The Gut Microbiota of Rural Papua New Guineans: Composition, Diversity Patterns, and Ecological Processes
Open accessAbstract
Although recent research revealed an impact of westernization on diversity and composition of the human gut microbiota, the exact consequences on metacommunity characteristics are insufficiently understood, and the underlying ecological mechanisms have not been elucidated. Here, we have compared the fecal microbiota of adults from two non-industrialized regions in Papua New Guinea (PNG) with that of United States (US) residents. Papua New Guineans harbor communities with greater bacterial diversity, lower inter-individual variation, vastly different abundance profiles, and bacterial lineages undetectable in US residents. A quantification of the ecological processes that govern community assembly identified bacterial dispersal as the dominant process that shapes the microbiome in PNG but not in the US. These findings suggest that the microbiome alterations detected in industrialized societies might arise from modern lifestyle factors limiting bacterial dispersal, which has implications for human health and the development of strategies aimed to redress the impact of westernization.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Gut microbiota of eight hunter-gatherer or rural farming populations has greater bacterial diversity than Western populations.
“The gut microbiota of eight hunter–gatherer or rural farming populations in various parts of the world showed increased bacterial diversity compared with those of Western populations19,40,52–55.”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [54]
Bacteroides has been used to distinguish between developing (low Bacteroides abundance) and industrialized (high Bacteroides abundance) populations.
“Bacteroides has been used to distinguish between developing (low Bacteroides abundance) and industrialized (high Bacteroides abundance) populations [22–28, 30]”
From Population structure of human gut bacteria in a diverse cohort from rural Tanzania and Botswana (2019) · cites this paper as [28]
The gut bacteria of urban-industrialized populations often have high abundances of Bacteroides, while the gut bacteria from traditional hunter-gatherer or agropastoral societies have higher abundances of Prevotella.
“The gut bacteria of urban-industrialized populations often have high abundances of Bacteroides, while the gut bacteria from traditional hunter-gatherer or agropastoral societies have higher abundances of Prevotella [22–28].”
From Population structure of human gut bacteria in a diverse cohort from rural Tanzania and Botswana (2019) · cites this paper as [28]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,706 · see citing works
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
vegan: Community Ecology Package
Oksanen, J., Simpson, G. L., Blanchet, F. G., Kindt, R., Legendre, P., Minchin, P. R., O’Hara, R. B., Sólymos, P., Stevens, M. H. H., Szöcs, E., et al. (2001) · doi:10.32614/cran.package.vegan · Cited by 27,099 · see citing works
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 20,966 · see citing works
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579 · see citing works
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386 · see citing works
Duodenal Infusion of Donor Feces for Recurrent <i>Clostridium difficile</i>
van Nood, E., Vrieze, A., Nieuwdorp, M., Fuentes, S., Zoetendal, E. G., de Vos, W. M., Visser, C. E., Kuijper, E. J., Bartelsman, J. F. W. M., Tijssen, J. G. P., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1205037 · Cited by 3,708 · see citing works
Gut Microbiota Metabolism of Dietary Fiber Influences Allergic Airway Disease and Hematopoiesis
Trompette, A., Gollwitzer, E. S., Yadava, K., Sichelstiel, A. K., Sprenger, N., Ngom-Bru, C., Blanchard, C., Junt, T., Nicod, L. P., Harris, N. L., et al. (2014) · Nature Medicine · doi:10.1038/nm.3444 · Cited by 2,862 · see citing works
