Ageing, adipose tissue, fatty acids and inflammation

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works

Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358 · see citing works

Journal of Biological Chemistry

Kurkinensp, M., CondongT, M. R., Blumberg, B., Barlow, D. P., Quiñones, S., Sausg, J., & Pihlajaniemisyy, T. (2021) · Journal of Biological Chemistry · doi:10.1074/jbc · Cited by 3,409 · see citing works

The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population

Bedogni, G., Bellentani, S., Miglioli, L., Masutti, F., Passalacqua, M., Castiglione, A., & Tiribelli, C. (2006) · BMC Gastroenterology · doi:10.1186/1471-230x-6-33 · Cited by 3,054 · see citing works

Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529 · see citing works

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193 · see citing works

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107 · see citing works

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561 · see citing works

Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390 · see citing works

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase

Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., & Simsolo, R. B. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117899 · Cited by 1,305 · see citing works

Saturated Fatty Acids, but Not Unsaturated Fatty Acids, Induce the Expression of Cyclooxygenase-2 Mediated through Toll-like Receptor 4

Lee, J. Y., Sohn, K. H., Rhee, S. H., & Hwang, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011695200 · Cited by 1,299 · see citing works

Prevalence of and Risk Factors for Nonalcoholic Fatty Liver Disease: The Dionysos Nutrition and Liver Study * #

Bedogni, G., Miglioli, L., Masutti, F., Tiribelli, C., Marchesini, G., & Bellentani, S. (2005) · Hepatology · doi:10.1002/hep.20734 · Cited by 1,250 · see citing works

Lipid-induced insulin resistance: unravelling the mechanism

Samuel, V. T., Petersen, K. F., & Shulman, G. I. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60408-4 · Cited by 1,189 · see citing works

"Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes.

Björntorp, P. A. (1990) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.10.4.493 · Cited by 1,115 · see citing works

A Paracrine Loop Between Adipocytes and Macrophages Aggravates Inflammatory Changes: Role of Free Fatty Acids and Tumor Necrosis Factor α

Suganami, T., Nishida, J., & Ogawa, Y. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000183883.72263.13 · Cited by 1,056 · see citing works

Fuel selection in human skeletal muscle in insulin resistance: a reexamination.

Kelley, D. E., & Mandarino, L. J. (2000) · Diabetes · doi:10.2337/diabetes.49.5.677 · Cited by 1,017 · see citing works

Cross-Regulation of C/EBPα and PPARγ Controls the Transcriptional Pathway of Adipogenesis and Insulin Sensitivity

Wu, Z., Rosen, E. D., Brun, R. P., Hauser, S., Adelmant, G., Troy, A. E., McKeon, C., Darlington, G., & Spiegelman, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80306-8 · Cited by 1,015 · see citing works

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation

Tomas, E., Tsao, T.-S., Saha, A. K., Murrey, H. E., Zhang, C. C., Itani, S. I., Lodish, H. F., & Ruderman, N. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222657499 · Cited by 973 · see citing works

Mechanisms of Disease: is osteoporosis the obesity of bone?

Rosen, C. J., & Bouxsein, M. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0070 · Cited by 961 · see citing works

Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis

Justesen, J., Stenderup, K., Ebbesen, E., Mosekilde, L., Steiniche, T., & Kassem, M. (2004) · Biogerontology (Dordrecht) · doi:10.1023/a:1011513223894 · Cited by 847 · see citing works

Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

Gaggini, M., Morelli, M., Buzzigoli, E., DeFronzo, R. A., Bugianesi, E., & Gastaldelli, A. (2013) · Nutrients · doi:10.3390/nu5051544 · Cited by 824 · see citing works

Role of the Toll-like Receptor 4/NF-κB Pathway in Saturated Fatty Acid–Induced Inflammatory Changes in the Interaction Between Adipocytes and Macrophages

Suganami, T., Tanimoto-Koyama, K., Nishida, J., Itoh, M., Yuan, X., Mizuarai, S., Kotani, H., Yamaoka, S., Miyake, K., Aoe, S., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000251608.09329.9a · Cited by 806 · see citing works

Age-related changes in total and regional fat distribution

Kuk, J. L., Saunders, T. J., Davidson, L. E., & Ross, R. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.06.001 · Cited by 778 · see citing works

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

Kim, J. K., Fillmore, J. J., Chen, Y., Yu, C., Moore, I. K., Pypaert, M., Lutz, E. P., Kako, Y., Velez-Carrasco, W., Goldberg, I. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121164498 · Cited by 753 · see citing works

Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans

Adams, J. M., Pratipanawatr, T., Berria, R., Wang, E. L., DeFronzo, R. A., Sullards, M. C., & Mandarino, L. J. (2004) · Diabetes · doi:10.2337/diabetes.53.1.25 · Cited by 670 · see citing works

Obesity, Regional Body Fat Distribution, and the Metabolic Syndrome in Older Men and Women

Goodpaster, B. H., Krishnaswami, S., Harris, T. B., Katsiaras, A., Kritchevsky, S. B., Simonsick, E. M., Nevitt, M., Holvoet, P., & Newman, A. B. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.7.777 · Cited by 637 · see citing works

A Ceramide-Centric View of Insulin Resistance

Chavez, J. A., & Summers, S. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.002 · Cited by 620 · see citing works

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

Huang, S., Rutkowsky, J. M., Snodgrass, R. G., Ono‐Moore, K. D., Schneider, D. A., Newman, J. W. I., Adams, S. H., & Hwang, D. H. (2012) · Journal of Lipid Research · doi:10.1194/jlr.d029546 · Cited by 591 · see citing works

Macrophage Infiltration into Omental <i>Versus</i> Subcutaneous Fat across Different Populations: Effect of Regional Adiposity and the Comorbidities of Obesity

Harman-Boehm, I., Blüher, M., Redel, H., Sion-Vardy, N., Ovadia, S., Avinoach, E., Shai, I., Klöting, N., Stumvoll, M., Bashan, N., et al. (2007) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2006-1811 · Cited by 574 · see citing works

Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased visceral adiposity

Bays, H. E., González-Campoy, J. M., Bray, G. A., Kitabchi, A. E., Bergman, D. A., Schorr, A. B., Rodbard, H. W., & Henry, R. R. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.3.343 · Cited by 531 · see citing works

Epidemiology of non-alcoholic fatty liver disease in China

Fan, J., & Farrell, G. C. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.10.010 · Cited by 501 · see citing works

Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes

Chavez, J. A., & Summers, S. A. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.08.020 · Cited by 498 · see citing works

Body composition changes with aging: The cause or the result of alterations in metabolic rate and macronutrient oxidation?

St-Onge, M.-P., & Gallagher, D. (2010) · Nutrition · doi:10.1016/j.nut.2009.07.004 · Cited by 494 · see citing works

Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity

McLaughlin, T., Lamendola, C., Liu, A., & Abbasi, F. (2011) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2011-0615 · Cited by 468 · see citing works

Skeletal muscle fat infiltration: impact of age, inactivity, and exercise

Marcus, R. L., Addison, O., Kidde, J. P., Dibble, L. E., & Lastayo, P. C. (2010) · The Journal of nutrition, health and aging · doi:10.1007/s12603-010-0081-2 · Cited by 449 · see citing works

Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36

Bonen, A., Parolin, M. L., Steinberg, G. R., Calles‐Escandon, J., Tandon, N. N., Glatz, J. F. C., Luiken, J. J. F. P., Heigenhauser, G. J. F., & Dyck, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1065fje · Cited by 410 · see citing works

Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance

Amati, F., Dubé, J. J., Alvarez-Carnero, E., Edreira, M. M., Chomentowski, P., Coen, P. M., Switzer, G. E., Bickel, P. E., Stefanovic-Racic, M., Toledo, F. G. S., et al. (2011) · Diabetes · doi:10.2337/db10-1221 · Cited by 395 · see citing works

Anthropometric assessment of 10-y changes in body composition in the elderly

HUGHES, V. A., Roubenoff, R., Wood, M., Frontera, W. R., Evans, W. J., & Singh, M. A. F. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.2.475 · Cited by 394 · see citing works

Glucose intolerance and aging

DeFronzo, R. A. (1981) · Diabetes Care · doi:10.2337/diacare.4.4.493 · Cited by 389 · see citing works

Aortic Stiffness Is Associated With Visceral Adiposity in Older Adults Enrolled in the Study of Health, Aging, and Body Composition

Sutton‐Tyrrell, K., Newman, A. B., Simonsick, E. M., Havlik, R. J., Pahor, M., Lakatta, E. G., Spurgeon, H. A., Vaitkevicius, P. V., & for the Health ABC Investigators (2001) · Hypertension · doi:10.1161/01.hyp.38.3.429 · Cited by 389 · see citing works

Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited

Dubé, J. J., Amati, F., Stefanovic-Racic, M., Toledo, F. G. S., Sauers, S. E., & Goodpaster, B. H. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00769.2007 · Cited by 378 · see citing works

Excessive adipose tissue infiltration in skeletal muscle in individuals with obesity, diabetes mellitus, and peripheral neuropathy: association with performance and function

Hilton, T. N., Tuttle, L. J., Bohnert, K. L., Mueller, M. J., & Sinacore, D. R. (2008) · Physical Therapy · doi:10.2522/ptj.20080079 · Cited by 373 · see citing works

Waist circumference and abdominal adipose tissue distribution: influence of age and sex

Kuk, J. L., Lee, S., Heymsfield, S. B., & Ross, R. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.6.1330 · Cited by 354 · see citing works

Marrow Fat and the Bone Microenvironment: Developmental, Functional, and Pathological Implications

Rosen, C. J., Ackert‐Bicknell, C. L., Rodriguez, J. P., & Pino, A. M. (2009) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v19.i2.20 · Cited by 353 · see citing works

Adipogenesis and aging: does aging make fat go MAD

Kirkland, J. L., Tchkonia, T., Pirtskhalava, T., Han, J., & Karagiannides, I. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00014-1 · Cited by 339 · see citing works

Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha

Zhang, B., Berger, J., Hu, E., Szalkowski, D., White-Carrington, S., Spiegelman, B. M., & Moller, D. E. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.11.8923470 · Cited by 328 · see citing works

Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content

Bruce, C. R., Thrush, A. B., Mertz, V. A., Bezaire, V., Chabowski, A., Heigenhauser, G. J. F., & Dyck, D. J. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00587.2005 · Cited by 328 · see citing works

Aging in adipocytes: Potential impact of inherent, depot-specific mechanisms

CARTWRIGHT, M., TCHKONIA, T., & KIRKLAND, J. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.03.003 · Cited by 318 · cited 2× · see citing works

Macrophage-secreted factors induce adipocyte inflammation and insulin resistance

Permana, P. A., Menge, C., & Reaven, P. D. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.012 · Cited by 307 · see citing works

Lipotoxicity, overnutrition and energy metabolism in aging

Slawik, M., & Vidal‐Puig, A. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.03.004 · Cited by 301 · see citing works

Aging Up-Regulates Expression of Inflammatory Mediators in Mouse Adipose Tissue

Wu, D., Ren, Z., Pae, M., Guo, W., Cui, X., Merrill, A. H., & Meydani, S. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4829 · Cited by 288 · see citing works

Comparison of proliferation and differentiation capacity of human adipocyte precursor cells from the omental and subcutaneous adipose tissue depot of obese subjects

van Harmelen, V., Röhrig, K., & Hauner, H. (2004) · Metabolism · doi:10.1016/j.metabol.2003.11.012 · Cited by 285 · see citing works

Non-Alcoholic Fatty Liver Disease in Older People

Frith, J., Day, C. P., Henderson, E., Burt, A. D., & Newton, J. L. (2009) · Gerontology · doi:10.1159/000235677 · Cited by 280 · see citing works

The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection

Bartlett, D. B., Firth, C. M., Phillips, A. C., Moss, P., Baylis, D., Syddall, H., Sayer, A. A., Cooper, C., & Lord, J. M. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00849.x · Cited by 278 · see citing works

Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle

Ellis, B. A., Poynten, A., Lowy, A. J., Furler, S. M., Chisholm, D. J., Kraegen, E. W., & Cooney, G. J. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.3.e554 · Cited by 273 · see citing works

Intramuscular and Liver Triglycerides Are Increased in the Elderly

Cree‐Green, M., Newcomer, B. R., Katsanos, C. S., Sheffield‐Moore, M., Chinkes, D. L., Aarsland, A. A., Urban, R. J., & Wolfe, R. R. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031986 · Cited by 273 · see citing works

Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes

Guo, W., Wong, S., Xie, W., Lei, T., & Luo, Z. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00523.2006 · Cited by 248 · see citing works

DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells

Montell, E., Turini, M., Marotta, M., Roberts, M., Noé, V., Ciudad, C. J., Macé, K., & Gómez-Foix, A. M. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.2.e229 · Cited by 245 · see citing works

Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state

van Loon, L. J. C., & Goodpaster, B. H. (2006) · Pflügers Archiv · doi:10.1007/s00424-005-1509-0 · Cited by 232 · see citing works

