Cited by 112Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

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Ageing, adipose tissue, fatty acids and inflammation

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Pararasa, Chathyan, Bailey, Clifford J., Griffiths, Helen R.·2015·Biogerontology

DOI 10.1007/s10522-014-9536-x

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Abstract

A common feature of ageing is the alteration in tissue distribution and composition, with a shift in fat away from lower body and subcutaneous depots to visceral and ectopic sites. Redistribution of adipose tissue towards an ectopic site can have dramatic effects on metabolic function. In skeletal muscle, increased ectopic adiposity is linked to insulin resistance through lipid mediators such as ceramide or DAG, inhibiting the insulin receptor signalling pathway. Additionally, the risk of developing cardiovascular disease is increased with elevated visceral adipose distribution. In ageing, adipose tissue becomes dysfunctional, with the pathway of differentiation of preadipocytes to mature adipocytes becoming impaired; this results in dysfunctional adipocytes less able to store fat and subsequent fat redistribution to ectopic sites. Low grade systemic inflammation is commonly observed in ageing, and may drive the adipose tissue dysfunction, as proinflammatory cytokines are capable of inhibiting adipocyte differentiation. Beyond increased ectopic adiposity, the effect of impaired adipose tissue function is an elevation in systemic free fatty acids (FFA), a common feature of many metabolic disorders. Saturated fatty acids can be regarded as the most detrimental of FFA, being capable of inducing insulin resistance and inflammation through lipid mediators such as ceramide, which can increase risk of developing atherosclerosis. Elevated FFA, in particular saturated fatty acids, maybe a driving factor for both the increased insulin resistance, cardiovascular disease risk and inflammation in older adults.

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Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358
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Kurkinensp, M., CondongT, M. R., Blumberg, B., Barlow, D. P., Quiñones, S., Sausg, J., & Pihlajaniemisyy, T. (2021) · Journal of Biological Chemistry · doi:10.1074/jbc · Cited by 3,427
The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population
Bedogni, G., Bellentani, S., Miglioli, L., Masutti, F., Passalacqua, M., Castiglione, A., & Tiribelli, C. (2006) · BMC Gastroenterology · doi:10.1186/1471-230x-6-33 · Cited by 3,146
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107
Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle
Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561
Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α
Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., & Simsolo, R. B. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117899 · Cited by 1,305
Saturated Fatty Acids, but Not Unsaturated Fatty Acids, Induce the Expression of Cyclooxygenase-2 Mediated through Toll-like Receptor 4
Lee, J. Y., Sohn, K. H., Rhee, S. H., & Hwang, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011695200 · Cited by 1,299
Prevalence of and Risk Factors for Nonalcoholic Fatty Liver Disease: The Dionysos Nutrition and Liver Study * #
Bedogni, G., Miglioli, L., Masutti, F., Tiribelli, C., Marchesini, G., & Bellentani, S. (2005) · Hepatology · doi:10.1002/hep.20734 · Cited by 1,270
Lipid-induced insulin resistance: unravelling the mechanism
Samuel, V. T., Petersen, K. F., & Shulman, G. I. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60408-4 · Cited by 1,189
"Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes.
Björntorp, P. A. (1990) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.10.4.493 · Cited by 1,115
A Paracrine Loop Between Adipocytes and Macrophages Aggravates Inflammatory Changes: Role of Free Fatty Acids and Tumor Necrosis Factor α
Suganami, T., Nishida, J., & Ogawa, Y. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000183883.72263.13 · Cited by 1,056 · cited 1×
“Saturated fatty acids are capable of inducing the production of proinflammatory cytokines from adipocytes (Permana et al. 2006; Suganami et al. 2005, 2007 ).”
Fuel selection in human skeletal muscle in insulin resistance: a reexamination.
Kelley, D. E., & Mandarino, L. J. (2000) · Diabetes · doi:10.2337/diabetes.49.5.677 · Cited by 1,017
Cross-Regulation of C/EBPα and PPARγ Controls the Transcriptional Pathway of Adipogenesis and Insulin Sensitivity
Wu, Z., Rosen, E. D., Brun, R. P., Hauser, S., Adelmant, G., Troy, A. E., McKeon, C., Darlington, G., & Spiegelman, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80306-8 · Cited by 1,015
Mechanisms of Disease: is osteoporosis the obesity of bone?
