinical applications
Campana, L., Esser, H., Huch, M., & Forbes, S. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00373-7 · Cited by 307
Links Between Hepatic Fibrosis, Ductular Reaction, and Progenitor Cell Expansion
Williams, M. J., Clouston, A. D., & Forbes, S. J. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.11.034 · Cited by 308
Print Me An Organ! Why We Are Not There Yet
Ng, W. L., Chua, C. K., & Shen, Y. (2019) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2019.101145 · Cited by 298
Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes
Deng, X., Zhang, X., Li, W., Feng, R.-X., Li, L., Yi, G.-R., Zhang, X.-N., Yin, C., Yu, H.-Y., Zhang, J.-P., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.05.022 · Cited by 289
Pluripotent stem cell-derived hepatocyte-like cells
Schwartz, R. E., Fleming, H. E., Khetani, S. R., & Bhatia, S. N. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2014.01.003 · Cited by 284
Regulation of liver regeneration by growth factors and cytokines
Böhm, F., Köhler, U. A., Speicher, T., & Werner, S. (2010) · EMBO Molecular Medicine · doi:10.1002/emmm.201000085 · Cited by 285
Design Considerations for Hydrogel Wound Dressings: Strategic and Molecular Advances
Veld, R. C. O. ‘., Walboomers, X. F., Jansen, J. A., & Wagener, F. A. D. T. G. (2020) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2019.0281 · Cited by 278
Liver zonation: Novel aspects of its regulation and its impact on homeostasis
Gebhardt, R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i26.8491 · Cited by 275
Nf2 /Merlin controls progenitor homeostasis and tumorigenesis in the liverPreprint
Benhamouche, S., Curto, M., Saotome, I., Gladden, A. B., Liu, C.-H., Giovannini, M., & McClatchey, A. I. (2010) · Genes & Development · doi:10.1101/gad.1938710 · Cited by 278
Tissue repair and regeneration with endogenous stem cells
Xia, H., Li, X., Gao, W., Fu, X., Fang, R. H., Zhang, L., & Zhang, K. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0027-6 · Cited by 275
Bird, T. G., Müller, M., Boulter, L., Vincent, D. F., Ridgway, R. A., Lopez-Guadamillas, E., Lu, W.-Y., Jamieson, T., Govaere, O., Campbell, A. D., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan1230 · Cited by 261
“INTRODUCTION After moderate liver injury or resection, the liver regenerates efficiently through hepatocyte proliferation (1, 2).”
Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad
Nejak-Bowen, K. N., & Monga, S. P. S. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.12.010 · Cited by 260
Identification of small molecules for human hepatocyte expansion and iPS differentiation
Shan, J., Schwartz, R. E., Ross, N. T., Logan, D. J., Thomas, D., Duncan, S. A., North, T. E., Goessling, W., Carpenter, A. E., & Bhatia, S. N. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1270 · Cited by 254
Cellular Homeostasis and Repair in the Mammalian Liver
Stanger, B. Z. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170255 · Cited by 248
Mao, S. A., Glorioso, J. M., & Nyberg, S. L. (2014) · Translational research · doi:10.1016/j.trsl.2014.01.005 · Cited by 260
Principles of Liver Regeneration and Growth Homeostasis
Michalopoulos, G. K. (2012) · Comprehensive physiology · doi:10.1002/cphy.c120014 · Cited by 278
Self-citationRecent Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: An Updated Review
Dzobo, K., Motaung, K. S., & Adesida, A. B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184628 · Cited by 243
Model systems for regeneration: zebrafish
Marques, I. J., Lupi, E., & Mercader, N. (2019) · Development · doi:10.1242/dev.167692 · Cited by 254
Liver sinusoidal endothelial cells and liver regeneration
DeLeve, L. D. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66025 · Cited by 233
Acetaminophen-induced Liver Injury: from Animal Models to Humans
Jaeschke, H., Xie, Y., & McGill, M. R. (2014) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2014.00014 · Cited by 227