Insulin Resistance Is Associated With Higher Intramyocellular Triglycerides in Type I but Not Type II Myocytes Concomitant With Higher Ceramide Content

Coen, P. M., Dubé, J. J., Amati, F., Stefanović-Račić, M., Ferrell, R. E., Toledo, F. G. S., & Goodpaster, B. H. (2009) · Diabetes · doi:10.2337/db09-0988 · Cited by 229 · see citing works

Gender-specific association between −1082 IL-10 promoter polymorphism and longevity

Lio, D., Scola, L., Crivello, A., Colonna‐Romano, G., Candore, G., Bonafè, M., Cavallone, L., Franceschi, C., & Caruso, C. (2002) · Genes and Immunity · doi:10.1038/sj.gene.6363827 · Cited by 227 · see citing works

Increased Adipogenesis and Myelopoiesis in the Bone Marrow of SAMP6, a Murine Model of Defective Osteoblastogenesis and Low Turnover Osteopenia

Kajkenova, O., Lecka‐Czernik, B., Gubrij, I. B., Hauser, S. P., Takahashi, K., PARFITT, A. M., Jilka, R. L., Manolagas, S. C., & Lipschitz, D. A. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.11.1772 · Cited by 226 · see citing works

Contribution of Abdominal Adiposity to Age-Related Differences in Insulin Sensitivity and Plasma Lipids in Healthy Nonobese Women

DeNino, W. F., Tchernof, A., Dionne, I. J., Toth, M. J., Ades, P. A., Sites, C. K., & Poehlman, É. T. (2001) · Diabetes Care · doi:10.2337/diacare.24.5.925 · Cited by 226 · see citing works

Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver

Perseghin, G., Lattuada, G., COBELLI, F. D., Esposito, A., Belloni, E., Ntali, G., Ragogna, F., Canu, T., Scifo, P., Maschio, A. D., et al. (2007) · Hepatology · doi:10.1002/hep.21983 · Cited by 210 · see citing works

Body composition changes in stable-weight elderly subjects: The effect of sex

Zamboni, M. M., Zoico, E., Scartezzini, T., Mazzali, G., Tosoni, P., Zivelonghi, A., Gallagher, D., Pergola, G. D., Francesco, V. D., & Bosello, O. (2003) · Aging Clinical and Experimental Research · doi:10.1007/bf03324517 · Cited by 207 · see citing works

Activation of CCAAT/Enhancer-binding Protein (C/EBP) α Expression by C/EBPβ during Adipogenesis Requires a Peroxisome Proliferator-activated Receptor-γ-associated Repression of HDAC1 at the C/ebpα Gene Promoter

Zuo, Y., Qiang, L., & Farmer, S. R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510682200 · Cited by 201 · see citing works

Free Fatty Acids Are Independently Associated with All-Cause and Cardiovascular Mortality in Subjects with Coronary Artery Disease

Pilz, S., Scharnagl, H., Tiran, B., Seelhorst, U., Wellnitz, B., Boehm, B. O., Schaefer, J. R., & März, W. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0195 · Cited by 199 · see citing works

Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis.

Stephens, J. M., & Pekala, P. H. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42251-x · Cited by 196 · see citing works

Abdominal Obesity Is an Independent Risk Factor for Chronic Heart Failure in Older People

Nicklas, B. J., Cesari, M., Penninx, B. W. J. H., Kritchevsky, S. B., Ding, J., Newman, A. B., Kitzman, D. W., Kanaya, A. M., Pahor, M., & Harris, T. B. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.00624.x · Cited by 195 · see citing works

Plasma and Serum Lipidomics of Healthy White Adults Shows Characteristic Profiles by Subjects’ Gender and Age

Ishikawa, M., Maekawa, K., Saito, K., Senoo, Y., Urata, M., Murayama, M., Tajima, Y., Kumagai, Y., & Saito, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091806 · Cited by 187 · see citing works

Thigh circumference and risk of heart disease and premature death: prospective cohort study

Heitmann, B. L., & Frederiksen, P. (2009) · BMJ · doi:10.1136/bmj.b3292 · Cited by 186 · see citing works

Altered expression of C/EBP family members results in decreased adipogenesis with aging

Karagiannides, I., Tchkonia, T., Dobson, D. E., Steppan, C. M., Cummins, P., Chan, G., Salvatori, K., Hadzopoulou‐Cladaras, M., & Kirkland, J. L. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.6.r1772 · Cited by 182 · see citing works

Epicardial Adipose Tissue Extent: Relationship With Age, Body Fat Distribution, and Coronaropathy

Silaghi, A., Piercecchi‐Marti, M., Grino, M., Leonetti, G., Alessi, M. C., Clement, K., Dadoun, F., & Dutour, A. (2008) · Obesity · doi:10.1038/oby.2008.379 · Cited by 181 · see citing works

Nutrient Modification of the Innate Immune Response

Schwartz, E. A., Zhang, W.-Y., Karnik, S. K., Borwege, S., Anand, V. R., Laine, P. S., Su, Y., & Reaven, P. D. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.201681 · Cited by 180 · see citing works

The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence

Youm, Y.-H., Kanneganti, T.-D., Vandanmagsar, B., Zhu, X., Ravussin, A., Adijiang, A., Owen, J. S., Thomas, M. J., Francis, J., Parks, J. S., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2011.11.005 · Cited by 172 · see citing works

Skeletal Muscle Insulin Resistance Promotes Increased Hepatic De Novo Lipogenesis, Hyperlipidemia, and Hepatic Steatosis in the Elderly

Flannery, C. A., Dufour, S., Rabøl, R., Shulman, G. I., & Petersen, K. F. (2012) · Diabetes · doi:10.2337/db12-0206 · Cited by 169 · see citing works

Effects of Insulin Treatment in Type 2 Diabetic Patients on Intracellular Lipid Content in Liver and Skeletal Muscle

Anderwald, C. H., Bernroider, E., Krššák, M., Stingl, H., Brehm, A., Bischof, M. G., Nowotny, P., Roden, M., & Waldhäusl, W. K. (2002) · Diabetes · doi:10.2337/diabetes.51.10.3025 · Cited by 168 · see citing works

Abdominal Adiposity Is a Stronger Predictor of Insulin Resistance Than Fitness Among 50–95 Year Olds

Racette, S. B., Evans, E. M., Weiss, E. P., Hagberg, J. M., & Holloszy, J. O. (2006) · Diabetes Care · doi:10.2337/diacare.29.03.06.dc05-1605 · Cited by 167 · see citing works

Liver‐Fat Accumulation and Insulin Resistance in Obese Women with Previous Gestational Diabetes

Tiikkainen, M., Tamminen, M., Häkkinen, A., Bergholm, R., Vehkavaara, S., Halavaara, J. T., Teramo, K., Rissanen, A., & Yki‐Järvinen, H. (2002) · Obesity Research · doi:10.1038/oby.2002.118 · Cited by 161 · see citing works

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Key Role for Ceramides in Mediating Insulin Resistance in Human Muscle Cells

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The Role of TNF-α in Human Adipose Tissue: Prevention of Weight Gain at the Expense of Insulin Resistance?

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The ageing male heart: myocardial triglyceride content as independent predictor of diastolic function

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Long-Chain Acyl CoA Regulation of Protein Kinase C and Fatty Acid Potentiation of Glucose-Stimulated Insulin Secretion in Clonalβ -Cells1

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Skeletal muscle GLUT4 protein concentration and aging in humans

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Skeletal muscle GLUT4 protein concentration and aging in humans

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A central role for ceramide in the age‐related acceleration of apoptosis in the female germline

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Intramyocellular Lipid Content and Molecular Adaptations in Response to a 1‐Week High‐Fat Diet

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Activation of sphingolipid turnover and chronic generation of ceramide and sphingosine in liver during aging

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Increased Epicardial Fat Volume Quantified by 64-Multidetector Computed Tomography is Associated With Coronary Atherosclerosis and Totally Occlusive Lesions

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Molecular Mechanisms in Aging and Current Strategies to Counteract Sarcopenia

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Aging, Resting Metabolic Rate, and Oxidative Damage: Results From the Louisiana Healthy Aging Study

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Evidence for Adipose-Muscle Cross Talk: Opposing Regulation of Muscle Proteolysis by Adiponectin and Fatty Acids

Zhou, Q., Du, J., Hu, Z., Walsh, K. X., & Wang, X. H. (2007) · Endocrinology · doi:10.1210/en.2007-0183 · Cited by 103 · see citing works

Increased protein kinase C theta in skeletal muscle of diabetic patients

Itani, S. I., Pories, W. J., MacDonald, K. G., & Dohm, G. L. (2001) · Metabolism · doi:10.1053/meta.2001.22512 · Cited by 101 · see citing works

Reduced skeletal muscle oxidative capacity and elevated ceramide but not diacylglycerol content in severe obesity

