Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction

Bariselli, Sebastiano; Hörnberg, Hanna; Prévost-Solié, Clément; Musardo, Stefano; Hatstatt-Burklé, Laetitia; Scheiffele, Peter; Bellone, Camilla

doi:10.1038/s41467-018-05382-3

Cited by 171Neuroscience and Neuropharmacology ResearchAutism Spectrum Disorder ResearchNeurotransmitter Receptor Influence on Behavior

Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction

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Bariselli, Sebastiano, Hörnberg, Hanna, Prévost-Solié, Clément, Musardo, Stefano, Hatstatt-Burklé, Laetitia, Scheiffele, Peter, Bellone, Camilla·2018·Nature Communications

DOI 10.1038/s41467-018-05382-3PMC PMC6085391

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Abstract

Atypical habituation and aberrant exploration of novel stimuli have been related to the severity of autism spectrum disorders (ASDs), but the underlying neuronal circuits are unknown. Here we show that chemogenetic inhibition of dopamine (DA) neurons of the ventral tegmental area (VTA) attenuates exploration toward nonfamiliar conspecifics and interferes with the reinforcing properties of nonfamiliar conspecific interaction in mice. Exploration of nonfamiliar stimuli is associated with the insertion of GluA2-lacking AMPA receptors at excitatory synapses on VTA DA neurons. These synaptic adaptations persist upon repeated exposure to social stimuli and sustain conspecific interaction. Global or VTA DA neuron-specific loss of the ASD-associated synaptic adhesion molecule neuroligin 3 alters the behavioral response toward nonfamiliar conspecifics and the reinforcing properties of conspecific interaction. These behavioral deficits are accompanied by an aberrant expression of AMPA receptors and an occlusion of synaptic plasticity. Altogether, these findings link impaired exploration of nonfamiliar conspecifics to VTA DA neuron dysfunction in mice.

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Increased activity in VTA dopaminergic neurons promotes social reinforcement learning.
“Specifically, research has demonstrated that VTA dopaminergic neurons become activated in rodents engaged in conspecific interactions, and increased activity in these neurons promotes social reinforcement learning (Bariselli et al., 2018; D ¨ olen et al., 2013; Soli ´ e et al., 2022).”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Bariselli et al., 2018
In Results > VTA DA neurons and nonfamiliar conspecific reinforcement (page unavailable), reducing VTA dopamine-neuron excitability prevented mice from developing a conditioned preference for a compartment associated with nonfamiliar conspecifics. This supports a role for these neurons in social reinforcement learning, but does not establish that increasing their activity promotes that learning. (LLM, conf=0.83)
Experimental — accuracy not yet measured
Dopaminergic neurons of the VTA that project to the NAc play a pivotal role in regulating both social cues and reward processing in both humans and rodents.
“Dopaminergic neurons of the VTA, which extend their projections to the nucleus accumbens (NAc), play a pivotal role in regulating both social cues and reward processing in both humans and rodents (Bariselli et al., 2018; Gunaydin et al., 2014, 2014; Kawamichi et al., 2016).”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Bariselli et al., 2018
The Discussion (page unavailable) says VTA dopamine neurons projecting to the NAc promote conspecific interaction and places projection-specific VTA neurons within reward circuitry. The Introduction and Results describe social exploration and reinforcement in rodents, but the paper does not establish that the VTA-to-NAc projection regulates social cues and reward processing in humans. (LLM, conf=0.87)
Experimental — accuracy not yet measured
VTA dopaminergic neurons become activated in rodents engaged in conspecific interactions.
“Specifically, research has demonstrated that VTA dopaminergic neurons become activated in rodents engaged in conspecific interactions, and increased activity in these neurons promotes social reinforcement learning (Bariselli et al., 2018; D ¨ olen et al., 2013; Soli ´ e et al., 2022).”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Bariselli et al., 2018
DA neurons in the VTA play a role in social behavior.
“Previous studies have indicated the role of DA neurons in the VTA in social behavior (Gunaydin et al., 2014; Bariselli et al., 2018; Bariselli et al., 2016b) and shown that chronic isolation alters DA levels in the NAc (Hall et al., 1998; ).”
From Oxytocin neurons mediate the effect of social isolation via the VTA circuits (2022) · cites this paper as Bariselli et al., 2018

