Cited by 230Alzheimer's disease research and treatmentsTraumatic Brain Injury ResearchDementia and Cognitive Impairment Research

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Tau isoform profile and phosphorylation state in dementia pugilistica recapitulate Alzheimer's disease

Schmidt, M., Zhukareva, V., Newell, K., Lee, V., Trojanowski, J.·2001·Acta Neuropathologica

DOI 10.1007/s004010000330

Open this paper in CoChat — free account

Abstract

Insights into mechanisms of familial Alzheimer's disease (AD) caused by genetic mutations have emerged rapidly compared to sporadic AD. Indeed, despite identification of several sporadic AD risk factors, it remains enigmatic how or why they predispose to neurodegenerative disease. For example, traumatic brain injury (TBI) predisposes to AD, and recurrent TBI in career boxers may cause a progressive memory disorder associated with AD-like brain pathology known as dementia pugilistica (DP). Although the reasons for this are unknown, repeated TBI may cause DP by mechanisms similar to those involved in AD. To investigate this possibility, we compared the molecular profile of tau pathologies in DP with those in AD and showed that the same tau epitopes map to filamentous tau inclusions in AD and DP brains, while the abnormal tau proteins isolated from DP brains are indistinguishable from the six abnormally phosphorylated brain tau isoforms in AD brains. Thus, these data suggest that recurrent TBI may cause DP by activating pathological mechanisms similar to those that cause brain degeneration due to accumulations of filamentous tau lesions in AD, and similar, albeit attenuated, activation of these processes by a single TBI may increase susceptibility to sporadic AD decades after the event.

Integrity signals

Registry

Crossref · 10.1007/s004010000330

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.
(1998) · Europe PMC (PubMed Central) · Cited by 1,594
Self-citation
A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau
Lee, V. M.-Y., Balin, B. J., Otvos, L., & Trojanowski, J. Q. (1991) · Science · doi:10.1126/science.1899488 · Cited by 1,418
Self-citation
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.
Hong, M., Zhukareva, V., Vogelsberg-Ragaglia, V., Wszolek, Z., Reed, L., Miller, B., Geschwind, D., Bird, T., McKeel, D., Goate, A., et al. (1998) · Science · doi:10.1126/science.282.5395.1914 · Cited by 1,024
Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding
Bramblett, G. T., Goedert, M., Jakes, R., Merrick, S. E., Trojanowski, J. Q., & Lee, V. M. Y. (1993) · Neuron · doi:10.1016/0896-6273(93)90057-x · Cited by 903
Self-citation
Association of apolipoprotein E polymorphism with outcome after head injury
Teasdale, G. M., Nicoll, J. A. R., Murray, G. D., & Fiddes, M. (1997) · The Lancet · doi:10.1016/s0140-6736(97)04318-3 · Cited by 683
Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing
Jordan, B. D. (1997) · JAMA · doi:10.1001/jama.278.2.136 · Cited by 665
Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205
Goedert, M., Jakes, R., & Vanmechelen, E. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11484-e · Cited by 608
Head Trauma as a Risk Factor for Alzheimer's Disease: A Collaborative Re-Analysis of Case-Control Studies
Mortimer, J. A., Van Duijn, C. M., Chandra, V, Fratiglioni, L., Graves, A. B., Heyman, A., Jorm, A. F., Kokmen, E., Kondo, K., Rocca, W. A., et al. (1991) · International Journal of Epidemiology · doi:10.1093/ije/20.supplement_2.s28 · Cited by 594
Synergistic Effects of Traumatic Head Injury and Apolipoprotein-epsilon4 in Patients With Alzheimer's Disease
Mayeux, R., Ottman, R., Maestre, G., Ngai, C., Tang, M.-X., Ginsberg, H., Chun, M., Tycko, B., & Shelanski, M. (1995) · Neurology · doi:10.1212/wnl.45.3.555 · Cited by 590
The occult aftermath of boxing.
Roberts, G. W., Allsop, D., & Bruton, C. (1990) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.53.5.373 · Cited by 518

