Mechanotransduction and the functional response of bone to mechanical strain

Calcium's Role in Mechanotransduction during Muscle Development

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Bone remodeling in response to in vivo fatigue microdamage

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Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers

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Mechanosensitive ion channels

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Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.

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Single stretch-activated ion channels in vascular endothelial cells as mechanotransducers?

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Parathyroid Hormone Stimulates the Bone Apposition Rate Independently of Its Resorptive Action: Differential Effects of Intermittent and Continuous Administration*

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Insulin-Like Growth Factor I Has Independent Effects on Bone Matrix Formation and Cell Replication*

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Increased intracortical remodeling following fatigue damage

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Prevention of Postmenopausal Osteoporosis: A Comparative Study of Exercise, Calcium Supplementation, and Hormone-Replacement Therapy

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Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures.

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Limb Mechanics as A Function of Speed and Gait: A Study of Functional Strains in the Radius and Tibia of Horse and Dog

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Mechanically adaptive bone remodelling

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The influence of strain rate on adaptive bone remodelling

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Skeletal structural adaptations to mechanical usage (SATMU): 2. Redefining Wolff's Law: The remodeling problem

Frost, H. M. (1990) · The Anatomical Record · doi:10.1002/ar.1092260403 · Cited by 478

Mechanical loading thresholds for lamellar and woven bone formation

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Bone Deformation Recorded in vivo from Strain Gauges Attached to the Human Tibial Shaft

Lanyon, L. E., Hampson, W. G. J., Goodship, A. E., & Shah, J. S. (1975) · Acta Orthopaedica Scandinavica · doi:10.3109/17453677508989216 · Cited by 475

Inhibition of Bone Formation During Space Flight

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Switching from differentiation to growth in hepatocytes: Control by extracellular matrix

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Morphological evidence of gap junctions between bone cells

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Physical Exercise as Prophylaxis against Involutional Vertebral Bone Loss: A Controlled Trial

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Functional adaptation of bone to increased stress. An experimental study.

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Mechanotransduction in bone: do bone cells act as sensors of fluid flow?

Turner, C. H., Forwood, M. R., & Otter, M. W. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.11.8070637 · Cited by 411

Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts.

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Bone loss in response to long-term immobilisation

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Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape.

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Bone matrix RGD glycoproteins: Immunolocalization and interaction with human primary osteoblastic bone cells in vitro

Grzesik, W. J., & Robey, P. G. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090408 · Cited by 368

Mechanotransduction in bone: role of strain rate

Turner, C. H., Owan, I., & Takano, Y. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.269.3.e438 · Cited by 358

Early strain-related changes in enzyme activity in osteocytes following bone loading in vivo

Skerry, T. M., Lanyon, L. E., Bitensky, L., & Chayen, J. (1989) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650040519 · Cited by 352

Function follows form: generation of intracellular signals by cell deformation

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Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production

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Parathyroid Hormone Enhances the Transcript and Polypeptide Levels of Insulin-Like Growth Factor I in Osteoblast-Enriched Cultures from Fetal Rat Bone*

MCCARTHY, T. L., CENTRELLA, M., & CANALIS, E. (1989) · Endocrinology · doi:10.1210/endo-124-3-1247 · Cited by 336

Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown.

McNamee, H. P., Ingber, D. E., & Schwartz, M. A. (1993) · The Journal of cell biology · doi:10.1083/jcb.121.3.673 · Cited by 334

Bone remodelling induced by physical stress is prostaglandin E2 mediated

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Quantitative studies of endothelial cell adhesion. Directional remodeling of focal adhesion sites in response to flow forces.

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Mechanoelectrical Transduction by Hair Cells

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Bone Strain: A Determinant of Gait and Speed?

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A determinant of bone architecture. The minimum effective strain.

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Prediction of bone adaptation using damage accumulation

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Biochemical signal transduction of mechanical strain in osteoblast-like cells

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Actin filaments regulate epithelial Na+ channel activity

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Increase in femoral bone density in young women following high-impact exercise

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Quantum concept of bone remodeling and turnover: Implications for the pathogenesis of osteoporosis

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Aging changes mechanical loading thresholds for bone formation in rats

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Altering the cellular mechanical force balance results in integrated changes in cell, cytoskeletal and nuclear shape

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Osteoblasts increase their rate of division and align in response to cyclic, mechanical tension in vitro.

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Suppression of the osteogenic response in the aging skeleton

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Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periostal pressure

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A cumulative damage model for bone fracture

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Bone histomorphometry

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Peripheral control of movement.

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Effect of flow on prostaglandin E2 and inositol trisphosphate levels in osteoblasts

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Prostaglandin E2 enhances cortical bone mass and activates intracortical bone remodeling in intact and ovariectomized female rats

Jee, W. S. S., Mori, S., Li, X. J., & Chan, S. (1990) · Bone · doi:10.1016/8756-3282(90)90078-d · Cited by 254

Mechanical transduction in biological systems.

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Increased bone formation by intermittent parathyroid hormone administration is due to the stimulation of proliferation and differentiation of osteoprogenitor cells in bone marrow

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Morphological study of intercellular junctions during osteocyte differentiation

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Bone curvature: Sacrificing strength for load predictability?

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Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin

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Role of G proteins in shear stress-mediated nitric oxide production by endothelial cells

Kuchan, M. J., Jo, H., & Frangos, J. A. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.267.3.c753 · Cited by 246

A noninvasive, in vivo model for studying strain adaptive bone modeling

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Control of intracellular pH and growth by fibronectin in capillary endothelial cells.

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Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium.

Schwartz, M. A. (1993) · The Journal of cell biology · doi:10.1083/jcb.120.4.1003 · Cited by 238

The role of mechanical loading histories in the development of diarthrodial joints

Carter, D. R., & Wong, M. (1988) · Journal of Orthopaedic Research · doi:10.1002/jor.1100060604 · Cited by 227

Increased trabecular bone density due to bone-loading exercises in postmenopausal osteoporotic women

Simkin, A., Ayalon, J., & Leichter, I. (1987) · Calcified Tissue International · doi:10.1007/bf02555706 · Cited by 225

Increased trabecular bone mass in rats treated with human synthetic parathyroid hormone

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Human osteoblast-like cells respond to mechanical strain with increased bone matrix protein production independent of hormonal regulation

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Mechanical stretching increases the number of cultured bone cells synthesizing DNA and alters their pattern of protein synthesis

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Cellular responses to mechanical loading in vitro

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Mechanical forces and their second messengers in stimulating cell growth in vitro

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Differentiation of canalicular cell processes in bone cells by basement membrane matrix components: Regulation by discrete domains of laminin

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Cyclic AMP and Cyclic GMP: Mediators of the Mechanical Effects on Bone Remodeling

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Scanning Electron Microscope Studies of Bone

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The role of prostaglandins in bone in vivo

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A hypothetical mechanism for the stimulation of osteonal remodelling by fatigue damage

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Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation

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Parathyroid Hormone Stimulates Release of Insulin-Like Growth Factor-I (IGF-I) and IGF-II from Neonatal Mouse Calvaria in Organ Culture*

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Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: A role for prostacyclin in adaptive bone remodeling?

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Integrating with integrins.

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Tensile forces enhance prostaglandin E synthesis in osteoblastic cells grown on collagen ribbons

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Microfilament modification by dihydrocytochalasin B causes retinoic acid-modulated chondrocytes to reexpress the differentiated collagen phenotype without a change in shape.

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Musculoskeletal ontogeny, phylogeny, and functional adaptation

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The effect of low-frequency electrical fields on osteogenesis.

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Alterations in chondrocyte cytoskeletal architecture during phenotypic modulation by retinoic acid and dihydrocytochalasin B-induced reexpression.

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Homeostatic control of bone structure: An application of feedback theory

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Parathyroid and Thyroid Hormones in the Development of Immobilization Osteoporosis

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Reversibility of nontraumatic disuse osteoporosis during its active phase

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Biochemical pathways involved in the translation of physical stimulus into biological message

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Induction of bone formation in rat tail vertebrae by mechanical loading

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The transduction of mechanical force into biochemical events in bone cells may involve activation of phospholipase A2

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