Conceptual Synthesis in Community Ecology
Vellend, M. (2010) · The Quarterly Review of Biology · doi:10.1086/652373 · Cited by 2,807 · see citing works
Quantifying community assembly processes and identifying features that impose them
Stegen, J., Lin, X., Fredrickson, J. K., et al. (2013) · The ISME Journal · doi:10.1038/ismej.2013.93 · Cited by 2,682 · see citing works
Self-citationStochastic and deterministic assembly processes in subsurface microbial communities
Stegen, J., Lin, X., Konopka, A. E., & Fredrickson, J. K. (2012) · The ISME Journal · doi:10.1038/ismej.2012.22 · Cited by 2,057 · see citing works
Self-citationPatterns and Processes of Microbial Community Assembly
Nemergut, D. R., Schmidt, S. K., Fukami, T., O’Neill, S., Bilinski, T. M., Stanish, L. F., Knelman, J. E., Darcy, J. L., Lynch, R. C., Wickey, P., et al. (2013) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00051-12 · Cited by 1,990 · see citing works
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921 · see citing works
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904 · see citing works
Disentangling the importance of ecological niches from stochastic processes across scales
Chase, J. M., & Myers, J. A. (2011) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0063 · Cited by 1,671 · see citing works
An ecological and evolutionary perspective on human–microbe mutualism and disease
Dethlefsen, L., McFall-Ngai, M., & Relman, D. A. (2007) · Nature · doi:10.1038/nature06245 · Cited by 1,660 · see citing works
The Application of Ecological Theory Toward an Understanding of the Human Microbiome
Costello, E. K., Stagaman, K., Dethlefsen, L., Bohannan, B. J. M., & Relman, D. A. (2012) · Science · doi:10.1126/science.1224203 · Cited by 1,437 · see citing works
Gut microbiome of the Hadza hunter-gatherers
Schnorr, S. L., Candela, M., Rampelli, S., Centanni, M., Consolandi, C., Basaglia, G., Turroni, S., Biagi, E., Peano, C., Severgnini, M., et al. (2014) · Nature Communications · doi:10.1038/ncomms4654 · Cited by 1,317 · see citing works
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
Berer, K., Mues, M., Koutrolos, M., Rasbi, Z. A., Boziki, M., Johner, C., Wekerle, H., & Krishnamoorthy, G. (2011) · Nature · doi:10.1038/nature10554 · Cited by 1,251 · see citing works
Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group
Karvonen, M., Viik-Kajander, M., Moltchanova, E., Libman, I., LaPorte, R., & Tuomilehto, J. (2000) · Diabetes Care · doi:10.2337/diacare.23.10.1516 · Cited by 1,072 · see citing works
Traces of Human Migrations in Helicobacter pylori Populations
Falush, D., Wirth, T., Linz, B., Pritchard, J. K., Stephens, M., Kidd, M. S., Blaser, M. J., Graham, D. Y., Vacher, S., Perez-Perez, G. I., et al. (2003) · Science · doi:10.1126/science.1080857 · Cited by 1,019 · see citing works
Using null models to disentangle variation in community dissimilarity from variation in α-diversity
Chase, J. M., Kraft, N. J. B., Smith, K. G., Vellend, M., & Inouye, B. D. (2011) · Ecosphere · doi:10.1890/es10-00117.1 · Cited by 958 · see citing works
Towards the human intestinal microbiota phylogenetic core
Tap, J., Mondot, S., Levenez, F., Pelletier, E., Caron, C., Furet, J., Ugarte, E., Muñoz‐Tamayo, R., Paslier, D. L. E., Nalin, R., et al. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01982.x · Cited by 927 · see citing works
Genomic variation landscape of the human gut microbiome
Schloissnig, S., Arumugam, M., Sunagawa, S., Mitreva, M., Tap, J., Zhu, A., Waller, A., Mende, D. R., Kultima, J. R., Martin, J., et al. (2013) · Nature · doi:10.1038/nature11711 · Cited by 907 · see citing works
Sonnenburg, E. D., & Sonnenburg, J. L. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.07.003 · Cited by 871 · see citing works
What are the consequences of the disappearing human microbiota?
