Androgen-dependent vasopressinergic neurons are involved in social recognition in rats
Abstract
Socal recognition of juvenile conspecifics by adult male rats has been shown to be modulated by vasopressin. Because part of the extrahypothalamic vasopressinergic innervation of the brain is androgen-dependent, the present experiments were undertaken to assess possible interactions between androgens and vasopressin in social recognition. Castrated male rats displayed a temporary disruption of social recognition when they were tested 1 week after surgery. There was no impairment, however, when they were tested every other day following surgery. The peripheral injection of a vasopressor antagonist of vasopressin, dPTyr(Me)AVP (30 micrograms/kg) impaired social recognition in normal male rats but was ineffective in castrated ones. This was not due to an effect of castration on the basic pharmacological properties of dPTyr(Me)AVP since the antagonist peptide was still able to block the facilitating effects of vasopressin on social recognition in castrated male rats. Implantation of a testosterone-filled capsule in castrated male rats restored sensitivity of social recognition to the action of the vasopressin antagonist. These results suggest that androgen-dependent vasopressinergic neurons are physiologically involved in the modulation of social recognition in male rats.
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Social discrimination is a complex behavior, and several other signaling molecules have been shown to play a role in social discrimination, including oxytocin and arginine vasopressin.
“social discrimination is a complex behavior, and several other signaling molecules have been shown to play a role in social discrimination, including oxytocin [35–37] and arginine vasopressin [24, 38–40].”
From Sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats (2021) · cites this paper as [38]
Some studies have shown effects of testosterone on long-term social recognition in rats.
“some studies have shown effects of testosterone on long-term social recognition in rats [20, 21]”
From Effects of sex and gonadectomy on social investigation and social recognition in mice (2015) · cites this paper as [20]
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- Authors
- Bluthe, R.-M., Schoenen, J., & Dantzer, R.
- Affiliations
- University of Liège (BE)
- Inserm (FR)
- Corresponding author
- Dantzer, Robert
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1990-06
- Volume
- 519
- Issue
- 1-2
- Pages
- 150-157
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2158342105
- Cited by
- 164
- References
- 4
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 7 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 3 · 2012: 4
- FWCI
- 15.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- vasopressin, androgens, social recognition, castration, testosterone, vasopressin receptor antagonists, male rats, social behavior
- MeSH terms
- Animals, Arginine Vasopressin, Brain, Male, Neurons, Orchiectomy, Rats, Inbred Strains, Reference Values, Serotonin, Social Behavior, Testosterone, Vasopressins, 2-Amino-5-phosphonovalerate, Rats
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