Mechano-modulatory synthetic niches for liver organoid derivation
Sorrentino, G., Rezakhani, S., Yildiz, E., Nuciforo, S., Heim, M. H., Lutolf, M. P., & Schoonjans, K. (2020) · Nature Communications · doi:10.1038/s41467-020-17161-0 · Cited by 224
Timchenko, N. A. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.01.005 · Cited by 222
The balancing act of the liver: tissue regeneration versus fibrosis
Cordero-Espinoza, L., & Huch, M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93562 · Cited by 233
Human Gut Microbiota and Drug Metabolism
Pant, A., Maiti, T. K., Mahajan, D., & Das, B. (2022) · Microbial Ecology · doi:10.1007/s00248-022-02081-x · Cited by 231
Evidence for Novel Hepaciviruses in Rodents
Drexler, J. F., Corman, V. M., Müller, M. A., Lukashev, A. N., Gmyl, A. P., Coutard, B., Adam, A. C., Ritz, D., Leijten, L. M. E., van Riel, D. A. J., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003438 · Cited by 226
Micrornas Control Hepatocyte Proliferation During Liver Regeneration
Song, G., Sharma, A. D., Roll, G. R., Ng, R., Lee, A. Y., Blelloch, R. H., Frandsen, N. M., & Willenbring, H. (2010) · Hepatology · doi:10.1002/hep.23547 · Cited by 209
MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration
Antony, A. N., Paillard, M., Moffat, C., Juskeviciute, E., Correnti, J., Bolon, B., Rubin, E., Csordás, G., Seifert, E. L., Hoek, J. B., et al. (2016) · Nature Communications · doi:10.1038/ncomms10955 · Cited by 206
Role of the Nrf2-ARE Pathway in Liver Diseases
Shin, S. M., Yang, J. H., & Ki, S. H. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/763257 · Cited by 209
Bhushan, B., Walesky, C. M., Manley, M. W., Gallagher, T., Borude, P. C., Edwards, G., Monga, S. P., & Apte, U. M. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.07.019 · Cited by 204
Goetzman, E. S., & Prochownik, E. V. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00129 · Cited by 199
Schlegel, A. A., Lesurtel, M., Melloul, E., Limani, P., Tschuor, C., Graf, R., Humar, B., & Clavien, P. (2014) · Annals of Surgery · doi:10.1097/sla.0000000000000949 · Cited by 194
Xiao, J., Liong, E. C., Ching, Y. P., Chang, R. C., So, K., Fung, M., & Tipoe, G. L. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.11.033 · Cited by 189
Prediction, prevention and management of postresection liver failure
Hammond, J. S., Guha, I. N., Beckingham, I. J., & Lobo, D. N. (2011) · British journal of surgery · doi:10.1002/bjs.7630 · Cited by 189
Mirshafiei, M., Rashedi, H., Yazdian, F. A., Rahdar, A., & Baino, F. (2024) · Materials & Design · doi:10.1016/j.matdes.2024.112853 · Cited by 197
Beta-Catenin Activation Promotes Liver Regeneration after Acetaminophen-Induced Injury
Apte, U. M., Singh, S., Zeng, G., Cieply, B. W., Virji, M. A., Wu, T., & Monga, S. P. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080976 · Cited by 179
Liver Regeneration after Acetaminophen Hepatotoxicity
Bhushan, B., & Apte, U. (2019) · The American Journal of Pathology · doi:10.1016/j.ajpath.2018.12.006 · Cited by 179
Extracellular Matrix Remodeling in Chronic Liver Disease
Ortiz, C., Schierwagen, R., Schaefer, L., Klein, S., Trepat, X., & Trebicka, J. (2021) · Current Tissue Microenvironment Reports · doi:10.1007/s43152-021-00030-3 · Cited by 197
The Transcription Factor FOXM1 (Forkhead box M1)
Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407173-5.00004-2 · Cited by 180
The EGFR signalling system in the liver: from hepatoprotection to hepatocarcinogenesis
Berasain, C., & Avila, M. A. (2013) · Journal of Gastroenterology · doi:10.1007/s00535-013-0907-x · Cited by 175
Apte, U. M., Gkretsi, V., Bowen, W. C., Mars, W. M., Luo, J., Donthamsetty, S., Orr, A., Monga, S. P., Wu, C., & Michalopoulos, G. K. (2009) · Hepatology · doi:10.1002/hep.23059 · Cited by 173
Self-citationMir-33 regulates cell proliferation and cell cycle progression