Blaser, M. J., & Falkow, S. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2245 · Cited by 859 · see citing works
The human gut microbiome: ecology and recent evolutionary changes
Walter, J., & Ley, R. (2011) · Annual Review of Microbiology · doi:10.1146/annurev-micro-090110-102830 · Cited by 720 · see citing works
Self-citationGut microbiome composition is linked to whole grain-induced immunological improvements
Martínez, I., Lattimer, J. M., Hubach, K. L., Case, J. A., Yang, J., Weber, C. G., Louk, J. A., Rose, D. J., Kyureghian, G., Peterson, D. A., et al. (2013) · The ISME Journal · doi:10.1038/ismej.2012.104 · Cited by 614 · see citing works
Self-citationFundamentals of Conservation Biology
Hill, C. J., & Hunter, M. L. (1996) · Journal of Animal Ecology · doi:10.2307/5790 · Cited by 519 · see citing works
Rivas, M. N., Burton, O. T., Wise, P. M., Zhang, Y., Hobson, S. A., Lloret, M. G., Chehoud, C., Kuczynski, J., DeSantis, T. Z., Warrington, J. A., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.10.026 · Cited by 488 · see citing works
The ‘microflora hypothesis’ of allergic diseases
Noverr, M. C., & Huffnagle, G. B. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02379.x · Cited by 394 · see citing works
Pop, M., Walker, A. W., Paulson, J. N., Lindsay, B. R., Antonio, M., Hossain, M. A., Oundo, J. O., Tamboura, B., Mai, V., Astrovskaya, I., et al. (2014) · Genome biology · doi:10.1186/gb-2014-15-6-r76 · Cited by 376 · see citing works
Martínez, I., Wallace, G., Zhang, C., Legge, R. M., Benson, A. K., Carr, T. P., Moriyama, E. N., & Walter, J. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.00380-09 · Cited by 355 · see citing works
Self-citationWalter, J., Britton, R. A., & Roos, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000099107 · Cited by 333 · see citing works
Self-citationDispersal and Species Diversity: A Meta-Analysis
Cadotte, M. W. (2006) · The American Naturalist · doi:10.1086/504850 · Cited by 321 · see citing works
Lin, A., Bik, E. M., Costello, E. K., Dethlefsen, L., Haque, R., Relman, D. A., & Singh, U. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053838 · Cited by 314 · see citing works
Risnes, K. R., Belanger, K., Murk, W., & Bracken, M. B. (2011) · American Journal of Epidemiology · doi:10.1093/aje/kwq400 · Cited by 297 · see citing works
Antibiotic Use in Children Is Associated With Increased Risk of Asthma
Marra, F., Marra, C. A., Richardson, K., Lynd, L. D., Kozyrskyj, A. L., Patrick, D. M., Bowie, W., & FitzGerald, J. M. (2009) · PEDIATRICS · doi:10.1542/peds.2008-1146 · Cited by 286 · see citing works
International Encyclopedia of Linguistics
Frawley, W. J. (2003) · Oxford University Press eBooks · doi:10.1093/acref/9780195139778.001.0001 · Cited by 234 · see citing works
Martínez, I., Muller, C. E., & Walter, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069621 · Cited by 181 · see citing works
Self-citationDiversity of human small intestinal Streptococcus and Veillonella populations
van den Bogert, B., Erkuş, O., Boekhorst, J., de Goffau, M. C., Smid, E. J., Zoetendal, E. G., & Kleerebezem, M. (2013) · FEMS Microbiology Ecology · doi:10.1111/1574-6941.12127 · Cited by 172 · see citing works