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A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388 · see citing works
Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564 · see citing works
The social motivation theory of autism
Chevallier, C., Kohls, G., Troiani, V., Brodkin, E. S., & Schultz, R. T. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.02.007 · Cited by 2,072 · see citing works
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046 · see citing works
Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism
Study, P. A. R. I. S., Jamain, S., Quach, H., Betancur, C., Råstam, M., Colineaux, C., Gillberg, I. C., Soderstrom, H., Giros, B., Leboyer, M., et al. (2003) · Nature Genetics · doi:10.1038/ng1136 · Cited by 1,851 · see citing works
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice
Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-1848.2004.00076.x · Cited by 1,545 · see citing works
Natural neural projection dynamics underlying social behavior
Gunaydin, L. A., Grosenick, L., Finkelstein, J. C., Kauvar, I. V., Fenno, L. E., Adhikari, A., Lammel, S., Mirzabekov, J. J., Airan, R. D., Zalocusky, K. A., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.017 · Cited by 1,389 · see citing works
Neuron-type-specific signals for reward and punishment in the ventral tegmental area
Cohen, J. Y., Haesler, S., Vong, L., Lowell, B. B., & Uchida, N. (2012) · Nature · doi:10.1038/nature10754 · Cited by 1,318 · see citing works
Input-specific control of reward and aversion in the ventral tegmental area
Lammel, S., Lim, B. K., Ran, C., Huang, K. W., Betley, M. J., Tye, K. M., Deisseroth, K., & Malenka, R. C. (2012) · Nature · doi:10.1038/nature11527 · Cited by 1,300 · see citing works
Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism
Sanders, S. J., Ercan-Sencicek, A. G., Hus, V., Luo, R., Murtha, M. T., Moreno-De-Luca, D., Chu, S. H., Moreau, M. P., Gupta, A. R., Thomson, S. A., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.002 · Cited by 1,263 · see citing works
Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring
Buffington, S. A., Di Prisco, G. V., Auchtung, T. A., Ajami, N. J., Petrosino, J. F., & Costa-Mattioli, M. (2016) · Cell · doi:10.1016/j.cell.2016.06.001 · Cited by 1,163 · see citing works
Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin
Dölen, G., Darvishzadeh, A., Huang, K. W., & Malenka, R. C. (2013) · Nature · doi:10.1038/nature12518 · Cited by 1,161 · see citing works
Drugs of Abuse and Stress Trigger a Common Synaptic Adaptation in Dopamine Neurons
Saal, D., Dong, Y., Bonci, A., & Malenka, R. C. (2003) · Neuron · doi:10.1016/s0896-6273(03)00021-7 · Cited by 1,147 · see citing works
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130 · see citing works
Circuit architecture of VTA dopamine neurons revealed by systematic input-output mapping
Beier, K. T., Steinberg, E. E., DeLoach, K. E., Xie, S., Miyamichi, K., Schwarz, L., Gao, X. J., Kremer, E. J., Malenka, R. C., & Luo, L. (2015) · Cell · doi:10.1016/j.cell.2015.07.015 · Cited by 1,068 · see citing works
A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice
Tabuchi, K., Blundell, J., Etherton, M. R., Hammer, R. E., Liu, X., Powell, C. M., & Südhof, T. C. (2007) · Science · doi:10.1126/science.1146221 · Cited by 997 · see citing works
The hippocampal CA2 region is essential for social memory
Hitti, F. L., & Siegelbaum, S. A. (2014) · Nature · doi:10.1038/nature13028 · Cited by 976 · see citing works
Pten Regulates Neuronal Arborization and Social Interaction in Mice
Kwon, C.-H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., Li, Y., Baker, S. J., & Parada, L. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.023 · Cited by 970 · see citing works
Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder
C Yuen, R. K., Merico, D., Bookman, M., L Howe, J., Thiruvahindrapuram, B., Patel, R. V., Whitney, J., Deflaux, N., Bingham, J., Wang, Z., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4524 · Cited by 844 · see citing works
Locus coeruleus and dopaminergic consolidation of everyday memory
Takeuchi, T., Duszkiewicz, A. J., Sonneborn, A., Spooner, P. A., Yamasaki, M., Watanabe, M., Smith, C. C., Fernández, G., Deisseroth, K., Greene, R. W., et al. (2016) · Nature · doi:10.1038/nature19325 · Cited by 827 · see citing works
Reward and aversion in a heterogeneous midbrain dopamine system
Lammel, S., Lim, B. K., & Malenka, R. C. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.019 · Cited by 804 · see citing works
Automated apparatus for quantitation of social approach behaviors in mice
Nadler, J. J., Moy, S. S., Dold, G., Trang, D., Simmons, N., Perez, A., Young, N. B., Barbaro, R. P., Piven, J., Magnuson, T. R., et al. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2004.00071.x · Cited by 775 · see citing works
Rare de novo and transmitted copy-number variation in autistic spectrum disorders
Levy, D., Ronemus, M., Yamrom, B., Lee, Y.-H., Leotta, A., Kendall, J., Marks, S., Lakshmi, B., Pai, D., Ye, K., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.015 · Cited by 712 · see citing works
From prediction error to incentive salience: mesolimbic computation of reward motivation.
Berridge, K. C. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.07990.x · Cited by 700 · see citing works
Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function
Won, H., Lee, H.-R., Gee, H. Y., Mah, W., Kim, J.-I., Lee, J., Ha, S., Chung, C., Jung, E. S., Cho, Y. S., et al. (2012) · Nature · doi:10.1038/nature11208 · Cited by 695 · see citing works
Developmental pathways to autism: A review of prospective studies of infants at risk
Jones, E. J. H., Gliga, T., Bedford, R., Charman, T., & Johnson, M. H. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.12.001 · Cited by 607 · see citing works
Automated Three‐Chambered Social Approach Task for Mice
Yang, M., Silverman, J. L., & Crawley, J. N. (2011) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0826s56 · Cited by 598 · see citing works
Gating of social reward by oxytocin in the ventral tegmental area
Hung, L. W., Neuner, S., Polepalli, J. S., Beier, K. T., Wright, M., Walsh, J. J., Lewis, E. M., Luo, L., Deisseroth, K., Dölen, G., et al. (2017) · Science · doi:10.1126/science.aan4994 · Cited by 578 · see citing works
Simple Behavioral Assessment of Mouse Olfaction
Yang, M., & Crawley, J. N. (2009) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0824s48 · Cited by 573 · see citing works
Learning and Memory and Synaptic Plasticity Are Impaired in a Mouse Model of Rett Syndrome
Moretti, P., Levenson, J. M., Battaglia, F., Atkinson, R., Teague, R., Antalffy, B., Armstrong, D., Arancio, O., Sweatt, J. D., & Zoghbi, H. Y. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2623-05.2006 · Cited by 545 · see citing works
Comorbid psychopathology with autism spectrum disorder in children: An overview
Matson, J. L., & Nebel-Schwalm, M. S. (2006) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2005.12.004 · Cited by 538 · see citing works
Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate
Stuber, G. D., Hnasko, T. S., Britt, J. P., Edwards, R. H., & Bonci, A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1754-10.2010 · Cited by 529 · see citing works
Neural Correlates of Face and Object Recognition in Young Children with Autism Spectrum Disorder, Developmental Delay, and Typical Development
Dawson, G., Carver, L., Meltzoff, A. N., Panagiotides, H., McPartland, J., & Webb, S. J. (2002) · Child Development · doi:10.1111/1467-8624.00433 · Cited by 523 · see citing works
Absolute Coding of Stimulus Novelty in the Human Substantia Nigra/VTA
Bunzeck, N., & Düzel, E. (2006) · Neuron · doi:10.1016/j.neuron.2006.06.021 · Cited by 503 · see citing works
Preference for geometric patterns early in life as a risk factor for autism
Pierce, K., Conant, D., Hazin, R., Stoner, R., & Desmond, J. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.113 · Cited by 486 · see citing works
Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors
Rothwell, P. E., Fuccillo, M. V., Maxeiner, S., Hayton, S. J., Gokce, O., Lim, B. K., Fowler, S. C., Malenka, R. C., & Südhof, T. C. (2014) · Cell · doi:10.1016/j.cell.2014.04.045 · Cited by 477 · see citing works
Characterization of a mouse strain expressing Cre recombinase from the 3′ untranslated region of the dopamine transporter locus
Bäckman, C. M., Malik, N., Zhang, Y., Shan, L., Grinberg, A., Hoffer, B. J., Westphal, H., & Tomac, A. C. (2006) · genesis · doi:10.1002/dvg.20228 · Cited by 463 · see citing works
Reward processing in autism
Scott‐Van Zeeland, A. A., Dapretto, M., Ghahremani, D. G., Poldrack, R. A., & Bookheimer, S. Y. (2010) · Autism Research · doi:10.1002/aur.122 · Cited by 458 · see citing works
Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression
Bellone, C., & Lüscher, C. (2006) · Nature Neuroscience · doi:10.1038/nn1682 · Cited by 429 · see citing works
Self-citation
Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization
Ferguson, S. M., Eskenazi, D., Ishikawa, M., Wanat, M. J., Phillips, P. E. M., Dong, Y., Roth, B. L., & Neumaier, J. F. (2011) · Nature Neuroscience · doi:10.1038/nn.2703 · Cited by 418 · see citing works
Dorsal raphe dopamine neurons represent the experience of social isolation
Matthews, G. A., Nieh, E. H., Vander Weele, C. M., Halbert, S. A., Pradhan, R. V., Yosafat, A. S., Glober, G. F., Izadmehr, E. M., Thomas, R. E., Lacy, G. D., et al. (2016) · Cell · doi:10.1016/j.cell.2015.12.040 · Cited by 402 · see citing works
Construction of implantable optical fibers for long-term optogenetic manipulation of neural circuits
Sparta, D. R., Stamatakis, A. M., Phillips, J. L., Hovelsø, N., van Zessen, R., & Stuber, G. D. (2012) · Nature Protocols · doi:10.1038/nprot.2011.413 · Cited by 394 · see citing works
A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward
Stamatakis, A. M., Jennings, J. H., Ung, R. L., Blair, G. A., Weinberg, R. J., Neve, R. L., Boyce, F., Mattis, J., Ramakrishnan, C., Deisseroth, K., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.023 · Cited by 364 · see citing works
Neuroligin‐3‐deficient mice: model of a monogenic heritable form of autism with an olfactory deficit
Radyushkin, K., Hammerschmidt, K., Boretius, S., Varoqueaux, F., El-Kordi, A., Ronnenberg, A., Winter, D., Frahm, J., Fischer, J., Brose, N., et al. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00487.x · Cited by 359 · see citing works
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function
Etherton, M. R., Földy, C., Sharma, M., Tabuchi, K., Liu, X., Shamloo, M., Malenka, R. C., & Südhof, T. C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111093108 · Cited by 340 · see citing works
Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc
Mameli, M., Halbout, B., Creton, C., Engblom, D., Parkitna, J. M. R., Spanagel, R., & Lüscher, C. (2009) · Nature Neuroscience · doi:10.1038/nn.2367 · Cited by 340 · see citing works
Clozapine N-Oxide Administration Produces Behavioral Effects in Long–Evans Rats: Implications for Designing DREADD Experiments
MacLaren, D. A. A., Browne, R. W., Shaw, J. K., Radhakrishnan, S. K., Khare, P., España, R. A., & Clark, S. D. (2016) · eNeuro · doi:10.1523/eneuro.0219-16.2016 · Cited by 334 · see citing works
Neuroligin‐3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses
Budreck, E. C., & Scheiffele, P. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05842.x · Cited by 323 · see citing works
Self-citation
Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice
Bhattacharya, A., Kaphzan, H., Alvarez-Dieppa, A. C., Murphy, J. P., Pierre, P., & Klann, E. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.022 · Cited by 316 · see citing works
Reward-Predictive Cues Enhance Excitatory Synaptic Strength onto Midbrain Dopamine Neurons
Stuber, G. D., Klanker, M., de Ridder, B., Bowers, M. S., Joosten, R. N. J. M. A., Feenstra, M. G. P., & Bonci, A. (2008) · Science · doi:10.1126/science.1160873 · Cited by 307 · see citing works
Hormonal gain control of a medial preoptic area social reward circuit
McHenry, J. A., Otis, J. M., Rossi, M. A., Robinson, J. E., Kosyk, O., Miller, N. W., McElligott, Z. A., Budygin, E. A., Rubinow, D. R., & Stuber, G. D. (2017) · Nature Neuroscience · doi:10.1038/nn.4487 · Cited by 304 · see citing works
Shared Synaptic Pathophysiology in Syndromic and Nonsyndromic Rodent Models of Autism
Baudouin, S. J., Gaudias, J., Gerharz, S., Hatstatt, L., Zhou, K., Punnakkal, P., Tanaka, K. F., Spooren, W., Hen, R., De Zeeuw, C. I., et al. (2012) · Science · doi:10.1126/science.1224159 · Cited by 293 · see citing works
Self-citation
Hippocampal oxytocin receptors are necessary for discrimination of social stimuli
Raam, T., McAvoy, K. M., Besnard, A., Veenema, A. H., & Sahay, A. (2017) · Nature Communications · doi:10.1038/s41467-017-02173-0 · Cited by 292 · see citing works
Minimal aberrant behavioral phenotypes of neuroligin‐3 R451C knockin mice
Chadman, K. K., Gong, S., Scattoni, M. L., Boltuck, S. E., Gandhy, S. U., Heintz, N., & Crawley, J. N. (2008) · Autism Research · doi:10.1002/aur.22 · Cited by 292 · see citing works
Neurobiology of Sensory Overresponsivity in Youth With Autism Spectrum Disorders
Green, S. A., Hernandez, L. M., Tottenham, N., Krasileva, K. E., Bookheimer, S. Y., & Dapretto, M. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.0737 · Cited by 286 · see citing works
Opposite initialization to novel cues in dopamine signaling in ventral and posterior striatum in mice
Menegas, W., Babayan, B. M., Uchida, N., & Watabe‐Uchida, M. (2017) · eLife · doi:10.7554/elife.21886 · Cited by 265 · see citing works
Reduced Neural Habituation in the Amygdala and Social Impairments in Autism Spectrum Disorders
Kleinhans, N. M., Johnson, L. C., Richards, T., Mahurin, R., Greenson, J., Dawson, G., & Aylward, E. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07101681 · Cited by 255 · see citing works
Social reward among juvenile mice
Panksepp, J. B., & Lahvis, G. P. (2007) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2006.00295.x · Cited by 248 · see citing works
Endocannabinoid signaling mediates oxytocin-driven social reward
Wei, D., Lee, D., Cox, C. D., Karsten, C. A., Peñagarikano, O., Geschwind, D. H., Gall, C. M., & Piomelli, D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1509795112 · Cited by 218 · see citing works
GABAB Receptor Agonist R-Baclofen Reverses Social Deficits and Reduces Repetitive Behavior in Two Mouse Models of Autism
Silverman, J. L., Pride, M. C., Hayes, J. E., Puhger, K. R., Butler-Struben, H. M., Baker, S., & Crawley, J. N. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.66 · Cited by 215 · see citing works
Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes
Gkogkas, C. G., Khoutorsky, A., Cao, R., Jafarnejad, S. M., Prager-Khoutorsky, M., Giannakas, N., Kaminari, A., Fragkouli, A., Nader, K., Price, T. J., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.064 · Cited by 201 · see citing works
Change detection in children with autism: an auditory event-related fMRI study
Gomot, M., Bernard, F. A., Davis, M. H., Belmonte, M. K., Ashwin, C., Bullmore, E. T., & Baron-Cohen, S. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.07.027 · Cited by 199 · see citing works
Novelty‐evoked elevations of nucleus accumbens dopamine: dependence on impulse flow from the ventral subiculum and glutamatergic neurotransmission in the ventral tegmental area
Legault, M., & Wise, R. A. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2000.01448.x · Cited by 191 · see citing works
Brief Report: Circumscribed Attention in Young Children with Autism
Sasson, N. J., Elison, J. T., Turner-Brown, L. M., Dichter, G. S., & Bodfish, J. W. (2011) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-010-1038-3 · Cited by 181 · see citing works
Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome
Piskorowski, R. A., Nasrallah, K., Diamantopoulou, A., Mukai, J., Hassan, S. I., Siegelbaum, S. A., Gogos, J. A., & Chevaleyre, V. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.036 · Cited by 180 · see citing works
SHANK3 controls maturation of social reward circuits in the VTA
Bariselli, S., Tzanoulinou, S., Glangetas, C., Prévost-Solié, C., Pucci, L., Viguié, J., Bezzi, P., O'Connor, E. C., Georges, F., Lüscher, C., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4319 · Cited by 168 · see citing works
Self-citation
Social reward-conditioned place preference: A model revealing an interaction between cocaine and social context rewards in rats
Thiel, K. J., Okun, A. C., & Neisewander, J. L. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.02.013 · Cited by 164 · see citing works
Novel designer receptors to probe GPCR signaling and physiology
Wess, J., Nakajima, K., & Jain, S. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.04.006 · Cited by 158 · see citing works
Cholinergic modulation of a decrement in social investigation following repeated contacts between mice
Winslow, J. T., & Camacho, F. (1995) · Psychopharmacology · doi:10.1007/bf02245626 · Cited by 156 · see citing works
AMPA receptor exchange underlies transient memory destabilization on retrieval
Hong, I., Kim, J., Kim, J., Lee, S., Ko, H.-G., Nader, K., Kaang, B.-K., Tsien, R. W., & Choi, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305235110 · Cited by 148 · see citing works
Male and Female Mice Lacking Neuroligin-3 Modify the Behavior of Their Wild-Type Littermates
Kalbassi, S., Bachmann, S. O., Cross, E., Roberton, V. H., & Baudouin, S. J. (2017) · eNeuro · doi:10.1523/eneuro.0145-17.2017 · Cited by 136 · see citing works
Novelty increases the mesolimbic functional connectivity of the substantia nigra/ventral tegmental area (SN/VTA) during reward anticipation: Evidence from high-resolution fMRI
Krebs, R. M., Heipertz, D., Schuetze, H., & Duzel, E. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.038 · Cited by 135 · see citing works
Common alterations in sensitivity to type but not amount of reward in ADHD and autism spectrum disorders
Demurie, E., Roeyers, H., Baeyens, D., & Sonuga‐Barke, E. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02374.x · Cited by 127 · see citing works
Reversal of cocaine‐conditioned place preference and mesocorticolimbic Zif268 expression by social interaction in rats
Fritz, M., Rawas, R. E., Salti, A., Klement, S., Bardo, M. T., Kemmler, G., Dechant, G., Saria, A., & Zernig, G. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00285.x · Cited by 117 · see citing works
Babies and Brains: Habituation in Infant Cognition and Functional Neuroimaging
Chun, M. M. (2008) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.016.2008 · Cited by 116 · see citing works
Analysis of dopamine transporter gene expression pattern − generation of DAT‐iCre transgenic mice
Turiault, M., Parnaudeau, S., Milet, A., Parlato, R., Rouzeau, J., Lazar, M., & Tronche, F. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05886.x · Cited by 114 · see citing works
Drug-Driven AMPA Receptor Redistribution Mimicked by Selective Dopamine Neuron Stimulation
Brown, M. T. C., Bellone, C., Mameli, M., Labouèbe, G., Bocklisch, C., Balland, B., Dahan, L., Luján, R., Deisseroth, K. A., & Lüscher, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015870 · Cited by 112 · see citing works
Self-citation
Toddlers with Elevated Autism Symptoms Show Slowed Habituation to Faces
Webb, S. J., Jones, E. J. H., Merkle, K. L., Namkung, J. M., Toth, K., Greenson, J., Murias, M., & Dawson, G. (2010) · Child Neuropsychology · doi:10.1080/09297041003601454 · Cited by 102 · see citing works
A Subtype-Specific Function for the Extracellular Domain of Neuroligin 1 in Hippocampal LTP
Shipman, S. L., & Nicoll, R. A. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.024 · Cited by 101 · see citing works
Flexible Accelerated STOP Tetracycline Operator-Knockin (FAST): A Versatile and Efficient New Gene Modulating System
Tanaka, K. F., Ahmari, S. E., Leonardo, E. D., Richardson-Jones, J. W., Budreck, E. C., Scheiffele, P., Sugio, S., Inamura, N., Ikenaka, K., & Hen, R. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.020 · Cited by 96 · see citing works
Self-citation
Autism‐Related Neuroligin‐3 Mutation Alters Social Behavior and Spatial Learning
Jaramillo, T. C., Liu, S., Pettersen, A., Birnbaum, S. G., & Powell, C. M. (2014) · Autism Research · doi:10.1002/aur.1362 · Cited by 95 · see citing works
Response to familiar faces, newly familiar faces, and novel faces as assessed by ERPs is intact in adults with autism spectrum disorders
Webb, S. J., Jones, E. J. H., Merkle, K., Murias, M., Greenson, J., Richards, T., Aylward, E., & Dawson, G. (2010) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2010.04.011 · Cited by 85 · see citing works
In utero exposure to cocaine delays postnatal synaptic maturation of glutamatergic transmission in the VTA
Bellone, C., Mameli, M., & Lüscher, C. (2011) · Nature Neuroscience · doi:10.1038/nn.2930 · Cited by 84 · see citing works
Self-citation
A circuit-based mechanism underlying familiarity signaling and the preference for novelty
Molas, S., Zhao-Shea, R., Liu, L., DeGroot, S. R., Gardner, P. D., & Tapper, A. R. (2017) · Nature Neuroscience · doi:10.1038/nn.4607 · Cited by 72 · see citing works
Differences in social interaction- vs. cocaine reward in mouse vs. rat
Kummer, K. K., Hofhansel, L., Barwitz, C. M., Schardl, A., Prast, J. M., Salti, A., Rawas, R. E., & Zernig, G. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00363 · Cited by 62 · see citing works
Abnormal electrodermal reactivity to novel visual stimuli in autistic children
van Engeland, H., Roelofs, J. W., Verbaten, M. N., & Slangen, J. L. (1991) · Psychiatry Research · doi:10.1016/0165-1781(91)90050-y · Cited by 58 · see citing works
Attention to novelty versus repetition: Contrasting habituation profiles in Autism and Williams syndrome
Vivanti, G., Hocking, D., Fanning, P. A. J., Uljarević, M., Postorino, V., Mazzone, L., & Dissanayake, C. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.01.006 · Cited by 56 · see citing works
Synaptic Plasticity onto Dopamine Neurons Shapes Fear Learning
Pignatelli, M., Umanah, G. K. E., Ribeiro, S. P., Chen, R., Karuppagounder, S. S., Yau, H., Eacker, S. M., Dawson, V. L., Dawson, T. M., & Bonci, A. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.030 · Cited by 54 · see citing works
Differential Effects of Accumbens Core vs. Shell Lesions in a Rat Concurrent Conditioned Place Preference Paradigm for Cocaine vs. Social Interaction
Fritz, M., Rawas, R. E., Klement, S., Kummer, K. K., Mayr, M. J., Eggart, V., Salti, A., Bardo, M. T., Saria, A., & Zernig, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026761 · Cited by 53 · see citing works
Ventral tegmental area subcircuits process rewarding and aversive experiences
Bariselli, S., Glangetas, C., Tzanoulinou, S., & Bellone, C. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13779 · Cited by 51 · see citing works
Self-citation
Serotonin transporter genotype impacts amygdala habituation in youth with autism spectrum disorders
Wiggins, J. L., Swartz, J. R., Martin, D. M., Lord, C., & Monk, C. S. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst039 · Cited by 44 · see citing works
Synaptic basis of social dysfunction: a focus on postsynaptic proteins linking group‐ I m G lu R s with AMPAR s and NMDAR s
O’Connor, E. C., Bariselli, S., & Bellone, C. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12510 · Cited by 38 · see citing works
Self-citation
Genetic background effects in Neuroligin‐3 mutant mice: Minimal behavioral abnormalities on C57 background
Jaramillo, T. C., Escamilla, C. O., Liu, S., Peca, L., Birnbaum, S. G., & Powell, C. M. (2017) · Autism Research · doi:10.1002/aur.1857 · Cited by 37 · see citing works

