The DOI matches its Crossref record; 87 of the 91 references it cites were found in a registry or an index.
Prior Stressor Exposure Sensitizes LPS-Induced Cytokine Production
Abstract
Exposure to stressors often alters the subsequent responsiveness of many systems. The present study tested whether prior exposure to inescapable tailshock (IS) alters the interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, or IL-6 response to an injection of bacterial endotoxin (lipopolysaccharide; LPS). Rats were exposed to IS or remained as home cage controls (HCC); 24 h later animals were injected i.p. with either 10 microg/kg LPS or equilvolume sterile saline. IS significantly increased plasma TNF-alpha, IL-1beta, and pituitary, hypothalamus, hippocampus, cerebellum IL-1beta 1 h, but not 2 h, after LPS, compared to controls. Additional animals were injected with LPS or saline 4, 10, or 21 days after exposure to IS and tail vein blood was collected and assayed for IL-1beta. An enhanced plasma IL-1beta response occurred 4 days after IS, but was gone by 10 days. These results suggest that exposure to IS sensitizes the innate immune response to LPS by resulting in either a larger or a more rapid induction of proinflammatory cytokines.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Stress and depression can permanently alter the responsiveness of the immune system (41-44).”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [41]
In the citing paper
“For example, prior stressor exposure appears to prime proinflammatory cytokine responses, such that subsequent exposure to a bacterial endotoxin, lipopolysaccharide, resulted in a larger or more rapid induction of proinflammatory cytokines in stressed rats compared with nonstressed controls (41).”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [41]
In the citing paper
“serum concentrations of lipocalin-type PGD synthase, which catalyzes the conversion from PGH2 to PGD2, have been reported to vary throughout the day, with highest levels at night (sleep period) and lowest levels in the afternoon. Total sleep deprivation blunted the nocturnal increase at night and elevated levels during the daytime (275)”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [275]
In the citing paper
“For example, acute stress 24 hr prior to lipopolysaccharide (LPS) treatment augments LPS-induced increases in plasma levels of IL-1β, TNF-α, and IL-6 (Johnson et al., 2002).”
From The Stressed CNS: When Glucocorticoids Aggravate Inflammation (2009) · cites this paper as Johnson et al., 2002
In the citing paper
“For instance, acute stressors such as inescapable tailshocks (IS) were demonstrated to potentiate the expression of pro-inflammatory mediators in specific regions of the brain following the peripheral administration of LPS in rodents (140–142).”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [141]
In the citing paper
“As a matter of act, both types of stress elicit an HPA response and were shown to exacerbate salient features of inflammation in the CNS provided that they occur prior to peripheral or cerebral immune insults.”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [141]
In the citing paper
“GR signaling was thus proposed to be essential for the cross-sensitization between stress and the inflammatory response to LPS.”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [141]
In the citing paper
“Interestingly, in these studies the priming effects of stress (regardless of its chronicity) on the ensuing immune response could be abated with RU486 or by experimentally maintaining plasma GCs to basal levels in adrenalectomized animals.”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [141]
Citations
Cites
Immunobiology: the immune system in health and disease
(1995) · Choice Reviews Online · doi:10.5860/choice.32-3876 · Cited by 4,111
Biological basis of the behavior of sick animals
Hart, B. L. (1988) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(88)80004-6 · Cited by 2,223
The psychology and neurobiology of addiction: an incentive–sensitization view
Robinson, T. E., & Berridge, K. C. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.19.x · Cited by 1,507
Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor
Sapolsky, R., Rivier, C., Yamamoto, G., Plotsky, P., & Vale, W. (1987) · Science · doi:10.1126/science.2821621 · Cited by 1,504
Fever: Role of Pyrogens and Cryogens
Kluger, M. J. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.1.93 · Cited by 1,220
Sickness behavior as a new target for drug development
Kent, S., Bluthé, R.-M., Kelley, K. W., & Dantzer, R. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90012-u · Cited by 867
The role of stress in drug self-administration
Piazza, P. V., & Moal, M. L. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01115-2 · Cited by 674
Interchangeability of Stress and Amphetamine in Sensitization
Antelman, S. M., Eichler, A. J., Black, C. A., & Kocan, D. J. (1980) · Science · doi:10.1126/science.7188649 · Cited by 562
The immune system as a sensory organ.