Rosen, C. J., & Bouxsein, M. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0070 · Cited by 974
Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation
Tomas, E., Tsao, T.-S., Saha, A. K., Murrey, H. E., Zhang, C. C., Itani, S. I., Lodish, H. F., & Ruderman, N. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222657499 · Cited by 973
Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease
Gaggini, M., Morelli, M., Buzzigoli, E., DeFronzo, R. A., Bugianesi, E., & Gastaldelli, A. (2013) · Nutrients · doi:10.3390/nu5051544 · Cited by 849
Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis
Justesen, J., Stenderup, K., Ebbesen, E., Mosekilde, L., Steiniche, T., & Kassem, M. (2004) · Biogerontology (Dordrecht) · doi:10.1023/a:1011513223894 · Cited by 847
Role of the Toll-like Receptor 4/NF-κB Pathway in Saturated Fatty Acid–Induced Inflammatory Changes in the Interaction Between Adipocytes and Macrophages
Suganami, T., Tanimoto-Koyama, K., Nishida, J., Itoh, M., Yuan, X., Mizuarai, S., Kotani, H., Yamaoka, S., Miyake, K., Aoe, S., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000251608.09329.9a · Cited by 820
Age-related changes in total and regional fat distribution
Kuk, J. L., Saunders, T. J., Davidson, L. E., & Ross, R. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.06.001 · Cited by 778
Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance
Kim, J. K., Fillmore, J. J., Chen, Y., Yu, C., Moore, I. K., Pypaert, M., Lutz, E. P., Kako, Y., Velez-Carrasco, W., Goldberg, I. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121164498 · Cited by 753
Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans
Adams, J. M., Pratipanawatr, T., Berria, R., Wang, E. L., DeFronzo, R. A., Sullards, M. C., & Mandarino, L. J. (2004) · Diabetes · doi:10.2337/diabetes.53.1.25 · Cited by 677
Obesity, Regional Body Fat Distribution, and the Metabolic Syndrome in Older Men and Women
Goodpaster, B. H., Krishnaswami, S., Harris, T. B., Katsiaras, A., Kritchevsky, S. B., Simonsick, E. M., Nevitt, M., Holvoet, P., & Newman, A. B. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.7.777 · Cited by 637
A Ceramide-Centric View of Insulin Resistance
Chavez, J. A., & Summers, S. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.002 · Cited by 637
Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways
Huang, S., Rutkowsky, J. M., Snodgrass, R. G., Ono‐Moore, K. D., Schneider, D. A., Newman, J. W. I., Adams, S. H., & Hwang, D. H. (2012) · Journal of Lipid Research · doi:10.1194/jlr.d029546 · Cited by 615
Macrophage Infiltration into Omental Versus Subcutaneous Fat across Different Populations: Effect of Regional Adiposity and the Comorbidities of Obesity
Harman-Boehm, I., Blüher, M., Redel, H., Sion-Vardy, N., Ovadia, S., Avinoach, E., Shai, I., Klöting, N., Stumvoll, M., Bashan, N., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1811 · Cited by 574
Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased visceral adiposity
Bays, H. E., González-Campoy, J. M., Bray, G. A., Kitabchi, A. E., Bergman, D. A., Schorr, A. B., Rodbard, H. W., & Henry, R. R. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.3.343 · Cited by 543
Epidemiology of non-alcoholic fatty liver disease in China
Fan, J., & Farrell, G. C. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.10.010 · Cited by 501
Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes
Chavez, J. A., & Summers, S. A. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.08.020 · Cited by 498
Body composition changes with aging: The cause or the result of alterations in metabolic rate and macronutrient oxidation?
St-Onge, M.-P., & Gallagher, D. (2010) · Nutrition · doi:10.1016/j.nut.2009.07.004 · Cited by 494
Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity
McLaughlin, T., Lamendola, C., Liu, A., & Abbasi, F. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0615 · Cited by 468
Skeletal muscle fat infiltration: impact of age, inactivity, and exercise
Marcus, R. L., Addison, O., Kidde, J. P., Dibble, L. E., & Lastayo, P. C. (2010) · The Journal of nutrition, health and aging · doi:10.1007/s12603-010-0081-2 · Cited by 449
Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36
Bonen, A., Parolin, M. L., Steinberg, G. R., Calles‐Escandon, J., Tandon, N. N., Glatz, J. F. C., Luiken, J. J. F. P., Heigenhauser, G. J. F., & Dyck, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1065fje · Cited by 410
Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance
Amati, F., Dubé, J. J., Alvarez-Carnero, E., Edreira, M. M., Chomentowski, P., Coen, P. M., Switzer, G. E., Bickel, P. E., Stefanovic-Racic, M., Toledo, F. G. S., et al. (2011) · Diabetes · doi:10.2337/db10-1221 · Cited by 395
Anthropometric assessment of 10-y changes in body composition in the elderly
HUGHES, V. A., Roubenoff, R., Wood, M., Frontera, W. R., Evans, W. J., & Singh, M. A. F. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.2.475 · Cited by 394
Glucose intolerance and aging
DeFronzo, R. A. (1981) · Diabetes Care · doi:10.2337/diacare.4.4.493 · Cited by 389
Aortic Stiffness Is Associated With Visceral Adiposity in Older Adults Enrolled in the Study of Health, Aging, and Body Composition
Sutton‐Tyrrell, K., Newman, A. B., Simonsick, E. M., Havlik, R. J., Pahor, M., Lakatta, E. G., Spurgeon, H. A., Vaitkevicius, P. V., & for the Health ABC Investigators (2001) · Hypertension · doi:10.1161/01.hyp.38.3.429 · Cited by 389
Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited
Dubé, J. J., Amati, F., Stefanovic-Racic, M., Toledo, F. G. S., Sauers, S. E., & Goodpaster, B. H. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00769.2007 · Cited by 378
Excessive adipose tissue infiltration in skeletal muscle in individuals with obesity, diabetes mellitus, and peripheral neuropathy: association with performance and function
Hilton, T. N., Tuttle, L. J., Bohnert, K. L., Mueller, M. J., & Sinacore, D. R. (2008) · Physical Therapy · doi:10.2522/ptj.20080079 · Cited by 373
Waist circumference and abdominal adipose tissue distribution: influence of age and sex
Kuk, J. L., Lee, S., Heymsfield, S. B., & Ross, R. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.6.1330 · Cited by 355
Marrow Fat and the Bone Microenvironment: Developmental, Functional, and Pathological Implications
Rosen, C. J., Ackert‐Bicknell, C. L., Rodriguez, J. P., & Pino, A. M. (2009) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v19.i2.20 · Cited by 353
Adipogenesis and aging: does aging make fat go MAD
Kirkland, J. L., Tchkonia, T., Pirtskhalava, T., Han, J., & Karagiannides, I. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00014-1 · Cited by 339
Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha
Zhang, B., Berger, J., Hu, E., Szalkowski, D., White-Carrington, S., Spiegelman, B. M., & Moller, D. E. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.11.8923470 · Cited by 328
Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content
Bruce, C. R., Thrush, A. B., Mertz, V. A., Bezaire, V., Chabowski, A., Heigenhauser, G. J. F., & Dyck, D. J. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00587.2005 · Cited by 328
Aging in adipocytes: Potential impact of inherent, depot-specific mechanisms
CARTWRIGHT, M., TCHKONIA, T., & KIRKLAND, J. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.03.003 · Cited by 318 · cited 2×
“Replication and maturation into adipocytes depends on the activity of CCAAT/enhancer binding protein a (C/EBPa) and peroxisome proliferator activatedreceptor c (PPAR-c) (Wu et al. 1999; Zuo et al. 2006) which are diminished in ageing (Cartwright et al. 2007; Karagiannides et al. 2001, 2006).”