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Dissecting the contribution of host genetics and the microbiome in complex behaviors
Buffington, S. A., Dooling, S. W., Sgritta, M., Noecker, C. A., Murillo, O. D., Felice, D., Turnbaugh, P. J., & Costa‐Mattioli, M. (2021) · Cell · doi:10.1016/j.cell.2021.02.009 · Cited by 221 · see citing works
VTA dopamine neuron activity encodes social interaction and promotes reinforcement learning through social prediction error
Solié, C., Girard, B., Righetti, B., Tapparel, M., & Bellone, C. (2022) · Nature Neuroscience · doi:10.1038/s41593-021-00972-9 · Cited by 186 · see citing works
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Responses and functions of dopamine in nucleus accumbens core during social behaviors
Dai, B., Sun, F., Tong, X., Ding, Y., Kuang, A., Osakada, T., Li, Y., & Lin, D. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111246 · Cited by 179 · see citing works
Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement
Corre, J., van Zessen, R., Loureiro, M., Patriarchi, T., Tian, L., Pascoli, V., & Lüscher, C. (2018) · eLife · doi:10.7554/elife.39945 · Cited by 168 · see citing works
The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota
Bermudez-Martin, P., Becker, J. A. J., Caramello, N., Fernández, S. P., Campos, R. C., Canaguier, J., Barbosa, S., Martínez-Gili, L., Myridakis, A., Dumas, M., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01103-z · Cited by 164 · see citing works
Rescue of oxytocin response and social behaviour in a mouse model of autism
Hörnberg, H., Pérez-Garci, E., Schreiner, D., Hatstatt-Burklé, L., Magara, F., Baudouin, S., Matter, A., Nacro, K., Pecho-Vrieseling, E., & Scheiffele, P. (2020) · Nature · doi:10.1038/s41586-020-2563-7 · Cited by 154 · see citing works
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Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex
Sacai, H., Sakoori, K., Konno, K., Nagahama, K., Suzuki, H., Watanabe, T., Watanabe, M., Uesaka, N., & Kano, M. (2020) · Nature Communications · doi:10.1038/s41467-020-18861-3 · Cited by 145 · see citing works
NAc-VTA circuit underlies emotional stress-induced anxiety-like behavior in the three-chamber vicarious social defeat stress mouse model
Qi, G., Zhang, P., Li, T., Li, M., Zhang, Q., He, F., Zhang, L., Cai, H., Lv, X., Qiao, H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28190-2 · Cited by 143 · see citing works
5-HT modulation of a medial septal circuit tunes social memory stability
Wu, X., Morishita, W., Beier, K. T., Heifets, B. D., & Malenka, R. C. (2021) · Nature · doi:10.1038/s41586-021-03956-8 · Cited by 116 · see citing works
Social isolation impairs the prefrontal-nucleus accumbens circuit subserving social recognition in mice
Park, G., Ryu, C., Kim, S., Jeong, S. J., Koo, J. W., Lee, Y., & Kim, S. J. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109104 · Cited by 105 · see citing works
Adolescent sleep shapes social novelty preference in mice
Bian, W.-J., Brewer, C. L., Kauer, J. A., & de Lecea, L. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01076-8 · Cited by 96 · see citing works
Dual action of ketamine confines addiction liability
Simmler, L. D., Li, Y., Hadjas, L. C., Hiver, A., van Zessen, R., & Lüscher, C. (2022) · Nature · doi:10.1038/s41586-022-04993-7 · Cited by 95 · see citing works
Cerebellar dopamine D2 receptors regulate social behaviors
Cutando, L., Puighermanal, E., Castell, L., Tarot, P., Belle, M., Bertaso, F., Arango-Lievano, M., Ango, F., Rubinstein, M., Quintana, A., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01092-8 · Cited by 78 · see citing works
Neuroligin-3: A Circuit-Specific Synapse Organizer That Shapes Normal Function and Autism Spectrum Disorder-Associated Dysfunction
Uchigashima, M., Cheung, A., & Futai, K. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.749164 · Cited by 89 · see citing works
Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity
Elias, L. J., Succi, I. K., Schaffler, M. D., Foster, W., Gradwell, M. A., Bohic, M., Fushiki, A., Upadhyay, A., Ejoh, L. L., Schwark, R., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.034 · Cited by 85 · see citing works
Hypothalamic control of innate social behaviors
Mei, L., Osakada, T., & Lin, D. (2023) · Science · doi:10.1126/science.adh8489 · Cited by 83 · see citing works
The Dopamine Hypothesis of Autism Spectrum Disorder Revisited: Current Status and Future Prospects
Pavăl, D., & Micluția, I. (2021) · Developmental Neuroscience · doi:10.1159/000515751 · Cited by 80 · see citing works
Oxytocin neurons mediate the effect of social isolation via the VTA circuits
Musardo, S., Contestabile, A., Knoop, M., Baud, O., & Bellone, C. (2022) · eLife · doi:10.7554/elife.73421 · Cited by 77 · see citing works
Self-citation
Dopamine Circuit Mechanisms of Addiction-Like Behaviors
Poisson, C. L., Engel, L., & Saunders, B. T. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.752420 · Cited by 75 · see citing works
Maternal gut microbiota mediate intergenerational effects of high-fat diet on descendant social behavior
Gesù, C. M. D., Matz, L. M., Bolding, I. J., Fultz, R., Hoffman, K. L., Marino, A., Petrosino, J. F., & Buffington, S. A. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111461 · Cited by 72 · see citing works
Systematic phenomics analysis of autism-associated genes reveals parallel networks underlying reversible impairments in habituation
McDiarmid, T. A., Belmadani, M., Liang, J., Meili, F., Mathews, E., Mullen, G. P., Hendi, A., Wong, W.-R., Rand, J. B., Mizumoto, K., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1912049116 · Cited by 67 · see citing works
Midbrain circuits of novelty processing
Tapper, A. R., & Molas, S. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107323 · Cited by 71 · see citing works
Superior Colliculus to VTA pathway controls orienting response and influences social interaction in mice
Solié, C., Contestabile, A., Espinosa, P., Musardo, S., Bariselli, S., Huber, C., Carleton, A., & Bellone, C. (2022) · Nature Communications · doi:10.1038/s41467-022-28512-4 · Cited by 58 · see citing works
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A Systematic Review of Brainstem Contributions to Autism Spectrum Disorder
Seif, A., Shea, C., Schmid, S., & Stevenson, R. A. (2021) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2021.760116 · Cited by 54 · see citing works
Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3