Cirera‐Salinas, D., Pauta, M., Allen, R. M., Salerno, A. G., Ramírez, C. M., Chamorro-Jorganes, A., Wanschel, A. C. B. A., Lasunción, M. A., Morales‐Ruiz, M., Suárez, Y., et al. (2012) · Cell Cycle · doi:10.4161/cc.11.5.19421 · Cited by 171
Molecular Biology of Liver Cancer Stem Cells
Oishi, N., Yamashita, T., & Kaneko, S. (2014) · Liver Cancer · doi:10.1159/000343863 · Cited by 172
Cell Plasticity in Liver Regeneration
Li, W., Li, L., & Hui, L. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.01.007 · Cited by 167
In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease
Stevens, K. R., Scull, M. A., Ramanan, V., Fortin, C. L., Chaturvedi, R. R., Knouse, K. A., Xiao, J., Fung, C., Mirabella, T., Chen, A. X., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah5505 · Cited by 168
Ng, R., Song, G., Roll, G. R., Frandsen, N. M., & Willenbring, H. (2012) · Journal of Clinical Investigation · doi:10.1172/jci46039 · Cited by 167
Epimorphic regeneration approach to tissue replacement in adult mammals
Agrawal, V., Johnson, S. A., Reing, J. E., Zhang, L., Tottey, S., Wang, G., Hirschi, K. K., Braunhut, S. J., Gudas, L. J., & Badylak, S. F. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905851106 · Cited by 162
Hepatic stem cells and transforming growth factor β in hepatocellular carcinoma
Majumdar, A., Curley, S. A., Wu, X., Brown, P. H., Hwang, J. P., Shetty, K., Yao, Z., He, A. R., Li, S., Katz, L. H., et al. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.114 · Cited by 163
ECM formation and degradation during fibrosis, repair, and regeneration
Mayorca-Guiliani, A. E., Leeming, D. J., Henriksen, K., Mortensen, J. H., Nielsen, S. H., Anstee, Q. M., Sanyal, A. J., Karsdal, M. A., & Schuppan, D. (2025) · npj Metabolic Health and Disease · doi:10.1038/s44324-025-00063-4 · Cited by 176
Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration
Grijalva, J., Huizenga, M. N., Mueller, K. A., Rodriguez, S., Brazzo, J. A., Camargo, F. D., Sadri‐Vakili, G., & Vakili, K. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00077.2014 · Cited by 159
The bright side of fibroblasts: molecular signature and regenerative cues in major organs
Gomes, R. N., Manuel, F., & Nascimento, D. S. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-021-00153-z · Cited by 185
Rizvi, F., Everton, E., Smith, A. R., Liu, H., Osota, E., Beattie, M. B., Tam, Y. K., Pardi, N., Weissman, D., & Gouon–Evans, V. (2021) · Nature Communications · doi:10.1038/s41467-021-20903-3 · Cited by 155
New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology
Giraldez, M. D., Carneros, D., Garbers, C., Rose-John, S., & Bustos, M. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00473-x · Cited by 156
To divide or not to divide: revisiting liver regeneration
Miyaoka, Y., & Miyajima, A. (2013) · Cell Division · doi:10.1186/1747-1028-8-8 · Cited by 156
Lipid Metabolism in Development and Progression of Hepatocellular Carcinoma
Sangineto, M., Villani, R., Cavallone, F., Romano, A. D., Loizzi, D., & Serviddio, G. (2020) · Cancers · doi:10.3390/cancers12061419 · Cited by 153
Elucidating the Metabolic Regulation of Liver Regeneration
Huang, J., & Rudnick, D. A. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.04.034 · Cited by 156
Liver regeneration by stem/progenitor cells
Itoh, T., & Miyajima, A. (2013) · Hepatology · doi:10.1002/hep.26753 · Cited by 155
Damania, A., Jaiman, D., Teotia, A. K., & Kumar, A. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0752-6 · Cited by 147
A Direct In Vivo RNAi Screen Identifies MKK4 as a Key Regulator of Liver Regeneration
Wuestefeld, T., Pesic, M., Rudalska, R., Dauch, D., Longerich, T., Kang, T.-W., Yevsa, T., Heinzmann, F., Hoenicke, L., Hohmeyer, A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.026 · Cited by 149
Kordes, C., & Häussinger, D. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66027 · Cited by 151