Lipotoxicity, overnutrition and energy metabolism in aging
Slawik, M., & Vidal‐Puig, A. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.03.004 · Cited by 308
Macrophage-secreted factors induce adipocyte inflammation and insulin resistance
Permana, P. A., Menge, C., & Reaven, P. D. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.012 · Cited by 307
Aging Up-Regulates Expression of Inflammatory Mediators in Mouse Adipose Tissue
Wu, D., Ren, Z., Pae, M., Guo, W., Cui, X., Merrill, A. H., & Meydani, S. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4829 · Cited by 293
Comparison of proliferation and differentiation capacity of human adipocyte precursor cells from the omental and subcutaneous adipose tissue depot of obese subjects
van Harmelen, V., Röhrig, K., & Hauner, H. (2004) · Metabolism · doi:10.1016/j.metabol.2003.11.012 · Cited by 285
Non-Alcoholic Fatty Liver Disease in Older People
Frith, J., Day, C. P., Henderson, E., Burt, A. D., & Newton, J. L. (2009) · Gerontology · doi:10.1159/000235677 · Cited by 280
The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection
Bartlett, D. B., Firth, C. M., Phillips, A. C., Moss, P., Baylis, D., Syddall, H., Sayer, A. A., Cooper, C., & Lord, J. M. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00849.x · Cited by 278
Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle
Ellis, B. A., Poynten, A., Lowy, A. J., Furler, S. M., Chisholm, D. J., Kraegen, E. W., & Cooney, G. J. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.3.e554 · Cited by 273
Intramuscular and Liver Triglycerides Are Increased in the Elderly
Cree‐Green, M., Newcomer, B. R., Katsanos, C. S., Sheffield‐Moore, M., Chinkes, D. L., Aarsland, A. A., Urban, R. J., & Wolfe, R. R. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031986 · Cited by 273
Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes
Guo, W., Wong, S., Xie, W., Lei, T., & Luo, Z. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00523.2006 · Cited by 248
DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells
Montell, E., Turini, M., Marotta, M., Roberts, M., Noé, V., Ciudad, C. J., Macé, K., & Gómez-Foix, A. M. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.2.e229 · Cited by 245
Insulin Resistance Is Associated With Higher Intramyocellular Triglycerides in Type I but Not Type II Myocytes Concomitant With Higher Ceramide Content
Coen, P. M., Dubé, J. J., Amati, F., Stefanović-Račić, M., Ferrell, R. E., Toledo, F. G. S., & Goodpaster, B. H. (2009) · Diabetes · doi:10.2337/db09-0988 · Cited by 236
Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state
van Loon, L. J. C., & Goodpaster, B. H. (2006) · Pflügers Archiv · doi:10.1007/s00424-005-1509-0 · Cited by 232
Contribution of Abdominal Adiposity to Age-Related Differences in Insulin Sensitivity and Plasma Lipids in Healthy Nonobese Women
DeNino, W. F., Tchernof, A., Dionne, I. J., Toth, M. J., Ades, P. A., Sites, C. K., & Poehlman, É. T. (2001) · Diabetes Care · doi:10.2337/diacare.24.5.925 · Cited by 229
Gender-specific association between −1082 IL-10 promoter polymorphism and longevity
Lio, D., Scola, L., Crivello, A., Colonna‐Romano, G., Candore, G., Bonafè, M., Cavallone, L., Franceschi, C., & Caruso, C. (2002) · Genes and Immunity · doi:10.1038/sj.gene.6363827 · Cited by 227
Increased Adipogenesis and Myelopoiesis in the Bone Marrow of SAMP6, a Murine Model of Defective Osteoblastogenesis and Low Turnover Osteopenia
Kajkenova, O., Lecka‐Czernik, B., Gubrij, I. B., Hauser, S. P., Takahashi, K., PARFITT, A. M., Jilka, R. L., Manolagas, S. C., & Lipschitz, D. A. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.11.1772 · Cited by 226
Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver
Perseghin, G., Lattuada, G., COBELLI, F. D., Esposito, A., Belloni, E., Ntali, G., Ragogna, F., Canu, T., Scifo, P., Maschio, A. D., et al. (2007) · Hepatology · doi:10.1002/hep.21983 · Cited by 213
Body composition changes in stable-weight elderly subjects: The effect of sex
Zamboni, M. M., Zoico, E., Scartezzini, T., Mazzali, G., Tosoni, P., Zivelonghi, A., Gallagher, D., Pergola, G. D., Francesco, V. D., & Bosello, O. (2003) · Aging Clinical and Experimental Research · doi:10.1007/bf03324517 · Cited by 209
Activation of CCAAT/Enhancer-binding Protein (C/EBP) α Expression by C/EBPβ during Adipogenesis Requires a Peroxisome Proliferator-activated Receptor-γ-associated Repression of HDAC1 at the C/ebpα Gene Promoter
Zuo, Y., Qiang, L., & Farmer, S. R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510682200 · Cited by 205
Free Fatty Acids Are Independently Associated with All-Cause and Cardiovascular Mortality in Subjects with Coronary Artery Disease
Pilz, S., Scharnagl, H., Tiran, B., Seelhorst, U., Wellnitz, B., Boehm, B. O., Schaefer, J. R., & März, W. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0195 · Cited by 199
Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis.
