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The Th1/Th2 paradigm: still important in pregnancy?
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1 retracted
Pregnancy-Associated Exosomes and Their Modulation of T Cell Signaling
Taylor, D. D., Akyol, S., & Gercel-Taylor, C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1534 · Cited by 297
RetractedWegmann, T. G., Lin, H., Guilbert, L., & Mosmann, T. R. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90235-d · Cited by 2,852
Kadowaki, N., Ho, S., Antonenko, S., de Waal Malefyt, R., Kastelein, R. A., Bazan, F., & Liu, Y.-J. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.863 · Cited by 1,964
Research works printed but not linked: 173
- Chaouat G, Assal Meliani A, Martal J, Raghupathy R, Elliot J, Mossmann T, Wegmann TG (1995) IL-10 prevents inflammatory cytokine-mediated fetal death and is inducible by tau interferon. J Immunol 152:2411–2420
- Moffett A, Loke C (2006) Immunology of placentation in eutherian mammals. Nat Rev Immunol 6:584–594 · DOI · Paper page
- Boyson JE, Iwanaga KK, Golos TG, Watkins DI (1997) Identification of a novel MHC class I gene, Mamu-AG, expressed in the placenta of a primate with an inactivated G locus. J Immunol 159(7):3311–3321 · doi:10.4049/jimmunol.159.7.3311
- Vaidya SV, Mathew PA (2006) Of mice and men: different functions of the murine and human 2B4 (CD244) receptor on NK cells. Immunol Lett 15 105(2):180–184 · doi:10.1016/j.imlet.2006.02.006
- Robillard PY, Dekker G, Chaouat G, Chaline J, Hulsey TC (2007) Possible role of eclampsia preeclampsia in the evolution of human reproduction. Evol Med. (in press)
- Hiby SE, Walker JJ, O’shaughnessy KM, Redman CW, Carrington M, Trowsdale J, Moffett A (2004) Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J Exp Med 200(8):957–965 · DOI · Paper page
- Allen WR, Kydd JH, Antzack DF (1986) Successful application of immunotherapy to a model of pregnancy failure in equids. In: Clark DA, Croy BA (eds) Reproductive immunology. Elsevier, pp 253–261
- Redline RW, Lu CY (1988) Specific defects in the anti listerial immune response in discrete regions of the murine uterus and placenta account for the susceptibility to infection. J Immunol 140:3497–4005 · doi:10.4049/jimmunol.140.11.3947
- Roth I, Corry DB, Locksley RM, Abrams JS, Litton MJ, Fisher SJ (1996) Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10. J Exp Med 184(2):539–548 · DOI · Paper page
- Kaliss N, Dagg MK (1964) Immune responses engendered in mice by multiparity. Transplantation 84:416–425 · doi:10.1097/00007890-196405000-00011
- Chaouat G, Voisin GA, Daeron M, Kanellopoulos J (1977) Enhancing antibodies and suppressive cells in maternal anti-fetal immune reaction. Ann Immunol (Paris) 128(1–2):21–24
- Bell SC, Billington WD (1983) Anti-fetal allo-antibody in the pregnant female. Immunol Rev 75:5–30 · doi:10.1111/j.1600-065x.1983.tb01089.x
- Dorman PJ, Searle RF (1988) Alloantigen presenting capacity of human decidual tissue. J Reprod Immunol 13(2):101–112; Jul · doi:10.1016/0165-0378(88)90054-x
- Matthews CJ, Searle RF (1988) Antigen presenting capacity of murine decidual tissue in vivo. J Reprod Immunol 12(4):287–295 · doi:10.1016/0165-0378(88)90014-9
- Athanassakis-Vassiliadis I, Thanos D, Papamatheakis J (1989) Induction of class II major histocompatibility complex antigens in murine placenta by 5-azacytidine and interferon-gamma involves different cell populations. Eur J Immunol 2341–2348 · DOI
- Ranella A, Vassiliadis S, Mastora C, Valentina M, Dionyssopoulou E, Athanassakis I (2005) Constitutive intracellular expression of human leukocyte antigen (HLA)-DO and HLA-DR but not HLA-DM in trophoblast cells. Hum Immunol 66(1):43–55 · doi:10.1016/j.humimm.2004.10.002
- Voisin GA, Chaouat G (1974) Demonstration, nature and properties of antibodies eluted from the placenta and directed against paternal antigens. J Reprod Fertil Suppl 21:89–108
- Wegman TG, Mossman TR, Carlson G, Oling O, Singh B (1979) The ability of the murine placenta to absorb monoclonal anti fetal H-2 K antibody from the maternal circulation. J Immunol 122:270–277 · doi:10.4049/jimmunol.122.1.270
- Singh B, Raghupathy R, Anderson DJ, Wegman TG (1983) The murine placenta as an immunological barrier between the mother and the fetus. In: Wegmann TG, Gill TJ III (eds) Immunology of reproduction (1st Banff conference). Oxford University Press, New York, pp 229–251