Coen, P. M., Hames, K. C., Leachman, E. M., DeLany, J. P., Ritov, V. B., Menshikova, E. V., Dubé, J. J., Stefanović-Račić, M., Toledo, F. G. S., & Goodpaster, B. H. (2013) · Obesity · doi:10.1002/oby.20381 · Cited by 97 · see citing works

Lower resting metabolic rate in the elderly may not be entirely due to changes in body composition

Krems, C., Lührmann, P. M., Straßburg, A., Hartmann, B., & Neuhäuser‐Berthold, M. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602066 · Cited by 96 · see citing works

Fatty liver as a consequence and cause of insulin resistance: Lessons from type 2 diabetic liver

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The Changing Balance Between Osteoblastogenesis and Adipogenesis in Aging and its Impact on Hematopoiesis

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Increased ceramide content and NFκB signaling may contribute to the attenuation of anabolic signaling after resistance exercise in aged males

Rivas, D. A., Morris, E. P., Haran, P. H., Pasha, E. P., Morais, M. D. S., Dolnikowski, G. G., Phillips, E. M., & Fielding, R. A. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00412.2012 · Cited by 92 · see citing works

CD36 in Myocytes Channels Fatty Acids to a Lipase-Accessible Triglyceride Pool That Is Related to Cell Lipid and Insulin Responsiveness

Bastie, C. C., Hajri, T., Drover, V. A. B., Grimaldi, P. A., & Abumrad, N. A. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2209 · Cited by 90 · see citing works

Prevalence and risk factors of fatty liver disease in Chengdu, Southwest China.

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Non‐alcoholic fatty liver disease – a common and benign finding in octogenarian patients

Kagansky, N., Levy, S., Keter, D., Rimon, E., Taiba, Z., Fridman, Z., Berger, D. L., Knobler, H., & Malnick, S. D. H. (2004) · Liver International · doi:10.1111/j.1478-3231.2004.0969.x · Cited by 86 · see citing works

Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity

Guo, W., Pirtskhalava, T., Tchkonia, T., Xie, W., Thomou, T., Han, J., Wang, T., Wong, S., Cartwright, A., Hegardt, F. G., et al. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00557.2006 · Cited by 85 · see citing works

Aging effects on human calf muscle properties assessed by MRI at 3 Tesla

Schwenzer, N. F., Martirosian, P., Machann, J., Schraml, C., Steidle, G., Claussen, C. D., & Schick, F. (2009) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21789 · Cited by 82 · see citing works

Increased TNFα and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis

Tchkonia, T., Pirtskhalava, T., Thomou, T., Cartwright, M. J., Wise, B. L., Karagiannides, I., Shpilman, A., Lash, T. L., Becherer, J. D., & Kirkland, J. L. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00295.2007 · Cited by 81 · see citing works

Greater adipose tissue infiltration in skeletal muscle among older men of African ancestry

Miljkovic, I., Cauley, J. A., Petit, M. A., Ensrud, K. E., Strotmeyer, E., Sheu, Y., Gordon, C. L., Goodpaster, B. H., Bunker, C. H., Patrick, A. L., et al. (2009) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2008-2541 · Cited by 79 · see citing works

JNK- and IκB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro

Takahashi, K., Yamaguchi, S., Shimoyama, T., Seki, H., Miyokawa, K., Katsuta, H., Tanaka, T., Yoshimoto, K., Ohno, H., Nagamatsu, S., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00131.2007 · Cited by 77 · see citing works

Altered body composition in type 2 diabetes mellitus

Heshka, S., Ruggiero, A. M., Bray, G. A., Foreyt, J. P., Kahn, S. E., Lewis, C. E., Saad, M. F., & Schwartz, A. V. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803802 · Cited by 75 · see citing works

Increased CUG Triplet Repeat-binding Protein-1 Predisposes to Impaired Adipogenesis with Aging

Karagiannides, I., Thomou, T., Tchkonia, T., Pirtskhalava, T., Kypreos, K. E., Cartwright, A., Dalagiorgou, G., Lash, T. L., Farmer, S. R., Timchenko, N. A., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513187200 · Cited by 71 · see citing works

Elevated concentrations of nonesterified fatty acids increase monocyte expression of CD11b and adhesion to endothelial cells.

Zhang, W.-Y., Schwartz, E., Wang, Y., Attrep, J., Li, Z., & Reaven, P. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000200226.53994.09 · Cited by 70 · see citing works

Elevated Free Fatty Acids Attenuate the Insulin-Induced Suppression of PDK4 Gene Expression in Human Skeletal Muscle: Potential Role of Intramuscular Long-Chain Acyl-Coenzyme A

Tsintzas, K., Chokkalingam, K., Jewell, K., Norton, L., Macdonald, I. A., & Constantin‐Teodosiu, D. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1104 · Cited by 69 · see citing works

Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis

Gao, D., Pararasa, C., Dunston, C. R., Bailey, C. J., & Griffiths, H. R. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.026 · Cited by 68 · see citing works

Effects of aging on the content, composition and synthesis of sphingomyelin in the central nervous system

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Intramuscular adipose tissue attenuates gains in muscle quality in older adults at high risk for falling. A brief report

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Adipose Tissue-Derived Tumor Necrosis Factor- Activity Is Elevated in Older Rats

Morin, C. L., Pagliassotti, M. J., Windmiller, D. A., & Eckel, R. H. (1997) · The Journals of Gerontology Series A · doi:10.1093/gerona/52a.4.b190 · Cited by 64 · see citing works

Independent and Opposite Associations of Trunk and Leg Fat Depots with Adipokines, Inflammatory Markers, and Metabolic Syndrome in Middle-Aged and Older Chinese Men and Women

Wu, H., Qi, Q., Yu, Z., Sun, Q., Wang, J., Franco, O. H., Sun, L. D., Li, H., Liu, Y., Hu, F. B., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0181 · Cited by 62 · see citing works

In vivo evidence that acyl coenzyme A regulates DNA binding by the Escherichia coli FadR global transcription factor

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Trunk Versus Extremity Adiposity and Cardiometabolic Risk Factors in White and African American Adults

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Fat in Liver/Muscle Correlates More Strongly With Insulin Sensitivity in Rats Than Abdominal Fat

Lim, S. K., Son, K. R., Song, I. C., Park, H. S., Jin, C. J., Jang, H. C., Park, K. S., Kim, Y., & Lee, H. K. (2008) · Obesity · doi:10.1038/oby.2008.486 · Cited by 51 · see citing works

Role of impaired intracellular glucose metabolism in the insulin resistance of aging

Gumbiner, B. M., Thorburn, A. W., Ditzler, T. M., Bulacan, F., & Henry, R. R. (1992) · Metabolism · doi:10.1016/0026-0495(92)90296-m · Cited by 49 · see citing works

Ceramide Mediates Age-associated Increase in Macrophage Cyclooxygenase-2 Expression

Claycombe, K., Wu, D., Nikolova‐Karakashian, M., Palmer, H. J., Beharka, A. A., Paulson, K. E., & Meydani, S. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204463200 · Cited by 49 · see citing works

A New Member of the Escherichia coli fad Regulon: Transcriptional Regulation of fadM ( ybaW )

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The association of insulin resistance and carotid atherosclerosis with thigh and calf circumference in patients with type 2 diabetes

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Adipose Tissue-Derived Tumor Necrosis Factor Activity Correlates with Fat Cell Size But Not Insulin Action in Aging Rats**This work was supported by National Institutes of Aging Grant KO1-AG00645 (to C.M.) and the National Institutes of Health Grant DK-47416 (to M.P.).

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Liver fat content is associated with increased carotid atherosclerosis in a Chinese middle-aged and elderly population: The Shanghai Changfeng study

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Altered expression of glucose transporter isoforms with aging in rats ? selective decrease in GluT4 in the fat tissue and skeletal muscle

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The Saturated Fatty Acid Palmitate Induces Human Monocytic Cell Toxicity Toward Neuronal Cells: Exploring a Possible Link Between Obesity-Related Metabolic Impairments and Neuroinflammation

Little, J. P., Madeira, J. M., & Klegeris, A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111262 · Cited by 44 · see citing works

Effects of aging on basal fat oxidation in obese humans

Solomon, T. P. J., Marchetti, C. M., Krishnan, R. K., González, F., & Kirwan, J. P. (2008) · Metabolism · doi:10.1016/j.metabol.2008.03.021 · Cited by 44 · see citing works

Associations Between Trunk, Leg and Total Body Adiposity with Arterial Stiffness

Lee, M., Choh, A. C., Demerath, E. W., Towne, B., Siervogel, R. M., & Czerwinski, S. A. (2012) · American Journal of Hypertension · doi:10.1038/ajh.2012.92 · Cited by 44 · see citing works

Shift in sphingolipid metabolism leads to an accumulation of ceramide in senescence

Venable, M. E., Webb-Froehlich, L. M., Sloan, E. F., & Thomley, J. E. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.01.003 · Cited by 43 · see citing works

Visceral adipose tissue, adiponectin levels and insulin resistance are related to atherosclerosis as assessed by whole-body magnetic resonance angiography in an elderly population

Hansen, T., Ahlström, H. K., Söderberg, S., Hulthe, J., Wikström, J., Lind, L., & Johansson, L. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.11.007 · Cited by 35 · see citing works

Age-related remodeling of small arteries is accompanied by increased sphingomyelinase activity and accumulation of long-chain ceramides

Ohanian, J., Liao, A., Forman, S. P., & Ohanian, V. (2014) · Physiological Reports · doi:10.14814/phy2.12015 · Cited by 34 · see citing works

Waist-to-thigh ratio and diabetes among US adults: The Third National Health and Nutrition Examination Survey

Li, C., Ford, E. S., Zhao, G., Kahn, H. S., & Mokdad, A. H. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2010.02.014 · Cited by 31 · see citing works

Peroxisome Proliferator-Activated Receptor Down-Regulation Is Associated With Enhanced Ceramide Levels in Age-Associated Cardiac Hypertrophy

Rodríguez‐Calvo, R., Serrano, L., Barroso, E., Coll, T., Palomer, X., Camins, A., Sanchez, R. M., Alegret, M., Merlos, M., Pallàs, M., et al. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.12.1326 · Cited by 31 · see citing works

Central and peripheral fat and subclinical vascular damage in older women

Fantin, F., Rossi, A. P., Cazzadori, M., Comellato, G., Mazzali, G., Gozzoli, M. P., Grison, E., & Zamboni, M. M. (2013) · Age and Ageing · doi:10.1093/ageing/aft005 · Cited by 29 · see citing works

Leg fat mass as measured by dual X‐ray absorptiometry (DXA) impacts insulin resistance differently in obese women versus men

Aasen, G., Fagertun, H., Tonstad, S., & Halse, J. (2008) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510802464641 · Cited by 28 · see citing works

Comparison of regional body composition and its relation with cardiometabolic risk between BMI-matched young and old subjects

Lee, Y., Shin, H., Vassy, J. L., Kim, J. T., Cho, S., Kang, S. M., Choi, S. H., Kim, K. W., Park, K. S., Jang, H. C., et al. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.07.013 · Cited by 27 · see citing works

Visceral Adiposity and Subclinical Coronary Artery Disease in Elderly Adults: Rancho Bernardo Study

Kim, D., Bergstrom, J., Barrett-Connor, E. L., & Laughlin, G. A. (2008) · Obesity · doi:10.1038/oby.2008.15 · Cited by 23 · see citing works

Macrophages Accumulation in Visceral and Subcutaneous Adipose Tissue Correlates with Age

Jerschow, E., Anwar, S., Barzilai, N., & Rosenstreich, D. L. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.12.066 · Cited by 21 · see citing works

Sex Differences in the Association of Thigh Fat and Metabolic Risk in Older Adults

Pelt, R. E. V., Jankowski, C. M., Gozansky, W. S., Wolfe, P., Schwartz, R. S., & Kohrt, W. M. (2010) · Obesity · doi:10.1038/oby.2010.140 · Cited by 19 · see citing works

Increase of ATP-sensitive potassium (KATP) channels in the heart of type-1 diabetic rats

Chen, Z., Cheng, Y., Chen, L., Cheng, K., Li, Y. X., & Cheng, J. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-8 · Cited by 19 · see citing works

Tissue- and isoform-specific effects of aging in rats on protein kinase C in insulin-sensitive tissues

Qu, X., Seale, J. P., & Donnelly, R. (1999) · Clinical Science · doi:10.1042/cs0970355 · Cited by 18 · see citing works

Metabolic memory effect of the saturated fatty acid, palmitate, in monocytes

Gao, D., Bailey, C. J., & Griffiths, H. R. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.07.160 · Cited by 16 · see citing works

Fatty acids differentially modify the expression of urokinase type plasminogen activator receptor in monocytes

Aßmann, A., Möhlig, M., Osterhoff, M. A., Pfeiffer, A. F. H., & Spranger, J. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.08.115 · Cited by 14 · see citing works

Increase of visceral fat area in Indonesians and Japanese with normal BMI

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