Preserved liver-specific functions of hepatocytes in 3D co-culture with endothelial cell sheets
Kim, K.-S., Ohashi, K., Utoh, R., Kano, K., & Okano, T. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.10.084 · Cited by 149
Lu, X., Cao, X., Zhu, Y., Wu, Z., Zhuang, X., Shao, M., Xu, Q., Zhou, Y., Ji, H., Lu, Q.-R., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0428-x · Cited by 146
Implications of microbiota and bile acid in liver injury and regeneration
Liu, H., Keane, R., Sheng, L., & Wan, Y. Y. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.08.001 · Cited by 145
Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma
Kowalik, M. A., Columbano, A., & Perra, A. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00087 · Cited by 152
Woo, D., Kim, S., Lim, H., Heo, J., Park, H. S., Kang, G., Kim, S. E., You, H., Hoeppner, D. J., Kim, Y., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.11.030 · Cited by 147
The oxidative DNA lesions 8,5′-cyclopurines accumulate with aging in a tissue-specific manner
Wang, J., Clauson, C. L., Robbins, P. D., Niedernhofer, L. J., & Wang, Y. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00828.x · Cited by 142
Allard, M.-A., Adam, R., Bucur, P.-O., Termos, S., Cunha, A. S., Bismuth, H., Castaing, D., & Vibert, E. (2013) · Annals of Surgery · doi:10.1097/sla.0b013e3182a64b38 · Cited by 142
Epithelial Plasticity during Liver Injury and Regeneration
Gadd, V. L., Aleksieva, N., & Forbes, S. J. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.08.016 · Cited by 142
Bipotent transitional liver progenitor cells contribute to liver regeneration
Pu, W., Zhu, H., Zhang, M., Pikiolek, M., Ercan, C., Li, J., Huang, X., Han, X., Zhang, Z., Lv, Z., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01335-9 · Cited by 138
Harnessing macrophage plasticity for tissue regeneration
Smith, T. D., Nagalla, R. R., Chen, E. Y., & Liu, W. F. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.04.012 · Cited by 138
A Mouse Model of Accelerated Liver Aging Caused by a Defect in DNA Repair
Gregg, S. Q., Gutiérrez, V., Robinson, A. R., Woodell, T. B., Nakao, A., Ross, M. A., Michalopoulos, G. K., Rigatti, L. H., Rothermel, C. E., Kamileri, I., et al. (2011) · Hepatology · doi:10.1002/hep.24713 · Cited by 140
Self-citationThe Polyploid State Restricts Hepatocyte Proliferation and Liver Regeneration in Mice
Wilkinson, P. D., Delgado, E. R., Alencastro, F., Leek, M. P., Roy, N., Weirich, M. P., Stahl, E. C., Otero, P. A., Chen, M. I., Brown, W. K., et al. (2019) · Hepatology · doi:10.1002/hep.30286 · Cited by 135
Advances in liver regeneration
Michalopoulos, G. K. (2014) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2014.934358 · Cited by 138
Self-citation
Metadata
- Authors
- Michalopoulos, G. K.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Michalopoulos, George K.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2007-06-08
- Volume
- 213
- Issue
- 2
- Pages
- 286-300
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- PMC
- PMC2701258
- OpenAlex
- W4210995852
- Cited by
- 1,384
- References
- 225
- Citations by year
- 2026: 32 · 2025: 60 · 2024: 78 · 2023: 58 · 2022: 74 · 2021: 81 · 2020: 81 · 2019: 82 · 2018: 88 · 2017: 77 · 2016: 89 · 2015: 90 · 2014: 84 · 2013: 84 · 2012: 72
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (2r01ca103958-06a1, UL1TR000005, CA 103958)
- National Cancer Institute (R01CA035373, CA035373, R01-CA103958, CA103958)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- liver regeneration, partial hepatectomy, hepatocytes, growth factors, cytokines, extracellular matrix remodeling, signaling pathways, liver homeostasis
- MeSH terms
- Animals, Epithelial Cells, Hemodynamics, Hepatectomy, Humans, Liver, Liver Regeneration, Mitosis, Stem Cells, Signal Transduction, Interleukin-6, Hepatocytes, Transforming Growth Factor beta1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