Flagged first, then by citations

Show all 26 references

Sorted by citations

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease
Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092
Self-citation
Chronic traumatic encephalopathy in athletes: Progressive tauopathy after repetitive head injury
McKee, A. C., Cantu, R. C., Nowinski, C. J., Hedley-Whyte, E. T., Gavett, B. E., Budson, A. E., Santini, V. E., Lee, H.-S., Kubilus, C. A., & Stern, R. A. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181a9d503 · Cited by 2,295
The spectrum of disease in chronic traumatic encephalopathy
McKee, A. C., Stein, T. D., Nowinski, C. J., Stern, R. A., Daneshvar, D. H., Alvarez, V. E., Lee, H.-S., Hall, G., Wojtowicz, S. M., Baugh, C. M., et al. (2013) · Brain · doi:10.1093/brain/aws307 · Cited by 2,098
Pathology of Neurodegenerative Diseases
Dugger, B. N., & Dickson, D. W. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028035 · Cited by 1,665
Brain homogenates from human tauopathies induce tau inclusions in mouse brain
Clavaguera, F., Akatsu, H., Fraser, G. M., Crowther, R. A., Frank, S., Hench, J., Probst, A., Winkler, D. T., Reichwald, J., Staufenbiel, M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301175110 · Cited by 792
Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules
Falcon, B., Zivanov, J., Zhang, W., Murzin, A. G., Garringer, H. J., Vidal, R., Crowther, R. A., Newell, K. L., Ghetti, B. F., Goedert, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1026-5 · Cited by 722
Self-citation
Chronic neuropathologies of single and repetitive TBI: substrates of dementia?
Smith, D. H., Johnson, V. E., & Stewart, W. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.29 · Cited by 699
The Neuropathology and Neurobiology of Traumatic Brain Injury
Blennow, K., Hardy, J., & Zetterberg, H. (2012) · Neuron · doi:10.1016/j.neuron.2012.11.021 · Cited by 669
Propagation of Tau aggregates and neurodegeneration
Goedert, M., Eisenberg, D. S., & Crowther, R. A. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031153 · Cited by 632
Risk factors for Alzheimer’s disease
Armstrong, R. A. (2019) · Folia Neuropathologica · doi:10.5114/fn.2019.85929 · Cited by 679
Tau and tauopathies
Arendt, T., Stieler, J. T., & Holzer, M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.08.018 · Cited by 609
Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease?
Johnson, V. E., Stewart, W., & Smith, D. H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2808 · Cited by 587
The Neuropathology of Chronic Traumatic Encephalopathy
McKee, A. C., Stein, T. D., Kiernan, P. T., & Alvarez, V. E. (2015) · Brain Pathology · doi:10.1111/bpa.12248 · Cited by 585
Long‐term Consequences of Repetitive Brain Trauma: Chronic Traumatic Encephalopathy
Stern, R. A., Riley, D., Daneshvar, D. H., Nowinski, C. J., Cantu, R. C., & McKee, A. C. (2011) · PM&R · doi:10.1016/j.pmrj.2011.08.008 · Cited by 598
Invited review: Neuropathology of tauopathies: principles and practice
Kovacs, G. G. (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12208 · Cited by 492
Chronic traumatic encephalopathy: Neurodegeneration following repetitive concussive and subconcussive brain trauma
Baugh, C. M., Stamm, J. M., Riley, D. O., Gavett, B. E., Shenton, M. E., Lin, A., Nowinski, C. J., Cantu, R. C., McKee, A. C., & Stern, R. A. (2012) · Brain Imaging and Behavior · doi:10.1007/s11682-012-9164-5 · Cited by 486
White matter and cognition: making the connection
Filley, C. M., & Fields, R. D. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00221.2016 · Cited by 479
Neuropathology underlying clinical variability in patients with synucleinopathies
Halliday, G. M., Holton, J. L., Révész, T., & Dickson, D. W. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0852-9 · Cited by 447
The neuropathology of sport
McKee, A. C., Daneshvar, D. H., Alvarez, V. E., & Stein, T. D. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1230-6 · Cited by 422
Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury
Ikonomovic, M. D., Uryu, K., Abrahamson, E. E., Ciallella, J. R., Trojanowski, J. Q., Lee, V. M.-Y., Clark, R. S., Marion, D. W., Wisniewski, S. R., & DeKosky, S. T. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.06.011 · Cited by 399
Self-citation
Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans
Uryu, K., Chen, X.-H., Martinez, D., Browne, K. D., Johnson, V. E., Graham, D. I., Lee, V. M.-Y., Trojanowski, J. Q., & Smith, D. H. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.06.018 · Cited by 360