Blalock, J. E. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.132.3.1067 · Cited by 551
Stress and immunity: An integrated view of relationships between the brain and the immune system
Dantzer, R., & Kelley, K. W. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90345-7 · Cited by 534
Cited by
Sorted by citations
Stress-induced immune dysfunction: implications for health
Glaser, R., & Kiecolt-Glaser, J. K. (2005) · Nature Reviews Immunology · doi:10.1038/nri1571 · Cited by 2,190
The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479
“For example, activation of the classical HPA and ANS stress axes can support or suppress inflammatory and adaptive immune responses in human and animal models, depending, among other factors, on whether it occurs before or after the immunological challenge (274, 371, 474).”
BackgroundChronic stress and age-related increases in the proinflammatory cytokine IL-6.
Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1531903100 · Cited by 1,267
Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa
Dantzer, R. (2018) · Physiological Reviews · doi:10.1152/physrev.00039.2016 · Cited by 1,073
Inflammation: Depression Fans the Flames and Feasts on the Heat
Kiecolt-Glaser, J. K., Derry, H. M., & Fagundes, C. P. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15020152 · Cited by 844
Obesity and neuroinflammation: A pathway to cognitive impairment
Miller, A. A., & Spencer, S. J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.04.001 · Cited by 834
Hostile Marital Interactions, Proinflammatory Cytokine Production, and Wound Healing
Kiecolt-Glaser, J. K., Loving, T. J., Stowell, J. R., Malarkey, W. B., Lemeshow, S., Dickinson, S. L., & Glaser, R. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.12.1377 · Cited by 715
Cytokines and their relationship to the symptoms and outcome of cancer
Seruga, B., Zhang, H., Bernstein, L. J., & Tannock, I. F. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2507 · Cited by 652
Linking immune defenses and life history at the levels of the individual and the species
Lee, K. A. (2006) · Integrative and Comparative Biology · doi:10.1093/icb/icl049 · Cited by 598
Frank, M. G., Baratta, M. V., Sprunger, D. B., Watkins, L. R., & Maier, S. F. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.03.005 · Cited by 578
Self-citationEffect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function
Tan, B. L., & Norhaizan, M. E. (2019) · Nutrients · doi:10.3390/nu11112579 · Cited by 546
An inflammatory review of glucocorticoid actions in the CNS
Sorrells, S. F., & Sapolsky, R. M. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.11.006 · Cited by 461
The Stressed CNS: When Glucocorticoids Aggravate Inflammation
Sorrells, S. F., Caso, J. R., Munhoz, C. D., & Sapolsky, R. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.032 · Cited by 425
Catecholamines mediate stress-induced increases in peripheral and central inflammatory cytokines
Johnson, J. D., Campisi, J., Sharkey, C. M., Kennedy, S. L., Nickerson, M., Greenwood, B. N., & Fleshner, M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.090 · Cited by 424
Self-citationThe HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain
Bellavance, M.-A., & Rivest, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00136 · Cited by 419
Postoperative Impairment of Cognitive Function in Rats
Wan, Y., Xu, J., Ma, D., Zeng, Y., Cibelli, M., & Maze, M. (2007) · Anesthesiology · doi:10.1097/00000542-200703000-00007 · Cited by 397
Kiecolt‐Glaser, J. K., Bennett, J. M., Andridge, R., Peng, J., Shapiro, C. L., Malarkey, W. B., Emery, C. F., Layman, R. M., Mrózek, E., & Glaser, R. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.51.8860 · Cited by 409
Anisman, H., Merali, Z., & Hayley, S. P. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.01.004 · Cited by 341
Neuroinflammation Associated with Aging Sensitizes the Brain to the Effects of Infection or Stress
Sparkman, N. L., & Johnson, R. W. (2008) · NeuroImmunoModulation · doi:10.1159/000156474 · Cited by 342
Acute and Chronic Stress-Induced Disturbances of Microglial Plasticity, Phenotype and Function
Walker, F. R., Nilsson, M., & Jones, K. (2013) · Current Drug Targets · doi:10.2174/13894501113149990208 · Cited by 336
Neuroinflammation in the normal aging hippocampus
Barrientos, R. M., Kitt, M. M., Watkins, L. R., & Maier, S. F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.007 · Cited by 338
Self-citationCytokine imbalance in the pathophysiology of major depressive disorder
Kim, Y., Na, K.-S., Shin, K.-H., Jung, H., Choi, S., & Kim, J.-B. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.03.004 · Cited by 319
Immune Dysregulation and Chronic Stress among Older Adults: A Review
Gouin, J.-P., Hantsoo, L. V., & Kiecolt‐Glaser, J. K. (2008) · NeuroImmunoModulation · doi:10.1159/000156468 · Cited by 320
Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses
Frank, M. G., Thompson, B. M., Watkins, L. R., & Maier, S. F. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.10.005 · Cited by 310
Self-citationFrank, M. G., Miguel, Z. D., Watkins, L. R., & Maier, S. F. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.07.008 · Cited by 303
Self-citationMiura, H., Ozaki, N., Sawada, M., Isobe, K., Ohta, T., & Nagatsu, T. (2008) · Stress · doi:10.1080/10253890701754068 · Cited by 282
Wohleb, E. S., Fenn, A. M., Pacenta, A. M., Powell, N. D., Sheridan, J. F., & Godbout, J. P. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.02.003 · Cited by 275
Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome
Busillo, J. M., Azzam, K. M., & Cidlowski, J. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.275370 · Cited by 264
Glaser, R., Robles, T. F., Sheridan, J. F., Malarkey, W. B., & Kiecolt‐Glaser, J. K. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.10.1009 · Cited by 242
Frank, M. G., Weber, M. D., Watkins, L. R., & Maier, S. F. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.010 · Cited by 237
Self-citationThe inflammation hypothesis in geriatric depression
Alexopoulos, G. S., & Morimoto, S. S. (2011) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2672 · Cited by 237
Sugama, S., Fujita, M., Hashimoto, M., & Conti, B. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.043 · Cited by 216
Weber, M. D., Frank, M. G., Tracey, K. J., Watkins, L. R., & Maier, S. F. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3561-14.2015 · Cited by 215
“The hippocampus was targeted because it is an area that shows robust IS-induced priming of neuroinflammatory processes in vivo (Johnson et al., 2002) and ex vivo (Frank et al., 2007) and yields a sufficient number of microglia to perform ex vivo experiments.”
Self-citationp23, a simple protein with complex activities
Felts, S. J., & Toft, D. O. (2003) · Cell Stress and Chaperones · doi:10.1379/1466-1268(2003)008 · Cited by 116
Depressive symptoms, omega-6:omega-3 fatty acids, and inflammation in older adults.
Kiecolt-Glaser, J. K., Belury, M. A., Porter, K., Beversdorf, D. Q., Lemeshow, S., & Glaser, R. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3180313a45 · Cited by 212
de Pablos, R. M., Herrera, A. J., Espinosa-Oliva, A. M., Sarmiento, M., Muñoz, M. F., Machado, A., & Venero, J. L. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-34 · Cited by 201
Christian, L. M. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.07.005 · Cited by 203
Socioeconomic status and stress-induced increases in interleukin-6
Brydon, L., Edwards, S., Mohamed‐Ali, V., & Steptoe, A. (2003) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.09.011 · Cited by 194
Regulatory and Mechanistic Actions of Glucocorticoids on T and Inflammatory Cells
Liberman, A. C., Budziñski, M. L., Sokn, C., Gobbini, R. P., Steininger, A., & ARZT, E. S. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00235 · Cited by 190
Inflammatory cytokine-associated depression
Lotrich, F. E. (2015) · Brain Research · doi:10.1016/j.brainres.2014.06.032 · Cited by 183
Frank, M. G., Hershman, S. A., Weber, M. D., Watkins, L. R., & Maier, S. F. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.11.006 · Cited by 187
Self-citationDysregulated neuronal–microglial cross-talk during aging, stress and inflammation
Jurgens, H. A., & Johnson, R. W. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2010.11.014 · Cited by 179
Cheng, Y., Pardo, M., Armini, R. D. S., Martinez, A., Mouhsine, H., Zagury, J.-F., Jope, R. S., & Beurel, E. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.12.012 · Cited by 174
Franklin, T., Wohleb, E. S., Zhang, Y., Fogaça, M. V., Hare, B. D., & Duman, R. S. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.034 · Cited by 174
Brydon, L., Walker, C., Wawrzyniak, A., Whitehead, D., Okamura, H., Yajima, J., Tsuda, A., & Steptoe, A. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.09.007 · Cited by 164
Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger
Frank, M. G., Watkins, L. R., & Maier, S. F. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.02.004 · Cited by 160
Self-citationMicroglia: Neuroimmune-sensors of stress
Frank, M. G., Fonken, L. K., Watkins, L. R., & Maier, S. F. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.01.001 · Cited by 165
Self-citationDepressive symptoms enhance stress-induced inflammatory responses.
Fagundes, C. P., Glaser, R., Hwang, B. S., Malarkey, W. B., & Kiecolt-Glaser, J. K. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.05.006 · Cited by 151
Reyes, T. M., Walker, J. R., DeCino, C., Hogenesch, J. B., & Sawchenko, P. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05607.2003 · Cited by 149
Frank, M. G., Weber, M. D., Watkins, L. R., & Maier, S. F. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2015.12.004 · Cited by 154
Self-citationEffects of prior stress on LPS-induced cytokine and sickness responses
Johnson, J. D., O'Connor, K. A., Hansen, M. K., Watkins, L. R., & Maier, S. F. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00230.2002 · Cited by 138
Self-citationBlandino, P., Barnum, C. J., Solomon, L. G., Larish, Y., Lankow, B. S., & Deak, T. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.04.013 · Cited by 137
Czerniawski, J. L., Miyashita, T., Lewandowski, G. A., & Guzowski, J. F. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.09.014 · Cited by 141
Frank, M. G., Weber, M. D., Fonken, L. K., Hershman, S. A., Watkins, L. R., & Maier, S. F. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.10.009 · Cited by 133
Self-citationRole of extracellular HSP72 in acute stress-induced potentiation of innate immunity in active rats
Campisi, J., & Fleshner, M. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00681.2002 · Cited by 136
Fleshner, M. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.08.012 · Cited by 126
Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice
Buchanan, J. B., Sparkman, N. L., Chen, J., & Johnson, R. W. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.02.013 · Cited by 128
Zhao, H., Zhang, M., Zhou, F., Cao, W., Bi, L., Xie, Y., Yang, Q., & Wang, S. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.10.017 · Cited by 124
Stress-induced sensitization: the hypothalamic–pituitary–adrenal axis and beyond
Belda, X., Fuentes, S., Daviu, N., Nadal, R., & Armario, A. (2015) · Stress · doi:10.3109/10253890.2015.1067678 · Cited by 123
Couch, Y., Трофимов, А. Н., Васильева, Н. А., Nikolenko, V. N., Steinbusch, H. W. M., Chekhonin, V. P., Schroeter, C. A., Lesch, K., Anthony, D. C., & Strekalova, T. V. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0572-0 · Cited by 127
Neuroinflammatory priming to stress is differentially regulated in male and female rats
Fonken, L. K., Frank, M. G., Gaudet, A. D., D’Angelo, H. M., Daut, R. A., Hampson, E. C., Ayala, M. T., Watkins, L. R., & Maier, S. F. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.03.005 · Cited by 119
Self-citationThe Pro-inflammatory Effects of Glucocorticoids in the Brain
Duque, É. D. A., & Munhoz, C. D. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00078 · Cited by 118
Finnell, J. E., Lombard, C. M., Padi, A. R., Moffitt, C. M., Wilson, L. B., Wood, C. S., & Wood, S. K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172868 · Cited by 118
Christian, L. M., Franco, A., Iams, J. D., Sheridan, J. F., & Glaser, R. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.05.055 · Cited by 114
Ramírez, K., Trías, J. F., & Sheridan, J. F. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_25 · Cited by 113
Gibb, J., Hayley, S. P., Gandhi, R., Poulter, M. O., & Anisman, H. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.12.001 · Cited by 111
Endogenous extra-cellular heat shock protein 72: Releasing signal(s) and function
Fleshner, M., & Johnson, J. D. (2005) · International Journal of Hyperthermia · doi:10.1080/02656730500088211 · Cited by 114
Self-citationPrior stressor exposure primes the HPA axis
Johnson, J. D., O'Connor, K. A., Deak, T., Spencer, R. L., Watkins, L. R., & Maier, S. F. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00057-9 · Cited by 110
Self-citationNeuroimmune and neuroendocrine abnormalities in depression: two sides of the same coin
Horowitz, M. A., & Zunszain, P. A. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12781 · Cited by 119
Johnson, J. D., O’Connor, K., Watkins, L. R., & Maier, S. F. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.046 · Cited by 107
Self-citationDeak, T., Quinn, M., Cidlowski, J. A., Victoria, N. C., Murphy, A. Z., & Sheridan, J. F. (2015) · Stress · doi:10.3109/10253890.2015.1053451 · Cited by 108
Lower subjective social status exaggerates interleukin-6 responses to a laboratory stressor
Derry, H. M., Fagundes, C. P., Andridge, R., Glaser, R., Malarkey, W. B., & Kiecolt‐Glaser, J. K. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.026 · Cited by 105
Sawicki, C. M., McKim, D. B., Wohleb, E. S., Jarrett, B. L., Reader, B. F., Norden, D. M., Godbout, J. P., & Sheridan, J. F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.10.004 · Cited by 101
Hermes, G. L., Rosenthal, L., Montag, A., & McClintock, M. K. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00368.2005 · Cited by 94
Gibb, J., Hayley, S. P., Poulter, M. O., & Anisman, H. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.11.008 · Cited by 96
A Biological Substrate for Somatoform Disorders: Importance of Pathophysiology
Dimsdale, J. E., & Dantzer, R. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31815b00e7 · Cited by 94
Weber, M. D., Frank, M. G., Sobesky, J. L., Watkins, L. R., & Maier, S. F. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.03.004 · Cited by 93
Self-citationGlucocorticoids regulate natural killer cell function epigenetically
Eddy, J. L., Krukowski, K., Janusek, L. W., & Mathews, H. L. (2014) · Cellular Immunology · doi:10.1016/j.cellimm.2014.05.013 · Cited by 93
Stress and aging act through common mechanisms to elicit neuroinflammatory priming
Fonken, L. K., Frank, M. G., Gaudet, A. D., & Maier, S. F. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.012 · Cited by 98
Self-citationInflammation and lithium: clues to mechanisms contributing to suicide-linked traits
Beurel, E., & Jope, R. S. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.129 · Cited by 92
Influenza, Immune System, and Pregnancy
Raj, R. S., Bonney, E. A., & Phillippe, M. (2014) · Reproductive Sciences · doi:10.1177/1933719114537720 · Cited by 90
Interleukin-1β with learning and memory
Huang, Z., & Sheng, G. (2010) · Neuroscience Bulletin · doi:10.1007/s12264-010-6023-5 · Cited by 89
Rankine, E. L., Hughes, P., Botham, M. S., Perry, V. H., & Felton, L. M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04891.x · Cited by 87
Connor, T. J., Brewer, C., Kelly, J. P., & Harkin, A. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.10.016 · Cited by 85
The old guard: Age-related changes in microglia and their consequences
Costa, J., Martins, S., Ferreira, P. A., Cardoso, A. M., Guedes, J. R., Peça, J., & Cardoso, A. L. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111512 · Cited by 88
Kelly, K. A., Miller, D. B., Bowyer, J. F., & O'Callaghan, J. P. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07864.x · Cited by 83
Monocytic, Th1 and Th2 Cytokine Alterations in the Pathophysiology of Schizophrenia
Na, K.-S., & Kim, Y. (2007) · Neuropsychobiology · doi:10.1159/000111535 · Cited by 82
Barrientos, R. M., Frank, M. G., Watkins, L. R., & Maier, S. F. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.02.010 · Cited by 88
Self-citationZelkha, S. A., Freilich, R. W., & Amar, S. (2010) · Periodontology 2000 · doi:10.1111/j.1600-0757.2010.00358.x · Cited by 81
Li, Z., Ma, L., Kulesskaya, N., Võikar, V., & Tian, L. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.02.008 · Cited by 81
Biobehavioral influences on recovery following hematopoietic stem cell transplantation
Costanzo, E. S., Juckett, M., & Coe, C. L. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.07.005 · Cited by 78
Rani, R. A., Ali, R. A. R., & Lee, Y. Y. (2016) · Intestinal Research · doi:10.5217/ir.2016.14.4.297 · Cited by 76
Meltzer, J. C., Macneil, B. J., Sanders, V., Pylypas, S. P., Jansen, A. H., Greenberg, A. H., & Nance, D. M. (2003) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.09.003 · Cited by 74
Northrop, N. A., & Yamamoto, B. K. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9391-y · Cited by 76
Evans, A. K., Ardestani, P. M., Yi, B., Park, H. H., Lam, R. K., & Shamloo, M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105089 · Cited by 74
Curtin, N. M., Boyle, N. T., Mills, K. H. G., & Connor, T. J. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.02.003 · Cited by 72
Stress-induced neuroinflammatory priming is time of day dependent
Fonken, L. K., Weber, M. D., Daut, R. A., Kitt, M. M., Frank, M. G., Watkins, L. R., & Maier, S. F. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.01.006 · Cited by 72
Self-citationChronic intermittent cold stress sensitizes neuro-immune reactivity in the rat brain
Girotti, M., Donegan, J. J., & Morilak, D. A. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.02.008 · Cited by 72
O’Loughlin, A., McGee, M., Waters, S. M., Doyle, S., & Earley, B. (2011) · BMC Veterinary Research · doi:10.1186/1746-6148-7-45 · Cited by 73
Cheng, Y., Jope, R. S., & Beurel, E. (2015) · BMC Neuroscience · doi:10.1186/s12868-015-0169-z · Cited by 70
Metadata
- Authors
- Johnson, J. D., O'Connor, K. A., Deak, T., Stark, M., Watkins, L. R., & Maier, S. F.
- Affiliations
- University of Colorado Boulder (US)
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 16
- Issue
- 4
- Pages
- 461-476
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2148779404
- Cited by
- 270
- References
- 91
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 8 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 12 · 2018: 14 · 2017: 17 · 2016: 12 · 2015: 21 · 2014: 20 · 2013: 14 · 2012: 12
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (MH-0314, MH-5045, MH-1558, MH-5283)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- lipopolysaccharide, endotoxin, IL-1β, TNF-α, interleukin-6, inflammatory cytokines, innate immune response, stress-immune interaction, hippocampus, hypothalamus, pituitary gland, rats
- MeSH terms
- Animals, Brain, Electroshock, Interleukin-1, Lipopolysaccharides, Male, Stress, Physiological, Time Factors, Tumor Necrosis Factor-alpha, Interleukin-6, Cytokines, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