Jeraldo, P., Sipos, M., Chia, N., Brulc, J. M., Dhillon, A. S., Konkel, M. E., Larson, C. L., Nelson, K. E., Qu, A., Schook, L. B., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206721109 · Cited by 149 · see citing works
Ochoa-Repáraz, J., Mielcarz, D., Haque-Begum, S., & Kasper, L. (2010) · Gut microbes · doi:10.4161/gmic.1.2.11515 · Cited by 142 · see citing works
Linking metacommunity theory and symbiont evolutionary ecology
Mihaljevic, J. R. (2012) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2012.01.011 · Cited by 142 · see citing works
Fundamentals of Conservation Biology
Williams, G. (2008) · Pacific Conservation Biology · doi:10.1071/pc080227 · Cited by 97 · see citing works
Krumbeck, J. A., Maldonado-Gómez, M. X., Martínez, I., Frese, S. A., Burkey, T. E., Rasineni, K., Ramer‐Tait, A. E., Harris, E. N., Hutkins, R. W., & Walter, J. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.03903-14 · Cited by 69 · see citing works
Self-citationBreastfeeding is associated with lower risk for multiple sclerosis
Conradi, S., Malzahn, U., Paul, F., et al. (2012) · Multiple Sclerosis Journal · doi:10.1177/1352458512459683 · Cited by 66 · see citing works
International encyclopedia of linguistics
(2003) · Choice Reviews Online · doi:10.5860/choice.41-1277 · Cited by 41 · see citing works
Tenconi, M. T., Devoti, G., Comelli, M., Pinon, M., Capocchiano, A., Calcaterra, V., Pretti, G. R., & and the Pavia T1DM Registry Group* (2007) · Acta Diabetologica · doi:10.1007/s00592-007-0235-9 · Cited by 40 · see citing works
Greenhill, A. R., Tsuji, H., Ogata, K., Natsuhara, K., Morita, A., Kevin Webby, S. O. L. I., Larkins, J., Tadokoro, K., Odani, S., Baba, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117427 · Cited by 28 · see citing works
Self-citationA STUDY OF ARTHRITIS IN PAPUA NEW GUINEA
Scrimgeour, E. M., Matz, L. R., & Aaskov, J. G. (1987) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.1987.tb05050.x · Cited by 16 · see citing works
Leach, J. D. (2013) · Nature · doi:10.1038/504033c · Cited by 15 · see citing works
Type 1 diabetes mellitus in children in Papua New Guinea.
Ogle, G. D., Lesley, J., Sine, P., et al. (2002) · PubMed · Cited by 12 · see citing works
Demography and the epidemiology of disease in Papua New Guinea.
Riley, I. D. (2011) · PubMed · Cited by 11 · see citing works
Antibiotic-resistant bacterial sepsis in Papua New Guinea.
Duke, T. (2001) · PubMed · Cited by 10 · see citing works
de Vrieze, J. (2014) · Science · doi:10.1126/science.343.6168.241 · Cited by 10 · see citing works
Baló's concentric sclerosis in a woman from Papua New Guinea
Hulcombe, J. E., Bradfield, J. M., Tannenberg, A. E. G., et al. (1999) · Journal of Clinical Neuroscience · doi:10.1016/s0967-5868(99)90603-3 · Cited by 5 · see citing works
Acute myocardial infarction in a young Papuan woman with systemic lupus erythematosus.
Currie, B., Kevau, I. H., & Naraqi, S. (1989) · PubMed · Cited by 3 · see citing works
Systemic lupus erythematosus in children: a case report and review.
Kemiki, A. D., Jimmy, S., & RONGAP, A. (2002) · PubMed · Cited by 2 · see citing works
Multiple sclerosis: report of a case in a Papua New Guinean.
Saweri, A., Dakulala, P., Tuck, R. R., et al. (1993) · PubMed · Cited by 2 · see citing works
Systemic lupus erythematosis in a Papua New Guinean highlander.
Bw, F. (1988) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The impact of dietary fiber on gut microbiota in host health and disease
Makki, K., Deehan, E. C., Walter, J., & Bäckhed, F. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.012 · Cited by 2,517 · see citing works
Self-citationPopulation-level analysis of gut microbiome variation
Falony, G., Joossens, M., Vieira-Silva, S., Wang, J., Darzi, Y., Faust, K., Kurilshikov, A., Bonder, M. J., Valles-Colomer, M., Vandeputte, D., et al. (2016) · Science · doi:10.1126/science.aad3503 · Cited by 2,400 · see citing works
Diet–microbiota interactions as moderators of human metabolism
Sonnenburg, J. L., & Bäckhed, F. (2016) · Nature · doi:10.1038/nature18846 · Cited by 2,257 · see citing works
You are what you eat: Diet, health and the gut microbiota
Zmora, N., Suez, J., & Elinav, E. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0061-2 · Cited by 1,792 · see citing works
Diet-induced extinctions in the gut microbiota compound over generations
Sonnenburg, E. D., Smits, S. A., Tikhonov, M., Higginbottom, S. K., Wingreen, N. S., & Sonnenburg, J. L. (2016) · Nature · doi:10.1038/nature16504 · Cited by 1,730 · see citing works
Gut-microbiota-targeted diets modulate human immune status
Wastyk, H. C., Fragiadakis, G. K., Perelman, D., Dahan, D., Merrill, B. D., Yu, F. B., Topf, M., Gonzalez, C. G., Van Treuren, W., Han, S., et al. (2021) · Cell · doi:10.1016/j.cell.2021.06.019 · Cited by 1,385 · see citing works
Salt-responsive gut commensal modulates TH17 axis and disease
Wilck, N., Matus, M. G., Kearney, S. M., Olesen, S. W., Forslund, K., Bartolomaeus, H., Haase, S., Mähler, A., Balogh, A., Markó, L., et al. (2017) · Nature · doi:10.1038/nature24628 · Cited by 1,310 · see citing works
Genetic determinants of the gut microbiome in UK twins
Goodrich, J. K., Davenport, E. R., Beaumont, M., Jackson, M. A., Knight, R., Ober, C., Spector, T. D., Bell, J. T., Clark, A. G., & Ley, R. E. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.04.017 · Cited by 1,048 · see citing works
Gupta, V. K., Paul, S., & Dutta, C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01162 · Cited by 1,019 · see citing works
Dietary fibre in gastrointestinal health and disease
Gill, S. K., Rossi, M., Bajka, B., & Whelan, K. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00375-4 · Cited by 979 · see citing works
Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania
Smits, S. A., Leach, J., Sonnenburg, E. D., Gonzalez, C. G., Lichtman, J. S., Reid, G., Knight, R., Manjurano, A., Changalucha, J., Elias, J. E., et al. (2017) · Science · doi:10.1126/science.aan4834 · Cited by 886 · see citing works
Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration
Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Physiology · doi:10.1113/jp273106 · Cited by 813 · see citing works
Dietary fibre modulates the gut microbiota
Cronin, P., Joyce, S. A., O’Toole, P. W., & O’Connor, E. M. (2021) · Nutrients · doi:10.3390/nu13051655 · Cited by 658 · see citing works
The ancestral and industrialized gut microbiota and implications for human health
Sonnenburg, E. D., & Sonnenburg, J. L. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0191-8 · Cited by 489 · see citing works
Song, Z., Cai, Y., Lao, X., Wang, X., Lin, X., Cui, Y., Kalavagunta, P. K., Liao, J., Jin, L., Shang, J., et al. (2019) · Microbiome · doi:10.1186/s40168-019-0628-3 · Cited by 505 · see citing works
Iljazovic, A., Roy, U., Gálvez, E. J. C., Lesker, T. R., Zhao, B., Gronow, A., Amend, L., Will, S. E., Hofmann, J. D., Pils, M. C., et al. (2021) · Mucosal Immunology · doi:10.1038/s41385-020-0296-4 · Cited by 454 · see citing works
The gut microbiota in human energy homeostasis and obesity
Rosenbaum, M., Knight, R., & Leibel, R. L. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.07.002 · Cited by 450 · see citing works
Microbiome and metabolic disease: revisiting the bacterial phylum Bacteroidetes
Johnson, E. L., Heaver, S. L., Walters, W. A., & Ley, R. E. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1492-2 · Cited by 389 · see citing works
The human microbiome in evolution
Davenport, E. R., Sanders, J. G., Song, S. J., Amato, K. R., Clark, A. G., & Knight, R. (2017) · BMC Biology · doi:10.1186/s12915-017-0454-7 · Cited by 393 · see citing works
Precup, G., & Vodnar, D.-C. (2019) · British Journal of Nutrition · doi:10.1017/s0007114519000680 · Cited by 378 · see citing works
Endocannabinoids–at the crossroads between the gut microbiota and host metabolism
Cani, P. D., Plovier, H., Van Hul, M., Geurts, L., Delzenne, N. M., Druart, C., & Everard, A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.211 · Cited by 367 · see citing works
De Filippo, C., Di Paola, M., Ramazzotti, M., Albanese, D., Pieraccini, G., Banci, E., Miglietta, F., Cavalieri, D., & Lionetti, P. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01979 · Cited by 270 · see citing works
Gomez, A., Petrzelkova, K. J., Burns, M. B., Yeoman, C. J., Amato, K. R., Vlckova, K., Modry, D., Todd, A., Jost Robinson, C. A., Remis, M. J., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.013 · Cited by 248 · see citing works
Morton, E. R., Lynch, J., Froment, A., Lafosse, S., Heyer, E., Przeworski, M., Blekhman, R., & Ségurel, L. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1005658 · Cited by 231 · see citing works
Yasmin, I., Saeed, M., Khan, W. A., Khaliq, A., Chughtai, M. F. J., Iqbal, R., Tehseen, S., Naz, S., Liaqat, A., Mehmood, T., et al. (2020) · Microorganisms · doi:10.3390/microorganisms8030354 · Cited by 233 · see citing works
The human gut microbiome in health: Establishment and resilience of microbiota over a lifetime
Greenhalgh, K., Meyer, K. M., Aagaard, K. M., & Wilmes, P. (2016) · Environmental Microbiology · doi:10.1111/1462-2920.13318 · Cited by 218 · see citing works
Leveraging diet to engineer the gut microbiome
Wolter, M., Grant, E. T., Boudaud, M., Steimle, A., Pereira, G. V., Martens, E. C., & Desai, M. S. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00512-7 · Cited by 211 · see citing works
Martínez, I., Maldonado-Gomez, M. X., Gomes-Neto, J. C., Kittana, H., Ding, H., Schmaltz, R., Joglekar, P., Cardona, R. J., Marsteller, N. L., Kembel, S. W., et al. (2018) · eLife · doi:10.7554/elife.36521 · Cited by 199 · see citing works
Self-citationA psychology of the human brain-gut-microbiome axis
Allen, A. P., Dinan, T. G., Clarke, G., & Cryan, J. F. (2017) · Social and Personality Psychology Compass · doi:10.1111/spc3.12309 · Cited by 174 · see citing works
Poeker, S. A., Geirnaert, A., Berchtold, L., Greppi, A., Krych, L., Steinert, R. E., de Wouters, T., & Lacroix, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-22438-y · Cited by 176 · see citing works
The microbiota, immunoregulation, and mental health: implications for public health
Lowry, C. A., Smith, D. G., Siebler, P. H., Schmidt, D., Stamper, C. E., Hassell, J. E., Yamashita, P. S., Fox, J. H., Reber, S. O., Brenner, L. A., et al. (2016) · Current Environmental Health Reports · doi:10.1007/s40572-016-0100-5 · Cited by 172 · see citing works
Griffin, N. W., Ahern, P. P., Cheng, J., Heath, A. C., Ilkayeva, O., Newgard, C. B., Fontana, L., & Gordon, J. I. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2016.12.006 · Cited by 164 · see citing works
Sodium in the microenvironment regulates immune responses and tissue homeostasis
Müller, D. N., Wilck, N., Haase, S., Kleinewietfeld, M., & Linker, R. A. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-018-0113-4 · Cited by 149 · see citing works
Manca, C., Boubertakh, B., Leblanc, N., Deschênes, T., Lacroix, S., Martin, C., Houde, A., Veilleux, A., Flamand, N., Muccioli, G. G., et al. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra119000424 · Cited by 152 · see citing works
Population structure of human gut bacteria in a diverse cohort from rural Tanzania and Botswana
Hansen, M. E. B., Rubel, M. A., Bailey, A. G., Ranciaro, A., Thompson, S. R., Campbell, M. C., Beggs, W., Dave, J. R., Mokone, G. G., Mpoloka, S. W., et al. (2019) · Genome Biology · doi:10.1186/s13059-018-1616-9 · Cited by 110 · see citing works
Experimental Evaluation of Host Adaptation of Lactobacillus reuteri to Different Vertebrate Species
Duar, R. M., Frese, S. A., Lin, X. B., Fernando, S. C., Burkey, T. E., Tasseva, G., Peterson, D. A., Blom, J., Wenzel, C. Q., Szymanski, C. M., et al. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.00132-17 · Cited by 104 · see citing works
Self-citationTamburini, F. B., Maghini, D., Oduaran, O. H., Brewster, R., Hulley, M. R., Sahibdeen, V., Norris, S. A., Tollman, S., Kahn, K., Wagner, R. G., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27917-x · Cited by 88 · see citing works
Geographic Differences in Gut Microbiota Composition Impact Susceptibility to Enteric Infection
Porras, A. M., Shi, Q., Zhou, H., Callahan, R., Montenegro-Bethancourt, G., Solomons, N., & Brito, I. L. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109457 · Cited by 74 · see citing works
Reber, S. O., Langgartner, D., Foertsch, S., Postolache, T. T., Brenner, L. A., Guendel, H., & Lowry, C. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.08.031 · Cited by 59 · see citing works
Response of the human gut and saliva microbiome to urbanization in Cameroon
Lokmer, A., Aflalo, S., Amougou, N., Lafosse, S., Froment, A., Tabe, F. E., Poyet, M., Groussin, M., Said-Mohamed, R., & Ségurel, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-59849-9 · Cited by 46 · see citing works
The shrinking human gut microbiome
Moeller, A. H. (2017) · Current Opinion in Microbiology · doi:10.1016/j.mib.2017.04.002 · Cited by 50 · see citing works
Phan, J., Nair, D., Jain, S., Montagne, T., Flores, D. V., Nguyen, A., Dietsche, S., Gombar, S., & Cotter, P. (2021) · mSystems · doi:10.1128/msystems.01215-21 · Cited by 33 · see citing works
Ye, Q., Sun, S., Deng, J., Chen, X., Zhang, J., Lin, S., Du, H., Gao, J., Zou, X., Lin, X., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-47760-y · Cited by 11 · see citing works
- Authors
- Martínez, I., Stegen, J. C., Maldonado-Gómez, M. X., Eren, A. M., Siba, P. M., Greenhill, A. R., & Walter, J.
- Affiliations
- University of Nebraska–Lincoln (US)
- Pacific Northwest National Laboratory (US)
- Marine Biological Laboratory (US)
- Papua New Guinea Institute of Medical Research (PG)
- Federation University (AU)
- Corresponding author
- Greenhill, Andrew R.
- Walter, Jens
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 11
- Issue
- 4
- Pages
- 527-538
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W1989496014
- Cited by
- 576
- References
- 66
- Citations by year
- 2026: 18 · 2025: 28 · 2024: 40 · 2023: 41 · 2022: 59 · 2021: 81 · 2020: 68 · 2019: 65 · 2018: 57 · 2017: 51 · 2016: 53 · 2015: 14
- FWCI
- 25.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Lincoln (University of Nebraska) (submittedVersion)
- FedUni ResearchOnline (Federation University Australia) (submittedVersion)
- Open Access Server of the Woods Hole Scientific Community (Woods Hole Scientific Community) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- U.S. Department of Energy (DE-AC05–76RL01830, 76RL01830, AC05-76RL01830, DE-AC05?)
- Battelle (AC05-76RL01830, DE- AC05-76RL01830, DE-AC05)
- Laboratory Directed Research and Development
- Pacific Northwest National Laboratory (DEAC0576RL01830, 76RL01830)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, fecal microbiota, Papua New Guinea, rural population, Westernization, bacterial diversity, interindividual variability, bacterial dispersal, community assembly, metacommunity ecology
- MeSH terms
- Gastrointestinal Microbiome, Adult, Feces, Female, Humans, Male, Papua New Guinea, Rural Population, DNA Barcoding, Taxonomic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