Hong, N., Kim, H. J., Kang, K., Park, J. O., Mun, S., Kim, H., Kang, B. H., Chung, P., Lee, M. Y., & Ahn, J. (2023) · Cell & Bioscience · doi:10.1186/s13578-022-00949-6 · Cited by 51 · see citing works
Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species
Rappeneau, V., & Castillo Díaz, F. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105675 · Cited by 51 · see citing works
“Dopaminergic neurons of the VTA, which extend their projections to the nucleus accumbens (NAc), play a pivotal role in regulating both social cues and reward processing in both humans and rodents (Bariselli et al., 2018; Gunaydin et al., 2014, 2014; Kawamichi et al., 2016).”
Background
Mechanisms Underlying Circuit Dysfunction in Neurodevelopmental Disorders
Exposito-Alonso, D., & Rico, B. (2022) · Annual Review of Genetics · doi:10.1146/annurev-genet-072820-023642 · Cited by 49 · see citing works
Possible Implication of the CA2 Hippocampal Circuit in Social Cognition Deficits Observed in the Neuroligin 3 Knock-Out Mouse, a Non-Syndromic Animal Model of Autism
Modi, B., Pimpinella, D., Pazienti, A., Zacchi, P., Cherubini, E., & Griguoli, M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00513 · Cited by 50 · see citing works
Post-weaning social isolation of mice: A putative animal model of developmental disorders
Matsumoto, K., Fujiwara, H., Araki, R., & Yabe, T. (2019) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2019.10.002 · Cited by 48 · see citing works
Inhibition of Trpv4 rescues circuit and social deficits unmasked by acute inflammatory response in a Shank3 mouse model of Autism
Tzanoulinou, S., Musardo, S., Contestabile, A., Bariselli, S., Casarotto, G., Magrinelli, E., Jiang, Y., Jabaudon, D., & Bellone, C. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01427-0 · Cited by 43 · see citing works
Self-citation
The Role of Synaptic Cell Adhesion Molecules and Associated Scaffolding Proteins in Social Affiliative Behaviors
Taylor, S. C., Ferri, S. L., Grewal, M., Smernoff, Z., Bućan, M., Weiner, J. A., Abel, T. G., & Brodkin, E. S. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.02.012 · Cited by 43 · see citing works
Overlapping representations of food and social stimuli in mouse VTA dopamine neurons
Willmore, L., Minerva, A. R., Engelhard, B., Murugan, M., McMannon, B., Oak, N., Thiberge, S. Y., Peña, C. J., & Witten, I. B. (2023) · Neuron · doi:10.1016/j.neuron.2023.08.003 · Cited by 42 · see citing works
Advancing social behavioral neuroscience by integrating ethology and comparative psychology methods through machine learning
Bordes, J., Miranda, L., Müller‐Myhsok, B., & Schmidt, M. V. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105243 · Cited by 42 · see citing works
Deconstructing the contribution of sensory cues in social approach
Contestabile, A., Casarotto, G., Girard, B., Tzanoulinou, S., & Bellone, C. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15179 · Cited by 36 · see citing works
Self-citation
The neurochemistry of social reward during development: What have we learned from rodent models?
Manduca, A., Carbone, E., Schiavi, S., Cacchione, C., Buzzelli, V., Campolongo, P., & Trezza, V. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15321 · Cited by 34 · see citing works
Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders
Risi, M. D., Tufano, M., Alvino, F. G., Ferraro, M. G., Torromino, G., Gigante, Y., Monfregola, J., Marrocco, E., Pulcrano, S., Tunisi, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23903-5 · Cited by 32 · see citing works
NMDA receptor hypofunction underlies deficits in parvalbumin interneurons and social behavior in neuroligin 3 R451C knockin mice
Cao, W., Li, J., Shen, L., Xia, Q.-Q., Du, Y.-L., Yang, Q., Ye, Y.-Z., Zeng, L., Li, X., Xu, J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111771 · Cited by 31 · see citing works
Presynaptic PTPσ regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms
Kim, K., Shin, W., Kang, M., Lee, S., Kim, D., Kang, R., Jung, Y., Cho, Y., Yang, E., Kim, H., et al. (2020) · eLife · doi:10.7554/elife.54224 · Cited by 28 · see citing works
Altered baseline and amphetamine-mediated behavioral profiles in dopamine transporter Cre (DAT-Ires-Cre) mice compared to tyrosine hydroxylase Cre (TH-Cre) mice
Chohan, M. O., Esses, S., Haft, J., Ahmari, S. E., & Veenstra-VanderWeele, J. M. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05635-4 · Cited by 30 · see citing works
Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder
Kaiser, F. M. P., Gruenbacher, S., Oyaga, M. R., Nio, E., Jaritz, M., Sun, Q., van der Zwaag, W., Kreidl, E., Zopf, L. M., Dalm, V. A. S. H., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220498 · Cited by 31 · see citing works
Dopamine control of social novelty preference is constrained by an interpeduncular-tegmentum circuit
Molas, S., Freels, T. G., Zhao-Shea, R., Lee, T., Giménez‐Gómez, P., Barbini, M., Martin, G. E., & Tapper, A. R. (2024) · Nature Communications · doi:10.1038/s41467-024-47255-y · Cited by 27 · see citing works
The Effect of Limosilactobacillus reuteri on Social Behavior Is Independent of the Adaptive Immune System
Dooling, S. W., Sgritta, M., Wang, I.-C., Duque, A. L. R. F., & Costa‐Mattioli, M. (2022) · mSystems · doi:10.1128/msystems.00358-22 · Cited by 28 · see citing works
SHANK3 Downregulation in the Ventral Tegmental Area Accelerates the Extinction of Contextual Associations Induced by Juvenile Non-familiar Conspecific Interaction
Bariselli, S., Contestabile, A., Tzanoulinou, S., Musardo, S., & Bellone, C. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00360 · Cited by 28 · see citing works
Self-citation
Species-typical group size differentially influences social reward neural circuitry during nonreproductive social interactions
Abreu, J. A. G., Rosenberg, A. E., Fricker, B. A., Wallace, K. J., Seifert, A. W., & Kelly, A. M. (2022) · iScience · doi:10.1016/j.isci.2022.104230 · Cited by 26 · see citing works
Reduction in the activity of VTA/SNc dopaminergic neurons underlies aging-related decline in novelty seeking
Shan, Q., Tian, Y., Chen, H., Lin, X., & Tian, Y. (2023) · Communications Biology · doi:10.1038/s42003-023-05571-x · Cited by 25 · see citing works
Postpartum changes in affect-related behavior and VTA dopamine neuron activity in rats
Rincón‐Cortés, M., & Grace, A. A. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109768 · Cited by 24 · see citing works