Stephens, J. M., & Pekala, P. H. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42251-x · Cited by 196
Abdominal Obesity Is an Independent Risk Factor for Chronic Heart Failure in Older People
Nicklas, B. J., Cesari, M., Penninx, B. W. J. H., Kritchevsky, S. B., Ding, J., Newman, A. B., Kitzman, D. W., Kanaya, A. M., Pahor, M., & Harris, T. B. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.00624.x · Cited by 195
Plasma and Serum Lipidomics of Healthy White Adults Shows Characteristic Profiles by Subjects’ Gender and Age
Ishikawa, M., Maekawa, K., Saito, K., Senoo, Y., Urata, M., Murayama, M., Tajima, Y., Kumagai, Y., & Saito, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091806 · Cited by 188
Thigh circumference and risk of heart disease and premature death: prospective cohort study
Heitmann, B. L., & Frederiksen, P. (2009) · BMJ · doi:10.1136/bmj.b3292 · Cited by 186
Altered expression of C/EBP family members results in decreased adipogenesis with aging
Karagiannides, I., Tchkonia, T., Dobson, D. E., Steppan, C. M., Cummins, P., Chan, G., Salvatori, K., Hadzopoulou‐Cladaras, M., & Kirkland, J. L. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.6.r1772 · Cited by 182
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Silaghi, A., Piercecchi‐Marti, M., Grino, M., Leonetti, G., Alessi, M. C., Clement, K., Dadoun, F., & Dutour, A. (2008) · Obesity · doi:10.1038/oby.2008.379 · Cited by 181
Nutrient Modification of the Innate Immune Response
Schwartz, E. A., Zhang, W.-Y., Karnik, S. K., Borwege, S., Anand, V. R., Laine, P. S., Su, Y., & Reaven, P. D. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.201681 · Cited by 180
Skeletal Muscle Insulin Resistance Promotes Increased Hepatic De Novo Lipogenesis, Hyperlipidemia, and Hepatic Steatosis in the Elderly
Flannery, C. A., Dufour, S., Rabøl, R., Shulman, G. I., & Petersen, K. F. (2012) · Diabetes · doi:10.2337/db12-0206 · Cited by 175
The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence
Youm, Y.-H., Kanneganti, T.-D., Vandanmagsar, B., Zhu, X., Ravussin, A., Adijiang, A., Owen, J. S., Thomas, M. J., Francis, J., Parks, J. S., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2011.11.005 · Cited by 172
Abdominal Adiposity Is a Stronger Predictor of Insulin Resistance Than Fitness Among 50–95 Year Olds
Racette, S. B., Evans, E. M., Weiss, E. P., Hagberg, J. M., & Holloszy, J. O. (2006) · Diabetes Care · doi:10.2337/diacare.29.03.06.dc05-1605 · Cited by 167
Effects of Insulin Treatment in Type 2 Diabetic Patients on Intracellular Lipid Content in Liver and Skeletal Muscle
Anderwald, C. H., Bernroider, E., Krššák, M., Stingl, H., Brehm, A., Bischof, M. G., Nowotny, P., Roden, M., & Waldhäusl, W. K. (2002) · Diabetes · doi:10.2337/diabetes.51.10.3025 · Cited by 166
Liver‐Fat Accumulation and Insulin Resistance in Obese Women with Previous Gestational Diabetes
Tiikkainen, M., Tamminen, M., Häkkinen, A., Bergholm, R., Vehkavaara, S., Halavaara, J. T., Teramo, K., Rissanen, A., & Yki‐Järvinen, H. (2002) · Obesity Research · doi:10.1038/oby.2002.118 · Cited by 165
Age and gender related effects on adipose tissue compartments of subjects with increased risk for type 2 diabetes: a whole body MRI / MRS study
Machann, J., Thamer, C., Schnödt, B., Stefan, N., Stümvoll, M., Häring, H.-U., Claussen, C. D., Schick, F., & Fritsche, A. (2005) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/s10334-005-0104-x · Cited by 157
Age-Associated Increase in Cytokine Production During Systemic Inflammation: Adipose Tissue as a Major Source of IL-6
Starr, M. E., Evers, B. M., & Saitō, H. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp046 · Cited by 154
Effect of Weight Loss on Insulin Sensitivity and Intramuscular Long-Chain Fatty Acyl-CoAs in Morbidly Obese Subjects
Houmard, J. A., Tanner, C. J., Yu, C., Cunningham, P. G., Pories, W. J., MacDonald, K. G., & Shulman, G. I. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2959 · Cited by 151
Key Role for Ceramides in Mediating Insulin Resistance in Human Muscle Cells
Pickersgill, L., Litherland, G. J., Greenberg, A. S., Walker, M., & Yeaman, S. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611157200 · Cited by 150
Intermuscular adipose tissue rivals visceral adipose tissue in independent associations with cardiovascular risk
Yim, J.-E., Heshka, S., Albu, J., Heymsfield, S. B., Kuznia, P., Harris, T. B., & Gallagher, D. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803621 · Cited by 149
Age, gender, and skeletal variation in bone marrow composition: A preliminary study at 3.0Tesla
Liney, G. P., Bernard, C. P., Manton, D. J., Turnbull, L. W., & Langton, C. M. (2007) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21072 · Cited by 148
The Role of TNF-α in Human Adipose Tissue: Prevention of Weight Gain at the Expense of Insulin Resistance?
Hube, F., & Hauner, H. (1999) · Hormone and Metabolic Research · doi:10.1055/s-2007-978810 · Cited by 142
A Brief Report
Davis, L. E., Johnson, S., Miller‐Cribbs, J., & Saunders, J. A. (2002) · Journal of Adolescent Research · doi:10.1177/0743558402173001 · Cited by 141
Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity
Skovbro, M., Baranowski, M., Skov-Jensen, C., Flint, A., Dela, F., Górski, J., & Helge, J. W. (2008) · Diabetologia · doi:10.1007/s00125-008-1014-z · Cited by 133
Effect of Dietary Fat Saturation on LDL Oxidation and Monocyte Adhesion to Human Endothelial Cells In Vitro
Mata, P., Rodrigo Alonso, K., López-Farré, A. J., Ordovás, J. M., Lahoz, C., Garcés, C., Caramelo, C. A., Codoceo, R., Blazquez, E., & de Oya, M. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.11.1347 · Cited by 133
Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance.
