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Cited by 32Nanoparticle-Based Drug DeliveryCancer Cells and Metastasis3D Printing in Biomedical Research

The DOI matches its Crossref record; 215 of the 215 references it cites were found in a registry or an index.

3D Tumor Spheroid Models for In Vitro Therapeutic Screening of Nanoparticles

Daunys, Simonas, Janonienė, Agnė, Januškevičienė, Indrė, Paškevičiūtė, Miglė, Petrikaitė, Vilma·2021·Advances in experimental medicine and biology
DOI 10.1007/978-3-030-58174-9_11
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Abstract

The anticancer activity of compounds and nanoparticles is most often determined in the cell monolayer. However, three-dimensional (3D) systems, such as tumor spheroids, are more representing the natural tumor microenvironment. They have been shown to have higher invasiveness and resistance to cytotoxic agents and radiotherapy compared to cells growing in 2D monolayer. Furthermore, to improve the prediction of clinical efficacy of drugs, in the past decades, even more sophisticated systems, such as multicellular 3D cultures, closely representing natural tumor microenvironment have been developed. Those cultures are formed from either cell lines or patient-derived tumor cells. Such models are very attractive and could improve the selection of tested materials for clinical trials avoiding unnecessary expensive tests in vivo. The microenvironment in tumor spheroids is different, and those differences or the interaction between several cell populations may contribute to different tumor response to the treatment. Also, different types of nanoparticles may have different behavior in 3D models, depending on their nature, physicochemical properties, the presence of targeting ligands on the surface, etc. Therefore, it is very important to understand in which cases which type of tumor spheroid is more suitable for testing specific types of nanoparticles, which conditions should be used, and which analytical method should be applied.

Overview

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Crossref · 10.1007/978-3-030-58174-9_11

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215 of 215 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Daunys, S., Janonienė, A., Januškevičienė, I., Paškevičiūtė, M., & Petrikaitė, V.
Affiliations
  • Vilnius University (LT)
  • Lithuanian University of Health Sciences (LT)
ORCID
Venue
Advances in experimental medicine and biology
Publisher
Springer International Publishing
Published
2021
Volume
1295
Pages
243-270
ISSN
  • 0065-2598 (ISSN-L)
  • 2214-8019
DOI
10.1007/978-3-030-58174-9_11
OpenAlex
W3127899697
Cited by
32
References
215
Citations by year
2026: 3 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 4 · 2021: 3
FWCI
8.39
Type
book chapter
Language
en
Open access
closed
Licence
Locations
  • Advances in experimental medicine and biology (publishedVersion)
  • PubMed (publishedVersion)
  • Lithuanian University of Health Sciences (submittedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords
tumor spheroids, 3D tumor models, nanoparticles, anticancer drug screening, tumor microenvironment, patient-derived tumor cells, nanoparticle physicochemical properties, drug resistance, in vitro tumor model
MeSH terms
Humans, Spheroids, Cellular, Cell Culture Techniques, Cell Line, Tumor, Nanoparticles, Tumor Microenvironment

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