Cited by 235Diabetes and associated disordersDiabetes Management and ResearchPancreatic function and diabetes

The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.

Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk

Open access

Parikka, V., Näntö-Salonen, K., Saarinen, M., Simell, T., Ilonen, J., Hyöty, H., Veijola, R., Knip, M., Simell, O.·2012·Diabetologia

DOI 10.1007/s00125-012-2523-3

Open this paper in CoChat — free account Open PDF

Abstract

Aims/hypothesis The aim of the study was to investigate the timing of the appearance of autoantibodies associated with type 1 diabetes between birth and puberty, the natural fate of these autoantibodies and the predictive power of autoantibody concentrations for early progression to clinical diabetes. Methods Children were recruited to the Type 1 Diabetes Prediction and Prevention Project, an ongoing study based on HLA-conferred genetic risk. Autoantibodies against islet cells, insulin, GAD65 and islet antigen 2 were analysed at 3-12 month intervals, starting from birth. Results During the follow-up, 1,320 children (18.4% of the cohort of 7,165 children) were autoantibody positive in at least one sample. Altogether, 184 autoantibody-positive children progressed to type 1 diabetes. Seroconversion occurred at an early age in the progressors (median 1.5 years), among whom 118 (64%) and 150 (82%) seroconverted to autoantibody positivity before the age of 2 and 3 years, respectively. The incidence of seroconversion peaked at 1 year of age. Compared with other autoantibody-positive children, the median autoantibody levels were already markedly higher 3 to 6 months after the seroconversion in children who later progressed to diabetes. Conclusions/interpretation Early initiation of autoimmunity and rapid increases in autoantibody titres strongly predict progression to overt diabetes before puberty, emphasising the importance of early life events in the development of type 1 diabetes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s00125-012-2523-3

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A Population-Based Study
Christakis, D., Richards, J. A., Zimmerman, F. J., Garrison, M. M., Xu, D., & Yapanel, U. H. (2009) · Cited by 2,290
Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study
Patterson, C. C., Dahlquist, G. G., Gyürüs, E., Green, A., & Soltész, G. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60568-7 · Cited by 1,854
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
The Type 1 Diabetes Genetics Consortium, Barrett, J. C., Clayton, D. G., Concannon, P., Akolkar, B., Cooper, J. D., Erlich, H. A., Julier, C., Morahan, G., Nerup, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.381 · Cited by 1,746
ISLET-CELL ANTIBODIES IN DIABETES MELLITUS WITH AUTOIMMUNE POLYENDOCRINE DEFICIENCIES
Bottazzo, G., Florin-Christensen, A., & Doniach, D. (1974) · The Lancet · doi:10.1016/s0140-6736(74)90140-8 · Cited by 1,469
Incidence and trends of childhood type 1 diabetes worldwide 1990–1999
The DIAMOND Project Group (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01925.x · Cited by 1,085
Worldwide increase in incidence of Type I diabetes – the analysis of the data on published incidence trends
Onkamo, P., Väänänen, S., Karvonen, M., & Tuomilehto, J. (1999) · Diabetologia · doi:10.1007/s001250051309 · Cited by 984
Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies
Verge, C. F., Gianani, R., Kawasaki, E., Yu, L., Pietropaolo, M., Chase, H. P., Eisenbarth, G. S., & Jackson, R. A. (1996) · Diabetes · doi:10.2337/diab.45.7.926 · Cited by 827
Termination of Pregnancy on Psychiatric Grounds
Graham-Stewart, C. W. (1964) · The Lancet · doi:10.1016/s0140-6736(64)92746-1 · Cited by 681
Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study
Harjutsalo, V., Sjöberg, L., & Tuomilehto, J. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60765-5 · Cited by 666
Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study.
