Linking neuronal structure to function in rodent hippocampus: a methodological prospective
Abstract
Since the discovery of place cells, hippocampus-dependent spatial navigation has proven to be an ideal model system for resolving the relationship between neural coding and behavior. Electrical recordings from the hippocampal formation in freely moving animals have revealed a rich repertoire of spatial firing patterns and have enormously advanced our understanding of the neural principles of spatial representation. However, limited progress has been achieved in resolving the underlying cellular mechanisms. This is partially attributable to the inability of standard recording techniques to link neuronal structure to function directly. In this review, we summarize recent efforts aimed at filling this gap. We also highlight the development of methodologies that allow functional measurements from identified neuronal elements in behaving rodents. Recent progress in the dentate gyrus serves as a showcase to reveal the potential of such methodologies and the necessity of resolving structure-function relationships in order to access the cellular mechanisms of hippocampal circuit computations.
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CA1 pyramidal neurons show a high level of heterogeneity at the molecular, cellular, connectivity, and in-vivo properties.
“CA1 pyramidal neurons show a high level of heterogeneity at the molecular, cellular, connectivity, and in-vivo properties90–92.”
From Place and behavioral modulation of hippocampal neurons during immobility (2026) · cites this paper as [90]
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Manipulating Hippocampal Place Cell Activity by Single-Cell Stimulation in Freely Moving Mice
Diamantaki, M., Coletta, S., Nasr, K., Zeraati, R., Laturnus, S., Berens, P., Preston-Ferrer, P., & Burgalossi, A. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.031 · Cited by 85 · see citing works
Self-citationPlace and behavioral modulation of hippocampal neurons during immobility
Sartorato, N., Zouridis, I. S., Narantsatsralt, U.-U., Blanco-Hernández, E., & Burgalossi, A. (2026) · Nature Communications · doi:10.1038/s41467-026-75492-w · Cited by 1 · see citing works
“CA1 pyramidal neurons show a high level of heterogeneity at the molecular, cellular, connectivity, and in-vivo properties 90 – 92 .”
Self-citation
- Authors
- Preston-Ferrer, P., & Burgalossi, A.
- Affiliations
- University of Tübingen (DE)
- Corresponding author
- Burgalossi, Andrea
- ORCID
- Burgalossi, Andrea
- Venue
- Cell and Tissue Research
- Published
- 2017-11-27
- Volume
- 373
- Issue
- 3
- Pages
- 605-618
- ISSN
- 0302-766X (ISSN-L)
- 1432-0878
- OpenAlex
- W2768267599
- Cited by
- 11
- References
- 151
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2022: 1 · 2021: 2 · 2019: 1 · 2018: 2
- FWCI
- 0.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell and Tissue Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (BU 3126/1-1, EXC 307)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- hippocampus, place cells, spatial navigation, neural coding, dentate gyrus, spatial firing patterns, identified neurons, rodent behavior
- MeSH terms
- Place Cells, Animals, Behavior, Hippocampus, Memory, Microelectrodes, Models, Neurological, Rodentia, Dentate Gyrus, Mice, Rats, Electrophysiological Phenomena, Single-Cell Analysis, Neuroimaging, Spatial Navigation
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