Cited by 11Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Linking neuronal structure to function in rodent hippocampus: a methodological prospective

Preston-Ferrer, Patricia, Burgalossi, Andrea·2018·Cell and Tissue Research

Abstract

Since the discovery of place cells, hippocampus-dependent spatial navigation has proven to be an ideal model system for resolving the relationship between neural coding and behavior. Electrical recordings from the hippocampal formation in freely moving animals have revealed a rich repertoire of spatial firing patterns and have enormously advanced our understanding of the neural principles of spatial representation. However, limited progress has been achieved in resolving the underlying cellular mechanisms. This is partially attributable to the inability of standard recording techniques to link neuronal structure to function directly. In this review, we summarize recent efforts aimed at filling this gap. We also highlight the development of methodologies that allow functional measurements from identified neuronal elements in behaving rodents. Recent progress in the dentate gyrus serves as a showcase to reveal the potential of such methodologies and the necessity of resolving structure-function relationships in order to access the cellular mechanisms of hippocampal circuit computations.

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Crossref · 10.1007/s00441-017-2732-7

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  • CA1 pyramidal neurons show a high level of heterogeneity at the molecular, cellular, connectivity, and in-vivo properties.

    “CA1 pyramidal neurons show a high level of heterogeneity at the molecular, cellular, connectivity, and in-vivo properties90–92.”

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Authors
Preston-Ferrer, P., & Burgalossi, A.
Affiliations
University of Tübingen (DE)
Corresponding author
Burgalossi, Andrea
Venue
Cell and Tissue Research
Published
2017-11-27
Volume
373
Issue
3
Pages
605-618
ISSN
  • 0302-766X (ISSN-L)
  • 1432-0878
OpenAlex
W2768267599
Cited by
11
References
151
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2022: 1 · 2021: 2 · 2019: 1 · 2018: 2
FWCI
0.09
Type
journal article
Language
en
Open access
closed
Locations
  • Cell and Tissue Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutsche Forschungsgemeinschaft (BU 3126/1-1, EXC 307)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
hippocampus, place cells, spatial navigation, neural coding, dentate gyrus, spatial firing patterns, identified neurons, rodent behavior
MeSH terms
Place Cells, Animals, Behavior, Hippocampus, Memory, Microelectrodes, Models, Neurological, Rodentia, Dentate Gyrus, Mice, Rats, Electrophysiological Phenomena, Single-Cell Analysis, Neuroimaging, Spatial Navigation

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