Ziegler, A., Hummel, M., Schenker, M., & Bonifacio, E. E. (1999) · Diabetes · doi:10.2337/diabetes.48.3.460 · Cited by 640

Show all 43 references

Sorted by citations

2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2022
American Diabetes Association Professional Practice Committee (2022) · Diabetes Care · doi:10.2337/dc22-s002 · Cited by 4,792
2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2021
American Diabetes Association (2021) · Diabetes Care · doi:10.2337/dc21-s002 · Cited by 3,116
Type 1 diabetes
Atkinson, M. A., Eisenbarth, G. S., & Michels, A. W. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60591-7 · Cited by 2,931
2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes—2023
ElSayed, N. A., Aleppo, G., Aroda, V. R., Bannuru, R. R., Brown, F. M., Bruemmer, D., Collins, B. S., Gaglia, J. L., Hilliard, M. E., Isaacs, D. M., et al. (2022) · Diabetes Care · doi:10.2337/dc23-s002 · Cited by 2,841
2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2024
American Diabetes Association Professional Practice Committee, ElSayed, N. A., Aleppo, G., Bannuru, R. R., Bruemmer, D., Collins, B. S., Ekhlaspour, L., Gaglia, J. L., Hilliard, M. E., Johnson, E. L., et al. (2024) · Diabetes Care · doi:10.2337/dc24-s002 · Cited by 2,086
2. Diagnosis and classification of diabetes: standards of care in diabetes-2025
American Diabetes Association Professional Practice Committee, ElSayed, N. A., McCoy, R. G., Aleppo, G., Balapattabi, K., Beverly, E. A., Briggs Early, K., Bruemmer, D., Ebekozien, O., Echouffo-Tcheugui, J. B., et al. (2025) · Diabetes Care · doi:10.2337/dc25-s002 · Cited by 1,393
Staging presymptomatic type 1 diabetes: A scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association
Insel, R. A., Dunne, J. L., Atkinson, M. A., Chiang, J. L., Dabelea, D., Gottlieb, P. A., Greenbaum, C. J., Herold, K. C., Krischer, J. P., Lernmark, Å., et al. (2015) · Diabetes Care · doi:10.2337/dc15-1419 · Cited by 1,216
Differentiation of diabetes by pathophysiology, natural history, and prognosis
Skyler, J. S., Bakris, G. L., Bonifacio, E., Darsow, T., Eckel, R. H., Groop, L., Groop, P.-H., Handelsman, Y., Insel, R. A., Mathieu, C., et al. (2017) · Diabetes · doi:10.2337/db16-0806 · Cited by 823
2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2026
American Diabetes Association Professional Practice Committee for Diabetes*, Bajaj, M., McCoy, R. G., Balapattabi, K., Bannuru, R. R., Bellini, N. J., Bennett, A. K., Beverly, E. A., Briggs Early, K., ChallaSivaKanaka, S., et al. (2026) · Diabetes Care · doi:10.2337/dc26-s002 · Cited by 473
The role of the intestinal microbiota in type 1 diabetes mellitus
Knip, M., & Siljander, H. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.218 · Cited by 444
Self-citation
Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes
Davis‐Richardson, A. G., Ardissone, A. N., Dias, R., Simell, V., Leonard, M. T., Kemppainen, K. M., Drew, J. C., Schatz, D., Atkinson, M. A., Kolaczkowski, B., et al. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00678 · Cited by 316
Self-citation
Screening for Type 1 Diabetes in the General Population: A Status Report and Perspective
Sims, E. K., Besser, R. E. J., Dayan, C. M., Rasmussen, C. G., Greenbaum, C. J., Griffin, K., Hagopian, W., Knip, M., Long, A. E., Martin, F., et al. (2022) · Diabetes · doi:10.2337/dbi20-0054 · Cited by 274
Self-citation
Patterns of β-Cell Autoantibody Appearance and Genetic Associations During the First Years of Life
Ilonen, J., Hammais, A., Laine, A., Lempainen, J., Vaarala, O., Veijola, R., Simell, O., & Knip, M. (2013) · Diabetes · doi:10.2337/db13-0300 · Cited by 206
Self-citation
Environmental Triggers of Type 1 DiabetesPreprint
Knip, M., & Simell, O. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007690 · Cited by 218
Self-citation
Predicting Type 1 Diabetes Using Biomarkers
Bonifacio, E. E. (2015) · Diabetes Care · doi:10.2337/dc15-0101 · Cited by 191
Capillary blood islet autoantibody screening for identifying pre-type 1 diabetes in the general population: design and initial results of the Fr1da study
Raab, J., Haupt, F., Scholz, M., Matzke, C., Warncke, K., Lange, K., Assfalg, R., Weininger, K., Wittich, S., Löbner, S., et al. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-011144 · Cited by 145
The Influence of the Microbiome on Type 1 Diabetes
Paun, A., Yau, C., & Danska, J. S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601519 · Cited by 130
Preclinical Autoimmune Disease: a Comparison of Rheumatoid Arthritis, Systemic Lupus Erythematosus, Multiple Sclerosis and Type 1 Diabetes
Frazzei, G., van Vollenhoven, R., de Jong, B. A., Siegelaar, S. E., & van Schaardenburg, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.899372 · Cited by 137
Type 1 diabetes: A predictable disease
Simmons, K. M. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i3.380 · Cited by 129
Prediction and Prevention of Type 1 Diabetes
Primavera, M., Giannini, C., & Chiarelli, F. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00248 · Cited by 130
The prenatal environment and type 1 diabetes
Stene, L. C., & Gale, E. A. M. (2013) · Diabetologia · doi:10.1007/s00125-013-2929-6 · Cited by 102
Care of diabetes in children and adolescents: controversies, changes, and consensus
Cameron, F. J., & Wherrett, D. K. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60971-0 · Cited by 99
Defining Pathways for Development of Disease-Modifying Therapies in Children With Type 1 Diabetes: A Consensus Report
Wherrett, D. K., Chiang, J. L., Delamater, A. M., DiMeglio, L. A., Gitelman, S. E., Gottlieb, P. A., Herold, K. C., Lovell, D. J., Orchard, T. J., Ryan, C. M., et al. (2015) · Diabetes Care · doi:10.2337/dc15-1429 · Cited by 96
Relationship between islet autoantibody status and the clinical characteristics of children and adults with incident type 1 diabetes in a UK cohort
Bravis, V., Kaur, A., Walkey, H. C., Godsland, I. F., Misra, S., Bingley, P. J., Williams, A. J. K., Dunger, D. B., Dayan, C. M., Peakman, M., et al. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-020904 · Cited by 91
Respiratory Infections in Early Life and the Development of Islet Autoimmunity in Children at Increased Type 1 Diabetes Risk
Beyerlein, A., Wehweck, F. S., Ziegler, A., & Pflueger, M. (2013) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2013.158 · Cited by 90
Cord Serum Lipidome in Prediction of Islet Autoimmunity and Type 1 Diabetes
Orešič, M., Gopalacharyulu, P. V., Mykkänen, J., Lietzén, N., Mäkinen, M., Nygrén, H., Simell, S., Simell, V., Hyöty, H., Veijola, R., et al. (2013) · Diabetes · doi:10.2337/db13-0159 · Cited by 89
Self-citation
Islet autoantibody phenotypes and incidence in children at increased risk for type 1 diabetes
Giannopoulou, E. Z., Winkler, C., Chmiel, R., Matzke, C., Scholz, M., Beyerlein, A., Achenbach, P., Bonifacio, E. E., & Ziegler, A. (2015) · Diabetologia · doi:10.1007/s00125-015-3672-y · Cited by 87
HbA1c Predicts Time to Diagnosis of Type 1 Diabetes in Children at Risk
Helminen, O., Aspholm, S., Pokka, T. M.-L., Hautakangas, M., Haatanen, N., Lempainen, J., Ilonen, J., Simell, O., Knip, M., & Veijola, R. (2014) · Diabetes · doi:10.2337/db14-0497 · Cited by 89
Self-citation
Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children
Achenbach, P., Hummel, M., Thümer, L., Boerschmann, H., Höfelmann, D., & Ziegler, A. G. (2013) · Diabetologia · doi:10.1007/s00125-013-2896-y · Cited by 76
Serum 25-Hydroxyvitamin D Concentrations in Children Progressing to Autoimmunity and Clinical Type 1 Diabetes
Mäkinen, M., Mykkänen, J., Koskinen, M. K., Simell, V., Veijola, R., Hyöty, H., Ilonen, J., Knip, M., Simell, O., & Toppari, J. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3504 · Cited by 76
Self-citation
Advances in Type 1 Diabetes Prediction Using Islet Autoantibodies: Beyond a Simple Count
So, M., Speake, C., Steck, A. K., Lundgren, M., Colman, P. G., Palmer, J. P., Herold, K. C., & Greenbaum, C. J. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab013 · Cited by 75
Association between maternal gluten intake and type 1 diabetes in offspring: national prospective cohort study in Denmark
Antvorskov, J. C., Halldorsson, T. I., Josefsen, K. E., Svensson, J., Granström, C., Roep, B. O., Olesen, T. H., Hrólfsdóttir, L., Buschard, K., & Olsen, S. F. (2018) · BMJ · doi:10.1136/bmj.k3547 · Cited by 73
The implications of autoantibodies to a single islet antigen in relatives with normal glucose tolerance: development of other autoantibodies and progression to type 1 diabetes
the Type 1 Diabetes TrialNet Study Group, Bingley, P. J., Boulware, D. C., & Krischer, J. P. (2015) · Diabetologia · doi:10.1007/s00125-015-3830-2 · Cited by 72
A divergent population of autoantigen-responsive CD4+T cells in infants prior to β cell autoimmunity
Heninger, A., Eugster, A., Kuehn, D., Buettner, F., Kühn, M., Lindner, A., Dietz, S., Jergens, S., Wilhelm, C., Beyerlein, A., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf8848 · Cited by 73
Immunoproteomic Profiling of Antiviral Antibodies in New-Onset Type 1 Diabetes Using Protein Arrays
Bian, X., Wallstrom, G. L., Davis, A., Wang, J., Park, J., Throop, A. L., Steel, J., Yu, X., Wasserfall, C. H., Schatz, D., et al. (2015) · Diabetes · doi:10.2337/db15-0179 · Cited by 71
Harmonization of immunoassays for biomarkers in diabetes mellitus
Hörber, S., Achenbach, P., Schleicher, E. D., & Peter, A. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.02.015 · Cited by 77
Pathogenesis of type 1 diabetes: lessons from natural history studies of high‐risk individuals
Nokoff, N., & Rewers, M. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12021 · Cited by 71
Primary prevention of beta-cell autoimmunity and type 1 diabetes – The Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) perspectives
Ziegler, A., Danne, T., Dunger, D. B., Berner, R., Puff, R., Kiess, W., Agiostratidou, G., Todd, J., & Bonifacio, E. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.02.003 · Cited by 62
TCF7L2 Genetic Variants Contribute to Phenotypic Heterogeneity of Type 1 Diabetes
REDONDO, M. J., Geyer, S. M., Steck, A. K., Sosenko, J. M., Anderson, M. S., Antinozzi, P. A., Michels, A. W., Wentworth, J. M., Xu, P., Pugliese, A., et al. (2017) · Diabetes Care · doi:10.2337/dc17-0961 · Cited by 66
Current understanding of the role of gut dysbiosis in type 1 diabetes
Abdellatif, A. M., & Sarvetnick, N. (2019) · Journal of Diabetes · doi:10.1111/1753-0407.12915 · Cited by 65
Dynamics of Islet Autoantibodies During Prospective Follow-Up From Birth to Age 15 Years
Pöllänen, P. M., Ryhänen, S. J., Toppari, J., Ilonen, J., Vähäsalo, P., Veijola, R., Siljander, H., & Knip, M. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa624 · Cited by 64
Self-citation
Impact of Age and Antibody Type on Progression From Single to Multiple Autoantibodies in Type 1 Diabetes Relatives
Bosi, E., Boulware, D. C., Becker, D. J., Buckner, J. H., Geyer, S. M., Gottlieb, P. A., Henderson, C., Kinderman, A., Sosenko, J. M., Steck, A. K., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00569 · Cited by 67
Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomised controlled trial
Assfalg, R., Knoop, J., Hoffman, K. L., Pfirrmann, M., Zapardiel‐Gonzalo, J., Hofelich, A., Eugster, A., Weigelt, M., Matzke, C., Reinhardt, J., et al. (2021) · Diabetologia · doi:10.1007/s00125-020-05376-1 · Cited by 68
Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials—GPPAD‐02 study design and first results
Winkler, C., Haupt, F., Heigermoser, M., Zapardiel‐Gonzalo, J., Ohli, J., Faure, T., Kalideri, E., Hommel, A., Delivani, P., Berner, R., et al. (2019) · Pediatric Diabetes · doi:10.1111/pedi.12870 · Cited by 63
Coxsackievirus and Type 1 Diabetes: Diabetogenic Mechanisms and Implications for Prevention
Carré, A., Vecchio, F., Flodström‐Tullberg, M., You, S., & Mallone, R. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad007 · Cited by 64
Birth and coming of age of islet autoantibodies
Bonifacio, E. E., & Achenbach, P. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13360 · Cited by 60
OGTT and random plasma glucose in the prediction of type 1 diabetes and time to diagnosis
Helminen, O., Aspholm, S., Pokka, T. M.-L., Ilonen, J., Simell, O., Veijola, R., & Knip, M. (2015) · Diabetologia · doi:10.1007/s00125-015-3621-9 · Cited by 57
Self-citation
A novel LIPS assay for insulin autoantibodies
Liberati, D., Wyatt, R. C., Brigatti, C., Marzinotto, I., Ferrari, M., Bazzigaluppi, E., Bosi, E., Gillard, B. T., Gillespie, K. M., Gorus, F., et al. (2018) · Acta Diabetologica · doi:10.1007/s00592-017-1082-y · Cited by 57
An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood
Bonifacio, E. E., Weiß, A., Winkler, C., Hippich, M., Rewers, M., Toppari, J., Lernmark, Å., She, J., Hagopian, W., Krischer, J. P., et al. (2021) · Diabetes Care · doi:10.2337/dc20-2122 · Cited by 57
Self-citation
Viruses and Type 1 Diabetes: From Enteroviruses to the Virome
Isaacs, S. R., Foskett, D. B., Maxwell, A. J., Ward, E. J., Faulkner, C. L., Luo, J. Y. X., Rawlinson, W. D., Craig, M. E., & Kim, K. W. (2021) · Microorganisms · doi:10.3390/microorganisms9071519 · Cited by 53
Roles of Commensal Microbiota in Pancreas Homeostasis and Pancreatic Pathologies
Leal‐Lopes, C., Velloso, F. J., Campopiano, J. C., Sogayar, M. C., & Correa, R. G. (2015) · Journal of Diabetes Research · doi:10.1155/2015/284680 · Cited by 54
Disease-Modifying Therapies in Type 1 Diabetes: A Look into the Future of Diabetes Practice
Greenbaum, C. J., VanBuecken, D., & Lord, S. M. (2019) · Drugs · doi:10.1007/s40265-018-1035-y · Cited by 56
Reduced β-cell function in early preclinical type 1 diabetes
Koskinen, M. K., Helminen, O., Matomäki, J., Aspholm, S., Mykkänen, J., Mäkinen, M., Simell, V., Vähä-Mäkilä, M., Simell, T. T., Ilonen, J., et al. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0674 · Cited by 51
Self-citation
Characterisation of rapid progressors to type 1 diabetes among children with HLA-conferred disease susceptibility
Pöllänen, P. M., Lempainen, J., Laine, A., Toppari, J., Veijola, R., Vähäsalo, P., Ilonen, J., Siljander, H., & Knip, M. (2017) · Diabetologia · doi:10.1007/s00125-017-4258-7 · Cited by 51
Self-citation
Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review
Felton, J. L., REDONDO, M. J., Oram, R. A., Speake, C., Long, S. A., Önengüt-Gümüşcü, S., Rich, S. S., Monaco, G. S. F., Harris-Kawano, A., Perez, D., et al. (2024) · Communications Medicine · doi:10.1038/s43856-024-00478-y · Cited by 63
Progression from single to multiple islet autoantibodies often occurs soon after seroconversion: implications for early screening
Chmiel, R., Giannopoulou, E. Z., Winkler, C., Achenbach, P., Ziegler, A., & Bonifacio, E. E. (2014) · Diabetologia · doi:10.1007/s00125-014-3443-1 · Cited by 50
General population screening for type 1 diabetes
Insel, R. A., Dunne, J. L., & Ziegler, A. (2015) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000173 · Cited by 49
Deciphering early development of complex diseases by progressive module network
Zeng, T., Zhang, C.-C., Zhang, W., Liu, R., Liu, J., & Chen, L. (2014) · Methods · doi:10.1016/j.ymeth.2014.01.021 · Cited by 46
Prognostic Classification Factors Associated With Development of Multiple Autoantibodies, Dysglycemia, and Type 1 Diabetes—A Recursive Partitioning Analysis
Xu, P., Krischer, J. P., & on behalf of the Type 1 Diabetes TrialNet Study Group (2016) · Diabetes Care · doi:10.2337/dc15-2292 · Cited by 45
Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children
Endesfelder, D., zu Castell, W., Bonifacio, E. E., Rewers, M., Hagopian, W., She, J., Lernmark, Å., Toppari, J., Vehik, K., Williams, A. J. K., et al. (2018) · Diabetes · doi:10.2337/db18-0594 · Cited by 45
Self-citation
General population screening for childhood type 1 diabetes: is it time for a UK strategy?
Besser, R. E. J., Ng, S. M., Gregory, J. W., Dayan, C. M., Randell, T. L., & Barrett, T. G. (2021) · Archives of Disease in Childhood · doi:10.1136/archdischild-2021-321864 · Cited by 49
Age at Seroconversion, HLA Genotype, and Specificity of Autoantibodies in Progression of Islet Autoimmunity in Childhood
Bauer, W., Veijola, R., Lempainen, J., Kiviniemi, M., Härkönen, T., Toppari, J., Knip, M., Gyenesei, A., & Ilonen, J. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00421 · Cited by 43
Self-citation
Continuous glucose monitoring and HbA1c in the evaluation of glucose metabolism in children at high risk for type 1 diabetes mellitus
Helminen, O., Pokka, T. M.-L., Tossavainen, P. H., Ilonen, J., Knip, M., & Veijola, R. (2016) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2016.07.027 · Cited by 42
Self-citation
Dysregulation of glucose metabolism in preclinical type 1 diabetes
Veijola, R., Koskinen, M. K., Helminen, O., & Hekkala, A. (2016) · Pediatric Diabetes · doi:10.1111/pedi.12392 · Cited by 41
Self-citation
Common ground: shared risk factors for type 1 diabetes and celiac disease
Verdu, E. F., & Danska, J. S. (2018) · Nature Immunology · doi:10.1038/s41590-018-0130-2 · Cited by 39
Type 1 Diabetes Mellitus
Eisenbarth, G. S., & Buse, J. B. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00032-8 · Cited by 39
Screening and Prevention of Type 1 Diabetes: Where Are We?
Simmons, K. M., & Sims, E. K. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad328 · Cited by 41
SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood
Lugar, M., Eugster, A., Achenbach, P., Berge, T. V. D., Berner, R., Besser, R. E. J., Casteels, K., Larsson, H. E., Gemulla, G., Kordonouri, O., et al. (2023) · JAMA · doi:10.1001/jama.2023.16348 · Cited by 38
The methylome of the gut microbiome: disparate Dam methylation patterns in intestinal Bacteroides dorei
Leonard, M. T., Davis‐Richardson, A. G., Ardissone, A. N., Kemppainen, K. M., Drew, J. C., Ilonen, J., Knip, M., Simell, O., Toppari, J., Veijola, R., et al. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00361 · Cited by 36
Self-citation
Allele-specific methylation of type 1 diabetes susceptibility genes
Kindt, A. S. D., Fuerst, R., Knoop, J., Laimighofer, M., Telieps, T., Hippich, M., Wörheide, M. A., Wahl, S., Wilson, R., Sedlmeier, E., et al. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.11.008 · Cited by 36
Peptide serum markers in islet autoantibody-positive children
von Toerne, C., Laimighofer, M., Achenbach, P., Beyerlein, A., Gala, T. D. L. H., Krumsiek, J., Theis, F. J., Ziegler, A. G., & Hauck, S. M. (2016) · Diabetologia · doi:10.1007/s00125-016-4150-x · Cited by 35
Circulating β cell-specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes
Yeo, L., Pujol‐Autonell, I., Baptista, R., Eichmann, M., Kronenberg‐Versteeg, D., Heck, S., Dolton, G. M., Sewell, A. K., Härkönen, T., Mikk, M.-L., et al. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13391 · Cited by 36
Self-citation
Activation of Islet Autoreactive Naïve T Cells in Infants Is Influenced by Homeostatic Mechanisms and Antigen-Presenting Capacity
Heninger, A., Monti, P., Wilhelm, C., Schwaiger, P., Kuehn, D., Ziegler, A., & Bonifacio, E. E. (2013) · Diabetes · doi:10.2337/db12-0942 · Cited by 33
Role of humoral beta-cell autoimmunity in type 1 diabetes
Knip, M., Siljander, H., Ilonen, J., Simell, O., & Veijola, R. (2016) · Pediatric Diabetes · doi:10.1111/pedi.12386 · Cited by 34
Self-citation
Intestinal Microbiota in Common Chronic Inflammatory Disorders Affecting Children
Torun, A., Hupalowska, A., Trzonkowski, P., Kierkuś, J., & Pyrzyńska, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.642166 · Cited by 40
Type 1 diabetes risk factors, risk prediction and presymptomatic detection: Evidence and guidance for screening
Bonifacio, E. E., & Ziegler, A. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16354 · Cited by 35
A Key to T1D Prevention: Screening and Monitoring Relatives as Part of Clinical Care
Greenbaum, C. J. (2021) · Diabetes · doi:10.2337/db20-1112 · Cited by 34
Late-onset islet autoimmunity in childhood: the Diabetes Autoimmunity Study in the Young (DAISY)
Frohnert, B. I., Ide, L. M., Dong, F., Barón, A. E., Steck, A. K., Norris, J. M., & Rewers, M. (2017) · Diabetologia · doi:10.1007/s00125-017-4256-9 · Cited by 33
Early infant growth is associated with the risk of islet autoimmunity in genetically susceptible children
Beyerlein, A., Thiering, E., Pflueger, M., Bidlingmaier, M., Stock, J., Knopff, A., Winkler, C., Heinrich, J., & Ziegler, A. (2014) · Pediatric Diabetes · doi:10.1111/pedi.12118 · Cited by 32
Islet autoantibody screening in at-risk adolescents to predict type 1 diabetes until young adulthood: a prospective cohort study
Ghalwash, M. F., Anand, V., Lou, O., Martin, F., Rewers, M., Ziegler, A., Toppari, J., Hagopian, W., Veijola, R., Achenbach, P., et al. (2023) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(22)00350-9 · Cited by 36
Self-citation
GAD autoantibody affinity in schoolchildren from the general population
Bender, C., Schlosser, M., Christen, U., Ziegler, A. G., & Achenbach, P. (2014) · Diabetologia · doi:10.1007/s00125-014-3294-9 · Cited by 32
The countdown to type 1 diabetes: when, how and why does the clock start?
Ziegler, A.-G. (2023) · Diabetologia · doi:10.1007/s00125-023-05927-2 · Cited by 30
Joint modeling of longitudinal autoantibody patterns and progression to type 1 diabetes: results from the TEDDY study
TEDDY study group, Köhler, M., Beyerlein, A., Vehik, K., Greven, S., Umlauf, N., Lernmark, Å., Hagopian, W., Rewers, M., She, J., et al. (2017) · Acta Diabetologica · doi:10.1007/s00592-017-1033-7 · Cited by 31
Could the high consumption of high glycaemic index carbohydrates and sugars, associated with the nutritional transition to the Western type of diet, be the common cause of the obesity epidemic and the worldwide increasing incidences of Type 1 and Type 2 diabetes?
Sjöblad, S. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.02.027 · Cited by 31
Materno-Fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevents Autoimmune Diabetes
Čulina, S., Gupta, N., Boisgard, R., Afonso, G., Gagnerault, M. C., Dimitrov, J. D., Østerbye, T., Justesen, S. F. L., Luce, S., Attias, M., et al. (2015) · Diabetes · doi:10.2337/db15-0024 · Cited by 33
Current and Future Clinical Applications of Zinc Transporter-8 in Type 1 Diabetes Mellitus
Yi, B., Huang, G., & Zhou, Z. (2015) · Chinese Medical Journal · doi:10.4103/0366-6999.163389 · Cited by 29
Lessons and gaps in the prediction and prevention of type 1 diabetes
Mameli, C., Triolo, T. M., Chiarelli, F., Rewers, M., Zuccotti, G., & Simmons, K. M. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106792 · Cited by 33
Do Electrochemiluminescence Assays Improve Prediction of Time to Type 1 Diabetes in Autoantibody-Positive TrialNet Subjects?
Fouts, A., Pyle, L. L., Yu, L., Miao, D., Michels, A. W., Krischer, J. P., Sosenko, J. M., Gottlieb, P. A., Steck, A. K., & the Type 1 Diabetes TrialNet Study Group (2016) · Diabetes Care · doi:10.2337/dc16-0302 · Cited by 30
Early life origin of type 1 diabetes
Knip, M., Luopajärvi, K., & Härkönen, T. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0665-6 · Cited by 29
Self-citation
Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes
Ekman, I., Vuorinen, T., Knip, M., Veijola, R., Toppari, J., Hyöty, H., Kinnunen, T. T., Ilonen, J., & Lempainen, J. (2018) · Pediatric Diabetes · doi:10.1111/pedi.12788 · Cited by 27
Self-citation
Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8 + T cell responses
Vecchio, F., Carré, A., Korenkov, D. A., Zhou, Z., Apaolaza, P. S., Tuomela, S., Morales, O. B., Snowhite, I. V., Perez-Hernandez, J., Brandao, B., et al. (2024) · Science Advances · doi:10.1126/sciadv.adl1122 · Cited by 29
Self-citation
The Changing Landscape of Type 1 Diabetes: Recent Developments and Future Frontiers
Vehik, K., Ajami, N. J., Hadley, D., Petrosino, J. F., & Burkhardt, B. R. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0406-8 · Cited by 27
Screening of ZnT8 autoantibodies in the diagnosis of autoimmune diabetes in a large French cohort
Garnier, L., Marchand, L., Benoit, M., Nicolino, M. P., Bendelac, N., Wright, C. C., Moulin, P., Lombard, C., Thivolet, C. H., & Fabien, N. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.12.043 · Cited by 26
New Insights into Immunotherapy Strategies for Treating Autoimmune Diabetes
Cabello-Olmo, M., Araña, M., Radichev, I., Smith, P., Huarte, E., & Barajas, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194789 · Cited by 28
Personalized Immunotherapies for Type 1 Diabetes: Who, What, When, and How?