Thompson, A. L., & Cooney, G. J. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1761 · Cited by 132
The ageing male heart: myocardial triglyceride content as independent predictor of diastolic function
van der Meer, R. W., Rijzewijk, L. J., Diamant, M., Hammer, S., Schär, M., Bax, J. J., Smit, J. W. A., Romijn, J. A., Roos, A., & Lamb, H. J. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn207 · Cited by 132
Molecular mechanisms of lipid‐induced insulin resistance in muscle, liver and vasculature
Krebs, M., & Roden, M. (2004) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2004.00439.x · Cited by 130
Tissue and isoform-selective activation of protein kinase C in insulin-resistant obese Zucker rats - effects of feeding.
Qu, X.-Q., Seale, J., & Donnelly, R. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1620207 · Cited by 123
Interrelations between fat distribution, muscle lipid content, adipocytokines, and insulin resistance: effect of moderate weight loss in older women
Mazzali, G., Di Francesco, V., Zoico, E., Fantin, F., Zamboni, G., Benati, C., Bambara, V., Negri, M., Bosello, O., & Zamboni, M. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.5.1193 · Cited by 120
Long-Chain Acyl CoA Regulation of Protein Kinase C and Fatty Acid Potentiation of Glucose-Stimulated Insulin Secretion in Clonalβ -Cells1
Yaney, G. C., Korchak, H. M., & Corkey, B. E. (2000) · Endocrinology · doi:10.1210/endo.141.6.7493 · Cited by 117
Skeletal muscle GLUT4 protein concentration and aging in humans
Houmard, J. A., Weidner, M. D., Dolan, P. L., Leggett-Frazier, N., Gavigan, K. E., Hickey, M. S., Tyndall, G. L., Zheng, D., Alshami, A., & Dohm, G. L. (1995) · Diabetes · doi:10.2337/diab.44.5.555 · Cited by 115
Skeletal muscle GLUT4 protein concentration and aging in humans
Houmard, J. A., Weidner, M. D., Dolan, P. L., Leggett-Frazier, N., Gavigan, K. E., Hickey, M. S., Tyndall, G. L., Zheng, D., Alshami, A., & Dohm, G. L. (1995) · Diabetes · doi:10.2337/diabetes.44.5.555 · Cited by 115
Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat
Laybutt, D. R., Schmitz‐Peiffer, C., Saha, A. K., Ruderman, N. B., Biden, T. J., & Kraegen, E. W. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.6.e1070 · Cited by 114
A central role for ceramide in the age‐related acceleration of apoptosis in the female germline
Perez, G. I., Jurisicova, A., Matikainen, T., Moriyama, T., Kim, M.-R., Takai, Y., Pru, J. K., Kolesnick, R., & Tilly, J. L. (2005) · The FASEB Journal · doi:10.1096/fj.04-2903fje · Cited by 114
Intramyocellular Lipid Content and Molecular Adaptations in Response to a 1‐Week High‐Fat Diet
Schrauwen‐Hinderling, V. B., Kooi, M. E., Hesselink, M. K. C., Moonen‐Kornips, E., Schaart, G., Mustard, K. J., Hardie, D. G., Saris, W. H. M., Nicolay, K., & Schrauwen, P. (2005) · Obesity Research · doi:10.1038/oby.2005.259 · Cited by 112
Activation of sphingolipid turnover and chronic generation of ceramide and sphingosine in liver during aging
Lightle, S. A., Oakley, J. I., & Nikolova‐Karakashian, M. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00191-3 · Cited by 112
Aging, Resting Metabolic Rate, and Oxidative Damage: Results From the Louisiana Healthy Aging Study
Frisard, M. I., Broussard, A. P., Davies, S. S., Roberts, L. J., Rood, J. C., de Jonge, L., Fang, X., Jazwinski, S. M., Deutsch, W. A., Ravussin, É., et al. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.7.752 · Cited by 109
Molecular Mechanisms in Aging and Current Strategies to Counteract Sarcopenia
Sakuma, K., & Yamaguchi, A. (2010) · Current Aging Science · doi:10.2174/1874609811003020090 · Cited by 106
Increased Epicardial Fat Volume Quantified by 64-Multidetector Computed Tomography is Associated With Coronary Atherosclerosis and Totally Occlusive Lesions
Ueno, K., Anzai, T., Jinzaki, M., Yamada, M., Jo, Y., Maekawa, Y., Kawamura, A., Yoshikawa, T., Tanami, Y., Satô, K., et al. (2009) · Circulation Journal · doi:10.1253/circj.cj-09-0266 · Cited by 105
Evidence for Adipose-Muscle Cross Talk: Opposing Regulation of Muscle Proteolysis by Adiponectin and Fatty Acids
Zhou, Q., Du, J., Hu, Z., Walsh, K. X., & Wang, X. H. (2007) · Endocrinology · doi:10.1210/en.2007-0183 · Cited by 105
Increased protein kinase C theta in skeletal muscle of diabetic patients
Itani, S. I., Pories, W. J., MacDonald, K. G., & Dohm, G. L. (2001) · Metabolism · doi:10.1053/meta.2001.22512 · Cited by 101
Reduced skeletal muscle oxidative capacity and elevated ceramide but not diacylglycerol content in severe obesity
Coen, P. M., Hames, K. C., Leachman, E. M., DeLany, J. P., Ritov, V. B., Menshikova, E. V., Dubé, J. J., Stefanović-Račić, M., Toledo, F. G. S., & Goodpaster, B. H. (2013) · Obesity · doi:10.1002/oby.20381 · Cited by 97
Lower resting metabolic rate in the elderly may not be entirely due to changes in body composition
Krems, C., Lührmann, P. M., Straßburg, A., Hartmann, B., & Neuhäuser‐Berthold, M. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602066 · Cited by 96
Fatty liver as a consequence and cause of insulin resistance: Lessons from type 2 diabetic liver
Takamura, T., Misu, H., Ota, T., & Kaneko, S. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej12-0228 · Cited by 96
Increased ceramide content and NFκB signaling may contribute to the attenuation of anabolic signaling after resistance exercise in aged males
Rivas, D. A., Morris, E. P., Haran, P. H., Pasha, E. P., Morais, M. D. S., Dolnikowski, G. G., Phillips, E. M., & Fielding, R. A. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00412.2012 · Cited by 95
The Changing Balance Between Osteoblastogenesis and Adipogenesis in Aging and its Impact on Hematopoiesis
Bethel, M., Chitteti, B. R., Srour, E. F., & Kacena, M. A. (2013) · Current Osteoporosis Reports · doi:10.1007/s11914-013-0135-6 · Cited by 93
CD36 in Myocytes Channels Fatty Acids to a Lipase-Accessible Triglyceride Pool That Is Related to Cell Lipid and Insulin Responsiveness
Bastie, C. C., Hajri, T., Drover, V. A. B., Grimaldi, P. A., & Abumrad, N. A. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2209 · Cited by 91
Aging effects on human calf muscle properties assessed by MRI at 3 Tesla
Schwenzer, N. F., Martirosian, P., Machann, J., Schraml, C., Steidle, G., Claussen, C. D., & Schick, F. (2009) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21789 · Cited by 88
Prevalence and risk factors of fatty liver disease in Chengdu, Southwest China.
