Novel multi-sided, microelectrode arrays for implantable neural applications
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A new parylene-based microfabrication process is presented for neural recording and drug delivery applications. We introduce a large design space for electrode placement and structural flexibility with a six mask process. By using chemical mechanical polishing, electrode sites may be created top-side, back-side, or on the edge of the device having three exposed sides. Added surface area was achieved on the exposed edge through electroplating. Poly(3,4-ethylenedioxythiophene) (PEDOT) modified edge electrodes having an 85-μm(2) footprint resulted in an impedance of 200 kΩ at 1 kHz. Edge electrodes were able to successfully record single unit activity in acute animal studies. A finite element model of planar and edge electrodes relative to neuron position reveals that edge electrodes should be beneficial for increasing the volume of tissue being sampled in recording applications.
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Implantation of functionalized devices demonstrated improved recording quality from electrode sites positioned on the lattice edge compared with the faces, verified through computational modeling.
“Further, implantation of functionalized devices demonstrated improved recording quality from electrode sites positioned on the lattice edge as compared to the faces and verified through computational modeling.67”
From Regenerative Electrode Interfaces for Neural Prostheses. (2016) · cites this paper as [67]
In §3.5 (Neural recordings), acute animal recordings yielded more isolatable units and higher signal amplitudes at edge electrodes than at planar sites. The finite-element model in §3.4 supports a wider viewing angle for edge electrodes, but finds planar electrodes more sensitive when directly facing a neuron; it does not verify an across-the-board improvement in recording quality. (LLM, conf=0.83)
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- Authors
- Seymour, J. P., Langhals, N. B., Anderson, D. J., & Kipke, D. R.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Seymour, John P.
- ORCID
- Seymour, John P.
- Venue
- Biomedical Microdevices
- Published
- 2011-02-08
- Volume
- 13
- Issue
- 3
- Pages
- 441-451
- ISSN
- 1387-2176 (ISSN-L)
- 1572-8781
- PMC
- PMC4013149
- OpenAlex
- W2149639865
- Cited by
- 95
- References
- 57
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 2 · 2017: 9 · 2016: 6 · 2015: 11 · 2014: 12 · 2013: 7 · 2012: 6
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Biomedical Microdevices (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Agriculture
- National Institutes of Health
- National Institute of Biomedical Imaging and Bioengineering (P41EB002030)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Advanced MEMS and NEMS Technologies
- Keywords
- neural recording, drug delivery, chemical mechanical polishing, electroplating, electrode impedance, single-unit activity, finite element analysis, neural implants
- MeSH terms
- Animals, Brain, Male, Microelectrodes, Polymers, Silicon Dioxide, Xylenes, Electric Impedance, Rats, Sprague-Dawley, Prostheses and Implants, Finite Element Analysis, Rats, Microtechnology, Electrophysiological Phenomena
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