Effects of pre-exercise feeding on serum hormone concentrations and biomarkers of myostatin and ubiquitin proteasome pathway activity

Dalbo, Vincent J.; Roberts, Michael D.; Hassell, Scott; Kerksick, Chad M.

doi:10.1007/s00394-012-0349-x

Cited by 35Muscle metabolism and nutritionMuscle Physiology and DisordersExercise and Physiological Responses

Effects of pre-exercise feeding on serum hormone concentrations and biomarkers of myostatin and ubiquitin proteasome pathway activity

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Dalbo, Vincent J., Roberts, Michael D., Hassell, Scott, Kerksick, Chad M.·2013·European Journal of Nutrition

DOI 10.1007/s00394-012-0349-x

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Abstract

Purpose The aim of the study was to examine the acute effects of pre-exercise ingestion of protein, carbohydrate, and a non-caloric placebo on serum concentrations of insulin and cortisol, and the intramuscular gene expression of myostatin- and ubiquitin proteasome pathway (UPP)-related genes following a bout of resistance exercise. Methods Ten untrained college-aged men participated in three resistance exercise sessions (3 × 10 at 80 % 1RM for bilateral hack squat, leg press, and leg extension) in a cross-over fashion, which were randomly preceded by protein, carbohydrate, or placebo ingestion 30 min prior to training. Pre-supplement/pre-exercise, 2 h and 6 h post-exercise muscle biopsies were obtained during each session and analyzed for mRNA fold changes in myostatin (MSTN), activin IIB, follistatin-like 3 (FSTL3), SMAD specific E3 ubiquitin protein ligase 1 (SMURF1), forkhead box O3, F-box protein 32 (FBXO32), and Muscle RING-finger protein-1, with beta-actin serving as the housekeeping gene. Gene expression of all genes was analyzed using real-time PCR. Results Acute feeding appeared to have no significant effect on myostatin or UPP biomarkers. However, resistance exercise resulted in a significant downregulation of MSTN and FBXO32 mRNA expression and a significant upregulation in FSTL3 and SMURF1 mRNA expression (p Conclusions An acute bout of resistance exercise results in acute post-exercise alterations in intramuscular mRNA expression of myostatin and UPP markers sug…

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Acute exercise significantly reduces skeletal muscle myostatin levels, and the extent of downregulation is positively correlated with exercise duration.
“Acute exercise significantly reduces skeletal muscle MSTN levels, and the extent of downregulation is positively correlated with exercise duration [58,59].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [58]
Exercise downregulates myostatin expression, with the magnitude of reduction depending on exercise mode, duration, and intensity.
“Exercise downregulates MSTN expression, with the magnitude of reduction depending on exercise mode, duration, and intensity.”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [58]

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Authors: Dalbo, V. J., Roberts, M. D., Hassell, S., & Kerksick, C. M.
Affiliations: Central Queensland University (AU)
University of Missouri (US)
University of Oklahoma (US)
Corresponding author: Dalbo, Vincent J.
ORCID: Dalbo, Vincent J.
Roberts, Michael D.
Kerksick, Chad M.
Venue: European Journal of Nutrition
Publisher: Springer Science and Business Media LLC
Published: 2012-04-05
Volume: 52
Issue: 2
Pages: 477-487
ISSN: 1436-6207 (ISSN-L)
1436-6215
DOI: 10.1007/s00394-012-0349-x
OpenAlex: W2081092205
Cited by: 35
References: 55
Citations by year: 2026: 2 · 2025: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 4
FWCI: 1.36
Type: journal article
Language: en
Open access: green
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Licence: cc-by
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Locations: European Journal of Nutrition (publishedVersion)
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Figshare (submittedVersion, cc-by)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords: pre-exercise feeding, resistance training, myostatin, ubiquitin-proteasome system, skeletal muscle gene expression, protein intake, carbohydrate intake, insulin, cortisol, FSTL3, Smurf1, atrogin-1, muscle growth
MeSH terms: Tripartite Motif Proteins, Forkhead Box Protein O3, Actins, Dietary Carbohydrates, Dietary Proteins, Eating, Humans, Hydrocortisone, Insulin, Male, Muscle Proteins, RNA, Messenger, Biomarkers, Down-Regulation, Up-Regulation, Single-Blind Method, Muscle, Skeletal, Cross-Over Studies, Follistatin-Related Proteins, Ubiquitin-Protein Ligases, SKP Cullin F-Box Protein Ligases, Forkhead Transcription Factors, Resistance Training, Myostatin, Young Adult, Real-Time Polymerase Chain Reaction

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Effects of pre-exercise feeding on serum hormone concentrations and biomarkers of myostatin and ubiquitin proteasome pathway activity

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