Self-citation
Assembly of recombinant tau into filaments identical to those of Alzheimer’s disease and chronic traumatic encephalopathy
Lövestam, S., Koh, F. A., van Knippenberg, B., Kotecha, A., Murzin, A. G., Goedert, M., & Scheres, S. H. W. (2022) · eLife · doi:10.7554/elife.76494 · Cited by 306
Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel
Stein, T. D., Alvarez, V. E., & McKee, A. C. (2014) · Alzheimer s Research & Therapy · doi:10.1186/alzrt234 · Cited by 280
Long-term intracerebral inflammatory response after traumatic brain injury
Gentleman, S. M., Leclercq, P. D., Moyes, L., Graham, D. I., Smith, C., Griffin, W. S. T., & Nicoll, J. A. R. (2004) · Forensic Science International · doi:10.1016/j.forsciint.2004.06.027 · Cited by 272
Tauopathies: classification and clinical update on neurodegenerative diseases associated with microtubule‐associated protein tau
Williams, D. R. (2006) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2006.01153.x · Cited by 259
Controlled Cortical Impact Traumatic Brain Injury in 3xTg-AD Mice Causes Acute Intra-Axonal Amyloid- Accumulation and Independently Accelerates the Development of Tau Abnormalities
Tran, H. T., LaFerla, F. M., Holtzman, D. M., & Brody, D. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0858-11.2011 · Cited by 255
Conformation Determines the Seeding Potencies of Native and Recombinant Tau Aggregates
Falcon, B., Cavallini, A., Angers, R. C., Glover, S. J., Murray, T. K., Barnham, L., Jackson, S., O'Neill, M. J., Isaacs, A. M., Hutton, M. L., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.589309 · Cited by 265
Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts
McKee, A. C., Stein, T. D., Huber, B. R., Crary, J. F., Bieniek, K., Dickson, D., Alvarez, V. E., Cherry, J. D., Farrell, K., Butler, M., et al. (2023) · Acta Neuropathologica · doi:10.1007/s00401-023-02540-w · Cited by 244
Tauopathies.
(2018) · Handbook of Clinical Neurology · doi:10.1016/b978-0-12-802395-2.00025-0 · Cited by 225
The neuroinflammatory response in humans after traumatic brain injury
Smith, C., Gentleman, S. M., Leclercq, P. D., Murray, L. S., Griffin, W. S. T., Graham, D. I., & Nicoll, J. A. R. (2012) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12008 · Cited by 213
Chronic Traumatic Encephalopathy: The Neuropathological Legacy of Traumatic Brain Injury
Hay, J. R., Johnson, V. E., Smith, D. H., & Stewart, W. B., Jr. (2016) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012615-044116 · Cited by 202
Polypathology and dementia after brain trauma: Does brain injury trigger distinct neurodegenerative diseases, or should they be classified together as traumatic encephalopathy?
Washington, P. M., Villapol, S., & Burns, M. P. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.06.015 · Cited by 197
Chronic traumatic encephalopathy in sport: a systematic review
Gardner, A. J., Iverson, G. L., & McCrory, P. R. (2013) · British Journal of Sports Medicine · doi:10.1136/bjsports-2013-092646 · Cited by 192
Tau prions from Alzheimer’s disease and chronic traumatic encephalopathy patients propagate in cultured cells
Woerman, A. L., Aoyagi, A., Patel, S. S., Kazmi, S. A., Lobach, I. V., Grinberg, L. T., McKee, A. C., Seeley, W. W., Olson, S. H., & Prusiner, S. B. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616344113 · Cited by 180
Chronic traumatic encephalopathy in contact sports: A systematic review of all reported pathological cases
Maroon, J. C., Winkelman, R., Bost, J., Amos, A., Mathyssek, C., & Miele, V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117338 · Cited by 175
Understanding Acquired Brain Injury: A Review
Goldman, L. V., Siddiqui, E. M., Khan, A., Jahan, S., Rehman, M. U., Mehan, S., Sharma, R. K., Budkin, S., Kumar, S. N., Sahu, A., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10092167 · Cited by 205
Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease
Ghoshal, N. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.8014 · Cited by 192
Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae
Albayram, Ö., Kondo, A., Mannix, R., Smith, C., Tsai, C.-Y., Li, C., Herbert, M. K., Qiu, J., Monuteaux, M. C., Driver, J. A., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01068-4 · Cited by 154
Prion-like Mechanisms in the Pathogenesis of Tauopathies and Synucleinopathies
Goedert, M., Falcon, B., Clavaguera, F., & Tolnay, M. (2014) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-014-0495-z · Cited by 152