Interconnected neural circuits mediating social reward
Isaac, J., & Murugan, M. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.10.004 · Cited by 25 · see citing works
Morphine reduces the interest for natural rewards
Piccin, A., Courtand, G., & Contarino, A. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06131-7 · Cited by 27 · see citing works
Impaired synaptic plasticity in an animal model of autism exhibiting early hippocampal GABAergic-BDNF/TrkB signaling alterations
Sgritta, M., Vignoli, B., Pimpinella, D., Griguoli, M., Santi, S., Bialowas, A., Wiera, G., Zacchi, P., Malerba, F., Marchetti, C., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105728 · Cited by 24 · see citing works
Autism-associated mutations in K V 7 channels induce gating pore current
El-Din, T. M. G., Lantin, T., Tschumi, C. W., Juarez, B., Quinlan, M. A., Hayano, J. H., Li, J., Zweifel, L. S., & Catterall, W. A. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2112666118 · Cited by 22 · see citing works
Synaptic ensembles between raphe and D 1 R-containing accumbens shell neurons underlie postisolation sociability in males
Choi, J. E., Choi, D. I., Lee, J., Kim, J., Kim, M. J., Hong, I., Jung, H., Sung, Y., Kim, J., Kim, T., et al. (2022) · Science Advances · doi:10.1126/sciadv.abo7527 · Cited by 23 · see citing works
Pharmacology profile of F17464, a dopamine D3 receptor preferential antagonist
Cosi, C., Martel, J., Auclair, A. L., Collo, G., Cavalleri, L., Heusler, P., Leriche, L., Gaudoux, F., Sokoloff, P., Moser, P. C., et al. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173635 · Cited by 22 · see citing works
Representation of sex-specific social memory in ventral CA1 neurons
Watarai, A., Tao, K., & Okuyama, T. (2025) · Science · doi:10.1126/science.adp3814 · Cited by 22 · see citing works
Genetics, molecular control and clinical relevance of habituation learning
Blok, L. E. R., Boon, M., van Reijmersdal, B., Höffler, K. D., Fencková, M., & Schenck, A. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104883 · Cited by 21 · see citing works
Increase in neuropeptide Y activity impairs social behaviour in association with glutamatergic dysregulation in diabetic mice
Ueda, D., Yonemochi, N., Kamata, T., Shibasaki, M., Kamei, J., Waddington, J. L., & Ikeda, H. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15326 · Cited by 21 · see citing works
Role of dopamine neurons in familiarity
Fleury, S., Kolaric, R., Espera, J., Ha, Q. H., Tomaio, J. N., Gether, U., Sørensen, A. T., & Mingote, S. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16326 · Cited by 21 · see citing works
Chemogenetic manipulation of the bed nucleus of the stria terminalis counteracts social behavioral deficits induced by early life stress in C57BL/6J mice
Emmons, R., Sadok, T., Rovero, N. G., Belnap, M. A., Henderson, H. J. M., Quan, A., Toro, N. J. D., & Halladay, L. R. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24644 · Cited by 19 · see citing works
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Chhabra, S., Nardi, L., Leukel, P., Sommer, C. J., & Schmeißer, M. J. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1110525 · Cited by 21 · see citing works
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Rashid, M., Thomas, S., Isaac, J., Karkare, S. C., Klein, H., & Murugan, M. (2024) · eLife · doi:10.7554/elife.97259.2 · Cited by 21 · see citing works
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Gioia, R., Seri, T., Diamanti, T., Fimmanò, S., Vitale, M., Ahlenius, H., Kokaia, Z., Tirone, F., Micheli, L., Biagioni, S., et al. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15753 · Cited by 19 · see citing works
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Molas, S., Zhao-Shea, R., Freels, T. G., & Tapper, A. R. (2023) · eNeuro · doi:10.1523/eneuro.0282-22.2022 · Cited by 24 · see citing works
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Ackermann, J., Qu, P.-Q., LeGoff, L., & Amar, M. B. (2021) · The European Physical Journal Plus · doi:10.1140/epjp/s13360-021-02205-1 · Cited by 19 · see citing works
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Bellone, C., Loureiro, M., & Lüscher, C. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039701 · Cited by 18 · see citing works
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Reynolds, L. M., Gulmez, A., Fayad, S. L., Campos, R. C., Rigoni, D., Nguyen, C., Le Borgne, T., Topilko, T., Rajot, D., Franco, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53327-w · Cited by 10 · see citing works
“Totestthispossibility, weused a chemogenetic approachto exclusively decrease the excitability of VTA DA neurons of mice exposed to NIC in adolescence 49 , by expressing an inhibitory DREADD (hM4D(G i )) in a projection-and neurotransmitter-speci ﬁ c manner (Fig.”
Background
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Adolescent sleep defects and dopaminergic hyperactivity in mice with a schizophrenia-linked Shank3 mutation
Bian, W.-J., Gonzalez, O. C., & de Lecea, L. (2023) · SLEEP · doi:10.1093/sleep/zsad131 · Cited by 8 · see citing works
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Wang, Z., Yueh, H., Chau, M., Veenstra-VanderWeele, J. M., & O’Reilly, K. C. (2023) · Autism Research · doi:10.1002/aur.2978 · Cited by 7 · see citing works
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Yost, R. T., Scott, A. M., Kurbaj, J. M., Walshe‐Roussel, B., Dukas, R., & Simon, A. F. (2024) · Royal Society Open Science · doi:10.1098/rsos.240604 · Cited by 8 · see citing works
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Zhou, P., Peng, S., Wen, S., Lan, Q., Zhuang, Y., Li, X., Shi, M., & Zhang, C. (2024) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s485487 · Cited by 7 · see citing works
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Díaz, F. C., Neumann, I. D., & Rappeneau, V. (2025) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2025.101200 · Cited by 7 · see citing works
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Henderson, H. J. M., Etem, G., Bjorni, M., Belnap, M. A., Rosellini, B., & Halladay, L. R. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113241 · Cited by 7 · see citing works
Blockade of orexin receptor 1 attenuates morphine protracted abstinence-induced anxiety-like behaviors in male mice
Ye, H., Cao, T., Shu, Q., Chen, Y., Lu, Y., He, Z., & Li, Z. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106080 · Cited by 7 · see citing works

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Solié, C., Girard, B., Righetti, B., Tapparel, M., & Bellone, C. (2021) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.5564892
Self-citation
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Zheng, C., Liu, X., Wei, A., Liu, B., Zhang, Q., Jiang, J., Gao, X., Fan, H., Zhao, A., Duan, X., et al. (2026) · Neuron · doi:10.1016/j.neuron.2025.12.007 · Cited by 1 · see citing works
The impact of sensory processing on social motivation in autism spectrum disorder animal models
Contestabile, A. (2022) · Archive ouverte UNIGE (University of Geneva) · doi:10.13097/archive-ouverte/unige:165942
SHANK3 Downregulation in the Ventral Tegmental Area Accelerates the Extinction of Contextual Associations Induced by Juvenile Non-familiar Conspecific Interaction
Bariselli, S., Contestabile, A., Tzanoulinou, S., Musardo, S., & Bellone, C. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00360 · Cited by 28 · see citing works
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VTA-ACC dopaminergic circuit mediates trait anxiety-related observational learning of social avoidance in male mice
Li, M., Ren, K., Cui, C., Shi, Y., Lei, J., Li, T., Yang, J., Peng, X., Yang, X., Yao, Y., et al. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02139-7 · Cited by 4 · see citing works

Authors: Bariselli, S., Hörnberg, H., Prévost-Solié, C., Musardo, S., Hatstatt-Burklé, L., Scheiffele, P., & Bellone, C.
Affiliations: University of Geneva (CH)
University of Basel (CH)
Corresponding author: Bellone, Camilla
ORCID: Bariselli, Sebastiano
Hörnberg, Hanna
Musardo, Stefano
Scheiffele, Peter
Bellone, Camilla
Venue: Nature Communications
Publisher: Springer Science and Business Media LLC
Published: 2018-08-09
Volume: 9
Issue: 1
Pages: 3173-3173
ISSN: 2041-1723 (ISSN-L)
DOI: 10.1038/s41467-018-05382-3
PMC: PMC6085391
OpenAlex: W2886986075
Cited by: 171
References: 94
Citations by year: 2026: 12 · 2025: 20 · 2024: 27 · 2023: 27 · 2022: 31 · 2021: 23 · 2020: 18 · 2019: 9 · 2018: 3
FWCI: 6.04
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Nature Communications (publishedVersion, cc-by)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
edoc (University of Basel) (submittedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders: National Science Foundation
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (150704)
Fondation Pierre Mercier
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: ventral tegmental area, dopaminergic neurons, neuroligin-3, autism spectrum disorder, sociability, habituation, synaptic plasticity, chemogenetic inhibition, social reinforcement, synaptic adhesion molecules
MeSH terms: Animals, Behavior, Animal, Female, Male, Membrane Proteins, Mice, Inbred C57BL, Mice, Transgenic, Nerve Tissue Proteins, Neuronal Plasticity, Neurons, Social Behavior, Synapses, Cell Adhesion Molecules, Neuronal, Ventral Tegmental Area, Receptors, AMPA, Mice, Dopaminergic Neurons

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Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction

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