Li, H., Wang, Y., Tan, K., Zeng, L., Liu, L., Liu, F., Zhou, T., Chen, E., & Tang, H. W. (2009) · PubMed · Cited by 86
Non‐alcoholic fatty liver disease – a common and benign finding in octogenarian patients
Kagansky, N., Levy, S., Keter, D., Rimon, E., Taiba, Z., Fridman, Z., Berger, D. L., Knobler, H., & Malnick, S. D. H. (2004) · Liver International · doi:10.1111/j.1478-3231.2004.0969.x · Cited by 86
Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity
Guo, W., Pirtskhalava, T., Tchkonia, T., Xie, W., Thomou, T., Han, J., Wang, T., Wong, S., Cartwright, A., Hegardt, F. G., et al. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00557.2006 · Cited by 85
Increased TNFα and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis
Tchkonia, T., Pirtskhalava, T., Thomou, T., Cartwright, M. J., Wise, B. L., Karagiannides, I., Shpilman, A., Lash, T. L., Becherer, J. D., & Kirkland, J. L. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00295.2007 · Cited by 81
Greater adipose tissue infiltration in skeletal muscle among older men of African ancestry
Miljkovic, I., Cauley, J. A., Petit, M. A., Ensrud, K. E., Strotmeyer, E., Sheu, Y., Gordon, C. L., Goodpaster, B. H., Bunker, C. H., Patrick, A. L., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2541 · Cited by 79
JNK- and IκB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro
Takahashi, K., Yamaguchi, S., Shimoyama, T., Seki, H., Miyokawa, K., Katsuta, H., Tanaka, T., Yoshimoto, K., Ohno, H., Nagamatsu, S., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00131.2007 · Cited by 79
Altered body composition in type 2 diabetes mellitus
Heshka, S., Ruggiero, A. M., Bray, G. A., Foreyt, J. P., Kahn, S. E., Lewis, C. E., Saad, M. F., & Schwartz, A. V. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803802 · Cited by 75
Elevated Free Fatty Acids Attenuate the Insulin-Induced Suppression of PDK4 Gene Expression in Human Skeletal Muscle: Potential Role of Intramuscular Long-Chain Acyl-Coenzyme A
Tsintzas, K., Chokkalingam, K., Jewell, K., Norton, L., Macdonald, I. A., & Constantin‐Teodosiu, D. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1104 · Cited by 74
Increased CUG Triplet Repeat-binding Protein-1 Predisposes to Impaired Adipogenesis with Aging
Karagiannides, I., Thomou, T., Tchkonia, T., Pirtskhalava, T., Kypreos, K. E., Cartwright, A., Dalagiorgou, G., Lash, T. L., Farmer, S. R., Timchenko, N. A., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513187200 · Cited by 71
Elevated concentrations of nonesterified fatty acids increase monocyte expression of CD11b and adhesion to endothelial cells.
Zhang, W.-Y., Schwartz, E., Wang, Y., Attrep, J., Li, Z., & Reaven, P. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000200226.53994.09 · Cited by 70
Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis
Gao, D., Pararasa, C., Dunston, C. R., Bailey, C. J., & Griffiths, H. R. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.026 · Cited by 69
Self-citation
Effects of aging on the content, composition and synthesis of sphingomyelin in the central nervous system
Giusto, N. M., Roque, M. E., & de Boschero, M. G. I. (1992) · Lipids · doi:10.1007/bf02535859 · Cited by 68
Intramuscular adipose tissue attenuates gains in muscle quality in older adults at high risk for falling. A brief report
Marcus, R. L., Addison, O., & LaStayo, P. C. (2013) · The Journal of nutrition, health and aging · doi:10.1007/s12603-012-0377-5 · Cited by 65
Adipose Tissue-Derived Tumor Necrosis Factor- Activity Is Elevated in Older Rats
Morin, C. L., Pagliassotti, M. J., Windmiller, D. A., & Eckel, R. H. (1997) · The Journals of Gerontology Series A · doi:10.1093/gerona/52a.4.b190 · Cited by 65
In vivo evidence that acyl coenzyme A regulates DNA binding by the Escherichia coli FadR global transcription factor
Cronan, J. E. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.5.1819-1823.1997 · Cited by 61
Independent and Opposite Associations of Trunk and Leg Fat Depots with Adipokines, Inflammatory Markers, and Metabolic Syndrome in Middle-Aged and Older Chinese Men and Women
Wu, H., Qi, Q., Yu, Z., Sun, Q., Wang, J., Franco, O. H., Sun, L. D., Li, H., Liu, Y., Hu, F. B., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0181 · Cited by 60
Trunk Versus Extremity Adiposity and Cardiometabolic Risk Factors in White and African American Adults
Hu, G., Bouchard, C., Bray, G. A., Greenway, F. L., Johnson, W. D., Newton, R. L., Ravussin, É., Ryan, D. H., & Katzmarzyk, P. T. (2011) · Diabetes Care · doi:10.2337/dc10-2019 · Cited by 54
Fat in Liver/Muscle Correlates More Strongly With Insulin Sensitivity in Rats Than Abdominal Fat
Lim, S. K., Son, K. R., Song, I. C., Park, H. S., Jin, C. J., Jang, H. C., Park, K. S., Kim, Y., & Lee, H. K. (2008) · Obesity · doi:10.1038/oby.2008.486 · Cited by 53
Role of impaired intracellular glucose metabolism in the insulin resistance of aging
Gumbiner, B. M., Thorburn, A. W., Ditzler, T. M., Bulacan, F., & Henry, R. R. (1992) · Metabolism · doi:10.1016/0026-0495(92)90296-m · Cited by 49
Ceramide Mediates Age-associated Increase in Macrophage Cyclooxygenase-2 Expression
Claycombe, K., Wu, D., Nikolova‐Karakashian, M., Palmer, H. J., Beharka, A. A., Paulson, K. E., & Meydani, S. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204463200 · Cited by 49
A New Member of the Escherichia coli fad Regulon: Transcriptional Regulation of fadM ( ybaW )
Feng, Y., & Cronan, J. E. (2009) · Journal of Bacteriology · doi:10.1128/jb.00835-09 · Cited by 48
The association of insulin resistance and carotid atherosclerosis with thigh and calf circumference in patients with type 2 diabetes
Park, J. S., Cho, M. H., Ahn, C. W., Kim, K. R., & Huh, K. B. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-62 · Cited by 48
Adipose Tissue-Derived Tumor Necrosis Factor Activity Correlates with Fat Cell Size But Not Insulin Action in Aging Rats**This work was supported by National Institutes of Aging Grant KO1-AG00645 (to C.M.) and the National Institutes of Health Grant DK-47416 (to M.P.).
Morin, C. L., Gayles, E. C., Podolin, D. A., Wei, Y., Xu, M., & Pagliassotti, M. J. (1998) · Endocrinology · doi:10.1210/endo.139.12.6369 · Cited by 46
The Saturated Fatty Acid Palmitate Induces Human Monocytic Cell Toxicity Toward Neuronal Cells: Exploring a Possible Link Between Obesity-Related Metabolic Impairments and Neuroinflammation
Little, J. P., Madeira, J. M., & Klegeris, A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111262 · Cited by 45
Liver fat content is associated with increased carotid atherosclerosis in a Chinese middle-aged and elderly population: The Shanghai Changfeng study
Li, X., Xia, M., Ma, H., Albert Hofman, D., Hu, Y., Yan, H., He, W., Lin, H., Jeekel, J. J., Zhao, N., et al. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.07.002 · Cited by 45
Altered expression of glucose transporter isoforms with aging in rats ? selective decrease in GluT4 in the fat tissue and skeletal muscle
Lin, J. L., Asano, T., Shibasaki, Y., Tsukuda, K., Katagiri, H., Ishihara, H., Takaku, F., & Oka, Y. (1991) · Diabetologia · doi:10.1007/bf00403283 · Cited by 45
Effects of aging on basal fat oxidation in obese humans
Solomon, T. P. J., Marchetti, C. M., Krishnan, R. K., González, F., & Kirwan, J. P. (2008) · Metabolism · doi:10.1016/j.metabol.2008.03.021 · Cited by 44
Associations Between Trunk, Leg and Total Body Adiposity with Arterial Stiffness
Lee, M., Choh, A. C., Demerath, E. W., Towne, B., Siervogel, R. M., & Czerwinski, S. A. (2012) · American Journal of Hypertension · doi:10.1038/ajh.2012.92 · Cited by 44
Shift in sphingolipid metabolism leads to an accumulation of ceramide in senescence
Venable, M. E., Webb-Froehlich, L. M., Sloan, E. F., & Thomley, J. E. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.01.003 · Cited by 43
Visceral adipose tissue, adiponectin levels and insulin resistance are related to atherosclerosis as assessed by whole-body magnetic resonance angiography in an elderly population
Hansen, T., Ahlström, H. K., Söderberg, S., Hulthe, J., Wikström, J., Lind, L., & Johansson, L. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.11.007 · Cited by 35
Age-related remodeling of small arteries is accompanied by increased sphingomyelinase activity and accumulation of long-chain ceramides
Ohanian, J., Liao, A., Forman, S. P., & Ohanian, V. (2014) · Physiological Reports · doi:10.14814/phy2.12015 · Cited by 34
Waist-to-thigh ratio and diabetes among US adults: The Third National Health and Nutrition Examination Survey
Li, C., Ford, E. S., Zhao, G., Kahn, H. S., & Mokdad, A. H. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2010.02.014 · Cited by 31
Peroxisome Proliferator-Activated Receptor Down-Regulation Is Associated With Enhanced Ceramide Levels in Age-Associated Cardiac Hypertrophy
Rodríguez‐Calvo, R., Serrano, L., Barroso, E., Coll, T., Palomer, X., Camins, A., Sanchez, R. M., Alegret, M., Merlos, M., Pallàs, M., et al. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.12.1326 · Cited by 31
Leg fat mass as measured by dual X‐ray absorptiometry (DXA) impacts insulin resistance differently in obese women versus men
Aasen, G., Fagertun, H., Tonstad, S., & Halse, J. (2008) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510802464641 · Cited by 29
Central and peripheral fat and subclinical vascular damage in older women
Fantin, F., Rossi, A. P., Cazzadori, M., Comellato, G., Mazzali, G., Gozzoli, M. P., Grison, E., & Zamboni, M. M. (2013) · Age and Ageing · doi:10.1093/ageing/aft005 · Cited by 29
Comparison of regional body composition and its relation with cardiometabolic risk between BMI-matched young and old subjects
Lee, Y., Shin, H., Vassy, J. L., Kim, J. T., Cho, S., Kang, S. M., Choi, S. H., Kim, K. W., Park, K. S., Jang, H. C., et al. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.07.013 · Cited by 27
Visceral Adiposity and Subclinical Coronary Artery Disease in Elderly Adults: Rancho Bernardo Study
Kim, D., Bergstrom, J., Barrett-Connor, E. L., & Laughlin, G. A. (2008) · Obesity · doi:10.1038/oby.2008.15 · Cited by 22
Macrophages Accumulation in Visceral and Subcutaneous Adipose Tissue Correlates with Age
Jerschow, E., Anwar, S., Barzilai, N., & Rosenstreich, D. L. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.12.066 · Cited by 21
Sex Differences in the Association of Thigh Fat and Metabolic Risk in Older Adults
Pelt, R. E. V., Jankowski, C. M., Gozansky, W. S., Wolfe, P., Schwartz, R. S., & Kohrt, W. M. (2010) · Obesity · doi:10.1038/oby.2010.140 · Cited by 19
Increase of ATP-sensitive potassium (KATP) channels in the heart of type-1 diabetic rats
Chen, Z., Cheng, Y., Chen, L., Cheng, K., Li, Y. X., & Cheng, J. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-8 · Cited by 19
Tissue- and isoform-specific effects of aging in rats on protein kinase C in insulin-sensitive tissues
Qu, X., Seale, J. P., & Donnelly, R. (1999) · Clinical Science · doi:10.1042/cs0970355 · Cited by 18
Metabolic memory effect of the saturated fatty acid, palmitate, in monocytes
Gao, D., Bailey, C. J., & Griffiths, H. R. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.07.160 · Cited by 16
Self-citation
Fatty acids differentially modify the expression of urokinase type plasminogen activator receptor in monocytes
Aßmann, A., Möhlig, M., Osterhoff, M. A., Pfeiffer, A. F. H., & Spranger, J. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.08.115 · Cited by 14
Increase of visceral fat area in Indonesians and Japanese with normal BMI
Fuke, Y., Okabe, S., Kajiwara, N., Suastika, K., Budhiarta, A. A. G., 前畑聡子, & Taniguchi, H. (2007) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2007.01.062 · Cited by 10
Regional adiposity and risk for coronary artery disease in type 1 diabetes: Does having greater amounts of gluteal-femoral adiposity lower the risk?
Shay, C. M., Secrest, A. M., Goodpaster, B. H., Kelsey, S. F., Strotmeyer, E. S., & Orchard, T. J. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2010.03.028 · Cited by 10
Age-related Differences in the Clinical Presentation, Associated Metabolic Abnormality, and Estimated Cardiovascular Risks from Nonalcoholic Fatty Liver Disease: A Cross-sectional Study from Health Evaluation Center in Taiwan
Liu, C., Hung, C., Shih, S., Ko, H.-J., Lu, Y., Wu, Y., Cheng, H.-Y., Hu, K., Yeh, H., & Chang, R. (2010) · International journal of gerontology · doi:10.1016/j.ijge.2010.11.005 · Cited by 7
Tissue- and isoform-specific effects of aging in rats on protein kinase C in insulin-sensitive tissues
Qu, X., Seale, J. P., & Donnelly, R. (1999) · Clinical Science · doi:10.1042/cs19990054 · Cited by 7
Research in practice: More than skin deep –aging of subcutaneous fat tissue
Berneburg, M. (2010) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2010.07480.x · Cited by 6

Research works printed but not linked: 1

Tchkonia T, Wise B, Chan G, Karagiannides I, Kirkland JL (2001) Aging, CHOP expression, and preadipocyte differentiation. Obes Res 9:147S–147S

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Authors: Pararasa, C., Bailey, C. J., & Griffiths, H. R.
Affiliations: Aston University (GB)
Corresponding author: Pararasa, Chathyan
ORCID: Bailey, Clifford J.
Griffiths, Helen R.
Venue: Biogerontology
Publisher: Springer Science and Business Media LLC
Published: 2014-11-04
Volume: 16
Issue: 2
Pages: 235-248
ISSN: 1389-5729 (ISSN-L)
1573-6768
DOI: 10.1007/s10522-014-9536-x
OpenAlex: W2037497975
Cited by: 110
References: 158
Citations by year: 2026: 6 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 13 · 2021: 12 · 2020: 11 · 2019: 8 · 2018: 15 · 2017: 7 · 2016: 8 · 2015: 2
FWCI: 0.76
Type: journal article
Language: en
Open access: green
publications.aston.ac.uk
Licence: www.springer.com/tdm (tdm)
Locations: Biogerontology (publishedVersion)
PubMed (publishedVersion)
Aston Publications Explorer (Aston University) (submittedVersion)
Funders: Biotechnology and Biological Sciences Research Council
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: aging, adipose tissue, ectopic fat, visceral fat, insulin resistance, adipocyte dysfunction, adipogenesis, free fatty acids, saturated fatty acids, ceramide, diacylglycerol, low-grade inflammation, inflammatory cytokines, atherosclerosis, cardiovascular risk, skeletal muscle
MeSH terms: Adipose Tissue, Aging, Animals, Fatty Acids, Humans, Inflammation, Insulin Resistance, Metabolic Diseases, Models, Immunological

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Ageing, adipose tissue, fatty acids and inflammation

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