- Drake BL, Head JR (1989) Murine trophoblast cells can be killed by allospecific cytototoxic T lymphocytes generated in Gibco OPTI MEM medium. J Reprod Immunol 15:71–77 · doi:10.1016/0165-0378(89)90045-4
- Ellis SA, Sargent IL, Redman CW, McMichael AJ (1986) HLA-G: evidence for a novel HLA antigen found on human extravillous trophoblast and a choriocarcinoma cell line. Immunology 4:595–601
- Geraghty DE, Koller BH, Orr HT (1987) A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment. Proc Natl Acad Sci USA 24:9145–9149 · DOI · Paper page
- King A, Boocock C, Sharkey AM, Gardner L, Beretta A, Siccardi AG, Loke YW (1996) Evidence for the expression of HLA A-C class I mRNA and protein by human first trimester trophoblast. J Immunol 156(6):2068–2076 · DOI · Paper page
- Bianchi DW, Flint AF, Pizzimenti MF, Knoll JH, Latt SA (1990) Isolation of fetal DNA from nucleated erythrocytes in maternal blood. Proc Natl Acad Sci USA 87(9):3279–3283 · DOI · Paper page
- Smith RN, Sternlicht M (1982) The alloantibody response in the allogeneically pregnant rat. III. The location of the alloantibody-forming cells. J Immunol 29(2):783–786 · doi:10.4049/jimmunol.129.2.783
- Beer AE, Scott JR, Billingham RE (1975) Histoincompatibility and maternal immunological status as determinants of fetoplacental weight and litter size in rodents. J Exp Med 142(1):180–196 · doi:10.1084/jem.142.1.180
- Chaouat G, Voisin GA, Escalier D, Robert P (1979) Facilitation reaction (enhancing antibodies and suppressor cells) and rejection reaction (sensitized cells) from the mother to the paternal antigens of the conceptus. Clin Exp Immunol 35:13–24
- Smith RN, Powell AE (1977) The adoptive transfer of pregnancy-induced unresponsiveness to male skin grafts with thymus-dependent cells. J Exp Med 146:899–904 · doi:10.1084/jem.146.3.899
- Simpson E, Chandler P, Pole D (1981) A model of T-cell unresponsiveness using the male-specific antigen, H-Y. Cell Immunol 2:251–257 · doi:10.1016/0008-8749(81)90323-3
- Engleman EG, McMichael AJ, McDevitt HO (1978) Suppression of the mixed lymphocyte reaction in man by a soluble T-cell factor. Specificity of the factor for both responder and stimulator. J Exp Med 1 147(4):1037–1043 · doi:10.1084/jem.147.4.1037
- Monnot P, Chaouat G (1984) Systemic active suppression is not necessary for successful allopregnancy. Am J Reprod Immunol 6:5–8 · doi:10.1111/j.1600-0897.1984.tb00100.x
- Clark DA, McDermott MR, Szewczuk MR (1980) Impairment of host-versus-graft reaction in pregnant mice. II. Selective suppression of cytotoxic T-cell generation correlates with soluble suppressor activity and with successful allogeneic pregnancy. Cell Immunol 1:106–118 · doi:10.1016/0008-8749(80)90404-9
- Chaouat G, Kolb JP, Wegmann TG (1983) The murine placenta as an immunological barrier between the mother and the foetus. Immunol Rev iews 75:29–60 · doi:10.1111/j.1600-065x.1983.tb01090.x
- Volumenie JL, Mognetti B, de Smedt D, Menu E, Chaouat G (1997) Induction of transient murine T cell anergy by a low molecular weight compound obtained from supernatants of human placental cultures is linked to defective phosphorylation of TCR CD3 chain. Am J Reprod Immunol 38(3):168–175 · doi:10.1111/j.1600-0897.1997.tb00294.x
- Kvirkvelia N, Vojnovic I, Warner TD, Athie-Morales V, Free P, Rayment N, Chain BM, Rademacher TW, Lund T, Roitt IM, Delves PJ (2002) Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells. Clin Exp Immunol 127/2:263–269 · DOI
- Clark DA, Flanders KC, Hirte H, Dasch JR, Coker R, McAnulty RJ, Laurent GJ (1995) Characterization of murine pregnancy decidua transforming growth factor beta. I. Transforming growth factor beta 2-like molecules of unusual molecular size released in bioactive form. Biol Reprod 6:1380–1388 · doi:10.1095/biolreprod52.6.1380
- Chaouat G, Kiger N, Wegmann TG (1983) Vaccination against spontaneous abortion in mice. J Reprod Immunol 8:389–394 · doi:10.1016/0165-0378(83)90248-6
- Chaouat G, Kolb JP, Kiger N, Stanislawski M, Wegmann TG (1985) Immunological concomitants of vaccination against abortion in mice. J Immunol 134:1594–1598 · DOI
- Chaouat G, Clark DA, Wegmann TG (1988) Genetics aspects of the CBA/J DBA/2 J and B10 B10.A models of murine spontaneous abortions and prevention by leukocyte immunisation. In:18th R.C.O.G. study group. Early Pregnancy loss. Mechanisms and treatment. Allen WR, Clark DA, Gill TJ III, Mowbray JF, Robertson WF RCOG London, pp 89–105 · doi:10.1007/978-1-4471-1658-5_10
- Baines MG, Gendron RL (1993) Natural and experimental animal models of reproductive failure. In: Chaouat G (ed) Immunology of pregnancy. CRC, Boca Raton, pp 173–203
- Chaouat G, Kiger N, Chaouat G, Kolb JP, Wegmann TG, Guenet JL (1985) Immunogenetic studies of spontaneous abortion in mice. I. Preimmunisation of the mother with allogeneic spleen cells. J Immunol 134:2966–2972 · DOI
- Schumacher A, Wollenberg I, Zambon Bertoja AC, Thure C, Gerlof K, Zenclussen ML, Sollwedel A, Leber J, Wafula P, Volk HD, Zenclussen AC (2006) Pregnancy-protective regulatory T cells act in an antigen-specific manner. Am J Reprod Immunol 56:7 · doi:10.1111/j.1600-0897.2006.00406.x
- Wegmann TG (1984) Fetal protection against abortion: is it immuno suppression or immuno stimulation? Ann Immuno. Inst Pasteur 135D:309–311 · DOI
- Szekeres-Bartho J, Wegmann TG (1996) A progesterone-dependent immunomodulatory protein alters the Th1/Th2 balance. J Reprod Immunol 31(1-2):81–95 · DOI · Paper page
- Athanassakis I, Bleackley RC, Paetkau V, Guibert LL, Barrp J, Wegmann TG (1987) The immunostimulatory effects of T cells and T cell lymphokines on murine fetally derived placental cells. J Immunol 138:37–44 · DOI · Paper page
- Chaouat G, Menu E, Dy M, Minkowski M, Clark DA, Wegmann TG (1990) Control of fetal survival in CBA × DBA/2 mice by lymphokine therapy. J Fertil Steril 89:447–458
- Pollard JW (1997) Role of colony-stimulating factor-1 in reproduction and development. Mol Reprod Dev 46(1):54–60 · DOI
- Robertson SA, Mau VJ, Hudson SN, Tremellen KP (1997) Cytokine leukocyte networks and the establishment of pregnancy. Am J Reprod Immunol 37:438–443 · DOI · Paper page
- Tangri S, Raghupathy R (1993) Expression of cytokines in placenta of mice undergoing immunologically mediated fetal resorption. Biol Reprod 49:840–850 · DOI
- Tangri S, Wegmann TG, Lin H, Raghupathy R (1994) Maternal anti-placental activity in natural, immunologically mediated foetal resorption. J Immunol 152:4903–4910 · DOI
- Lin H, Mossmann TR, Guibert L, Tuntipopat S, Wegmann TG (1993) Synthesis of T helper-2 cytokines at the maternal fetal interface. J Immunol 151:4562–4573 · DOI · Paper page
- Delassus S, Couthino A, Saucier C, Darche S, Kourilsky P (1994) Differential cytokine expression in maternal blood and placenta during murine gestation. J Immunol 152:2411–2420 · DOI · Paper page
- Krishnan Guilbert LJ, Russell AS, Wegmann TG, Mosmann TR, Belosevic M (1996) Pregnancy impairs resistance of C57Bl/6 mice to Leishmania major infection and causes decreased antigen-specific IFN-γ response and increased production of T helper 2 cytokines. J Immunol 156:644–653 · DOI · Paper page
- Krishnan L, Guilbert LJ, Wegmann TG, Belosevic M, Mossman TR (1996) Helper 1 response against Leishmania major in pregnant C57BL/6 mice increases implantation failure and fetal resorption: correlation with increased IFN-γ and TNF and reduced IL-10 production by placental cells. J Immunol 156:653–662 · DOI · Paper page
- Buendia A, Fallon PG, Del Rio L, Ortega N, Caro MR, Gallego MC, Salinas J (2002) Previous infection with the nematode Nippostrongylus brasiliensis alters the immune specific response against Chlamydophila abortus infection. Microb Pathog 33/1:7–15 · DOI
- Kinsky R, Delage G, Rosin N, Thang MN, Hoffman M, Chaouat G (1990) A murine model of NK mediated fetal resorption. Am J Reprod Immunol 123(3):73–78 · DOI
- Clark DA, Chaouat G, Arck PC, Mittruecker HW, Levy GA (1998) Cytokine dependent abortion in CBA DBA/2 mice is mediated by the procoagulant fgl/2 prothrombinase. J Immunol 160(2):550–555 · DOI · Paper page
- Brunda MJ (1994) Interleukin-12. J Leukoc Biol 55(2):280–288 · DOI · Paper page
- Zurawski G, de Vries JE (1994) Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol Today 15(1):19–26 · DOI · Paper page
- Zourbas S, Dubanchet S, Martal J, Chaouat G (2001) Localization of pro-inflammatory (IL-12, IL-15) and anti-inflammatory (IL-11, IL-13) cytokines at the feto maternal interface during murine pregnancy. Clin Exp Immunol 126(3):519–528 · DOI
- Ostojic S, Dubanchet S, Mjihdi A, Truyens C, Capron F, Chaouat G (2003) Demonstration of the presence of IL-16, IL-17 and IL-18 at the murine fetomaternal interface during murine pregnancy. Am J Reprod Immunol 49:101–113 · DOI
- Kapsenberg ML, Hilkens CM, Wierenga EA, Kalinski P (1999) The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy. Clin Exp Allergy Suppl 2:33–36 · DOI
- Arpinati M, Green CL, Heimfeld S, Heuser JE, Anasetti C (2000) Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells. Blood 95(8):2484–2490 · DOI · Paper page
- Tsuda H, Sakai M, Michimata T, Tanebe K, Hayakawa S, Saito S (2001) Characterization of NKT cells in human peripheral blood and decidual lymphocytes. Am J Reprod Immunol 45(5):295–302 · doi:10.1111/j.8755-8920.2001.450505.x
- Bendelac A, Schwartz RH (1991) Th0 cells in the thymus: the question of T-helper lineages. Immunol Rev 123:169–188 · DOI
- Mitchison A, Sieper J (1995) Immunological basis of oral tolerance. Z Rheumatol 54(3):141–144
- Bach JF (2001) Non-Th2 regulatory T-cell control of Th1 autoimmunity. Scand J Immunol 1–2:21–29 · DOI
- Raghupathy R (2001) Pregnancy: success and failure within the Th1/Th2/Th3 paradigm. Semin Immunol 13(4):219–227 · DOI · Paper page
- Saito S, Tsukaguchi N, Hasegawa T, Michimata T, Tsuda H, Narita N (1999) Distribution of Th1, Th2, and Th0 and the Th1/Th2 cell ratios in human peripheral and endometrial T cells. Am J Reprod Immunol 42(4):240–245 · DOI
- Nagaeva O, Jonsson L, Mincheva-Nilsson L (2002) Dominant IL-10 and TGF-beta mRNA expression in gamma delta T cells of human early pregnancy decidua suggests immunoregulatory potential. Am J Reprod Immunol 48(1):9–17 · DOI · Paper page
- Sanford TR, De M, Wood G (1992) Expression of colony stimulating factors and inflammatory cytokines in the uterus if CD1 mice during days 1 to days 3 of pregnancy. J Reprod Fertil 94(1):213–220 · DOI
- Mac Master MT, Newton RC, Dey SK, Andrews GK (1992) Activation and distribution of inflammatory cells in the mouse uterus during the preimplantation period. J Immunol 148:1699–1705 · DOI · Paper page
- Head JR, Billingham RE (1981) Immunobiological aspects of the feto maternal relationship. In: Lachman P, Peters D (eds) Clinical aspects of Immunology. Blackwell Scientific, Oxford
- Hogarth PJ (1982) Immunological aspects of mammalian reproduction. Blackie, Glasgow · doi:10.1007/978-94-011-6859-5
- Claman HN (1993) Immunology of human pregnancy. Humana, Totowa, NJ · DOI
- Woodruff M (1985) The immunology of host–tumour relationships. Nature 317(6038):582 · doi:10.1038/317582a0
- El-Roeiy A, Shoenfeld Y (1985) Autoimmunity and pregnancy. Am J Reprod Immunol Microbiol 9(1):25–32 · DOI
- Draca S (2002) Is pregnancy a model how we should control some autoimmune diseases? Autoimmunity 35(5):307–312 · DOI
- Ostensen M, Villiger PM (2002) Immunology of pregnancy–pregnancy as a remission inducing agent in rheumatoid arthritis. Transpl Immunol 2–4:155–160 · DOI
- Furukawa K, Itoh K, Okamura K, Kumagai K, Suzuki M (1984) Changes in NK cell activity during the estrous cycle and pregnancy in mice. J Reprod Immunol 6:353–363 · doi:10.1016/0165-0378(84)90045-7
- Loke YW, King A (1995) Human implantation. Cell Biology and Immunology. Cambridge University Press · DOI
- Clarke AG (1979) Pregnancy-induced involution of the thymus can be prevented by immunizing with paternal skin grafts: a strain-dependent effect. Clin Exp Immunol 35(3):421–424
- Maroni ES, de Sousa MA (1973) The lymphoid organs during pregnancy in the mouse. A comparison between a syngeneic and an allogeneic mating. Clin Exp Immunol 13(1):107–124
- Adelstein S, Pritchard-Briscoe H, Loblay RH, Basten A (1990) Suppressor T-cell memory. Curr Top Microbiol Immunol 159:123–138
- Tafuri A, Alferink J, Moller P, Hammerling GJ, Arnold B (1995) T cell awareness of paternal alloantigens during pregnancy. Science 270(5236):630–633 · DOI · Paper page
- Jiang SP, Vacchio MS (1998) Multiple mechanisms of peripheral T cell tolerance to the foetal ‘allograft’. J Immunol 160:3086–3090 · DOI · Paper page
- Eblen AC, Gercel-Taylor C, Nakajima ST, Taylor DD (2002) Modulation of T-cell CD3-zeta chain expression in early pregnancy. Am J Reprod Immunol 47(3):167–173 · doi:10.1034/j.1600-0897.2002.1o050.x
- Vacchio MS, Hodes RJ (2005) Fetal expression of Fas ligand is necessary and sufficient for induction of CD8 T cell tolerance to the fetal antigen H-Y during pregnancy. J Immunol 174(8):4657–4661 · DOI
- Hunt JS, Vasmer D, Ferguson TA, Miller L (1997) Fas ligand is positioned in mouse uterus and placenta to prevent trafficking of activated leukocytes between the mother and the conceptus. J Immunol 158:4122–4128 · DOI · Paper page
- Uckan D, Steele A, Chery BY, Chamizo W, Koutsonikolos A, Gilbert-Barnes E, Good RA (1997) Trophoblasts express Fas ligand. A proposed mechanism for immune privilege in placenta and maternal invasion. Mol Hum Reprod 3:655–662 · DOI · Paper page
- Chaouat G, Clark DA (2001) FAS/FAS ligand interaction at the placental interface is not required for the success of allogeneic pregnancy in anti-paternal MHC preimmunized mice. Am J Reprod Immunol 2:108–115 · DOI
- Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B, Brown C, Mellor AL (1998) Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 281(5380):1191–1993 · DOI · Paper page
- Clark DA, Blois S, Kandil J, Handjiski B, Manuel J, Arck PC (2005) Reduced uterine indoleamine 2,3-dioxygenase versus increased Th1/Th2 cytokine ratios as a basis for occult and clinical pregnancy failure in mice and humans. Am J Reprod Immunol 54(4):203–216 · DOI
- Comiskey M, Goldstein CY, De Fazio SR, Mammolenti M, Newmark JA, Warner CM (2003) Evidence that HLA-G is the functional homolog of mouse Qa-2, the Ped gene product. Hum Immunol 64(11):999–1004 · doi:10.1016/j.humimm.2003.08.352
- Roth I, Corry DB, Locksley RM, Anrams JS, Litton MJ, Fisher SJ (1996) Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10. J Exp Med 184:539–548 · DOI · Paper page
- Hill JA (1995) T helper 1 immunity to trophoblast: evidence for a new immunological mechanism for recurrent abortion in women. Hum Reprod 10:114–120 · DOI
- Tranchot Diallo J, Gras G, Parnet Mathieru F, Benveniste O, Marcé D, Roques P, Milliez J, Chaouat G, Dormont D (1996) Modulation of cytokine expression in pregnant women. Am J Reprod Immunol 37/3:215–227
- Raghupathy R, Makhseed M, Azizieh F, Hassan N, Al-Azemi M, Al-Shamali E (1999) Maternal Th1-and Th2-type reactivity to placental antigens in normal human pregnancy and unexplained recurrent spontaneous abortions. Cell Immunol 196/2:122–130 · DOI · Paper page
- Jenkins C, Roberts J, Wilson R, MacLean MA, Shilito J, Walker JJ (2000) Evidence of a T(H) 1 type response associated with recurrent miscarriage. Fertil Steril 73:1206–1208 · DOI · Paper page
- Piccinni MP, Scaletti C, Vultaggio A, Maggi E, Romagnani S (2001) Defective production of LIF, M-CSF and Th2-type cytokines by T cells at fetomaternal interface is associated with pregnancy loss. J Reprod Immunol 52/1–2:35–43 · DOI
- Stewart C, Kaspar P, Brunet LJ, Bhatt H, Gadi I, Köntgen F, Abbondanzo S (1992) Blastocyst implantation depends on maternal expression of leukemia inhibitory factor. Nature 359:76–79 · DOI · Paper page
- Delage G, Moreau J-F, Taupin J-L, Freitas S, Hambartsoumian E, Olivennes F, Fanchin R, Letut-Körnish H, Fydman R, Chaouat G (1995) In vitro endometrial secretion of human interleukin for DA cells/leukaemia inhibitory factor by explant cultures from fertile and infertile women. Hum Reprod 10:2483–2488 · doi:10.1093/oxfordjournals.humrep.a136328
- Laird SM, Tuckerman EM, Dalton CF, Dunphy BC, LiI TC, Zhang X (1997) The production of leukemia inhibitory factor by human endometrium: presence in uterine flushings and production by cells in culture. Hum Reprod 12:569–574 · DOI · Paper page
- Giess R, Tanasescu I, Steck T, Sendtner M (1999) Leukaemia inhibitory factor gene mutations in infertile women. Mol Hum Reprod 6:581–586 · DOI
- Laird SM, Tuckerman EM, Li TC (2006) Cytokine expression in the endometrium of women with implantation failure and recurrent miscarriage. Reprod Biomed Online 1:13–23 · DOI
- Ntrivalas EI, Kwak-Kim JY, Gilman-Sachs A, Chung-Bang H, Ng SC, Beaman KD, Mantouvalos HP, Beer AE (2001) Status of peripheral blood natural killer cells in women with recurrent spontaneous abortions and infertility of unknown aetiology. Hum Reprod 16:855–861 · DOI · Paper page
- Kwak-Kim JY, Chung-Bang HS, Ng SC, Ntrivalas EI, Mangubat CP, Beaman KD, Beer AE, Gilman-Sachs A (2003) Increased T helper 1 cytokine responses by circulating T cells are present in women with recurrent pregnancy losses and in infertile women with multiple implantation failures after IVF. Hum Reprod 18:767–773 · DOI · Paper page
- Ng SC, Gilman-Sachs A, Thaker P, Beaman KD, Beer AE, Kwak-Kim J (2002) Expression of intracellular Th1 and Th2 cytokines in women with recurrent spontaneous abortion, implantation failures after IVF/ET or normal pregnancy. Am J Reprod Immunol 48/2:77–86
- Saito S, Umekage H, Sakamoto Y, Sakai M, Tanebe K, Sasaki Y, Morikawa H (1999) Increased T-helper-1-type immunity and decreased T-helper-2-type immunity in patients with preeclampsia. Am J Reprod Immunol 41/5:297–306 · DOI · Paper page
- Dong M, He J, Wang Z, Xie X, Wang H (2005) Placental imbalance of Th1- and Th2-type cytokines in preeclampsia. Acta Obstet Gynecol Scand 84(8):788–793 · DOI
- Azizieh F, Raghupathy R, Makhseed M (2005) Maternal cytokine production patterns in women with pre-eclampsia. Am J Reprod Immunol 54(1):30–37 · DOI
- Darmochwal-Kolarz D, Leszczynska-Gorzelak B, Rolinski J, Oleszczuk J (1999) T helper 1- and T helper 2-type cytokine imbalance in pregnant women with pre-eclampsia. Eur J Obstet Gynecol Reprod Biol 86(2):165–170 · DOI
- Kelsö A (1995) Th1 and Th2 subsets: paradigms lost? Immunol Today 16:374–379 · DOI · Paper page
- Allen JE, Maizels RM (1997) Th1–Th2: reliable paradigm or dangerous dogma? Immunol Today 18:387–389 · DOI · Paper page
- Vince GS, Johnson PM (1996) Is there a Th2 bias in human pregnancy? J Reprod Immunol 32/2:101–104 · DOI
- Dosiou C, Giudice LC (2005) Natural killer cells in pregnancy and recurrent pregnancy loss: endocrine and immunologic perspectives. Endocr Rev 26(1):44–62 · DOI · Paper page
- Moffett A, Regan L, Braude P (2004) Natural killer cells, miscarriage, and infertility. Br Med J (BMJ) 329(7477):1283–1285 · DOI
- Hess AP, Dosiou C, Hamilton AE, Talbi S, Nyegaard M, Nayak N, Genbecev-Krtolica O, Mavrogianis P, Ferrer K, Kruessel J, Fazleabas AT, Fisher SJ, Giudice LC (2007) Decidual stromal cell response to paracrine signals from the trophoblast: amplification of immune and angiogenic modulators. Biol Reprod 76(1):102–117 · DOI · Paper page
- Mohamed OA, Jonnaert M, Labelle-Dumais C, Kuroda K, Clarke HJ, Dufort D (2005) Uterine Wnt/beta-catenin signaling is required for implantation. Proc Natl Acad Sci USA 102(24):8579–8584 · DOI · Paper page
- Sengupta J, Lalitkumar PG, Najwa AR, Ghosh D (2006) Monoclonal anti-leukemia inhibitory factor antibody inhibits blastocyst implantation in the rhesus monkey. Contraception 74(5):419–425 · DOI
- Kralickova M, Sima R, Vanecek T, Sima P, Rokyta Z, Ulcova-Gallova Z, Sucha R, Uher P, Hes O (2006) Leukemia inhibitory factor gene mutations in the population of infertile women are not restricted to nulligravid patients. Eur J Obstet Gynecol Reprod Biol 127(2):231–235 · DOI
- Takamoto N, Kurihara I, Lee K, Demayo FJ, Tsai MJ, Tsai SY (2005) Haploinsufficiency of chicken ovalbumin upstream promoter transcription factor II in female reproduction. Mol Endocrinol 19(9):2299–2308 · DOI
- Bilinski P, Roopenian D, Gossler A (1998) Maternal IL-11R alpha function is required for normal decidua and fetoplacental development in mice. Genes Dev 12:2234–2243 · DOI · Paper page
- Robb L, Li R, Hartley L, Nandurkar H, Koetgen F, Begley CG (1998) Infertility in female mice lacking the receptor for interleukin-11 is due to a defective uterine response to implantation. Nat Med 4:303–308 · DOI · Paper page
- White CA, Robb L, Salamonsen LA (2004) Uterine extracellular matrix components are altered during defective decidualization in interleukin-11 receptor alpha deficient mice. Reprod Biol Endocrinol 2004 10:2:76
- Ain R, Trinh ML, Soares MJ (2004) Interleukin-11 signaling is required for the differentiation of natural killer cells at the maternal–fetal interface. Dev Dyn 231(4):700–708 · DOI
- Pollard JW, Hunt JW, Wiktor Jedrzejczack W, Stanley ER (1991) A pregnancy defect in the osteopetrotic (op/op) mouse demonstrates the requirement for CSF-1 in female fertility. Dev Biol 148:273–283 · DOI · Paper page
- Cohen PE, Chisholm O, Arceci RJ, Stanley ER, Pollard JW (1996) Abscence of CSF1 in osteopetrotic (csfmop/csfmop) mice results in male fertility defects. Biol Reprod 55:310–317 · DOI
- Makrigiannakis A, Minas V, Kalantaridou SN, Nikas G, Chrousos GP (2006) Hormonal and cytokine regulation of early implantation. Trends Endocrinol Metab 17(5):178–185 · DOI
- Simon C, Frances A, Piquette GN, Danasouri IE, Zurawski G, Dang W, Polan ML (1994) IL-1 receptor antagonist prevents successful implantation in mice. Endocrinology 134:521–528 · doi:10.1210/endo.134.2.8299552 · Paper page
- Simon C, Mercader A, Gimeno MJ, Pellicer A (1997) The interleukin 1 system and human implantation. Am J Reprod Immunol 37/1:64–72 · DOI
- Abbondanzo SJ, Cullinan EB, McIntyre K, Labow MA, Stewart CL (1996) Reproduction in mice lacking a functional type 1 IL-1 receptor. Endocrinology 137:3598–3601 · doi:10.1210/endo.137.8.8754793
- Paulesu L, Romagnoli R, Bigliardi E (2005) Materno–fetal immunotolerance: is interleukin-1 a fundamental mediator in placental viviparity? Dev Comp Immunol 29(5):409–415 · DOI
- Mas A E, Dubanchet S, Fay S, Ledée N, Chaouat G (2006) Immune regulation at the interface during early steps of murine implantation: involvement of new IL-12 family cytokines (IL-23 and IL-27) and TWEAK. Submitted for publication and presentation at the Banff JRI/Elsevier conference on Reproductive Immunology. Banff. November 15–18 2006
- Clark DA, Chaouat G (2005) Loss of surface CD200 on stored allogeneic leukocytes may impair anti-abortive effect in vivo. Am J Reprod Immunol 53(1):13–20 · doi:10.1111/j.1600-0897.2005.00240.x
- Somigliana E, Vigano P, Rossi G, Carinelli S, Vignali M, Panina-Bordignon P (1999) Endometrial ability to implant in ectopic sites can be prevented by interleukin-12 in a murine model of endometriosis. Hum Reprod 12:2944–2950 · DOI · Paper page
- Svensson L, Arvola M, Sallstrom MA, Holmdahl R, Mattsson R (2001) The Th2 cytokines IL-4 and IL-10 are not crucial for the completion of allogeneic pregnancy in mice. J Reprod Immunol 51(1):3–7 · DOI
- Fallon PG, Jolin HE, Smith P, Emson CL, Townsend MJ, Fallon R, Smith P, Mc Kenzie AN (2002) IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13. Immunity 17(1):7–17 · DOI · Paper page
- White CA, Johansson M, Roberts CT, Ramsay AJ, Robertson SA (2004) Effect of interleukin-10 null mutation on maternal immune response and reproductive outcome in mice. Biol Reprod 70(1):123–131 · DOI
- Robertson SA, Skinner RJ, Care AS (2006) Essential role for IL-10 in resistance to lipopolysaccharide-induced preterm labor in mice. J Immunol 177(7):4888–4896 · DOI · Paper page
- Guimond MJ, Wang B, Croy BA (1998) Engraftment of bone marrow from severe combined immunodeficiency (SCID) mice reverses the reproductive deficit in natural killer cells deficient TgE26 mice. J Exp Med 187:217–223 · DOI · Paper page
- Barber EM, Pollard JW (2003) The uterine NK cell population requires IL-15 but these cells are not required for pregnancy nor the resolution of a Listeria monocytogenes infection. J Immunol 171/1:37–46 · DOI · Paper page
- Miyazaki S, Tanebe K, Sakai M, Michimata T, Tsuda H, Fujimura M, Nakamura M, Kiso Y, Saito S (2002) Interleukin 2 receptor gamma chain (gamma(c)) knockout mice show less regularity in estrous cycle but achieve normal pregnancy without fetal compromise. Am J Reprod Immunol 47/4:222–230 · doi:10.1034/j.1600-0897.2002.01074.x
- Ashkar AA, Black GP, Wei Q, He H, Liang L, Head JR, Croy BA (2003) Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy. J Immunol 171(6):2937–2944 · DOI · Paper page
- Leonard S, Murrant C, Tayade C, van den Heuvel M, Watering R, Croy BA (2006) Mechanisms regulating immune cell contributions to spiral artery modification—facts and hypotheses—a review. Placenta Suppl A:S40–S46 · DOI
- Li XF, Charnock-Jones DS, Zhang E, Hiby S, Malik S, Day K, Licence D, Bowen JM, Gardner L, King A, Loke YW, Smith SK (2001) Angiogenic growth factor messenger ribonucleic acids in uterine natural killer cells. J Clin Endocrinol Metab 86(4):1823–1834
- Lash GE, Schiessl B, Kirkley M, Innes BA, Cooper A, Searle RF, Robson SC, Bulmer JN (2006) Expression of angiogenic growth factors by uterine natural killer cells during early pregnancy. J Leukoc Biol 80(3):572–580 · DOI · Paper page
- Xie X, He H, Colonna M, Seya T, Takai T, Croy BA (2005) Pathways participating in activation of mouse uterine natural killer cells during pregnancy. Biol Reprod 73(3):510–518 · doi:10.1095/biolreprod.104.033951
- Sacks GP, Redman CW, Sargent IL (2003) Monocytes are primed to produce the Th1 type cytokine IL-12 in normal human pregnancy: an intracellular flow cytometric analysis of peripheral blood mononuclear cells. Clin Exp Immunol 131:490–497 · DOI
- Zenclussen AC, Fest S, Busse P, Joachim R, Klapp BF, Arck PC (2002) Questioning the Th1/Th2 paradigm in reproduction: peripheral levels of IL-12 are down-regulated in miscarriage patients. Am J Reprod Immunol 48/4:245–251 · DOI
- Ledee-Bataille N, Bonnet-Chea K, Hosny G, Dubanchet S, Frydman R, Chaouat G (2005) Role of the endometrial tripod interleukin-18, -15, and -12 in inadequate uterine receptivity in patients with a history of repeated in vitro fertilization-embryo transfer failure. Fertil Steril 83(3):598–605 · DOI · Paper page
- Cohen M, Meisser A, Haenggeli L, Bischof P (2006) Involvement of MAPK pathway in TNF-alpha-induced MMP-9 expression in human trophoblastic cells. Mol Hum Reprod 12(4):225–232 · doi:10.1093/molehr/gal023
- Bell E (2006) TWEAK and TNF: Yin and Yang in innate immunity. Nat Rev Immunol 6:91 · doi:10.1038/nri1790
- Devergne O, Coulomb-L’Hermine A, Capel F, Moussa M, Capron F (2001) Expression of Epstein–Barr virus-induced gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy: involvement of syncytio trophoblasts and extra villous trophoblasts. Am J Pathol 159(5):1763–1776 · DOI
- Haddad EK, Duclos AJ, Baines MG (1995) Early embryo loss is associated with local production of nitric oxide by activated macrophages. J Exp Med 182:1143–1152 · DOI
- Jerzak M, Bischof P (2002) Apoptosis in the first trimester human placenta: the role in maintaining immune privilege at the maternal–foetal interface and in the trophoblast remodelling. Eur J Obstet Gynecol Reprod Biol 100(2):138–142 · DOI
- Girardi G, Yarilin D, Thurman JM, Holers VM, Salmon JE (2006) Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction. J Exp Med 203(9):2165–2175 · DOI · Paper page
- Paldi A (1991) Genomic imprinting and feto maternal relationship. In: Chaouat G (ed) Biologie cellulaire et moléculaire de la relation materno fetale. Colloque INSERM 254. INSERM John Libbey, Paris, pp 61–66
- Tartakovsky B, Ben-Yair E (1991) Cytokines modulate preimplantation development and pregnancy. Dev Biol 146(2):345–352 · DOI
- Du MR, Dong L, Zhou WH, Yan FT, Li DJ (2006) Cyclosporin A improves pregnant outcome by promoting functions of trophoblasts and inducing maternal tolerance to the allogeneic fetus. Biol Reprod 2007 Jan 17; (in press)
- Xu C, Mao D, Holmers M, Palanca B, Cheng AM, Molina H (2000) A critical role for complement regulatory Crry in feto maternal tolerance. Science 287:498–499 · DOI · Paper page
- Girardi G, Bulla R, Salmon JE, Tedesco F (2006) The complement system in the pathophysiology of pregnancy. Mol Immunol 43(1–2):68–77 · DOI · Paper page
- Berman J, Girardi G, Salmon JE (2005) TNF-alpha is a critical effector and a target for therapy in antiphospholipid antibody-induced pregnancy loss. J Immunol 174(1):485–490 · DOI · Paper page
- Holmes CH, Simpson KL, Wainwright SD, Tate CG, Houlihan JM, Sawyer JH, Roger IP, Spring FA, Amstee DJ, Tanner MJ (1990) Preferential expression of the complement regulatory protein decay accelerating factor at the foetomaternal interface during human pregnancy. J Immunol 144:3099–3115 · DOI
- Baban B, Chandler P, McCool D, Marshall B, Munn DH, Mellor AL (2004) Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific. J Reprod Immunol (2):67–77 · DOI · Paper page
- Lokki ML, Laitinen T (2001) Role of major histocompatibility complex class III genes in recurrent spontaneous abortions. Front Biosci 1(6):E23 · doi:10.2741/lokki
- Aluvihare VR, Kallikourdis M, Betz AG (2004) Regulatory T cells mediate maternal tolerance to the fetus. Nat Immunol 5:266–271 · DOI · Paper page
- Saito S, Sasaki Y, Sakai M (2005) CD4(+)CD25 high regulatory T cells in human pregnancy. J Reprod Immunol 65(2):111–120 · DOI · Paper page
- Zhang C, Zhang J, Tian Z (2006) The regulatory effect of natural killer cells: do “NK-reg cells” exist? Cell Mol Immunol 3(4):241–254
- Shao L, Jacobs AR, Johnson VV, Mayer L (2005) Activation of CD8+ regulatory T cells by human placental trophoblasts. J Immunol 174(12):7539–7547 · DOI
- Fourth International Workshop on Immunology of Pre-eclampsia, December 2004, Reunion, France. J Reprod Immunol 2005 67(1–2):103–111 · DOI
- Sargent IL, Borzychowski AM, Redman CW (2006) NK cells and human pregnancy—an inflammatory view. Trends Immunol 27(9):399–404 · DOI · Paper page
- Chaouat G (2003) Opinion: should we re-examine the status of lymphocyte allo-immunisation therapy for recurrent spontaneous abortion? Am J Reprod Immunol 50(6):433–438 · doi:10.1046/j.8755-8920.2003.00132.x
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Metadata
- Authors
- Chaouat, G.
- Venue
- Seminars in Immunopathology
- Published
- 2007-05-03
- Volume
- 29
- Issue
- 2
- Pages
- 95-113
- ISSN
- 1863-2297 (ISSN-L)
- 1863-2300
- OpenAlex
- W2014185316
- Cited by
- 232
- References
- 3
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- www.springer.com/tdm (vor)
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