Cited by 170Circadian rhythm and melatoninNeurotransmitter Receptor Influence on BehaviorSleep and Wakefulness Research

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The Brain’s Reward System in Health and Disease

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Lewis, Robert G., Florio, Ermanno, Punzo, Daniela, Borrelli, Emiliana·2021·Advances in experimental medicine and biology

DOI 10.1007/978-3-030-81147-1_4PMC PMC8992377

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Abstract

Rhythmic gene expression is found throughout the central nervous system. This harmonized regulation can be dependent on- and independent of- the master regulator of biological clocks, the suprachiasmatic nucleus (SCN). Substantial oscillatory activity in the brain's reward system is regulated by dopamine. While light serves as a primary time-giver (zeitgeber) of physiological clocks and synchronizes biological rhythms in 24-h cycles, nonphotic stimuli have a profound influence over circadian biology. Indeed, reward-related activities (e.g., feeding, exercise, sex, substance use, and social interactions), which lead to an elevated level of dopamine, alters rhythms in the SCN and the brain's reward system. In this chapter, we will discuss the influence of the dopaminergic reward pathways on circadian system and the implication of this interplay on human health.

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Authors: Lewis, R. G., Florio, E., Punzo, D., & Borrelli, E.
Affiliations: University of California, Irvine (US)
Corresponding author: Borrelli, Emiliana
ORCID: Lewis, Robert G.
Punzo, Daniela
Borrelli, Emiliana
Venue: Advances in experimental medicine and biology
Publisher: Springer International Publishing
Published: 2021
Volume: 1344
Pages: 57-69
ISSN: 0065-2598 (ISSN-L)
2214-8019
DOI: 10.1007/978-3-030-81147-1_4
PMC: PMC8992377
OpenAlex: W3212367742
Cited by: 170
References: 144
Citations by year: 2026: 33 · 2025: 68 · 2024: 53 · 2023: 13 · 2022: 3
FWCI: 26.68
Type: book chapter
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Advances in experimental medicine and biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute on Drug Abuse (T32DA050558)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: brain reward system, circadian rhythm, suprachiasmatic nucleus, dopamine, rhythmic gene expression, circadian clock, feeding behavior, substance use, social interaction, physical activity, sexual behavior
MeSH terms: Biological Clocks, Circadian Rhythm, Dopamine, Humans, Reward, Suprachiasmatic Nucleus

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The Brain’s Reward System in Health and Disease

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