Deligne, C., You, S., & Mallone, R. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12040542 · Cited by 26
Immune Intervention and Preservation of Pancreatic Beta Cell Function in Type 1 Diabetes
Simmons, K. M., Gottlieb, P. A., & Michels, A. W. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0793-8 · Cited by 26
The Use of Continuous Glucose Monitoring to Diagnose Stage 2 Type 1 Diabetes
Mader, J. K., Wong, J. C., Freckmann, G., Garcia‐Tirado, J., Hirsch, I. B., Johnson, S. B., Kerr, D. E., Kim, S. H., Lal, R., Montaser, E., et al. (2025) · Journal of Diabetes Science and Technology · doi:10.1177/19322968251333441 · Cited by 27
Autoantibody‐defined risk for Type 1 diabetes mellitus in a general population of schoolchildren: results of the Karlsburg Type 1 Diabetes Risk Study after 18 years
Till, A. ‐., Kenk, H., Rjasanowski, I. M., Waßmuth, R., Walschus, U., Kerner, W., & Schlosser, M. (2014) · Diabetic Medicine · doi:10.1111/dme.12677 · Cited by 25
Novel Autoantibodies to the β-Cell Surface Epitopes of ZnT8 in Patients Progressing to Type-1 Diabetes
Gu, Y., Merriman, C., Guo, Z., Jia, X., Wenzlau, J. M., Li, H., Li, H., Rewers, M., Yu, L., & Fu, D. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2021.102677 · Cited by 24
Maternal Microchimerism: Increased in the Insulin Positive Compartment of Type 1 Diabetes Pancreas but Not in Infiltrating Immune Cells or Replicating Islet Cells
Ye, Y., Vives‐Pi, M., & Gillespie, K. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086985 · Cited by 24

Authors: Parikka, V., Näntö-Salonen, K., Saarinen, M., Simell, T., Ilonen, J., Hyöty, H., Veijola, R., Knip, M., & Simell, O.
Affiliations: Turku University Hospital (FI)
University of Turku (FI)
Tampere University (FI)
Oulu University Hospital (FI)
University of Helsinki (FI)
Corresponding author: Parikka, V.
ORCID: Parikka, V.
Saarinen, M.
Ilonen, J.
Hyöty, H.
Veijola, R.
Knip, M.
Venue: Diabetologia
Publisher: Springer Science and Business Media LLC
Published: 2012-03-23
Volume: 55
Issue: 7
Pages: 1926-1936
ISSN: 0012-186X (ISSN-L)
1432-0428
DOI: 10.1007/s00125-012-2523-3
OpenAlex: W2049204060
Cited by: 235
References: 43
Citations by year: 2026: 9 · 2025: 11 · 2024: 10 · 2023: 19 · 2022: 14 · 2021: 21 · 2020: 8 · 2019: 16 · 2018: 14 · 2017: 17 · 2016: 25 · 2015: 25 · 2014: 21 · 2013: 16 · 2012: 7
FWCI: 13.30
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Diabetologia (publishedVersion)
PubMed (publishedVersion)
Funders: Juvenile Diabetes Research Foundation International (4‐1998‐274, 4‐1999‐731, 68292, 4-1998-274, 4-1999-731, 4-2001-435, 4‐2001‐435)
European Commission (BMH4‐CT98‐3314, 4-1998-274, 4-1999-731, 68292, 4-2001-435)
Academy of Finland (114666, 68292)
Suomen Kulttuurirahasto
Tekes (4-1998-274, 68292, 4-1999-731, 4-2001-435)
Päivikki ja Sakari Sohlbergin Säätiö (68292, 4-1998-274, 4-2001-435, 4-1999-731)
Signe ja Ane Gyllenbergin Säätiö (4-1999-731, 4-2001-435, 4-1998-274, 68292)
Emil Aaltosen Säätiö
Lastentautien Tutkimussäätiö (BMH4- CT98-3314, 4-2001-435, 68292, 4-1998-274, 4-1999-731)
Fonds Spéciaux de Recherche
Varsinais-Suomen Rahasto
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords: type 1 diabetes, autoantibodies, seroconversion, prepubertal onset, islet autoimmunity, GAD65, insulin autoantibodies, disease progression prediction, autoantibody titres, early life events
MeSH terms: Autoantibodies, Child, Preschool, Diabetes Mellitus, Type 1, Disease Susceptibility, Female, Finland, HLA Antigens, Humans, Infant, Infant, Newborn, Male, Prediabetic State, Predictive Value of Tests, Pregnancy, Biomarkers, Age of Onset, Disease Progression

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks