Unidirectional relationship between heroin self-administration and impulsive decision-making in rats
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RATIONALE: There is growing clinical evidence for a strong relationship between drug addiction and impulsivity. However, it is not fully clear whether impulsivity is a pre-existing trait or a consequence of drug abuse. Recent observations in the animal models show that pre-existing levels of impulsivity predict cocaine and nicotine seeking. Whether such relationships also exist with respect to non-stimulant drugs is largely unknown. OBJECTIVE: We studied the relationship between impulsive choice and vulnerability to heroin taking and seeking. MATERIALS AND METHODS: Rats were selected in the delayed reward task based on individual differences in impulsive choice. Subsequently, heroin intravenous self-administration behaviour was analysed, including acquisition of heroin intake, motivation, extinction and drug- and cue-induced reinstatement. Throughout the entire experiment, changes in impulsive choice were monitored weekly. RESULTS AND DISCUSSION: High impulsivity did not predict measures of heroin taking. Moreover, high impulsive rats did not differ from low impulsive rats in extinction rates or heroin- and cue-induced reinstatement. However, both groups became more impulsive as heroin self-administration continued. During abstinence, impulsivity levels returned towards baseline (pre-heroin) levels. Our results indicate that, in contrast to psychostimulants, impulsive choice does not predict vulnerability to heroin seeking and taking. CONCLUSION: These data implicate that different neural mechanisms may underlie the vulnerability to opiate and psychostimulant dependence. Moreover, our data suggest that elevated impulsivity levels as observed in heroin-dependent subjects are a consequence of heroin intake rather than a pre-existing vulnerability trait.
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The relation between impulsive choice and acquisition of self-administration has been inconsistently replicated with other drugs of abuse.
“This finding has been inconsistently replicated, however, with other drugs of abuse”
From Changing Delay Discounting and Impulsive Choice: Implications for Addictions, Prevention, and Human Health (2019) · cites this paper as Schippers et al., 2012
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- Authors
- Schippers, M. C., Binnekade, R., Schoffelmeer, A. N. M., Pattij, T., & De Vries, T. J.
- Affiliations
- Amsterdam Neuroscience (NL)
- Corresponding author
- Pattij, Tommy
- Venue
- Psychopharmacology
- Published
- 2011-09-02
- Volume
- 219
- Issue
- 2
- Pages
- 443-452
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC3249213
- OpenAlex
- W2139302013
- Cited by
- 67
- References
- 53
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 8 · 2018: 6 · 2017: 3 · 2016: 7 · 2015: 1 · 2014: 12 · 2013: 9 · 2012: 4
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Psychopharmacology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- ZonMw (31160204)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- heroin self-administration, impulsivity, impulsive choice, heroin addiction, drug-seeking behavior, reinstatement, extinction, abstinence, individual differences, opioid use disorder, stimulant use disorder, rats
- MeSH terms
- Animals, Choice Behavior, Cues, Decision Making, Heroin, Extinction, Psychological, Impulsive Behavior, Male, Reward, Self Administration, Rats, Wistar, Rats, Drug-Seeking Behavior
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