Tau Pathology in Chronic Traumatic Encephalopathy and Alzheimer's Disease: Similarities and Differences
Katsumoto, A., Takeuchi, H., & Tanaka, F. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00980 · Cited by 151
Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease
Kraus, A., Saijo, E., Metrick, M. A., Newell, K., Sigurdson, C. J., Zanusso, G., Ghetti, B., & Caughey, B. (2019) · Acta Neuropathologica · doi:10.1007/s00401-018-1947-3 · Cited by 143
Self-citation
Protein Accumulation in Traumatic Brain Injury
Smith, D. H., Uryu, K., Saatman, K. E., Trojanowski, J. Q., & McIntosh, T. K. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:4:1-2:59 · Cited by 144
Self-citation
Current and emerging avenues for Alzheimer's disease drug targets
Loera‐Valencia, R., Cedazo-Mínguez, Á., Kenigsberg, P.-A., Page, G., Duarte, A. I., Giusti, P., Zusso, M., Robert, P. H., Frisoni, G. B., Cattaneo, A., et al. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12959 · Cited by 142
Repetitive mild traumatic brain injury augments tau pathology and glial activation in aged hTau mice
Ojo, J.-O., Mouzon, B., Greenberg, M. B., Bachmeier, C., Mullan, M., & Crawford, F. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182814cdf · Cited by 166
What is the Relationship of Traumatic Brain Injury to Dementia?
Mendez, M. F. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161002 · Cited by 141
Chronic traumatic encephalopathy: Where are we and where are we going?
Mez, J., Stern, R. A., & McKee, A. C. (2013) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-013-0407-7 · Cited by 120
Abnormal TDP-43 expression is identified in the neocortex in cases of dementia pugilistica, but is mainly confined to the limbic system when identified in high and moderate stages of Alzheimer's disease
King, A., Sweeney, F., Bódi, I., Troakes, C., Maekawa, S., & Al‐Sarraj, S. (2010) · Neuropathology · doi:10.1111/j.1440-1789.2009.01085.x · Cited by 121
The neuropathology of chronic traumatic encephalopathy
McKee, A. C., Abdolmohammadi, B., & Stein, T. D. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63954-7.00028-8 · Cited by 122
Tau biology, tauopathy, traumatic brain injury, and diagnostic challenges
Castellani, R. J., & Perry, G. (2019) · Journal of Alzheimer’s Disease · doi:10.3233/jad-180721 · Cited by 110
Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy
Kanaan, N. M., Cox, K. K., Alvarez, V. E., Stein, T. D., Poncil, S., & McKee, A. C. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlv001 · Cited by 110
Review: Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates
Costanza, A., Weber, K., Gandy, S., Bouras, C., Hof, P. R., Giannakopoulos, P., & Canuto, A. (2011) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2011.01186.x · Cited by 109
Injury Risk in Professional Boxing
Bledsoe, G. H., Li, G., & Levy, F. (2005) · Southern Medical Journal · doi:10.1097/01.smj.0000182498.19288.e2 · Cited by 106
Brain injury, neuroinflammation and Alzheimer's disease
Breunig, J. J., Guillot‐Sestier, M., & Town, T. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00026 · Cited by 106
Heading in Soccer
Spiotta, A. M., Bartsch, A., & Benzel, E. C. (2011) · Neurosurgery · doi:10.1227/neu.0b013e31823021b2 · Cited by 107
Enhanced neurofibrillary tangle formation, cerebral atrophy, and cognitive deficits induced by repetitive mild brain injury in a transgenic tauopathy mouse model
Yoshiyama, Y., Uryu, K., Higuchi, M., Longhi, L., Hoover, R., Fujimoto, S., McIntosh, T., Lee, V. M.-Y., & Trojanowski, J. Q. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.1134 · Cited by 133
Self-citation
Sports Concussion and the Risk of Chronic Neurological Impairment
McCrory, P. R. (2010) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0b013e318204db50 · Cited by 104
A critical review of chronic traumatic encephalopathy
Iverson, G. L., Gardner, A. J., McCrory, P., Zafonte, R., & Castellani, R. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.008 · Cited by 103
Oxidative insults to neurons and synapse are prevented by aged garlic extract and S-allyl-l-cysteine treatment in the neuronal culture and APP-Tg mouse model
Ray, B., Chauhan, N. B., & Lahiri, D. K. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07145.x · Cited by 104
Traumatic Brain Injury as a Trigger of Neurodegeneration
Johnson, V. E., Stewart, W. B., Jr., Arena, J. D., & Smith, D. H. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-57193-5_15 · Cited by 103
Rapid Tau Aggregation and Delayed Hippocampal Neuronal Death Induced by Persistent Thrombin Signaling
Suo, Z., Wu, M., Citron, B. A., Palazzo, R. E., & Festoff, B. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301406200 · Cited by 99
Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies
Zhang, X., Wang, J., Zhang, Z., & Ye, K. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00429-6 · Cited by 119
Tau immunohistochemistry in acute brain injury
Smith, C., Graham, D. I., Murray, L. S., & Nicoll, J. A. R. (2003) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2003.00488.x · Cited by 110
Inhibition of JNK by a Peptide Inhibitor Reduces Traumatic Brain Injury–Induced Tauopathy in Transgenic Mice
Tran, H., Sanchez, L., & Brody, D. L. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182456aed · Cited by 93
Traumatic encephalopathy: Review and provisional research diagnostic criteria
Victoroff, J. (2013) · Neurorehabilitation · doi:10.3233/nre-130839 · Cited by 91
Quadratic trajectories of brain myelin content: unifying construct for neuropsychiatric disorders
Bartzokis, G. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.001 · Cited by 97
Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men
Ojo, J. O., Mouzon, B., & Crawford, F. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.06.003 · Cited by 89
Frontal Cortex Neuropathology in Dementia Pugilistica
Saing, T., Dick, M. B., Nelson, P. T., Kim, R. C., Cribbs, D. H., & Head, E. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2011.1957 · Cited by 92
The Fluorescent Congo Red Derivative, (Trans, Trans)−1-Bromo-2,5-Bis-(3-Hydroxycarbonyl-4-Hydroxy)Styrylbenzene (BSB), Labels Diverse β-Pleated Sheet Structures in Postmortem Human Neurodegenerative Disease Brains
Schmidt, M. L., Schuck, T., Sheridan, S., Kung, M., Kung, H. F., Zhuang, Z., Bergeron, C., Lamarche, J. S., Skovronsky, D., Giasson, B. I., et al. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61769-5 · Cited by 86
Self-citation
GSK3β Signalling: Casting a Wide Net in Alzheimer’s Disease
Bhat, R. V., & Budd, S. L. (2002) · Neurosignals · doi:10.1159/000067423 · Cited by 85
Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer’s disease pathology
Wu, Z., Wang, Z.-H., Liu, X., Zhang, Z., Gu, X., Yu, S. P., Keene, C. D., Cheng, L., & Ye, K. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101730 · Cited by 81
Experimental models of repetitive brain injuries.
Weber, J. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(06)61018-2 · Cited by 115
Central Nervous System Injuries in Sport and Recreation
Toth, C. C., McNeil, S. M., & Feasby, T. E. (2005) · Sports Medicine · doi:10.2165/00007256-200535080-00003 · Cited by 77
Traumatic brain injury: cause or risk of Alzheimer’s disease? A review of experimental studies
Szczygielski, J., Mautes, A. E. M., Steudel, W. I., Falkai, P., Bayer, T. A., & Wirths, O. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-005-0326-0 · Cited by 75
Potential of the Antibody Against cis–Phosphorylated Tau in the Early Diagnosis, Treatment, and Prevention of Alzheimer Disease and Brain Injury
Lu, K. P., Kondo, A., Albayram, Ö., Herbert, M. K., Liu, H., & Zhou, X. Z. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.2027 · Cited by 74
Tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and Alzheimer’s disease
Arena, J. D., Smith, D. H., Lee, E. B., Gibbons, G. S., Irwin, D. J., Robinson, J. L., Lee, V. M. ‐., Trojanowski, J. Q., Stewart, W. B., Jr., & Johnson, V. E. (2020) · Brain · doi:10.1093/brain/awaa071 · Cited by 77
Self-citation
Chronic traumatic encephalopathy-integration of canonical traumatic brain injury secondary injury mechanisms with tau pathology
Kulbe, J. R., & Hall, E. D. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.08.003 · Cited by 70
Untangling senescent and damage‐associated microglia in the aging and diseased brain
Ng, P. Y., McNeely, T. L., & Baker, D. J. (2023) · The FEBS Journal · doi:10.1111/febs.16315 · Cited by 68
Evolution of neuronal and glial tau isoforms in chronic traumatic encephalopathy
Cherry, J. D., Kim, S. H., Stein, T. D., Pothast, M. J., Nicks, R., Meng, G., Huber, B. R., Mez, J., Alosco, M. L., Tripodis, Y., et al. (2020) · Brain Pathology · doi:10.1111/bpa.12867 · Cited by 68
Prevalence of Traumatic Brain Injury in Early Versus Late-Onset Alzheimer’s Disease
Mendez, M. F., Paholpak, P., Lin, A., Zhang, J. Y., & Teng, E. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-143207 · Cited by 62
Tau phosphorylation induced by severe closed head traumatic brain injury is linked to the cellular prion protein
Rubenstein, R., Chang, B., Grinkina, N., Drummond, E., Davies, P., Ruditzky, M., Sharma, D. R., Wang, K., & Wısnıewskı, T. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0435-7 · Cited by 63
Dementia after traumatic brain injury
STARKSTEIN, S. E., & Jorge, R. E. (2005) · International Psychogeriatrics · doi:10.1017/s1041610205001973 · Cited by 61
What initiates the formation of senile plaques? The origin of Alzheimer-like dementias in capillary haemorrhages
Stone, J. (2008) · Medical Hypotheses · doi:10.1016/j.mehy.2008.04.007 · Cited by 62
Intercellular transfer of tau aggregates and spreading of tau pathology: Implications for therapeutic strategies
Clavaguera, F., Grueninger, F., & Tolnay, M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.037 · Cited by 68
Review: The long‐term consequences of microglial activation following acute traumatic brain injury
Smith, C. (2012) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12006 · Cited by 61
Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy
Seo, J., Lee, S., Shin, J.-Y., Hwang, Y. J., Cho, H., Yoo, S., Kim, Y., Lim, S., Kim, Y. K., Hwang, E. M., et al. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.56 · Cited by 56
Do infectious agents play a role in dementia?
Dobson, C. B., Wozniak, M. A., & Itzhaki, R. F. (2003) · Trends in Microbiology · doi:10.1016/s0966-842x(03)00146-x · Cited by 56
Function and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegeneration
Albayram, Ö., Herbert, M. K., Kondo, A., Tsai, C.-Y., Baxley, S., Lian, X., Hansen, M. R., Zhou, X. Z., & Lu, K. P. (2016) · Cell & Bioscience · doi:10.1186/s13578-016-0124-4 · Cited by 58
Dementia Pugilistica Revisited
Castellani, R. J., & Perry, G. L. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170669 · Cited by 65
Spinal Cord Neurofibrillary Pathology in Alzheimer Disease and Guam Parkinsonism-Dementia Complex
Schmidt, M. L., Zhukareva, V. A., Perl, D. P., Sheridan, S. K., Schuck, T., Lee, V. M. ‐., & Trojanowski, J. Q. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.11.1075 · Cited by 55
Self-citation
Subconcussive Impact in Sports: A New Era of Awareness
Spiotta, A. M., Shin, J. H., Bartsch, A., & Benzel, E. C. (2011) · World Neurosurgery · doi:10.1016/j.wneu.2011.01.019 · Cited by 51
Disordered APP metabolism and neurovasculature in trauma and aging: Combined risks for chronic neurodegenerative disorders
Ikonomović, M. D., Mi, Z., & Abrahamson, E. E. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.11.003 · Cited by 53
Glial AP1 is activated with aging and accelerated by traumatic brain injury
Byrns, C. N., Saikumar, J., & Bonini, N. M. (2021) · Nature Aging · doi:10.1038/s43587-021-00072-0 · Cited by 50
Tau Cleavage at D421 by Caspase-3 is Induced in Neurons and Astrocytes Infected with Herpes Simplex Virus Type 1
Lerchundi, R., Neira, R., Valdivia, S., Vío, K., Concha, M. I., Zambrano, Á., & Carola Otth, L. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101386 · Cited by 50
Inhibition of Glycogen Synthase Kinase-3: An Emerging Target in the Treatment of Traumatic Brain Injury
Shim, S. S., & Stutzmann, G. E. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2015.4177 · Cited by 50
A comparison between tau and amyloid-β cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease
Turk, K. W., Geada, A., Alvarez, V. E., Xia, W., Cherry, J. D., Nicks, R., Meng, G., Daley, S. A., Tripodis, Y., Huber, B. R., et al. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-00976-y · Cited by 47
Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold
Qi, C., Verheijen, B. M., Kokubo, Y., Shi, Y., Tetter, S., Murzin, A. G., Nakahara, A., Morimoto, S., Vermulst, M., Sasaki, R., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2306767120 · Cited by 51
Tissue transglutaminase, protein cross-linking and Alzheimer's disease: review and views.
Wang, D., Dickson, D. W., & Malter, J. S. (2008) · PubMed Central · Cited by 47
Neurodegeneration and sport
Davis, G. A., Castellani, R. J., & McCrory, P. (2015) · Neurosurgery · doi:10.1227/neu.0000000000000722 · Cited by 47
Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy
Qi, C., Hasegawa, M., Takao, M., Sakai, M., Sasaki, M., Mizutani, M., Akagi, A., Iwasaki, Y., Miyahara, H., Yoshida, M., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01565-2 · Cited by 41
Neuroimaging assessment of early and late neurobiological sequelae of traumatic brain injury: implications for CTE
Sundman, M., Doraiswamy, P. M., & Morey, R. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00334 · Cited by 46

Authors: Schmidt, M., Zhukareva, V., Newell, K., Lee, V., & Trojanowski, J.
Affiliations: University of Pennsylvania (US)
Hospital of the University of Pennsylvania (US)
Harvard University (US)
Corresponding author: Trojanowski, J.
ORCID: Newell, K.
Trojanowski, J.
Venue: Acta Neuropathologica
Publisher: Springer Science and Business Media LLC
Published: 2001-05
Volume: 101
Issue: 5
Pages: 518-524
ISSN: 0001-6322 (ISSN-L)
1432-0533
DOI: 10.1007/s004010000330
OpenAlex: W1585890093
Cited by: 230
References: 26
Citations by year: 2026: 4 · 2025: 6 · 2024: 10 · 2023: 13 · 2022: 8 · 2021: 12 · 2020: 8 · 2019: 12 · 2018: 15 · 2017: 19 · 2016: 17 · 2015: 17 · 2014: 11 · 2013: 14 · 2012: 11
FWCI: 2.39
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Acta Neuropathologica (publishedVersion)
PubMed (publishedVersion)
Funders: Massachusetts General Hospital
National Institutes of Health
National Institute on Aging (AG09215, P30AG010124, P01AG009215, AG-10124)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: chronic traumatic encephalopathy, tau isoforms, tau phosphorylation, Alzheimer's disease, traumatic brain injury, boxers, tau pathology, sporadic Alzheimer's disease, memory disorders, neurodegeneration
MeSH terms: Aged, Alzheimer Disease, Epitopes, Athletic Injuries, Boxing, Brain Injuries, Central Nervous System, Humans, Immunohistochemistry, Male, Neurons, Phosphorylation, Blotting, Western, Neurofibrillary Tangles, tau Proteins, Protein Isoforms

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Tau isoform profile and phosphorylation state in dementia pugilistica recapitulate Alzheimer's disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks