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Biodistribution of extracellular vesicles following administration into animals: A systematic review
Open accessAbstract
In recent years, attention has turned to examining the biodistribution of EVs in recipient animals to bridge between knowledge of EV function in vitro and in vivo. We undertook a systematic review of the literature to summarize the biodistribution of EVs following administration into animals. There were time‐dependent changes in the biodistribution of small‐EVs which were most abundant in the liver. Detection peaked in the liver and kidney in the first hour after administration, while distribution to the lungs and spleen peaked between 2–12 h. Large‐EVs were most abundant in the lungs with localization peaking in the first hour following administration and decreased between 2–12 h. In contrast, large‐EV localization to the liver increased as the levels in the lungs decreased. There was moderate to low localization of large‐EVs to the kidneys while localization to the spleen was typically low. Regardless of the origin or size of the EVs or the recipient species into which the EVs were administered, the biodistribution of the EVs was largely to the liver, lungs, kidneys, and spleen. There was extreme variability in the methodology between studies and we recommend that guidelines should be developed to promote standardization where possible of future EV biodistribution studies.
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Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042
Wang, G., Ma, R., Qiao, G., Wada, K., Aizawa, Y., & Satoh, T. (2015) · Integrative Medicine International · doi:10.1159/000368408 · Cited by 18,657
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099
Self-citationTumour exosome integrins determine organotropic metastasis
Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101
Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715
B lymphocytes secrete antigen-presenting vesicles.
Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546
Routes and mechanisms of extracellular vesicle uptake
Mulcahy, L. A., Pink, R. C., & Carter, D. R. F. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24641 · Cited by 2,832
Longmire, M., Choyke, P. L., & Kobayashi, H. (2008) · Nanomedicine · doi:10.2217/17435889.3.5.703 · Cited by 2,149
Targeted drug delivery to tumors: Myths, reality and possibility
Bae, Y. H., & Park, K. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.06.001 · Cited by 1,935
Tian, Y., Li, S., Song, J., Ji, T., Zhu, M., Anderson, G. J., Wei, J., & Nie, G. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.083 · Cited by 1,801
Wiklander, O. P. B., Nordin, J. Z., O'Loughlin, A., Gustafsson, Y., Corso, G., Mäger, I., Vader, P., Lee, Y., Sork, H., Seow, Y., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26316 · Cited by 1,730
Ratajczak, J., Miekus, K., Kucia, M., Zhang, J., Reca, R., Dvorak, P., & Ratajczak, M. Z. (2006) · Leukemia · doi:10.1038/sj.leu.2404132 · Cited by 1,627
Zhang, H., Freitas, D., Kim, H. S., Fabijanic, K., Li, Z., Chen, H., Mark, M. T., Molina, H., Martin, A. B., Bojmar, L., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0040-4 · Cited by 1,613
Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter
Lai, C. P., Mardini, O., Ericsson, M., Prabhakar, S., Maguire, C. A., Chen, J. W., Tannous, B. A., & Breakefield, X. O. (2014) · ACS Nano · doi:10.1021/nn404945r · Cited by 902
Crescitelli, R., Lässer, C., Szabó, T. G., Kittel, A., Eldh, M., Dianzani, I., Buzás, E. I., & Lötvall, J. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20677 · Cited by 876
Exosome-delivered microRNAs modulate the inflammatory response to endotoxin
Alexander, M., Hu, R., Runtsch, M. C., Kagele, D. A., Mosbruger, T. L., Tolmachova, T., Seabra, M. C., Round, J. L., Ward, D. M., & O’Connell, R. M. (2015) · Nature Communications · doi:10.1038/ncomms8321 · Cited by 769
Molecular lipidomics of exosomes released by PC-3 prostate cancer cells
Llorente, A., Skotland, T., Sylvänne, T., Kauhanen, D., Róg, T., Orłowski, A., Vattulainen, I., Ekroos, K., & Sandvig, K. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.04.011 · Cited by 768
Takahashi, Y., Nishikawa, M., Shinotsuka, H., Matsui, Y., Ohara, S., Imai, T., & Takakura, Y. (2013) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2013.03.013 · Cited by 728
Biodistribution and delivery efficiency of unmodified tumor-derived exosomes
Smyth, T., Kullberg, M., Malik, N., Smith-Jones, P., Graner, M. W., & Anchordoquy, T. J. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.013 · Cited by 722
Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking
Murphy, D. E., de Jong, O. G., Brouwer, M., Wood, M. J., Lavieu, G., Schiffelers, R. M., & Vader, P. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0223-5 · Cited by 705
Nordin, J. Z., Lee, Y., Vader, P., Mäger, I., Johansson, H. J., Heusermann, W., Wiklander, O. P. B., Hällbrink, M., Seow, Y., Bultema, J. J., et al. (2015) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2015.01.003 · Cited by 678
THE BIOLOGICAL SIGNIFICANCE OF THE THROMBOPLASTIC PROTEIN OF BLOOD
Chargaff, E., & West, R. (1946) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34997-9 · Cited by 659
PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time
Kooijmans, S. A. A., Fliervoet, L. A. L., van der Meel, R., Fens, M. H. A. M., Heijnen, H. F. G., van Bergen en Henegouwen, P. M. P., Vader, P., & Schiffelers, R. M. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.009 · Cited by 625
Imai, T., Takahashi, Y., Nishikawa, M., Kato, K., Morishita, M., Yamashita, T., Matsumoto, A., Charoenviriyakul, C., & Takakura, Y. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26238 · Cited by 579
Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson’s disease
Qu, M., Lin, Q., Huang, L., Fu, Y., Wang, L., He, S., Fu, Y., Yang, S., Zhang, Z., Zhang, L., et al. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.08.035 · Cited by 543
Witwer, K. W., & Théry, C. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1648167 · Cited by 538
Kim, S. M., Yang, Y., Oh, S. J., Hong, Y., Seo, M., & Jang, M. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.013 · Cited by 481 · cited 2×
“Between 2–12 h and at 24 h, moderate levels of EVs were detected in tumours (Abello et al., 2019; Gao et al., 2018; Goh et al., 2017; Kim et al., 2017; Kooijmans et al., 2016; Lee et al., 2018; Li et al., 2018; Smyth et al., 2015; Wiklander et al., 2015).”
BackgroundExtracellular vesicle-based drug delivery systems for cancer treatment
Walker, S., Busatto, S., Pham, A., Tian, M., Suh, A., Carson, K., Quintero, A., Lafrence, M., Malik, H., Santana, M. X., et al. (2019) · Theranostics · doi:10.7150/thno.37097 · Cited by 429
Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy
Gao, X., Ran, N., Dong, X., Zuo, B., Yang, R., Zhou, Q., Moulton, H. M., Seow, Y., & Yin, H. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat0195 · Cited by 426
Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns
Manca, S., Upadhyaya, B., Mutai, E., Desaulniers, A. T., Cederberg, R. A., White, B. R., & Zempleni, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-29780-1 · Cited by 399
CD169 mediates the capture of exosomes in spleen and lymph node
Saunderson, S. C., Dunn, A. C., Crocker, P. R., & McLellan, A. D. (2014) · Blood · doi:10.1182/blood-2013-03-489732 · Cited by 395
GRANGE, C., TAPPARO, M., BRUNO, S., CHATTERJEE, D., QUESENBERRY, P. J., TETTA, C., & CAMUSSI, G. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1663 · Cited by 361
Imaging extracellular vesicles: current and emerging methods
Chuo, S. T.-Y., Chien, J. C.-Y., & Lai, C. P.-K. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0494-5 · Cited by 359
A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease
PrabhuDas, M. R., Baldwin, C. L., Bollyky, P. L., Bowdish, D. M. E., Drickamer, K., Febbraio, M., Herz, J., Kobzik, L., Krieger, M., Loike, J., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700373 · Cited by 329
Yamashita, T., Takahashi, Y., & Takakura, Y. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00133 · Cited by 306
The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Wen, S. W., Sceneay, J., Lima, L. G., Wong, C. S. F., Becker, M., Krumeich, S., Lobb, R. J., Castillo, V., Wong, K. N., Ellis, S., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0868 · Cited by 289
Morishita, M., Takahashi, Y., Nishikawa, M., Sano, K., Kato, K., Yamashita, T., Imai, T., Saji, H., & Takakura, Y. (2015) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24251 · Cited by 285
Willekens, F. L. A., Werre, J. M., Kruijt, J. K., Roerdinkholder-Stoelwinder, B., Groenen-Döpp, Y. A. M., van den Bos, A. G., Bosman, G. J. C. G. M., & van Berkel, T. J. C. (2005) · Blood · doi:10.1182/blood-2004-04-1578 · Cited by 280
Structure and Composition of Pulmonary Arteries, Capillaries, and Veins
Townsley, M. I. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c100081 · Cited by 277
Targeting extracellular vesicles to injured tissue using membrane cloaking and surface display
Antes, T. J., Middleton, R. C., Luther, K. M., Ijichi, T., Peck, K. A., Liu, W. J., Valle, J., Echavez, A. K., & Marbán, E. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0388-4 · Cited by 250
Matsumoto, A., Takahashi, Y., Nishikawa, M., Sano, K., Morishita, M., Charoenviriyakul, C., Saji, H., & Takakura, Y. (2017) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2016.07.022 · Cited by 232
Development and MPI tracking of novel hypoxia-targeted theranostic exosomes
Jung, K. O., Jo, H., Yu, J. H., Gambhir, S. S., & Pratx, G. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.048 · Cited by 229
A33 antibody-functionalized exosomes for targeted delivery of doxorubicin against colorectal cancer
Li, Y., Gao, Y., Gong, C., Wang, Z., Xia, Q., Gu, F., Hu, C., Zhang, L., Guo, H., & Gao, S. (2018) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2018.05.020 · Cited by 222
Matrix Vesicles in Atherosclerotic Calcification
Tanimura, A., McGregor, D. H., & Anderson, H. C. (1983) · Experimental Biology and Medicine · doi:10.3181/00379727-172-41542 · Cited by 219
Tumor-exosomes and leukocyte activation: an ambivalent crosstalk
Zech, D., Rana, S., Büchler, M. W., & Zöller, M. (2012) · Cell Communication and Signaling · doi:10.1186/1478-811x-10-37 · Cited by 217
Prostasomes: extracellular vesicles from the prostate
Aalberts, M., Stout, T. A. E., & Stoorvogel, W. (2014) · Reproduction · doi:10.1530/rep-13-0358 · Cited by 211
Goh, W. J., Zou, S., Ong, W. Y., Torta, F., Alexandra, A. F., Schiffelers, R. M., Storm, G., Wang, J.-W., Czarny, B., & Pastorin, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-14725-x · Cited by 201
Modification of the glycosylation of extracellular vesicles alters their biodistribution in mice
Royo, F., Cossío, U., Ruiz de Angulo, A., Llop, J., & Falcon-Perez, J. M. (2019) · Nanoscale · doi:10.1039/c8nr03900c · Cited by 199
Wang, Y., Chen, X., Tian, B., Liu, J., Yang, L., Zeng, L., Chen, T., Hong, A., & Wang, X. (2017) · Theranostics · doi:10.7150/thno.16532 · Cited by 196
Advances in Analysis of Biodistribution of Exosomes by Molecular Imaging
Yi, Y. W., Lee, J. H., Kim, S.-Y., Pack, C.-G., Ha, D. H., Park, S. R., Youn, J., & Cho, B. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020665 · Cited by 190
Augmented liver targeting of exosomes by surface modification with cationized pullulan
Tamura, R., Uemoto, S., & Tabata, Y. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.05.013 · Cited by 186
Jalabert, A., Vial, G., Guay, C., Wiklander, O. P. B., Nordin, J. Z., Aswad, H., Forterre, A., Meugnier, E., Pesenti, S., Regazzi, R., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-3882-y · Cited by 177
On the Origin of Microparticles: From “Platelet Dust” to Mediators of Intercellular Communication
Hargett, L. A., & Bauer, N. N. (2013) · Pulmonary Circulation · doi:10.4103/2045-8932.114760 · Cited by 175
Fluorescence Molecular Tomography: Principles and Potential for Pharmaceutical Research
Stuker, F., Ripoll, J., & Rudin, M. (2011) · Pharmaceutics · doi:10.3390/pharmaceutics3020229 · Cited by 173
Zhang, W., Yu, Z.-L., Wu, M., Ren, J.-G., Xia, H.-F., Sa, G.-L., Zhu, J.-Y., Pang, D.-W., Zhao, Y.-F., & Chen, G. (2017) · ACS Nano · doi:10.1021/acsnano.6b05630 · Cited by 171
A translational study of urine miRNAs in acute myocardial infarction
Cheng, Y., Wang, X., Yang, J., Duan, X., Yao, Y., Shi, X., Chen, Z., Fan, Z., Liu, X., Qin, S., et al. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.08.010 · Cited by 169
Molecular imaging perspectives
Cassidy, P. J., & Radda, G. K. (2005) · Journal of The Royal Society Interface · doi:10.1098/rsif.2005.0040 · Cited by 169
Placental Extracellular Vesicles and Feto-Maternal CommunicationPreprint
Tong, M., & Chamley, L. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a023028 · Cited by 158
Self-citationHaney, M. J., Klyachko, N. L., Harrison, E. B., Zhao, Y., Kabanov, A. V., & Batrakova, E. V. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801271 · Cited by 152
Noninvasive Bioluminescence Imaging in Small Animals
Zinn, K. R., Chaudhuri, T. R., Szafran, A. A., O’Quinn, D. B., Weaver, C. T., Dugger, K. J., Lamar, D. L., Kesterson, R. A., Wang, X., & Frank, S. J. (2008) · ILAR Journal · doi:10.1093/ilar.49.1.103 · Cited by 149
Rocco, G. D., Baldari, S., & Toietta, G. (2016) · Stem Cells International · doi:10.1155/2016/5029619 · Cited by 147
Faruqu, F. N., Wang, J. T.-W., Xu, L., McNickle, L., Chong, E. M.-Y., Walters, A. A., Gurney, M., Clayton, A., Smyth, L. A., Hider, R. C., et al. (2019) · Theranostics · doi:10.7150/thno.27891 · Cited by 147
An Update on in Vivo Imaging of Extracellular Vesicles as Drug Delivery Vehicles
Gangadaran, P., Hong, C. M., & Ahn, B. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00169 · Cited by 146
Biodistribution and function of extracellular miRNA-155 in mice
Bala, S., Csák, T., Momen‐Heravi, F., Lippai, D., Kodys, K., Catalano, D., Satishchandran, A., Ambros, V., & Szabó, G. (2015) · Scientific Reports · doi:10.1038/srep10721 · Cited by 144
Abello, J., Nguyen, T. D. T., Marasini, R., Aryal, S., & Weiss, M. L. (2019) · Theranostics · doi:10.7150/thno.30030 · Cited by 142
Grabowska, J. A., Venegas, M. L., Affandi, A. J., & den Haan, J. M. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02472 · Cited by 138
Wan, L., Xia, T., Du, Y., Liu, J., Xie, Y., Zhang, Y., Guan, F., Wu, J., Wang, X., & Shi, C. (2019) · The FASEB Journal · doi:10.1096/fj.201802675r · Cited by 131
Gangadaran, P., Li, X. J., Lee, H., Oh, J. M., Kalimuthu, S., Rajendran, R. L., Son, S. H., Baek, S. H., Singh, T. D., Zhu, L., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.22493 · Cited by 122
Role of Extracellular Vesicle Surface Proteins in the Pharmacokinetics of Extracellular Vesicles
Charoenviriyakul, C., Takahashi, Y., Morishita, M., Nishikawa, M., & Takakura, Y. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00950 · Cited by 118
Radiolabeling of Extracellular Vesicles with 99m Tc for Quantitative In Vivo Imaging Studies
Varga, Z., Gyurkó, I., Pálóczi, K., Buzás, E. I., Horváth, I., Hegedűs, N., Máthé, D., & Szigeti, K. (2016) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2016.2009 · Cited by 116
A mouse model for calculating cross-organ beta doses from yttrium-90-labeled immunoconjugates
Hui, T. E., Fisher, D. R., Kuhn, J. A., Williams, L. E., Nourigat, C., Badger, C. C., Beatty, B., & Beatty, J. D. (1994) · Cancer · Cited by 114
Cheng, S., Li, F., Souris, J. S., Yang, C., Tseng, F., Lee, M., Chen, C.-T., Dong, C., & Lo, L. (2012) · ACS Nano · doi:10.1021/nn300558p · Cited by 112
Facile metabolic glycan labeling strategy for exosome tracking
Lee, T. S., Kim, Y., Zhang, W., Song, I. H., & Tung, C. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.02.001 · Cited by 111
Jaiswal, R., Luk, F., Dalla, P. V., Grau, G. E., & Bebawy, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061515 · Cited by 110
Viñas, J. L., Spence, M. C., Gutsol, A. A., Knoll, W., Burger, D. E., Zimpelmann, J., Allan, D., & Burns, K. D. (2018) · Scientific Reports · doi:10.1038/s41598-018-34557-7 · Cited by 107
Garofalo, M., Villa, A. M., Rizzi, N., Kuryk, Ł., Mazzaferro, V., & Ciana, P. (2018) · Viruses · doi:10.3390/v10100558 · Cited by 101
Wei, G., Jie, Y., Haibo, L., Chaoneng, W., Huang, D., Jianbing, Z., Junjie, G., Ma, L., Hongtao, S., Yunzeng, Z., et al. (2017) · Scientific Reports · doi:10.1038/srep42996 · Cited by 83
Pathways of production and delivery of hepatocyte exosomes
Chen, L., Chen, R., Kemper, S., & Brigstock, D. R. (2017) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-017-0421-7 · Cited by 82
Wang, Q., Zhuang, X., Sriwastva, M. K., Mu, J., Teng, Y., Deng, Z., Zhang, L., Sundaram, K., Kumar, A., Miller, D. M., et al. (2018) · Theranostics · doi:10.7150/thno.27608 · Cited by 74
In Vivo Tracking of Multiple Tumor Exosomes Labeled by Phospholipid-Based Bioorthogonal Conjugation
Zhang, P., Dong, B., Zeng, E., Wang, F., Jiang, Y. Y., Li, D., & Liu, D. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b01506 · Cited by 63
Placental Nano-vesicles Target to Specific Organs and Modulate Vascular Tone In Vivo
Tong, M., Stanley, J. L., Chen, Q., James, J. L., STONE, P. R., & Chamley, L. (2017) · Human Reproduction · doi:10.1093/humrep/dex310 · Cited by 60
Self-citationIn vivo targets of human placental micro-vesicles vary with exposure time and pregnancy
Tong, M., Chen, Q., James, J. L., WISE, M. R., STONE, P. R., & Chamley, L. (2017) · Reproduction · doi:10.1530/rep-16-0615 · Cited by 52
Self-citationDexosomes as a therapeutic cancer vaccine: From bench to bedside
Pecq, J. L. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.06.003 · Cited by 45
Hayashi, K., Yamada, S., Hayashi, H., Sakamoto, W., & Yogo, T. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.031 · Cited by 42
Biomimetic surface modification of discoidal polymeric particles
Nguyen, T. D. T., Aryal, S., Pitchaimani, A., Park, S., Key, J., & Aryal, S. (2018) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2018.11.011 · Cited by 28
Hematopoietic and Lymphoid Tissues
Linden, M. A., Ward, J. M., & Cherian, S. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-381361-9.00019-6 · Cited by 18
Antigen Acquisition In Vivo and its Role in B Cell Activation
Batista, F. D., Coleman, J., Frederico, B., & Gaya, M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-374279-7.09002-0 · Cited by 3
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Liu, Q., Li, D., Pan, X., & Liang, Y. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02081-0 · Cited by 201
Giovannelli, L., Bari, E., Jommi, C., Tartara, F., Armocida, D., Garbossa, D., Cofano, F., Torre, M. L., & Segale, L. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.06.013 · Cited by 102
Biocompatibility and biodistribution of matrix-bound nanovesicles in vitro and in vivo
Crum, R. J., Capella-Monsonís, H., Chang, J., Dewey, M. J., Kolich, B. D., Hall, K. T., El-Mossier, S. O., Nascari, D. G., Hussey, G. S., & Badylak, S. F. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.11.026 · Cited by 42
Metadata
- Authors
- Kang, M., Jordan, V., Blenkiron, C., & Chamley, L. W.
- Venue
- Journal of Extracellular Vesicles
- Publisher
- Wiley
- Published
- 2021-06
- Volume
- 10
- Issue
- 8
- Pages
- e12085-e12085
- ISSN
- 2001-3078 (ISSN-L)
- OpenAlex
- W3173559534
- Cited by
- 485
- References
- 90
- FWCI
- 5.56
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
