Dunaliella biotechnology: methods and applications
Abstract
The microalga Dunaliella salina is the best commercial source of natural beta-carotene. Additionally, different species of Dunaliella can accumulate significant amounts of valuable fine chemicals such as carotenoids, glycerol, lipids, vitamins, minerals and proteins. They also have a large potential for biotechnological processes such as expressing of foreign proteins and treatment of wastewater. In this review, we discussed several biotechnological aspects of the mass cultivation of D. salina like strain selection, carotenoid induction, culture conditions, culture systems and downstream processes. We also discuss several traditional and new applications of the genus.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dunaliella salina readily produces vitamins A and E, pyridoxine, nicotinic acid thiamine, riboflavin, and biotin.
“The microalga D. salina readily produces vitamins A and E, pyridoxine, nicotinic acid thiamine, riboflavin, and biotin [205].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [205]
Cites
Standard methods: For the examination of water and waste water
Water Environment Federation., Water Pollution Control Federation., American Water Works Association., & American Public Health Association. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90598-4 · Cited by 72,107 · see citing works
Chisti, Y. (2007) · Biotechnology Advances · doi:10.1016/j.biotechadv.2007.02.001 · Cited by 9,524 · see citing works
Guillard, R. R., & Ryther, J. (1962) · Canadian Journal of Microbiology (print) · doi:10.1139/m62-029 · Cited by 7,663 · see citing works
Recovery of microalgal biomass and metabolites: Process options and economics
Molina Grima, E., Belarbi, E.-H., Acién Fernández, F. G., Robles Medina, A., & Chisti, Y. (2003) · Biotechnology Advances · doi:10.1016/s0734-9750(02)00050-2 · Cited by 2,286 · see citing works
Valuable Products from Biotechnology of Microalgae
Pulz, O., & Gross, W. (2004) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-004-1647-x · Cited by 2,132 · cited 3× · see citing works
“1986; Moulton and Burford 1990) and the flesh and shell of aquatic animals, such as prawns and ornamental fishes, to make them more attractive in the market (Pulz and Gross 2004).”
BackgroundCommercial production of microalgae: ponds, tanks, tubes and Fermenters.
Borowitzka, M. A. (1999) · Journal of Biotechnology · doi:10.1016/s0168-1656(99)00083-8 · Cited by 1,317 · see citing works
Rogers, L. J. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80268-0 · Cited by 1,289 · see citing works
Photobioreactors: Production systems for phototrophic microorganisms
O., P. (2001) · Applied Microbiology and Biotechnology · doi:10.1007/s002530100702 · Cited by 987 · see citing works
Krinsky, N. I., Landrum, J. T., & Bone, R. A. (2003) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.23.011702.073307 · Cited by 779 · see citing works
Risk of angina pectoris and plasma concentrations of vitamins A, C, and E and carotene
Riemersma, R. A., Wood, D. A., Oliver, M. F., Elton, R. A., Macintyre, C. C. A., & GEY, K. F. (1991) · The Lancet · doi:10.1016/0140-6736(91)93327-6 · Cited by 771 · see citing works
Outdoor cultivation of microalgae for carotenoid production: Current state and perspectives
Del Campo, J. A., García-González, M., & Guerrero, M. G. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-007-0844-9 · Cited by 739 · see citing works
Dufossé, L., Galaup, P., Yaron, A., Arad, S. M., Blanc, P., Chidambara Murthy, K. N., & Ravishankar, G. A. (2005) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2005.02.006 · Cited by 681 · see citing works
CO2 Mitigation and Renewable Oil from Photosynthetic Microbes: A New Appraisal
Huntley, M. E., & Redalje, D. G. (2007) · Mitigation and Adaptation Strategies for Global Change · doi:10.1007/s11027-006-7304-1 · Cited by 633 · see citing works
Takagi, M., Karseno, & Yoshida, T. (2006) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.101.223 · Cited by 629 · see citing works
Biotechnological potential of immobilized algae for wastewater N, P and metal removal: A review
Mallick, N. (2002) · BioMetals · doi:10.1023/a:1020238520948 · Cited by 571 · see citing works
Microalgal mass culture systems and methods: their limitation and potential
Lee, Y.-K. (2001) · Journal of Applied Phycology · doi:10.1023/a:1017560006941 · Cited by 528 · see citing works
Microalgae as sources of pharmaceuticals and other biologically active compounds
Borowitzka, M. A. (1995) · Journal of Applied Phycology · doi:10.1007/bf00003544 · Cited by 520 · see citing works
Microalgae immobilization: Current techniques and uses
Moreno‐Garrido, I. (2007) · Bioresource Technology · doi:10.1016/j.biortech.2007.05.040 · Cited by 487 · see citing works
Removal of chromium(VI) from saline wastewaters by Dunaliella species
Dönmez, G., & Aksu, Z. (2002) · Process Biochemistry · doi:10.1016/s0032-9592(02)00204-2 · Cited by 445 · see citing works
Hydrodynamic focusing of motile algal cells
Kessler, J. O. (1985) · Nature · doi:10.1038/313218a0 · Cited by 435 · see citing works
Microalgae as food and supplement
Kay, R. A., & Barton, L. L. (1991) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408399109527556 · Cited by 408 · see citing works
A Hundred Years of Dunaliella Research: 1905–2005
Oren, A. (2005) · Saline Systems · doi:10.1186/1746-1448-1-2 · Cited by 400 · see citing works
Ben‐Amotz, A., & Avron, M. (1983) · PLANT PHYSIOLOGY · doi:10.1104/pp.72.3.593 · Cited by 365 · see citing works
Peach, C., & Velten, J. P. (1991) · Plant Molecular Biology · doi:10.1007/bf00036805 · Cited by 356 · see citing works
Enigmatic Microorganisms and Life in Extreme Environments
Seckbach, J. (1999) · Springer eBooks · doi:10.1007/978-94-011-4838-2 · Cited by 336 · see citing works
Perspectives on Cancer Chemoprevention Research and Drug Development
Kelloff, G. J. (1999) · Advances in cancer research · doi:10.1016/s0065-230x(08)61026-x · Cited by 317 · see citing works
Algae biomass: production and use
Shelef, G., Soeder, C. J., Balaban, M., ule-fituaḥ, M. H.-L. L.-M., & Umweltforschung, G. F. S. U. (1980) · Cited by 304 · see citing works
In vivo antioxidant activity of carotenoids from Dunaliella salina — a green microalga
Murthy, K. N. C., Vanitha, A., Rajesha, J., Swamy, M. M., Sowmya, P. R., & Ravishankar, G. A. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.10.015 · Cited by 280 · see citing works
Liquid Fuel Production Using Microalgae
Tsukahara, K., & Sawayama, S. (2005) · Journal of the Japan Petroleum Institute · doi:10.1627/jpi.48.251 · Cited by 280 · see citing works
Exploitation of Dunaliella for β-carotene production
Raja, R., Hemaiswarya, S., & Rengasamy, R. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0777-8 · Cited by 276 · see citing works
STICH, H. F., Rosin, M. P., Hornby, A. P., Mathew, B., Sankaranarayanan, R., & Nair, M. K. (1988) · International Journal of Cancer · doi:10.1002/ijc.2910420209 · Cited by 266 · see citing works
Rabbani, S., Beyer, P., Lintig, J. V., Hugueney, P., & Kleinig, H. (1998) · PLANT PHYSIOLOGY · doi:10.1104/pp.116.4.1239 · Cited by 263 · see citing works
García-González, M., Moreno, J., Manzano, J. C., Florencio, F. J., & Guerrero, M. G. (2005) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2004.07.010 · Cited by 258 · see citing works
The biotechnology of cultivating the halotolerant algaDunaliella
Ben‐Amotz, A., & Avron, M. (1990) · Trends in biotechnology · doi:10.1016/0167-7799(90)90152-n · Cited by 251 · see citing works
Borowitzka, M. A., & Siva, C. J. (2007) · Journal of Applied Phycology · doi:10.1007/s10811-007-9171-x · Cited by 248 · see citing works
Biosynthesis and regulation of carotenoids in Dunaliella: Progresses and prospects
Ye, Z.-W., Jiang, J.-G., & Wu, G.-H. (2008) · Biotechnology Advances · doi:10.1016/j.biotechadv.2008.03.004 · Cited by 238 · see citing works
Lagarde, D., Beuf, L., & Vermaas, W. F. J. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.1.64-72.2000 · Cited by 236 · see citing works
Algal autoflocculation—verification and proposed mechanism
Sukenik, A., & Shelef, G. (1984) · Biotechnology and Bioengineering · doi:10.1002/bit.260260206 · Cited by 221 · see citing works
Algal and cyanobacterial biotechnology
Cresswell, R. C., Rees, T. A. V., & Shah, N. (1989) · Longman Scientific & Technical , Wiley eBooks · Cited by 216 · see citing works
Comstock, G. W., Kj, H., & Tl, B. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.1.260s · Cited by 205 · see citing works
Dunaliella: Physiology, biochemistry, and biotechnology
Turner, M. F. (1993) · Journal of Experimental Marine Biology and Ecology · doi:10.1016/0022-0981(93)90147-g · Cited by 204 · see citing works
Stereoisomers of β-Carotene and Phytoene in the Alga Dunaliella bardawil
Ben‐Amotz, A., Lers, A., & Avron, M. (1988) · PLANT PHYSIOLOGY · doi:10.1104/pp.86.4.1286 · Cited by 202 · see citing works
SUPAMATTAYA, K., Kiriratnikom, S., Boonyaratpalin, M., & Borowitzka, L. J. (2005) · Aquaculture · doi:10.1016/j.aquaculture.2005.04.014 · Cited by 197 · see citing works
Herrero, M., Jaime, L., Martín‐Álvarez, P. J., Cifuentes, A., & Ibáñez, E. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf060546q · Cited by 194 · see citing works
Co-carcinogenic effect of β-carotene
Paolini, M., Cantelli‐Forti, G., Perocco, P., Pedulli, G. F., Abdel-Rahman, S. Z., & Legator, M. S. (1999) · Nature · doi:10.1038/19655 · Cited by 192 · see citing works
Carotenoids and cancer: An update with emphasis on human intervention studies
van Poppel, G. (1993) · European Journal of Cancer · doi:10.1016/0959-8049(93)90087-v · Cited by 188 · see citing works
Xanthophylls in Microalgae: From Biosynthesis to Biotechnological Mass Production and Application
Jin, E., Polle, J. E. W., Lee, H. K., Hyun, S. M., & Chang, M. (2003) · Journal of Microbiology and Biotechnology · Cited by 185 · see citing works
The protozoa of a Western Australian hypersaline lagoon
Post, F. J., Borowitzka, L. J., Borowitzka, M. A., Mackay, B., & Moulton, T. P. (1983) · Hydrobiologia · doi:10.1007/bf00025180 · Cited by 179 · see citing works
Importance of -Carotene, beta-Carotene, and Other Phytochemicals in the Etiology of Lung Cancer
Ziegler, R. G., Colavito, E. A., Hartge, P. A., McAdams, M., Schoenberg, J. B., Mason, T. J., & Fraumeni, J. F. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.9.612 · Cited by 168 · see citing works
Vitamins and fine chemicals from micro-algae
Borowitzka, M. A. (1988) · Murdoch University Research Portal · Cited by 168 · see citing works
Denery, J. R., Dragull, K., Tang, C. S., & Li, Q. X. (2003) · Analytica Chimica Acta · doi:10.1016/j.aca.2003.09.026 · Cited by 165 · see citing works
Hu, C.-C., Lin, J.-T., Lu, F.-J., Chou, F., & Yang, D. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.12.043 · Cited by 164 · see citing works
Boonyaratpalin, M., Thongrod, S., SUPAMATTAYA, K., et al. (2001) · Aquaculture Research · doi:10.1046/j.1355-557x.2001.00039.x · Cited by 163 · see citing works
Cancer Prevention by Carotenoids
Bertram, J. S. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb26169.x · Cited by 160 · see citing works
Stable expression of hepatitis B surface antigen gene in Dunaliella salina (Chlorophyta)
Geng, D., Wang, Y., Wang, P., Li, W., & Sun, Y. (2003) · Journal of Applied Phycology · doi:10.1023/b:japh.0000004298.89183.e5 · Cited by 157 · see citing works
New mode of Dunaliella biotechnology: two-phase growth for β-carotene production
Ben‐Amotz, A. (1995) · Journal of Applied Phycology · doi:10.1007/bf00003552 · Cited by 150 · see citing works
Lutein production by Muriellopsis sp. in an outdoor tubular photobioreactor
Campo, J. A. D., Rodrı́guez, H., Moreno, J., Vargas, M. A., Rivas, J., & Guerrero, M. G. (2001) · Journal of Biotechnology · doi:10.1016/s0168-1656(00)00380-1 · Cited by 150 · see citing works
Cancer prevention by carotenoids
Nishino, H. (1998) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(97)00293-5 · Cited by 147 · see citing works
Bleaching Herbicide Norflurazon Inhibits Phytoene Desaturase by Competition with the Cofactors
Breitenbach, J., Zhu, C., & Sandmann, G. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0106751 · Cited by 142 · see citing works
Cryopreservation of eukaryotic algae – a review of methodologies
Taylor, R., & Fletcher, R. L. (1998) · Journal of Applied Phycology · doi:10.1023/a:1008094622412 · Cited by 139 · see citing works
Albrecht, M., Misawa, N., & Sandmann, G. (1999) · Biotechnology Letters · doi:10.1023/a:1005547827380 · Cited by 134 · see citing works
Coesel, S., Baumgartner, A., Teles, L. M., Ramos, A., Henriques, N., Cancela, M. L., & Varela, J. C. S. (2008) · Marine Biotechnology · doi:10.1007/s10126-008-9100-2 · Cited by 134 · see citing works
Tsuji, N., Hirayanagi, N., Okada, M., Miyasaka, H., Hirata, K., Zenk, M. H., & Miyamoto, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00265-6 · Cited by 132 · see citing works
Loeblich, L. A. (1982) · Journal of the Marine Biological Association of the United Kingdom · doi:10.1017/s0025315400019706 · Cited by 131 · see citing works
Jin, E., Feth, B., & Melis, A. (2002) · Biotechnology and Bioengineering · doi:10.1002/bit.10459 · Cited by 130 · see citing works
Butinar, L., Sonjak, S., Zalar, P., et al. (2005) · Botanica Marina · doi:10.1515/bot.2005.007 · Cited by 129 · see citing works
Improved recombinant gene expression in CHO cells using matrix attachment regions
Kim, S., Kim, J.-S., Park, D.-H., Kang, H. S., Yoon, J., Baek, K., & Yoon, Y. (2003) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2003.09.015 · Cited by 129 · see citing works
Dunaliella salina Microalga Pressurized Liquid Extracts as Potential Antimicrobials
Herrero, M., Ibáñez, E., Cifuentes, A., Reglero, G., & Santoyo, S. (2006) · Journal of Food Protection · doi:10.4315/0362-028x-69.10.2471 · Cited by 128 · see citing works
Moreno‐Garrido, I., & Cañavate, J. P. (2001) · Aquacultural Engineering · doi:10.1016/s0144-8609(00)00067-4 · Cited by 118 · see citing works
Götz, T., Windhövel, U., Böger, P., & Sandmann, G. (1999) · PLANT PHYSIOLOGY · doi:10.1104/pp.120.2.599 · Cited by 116 · see citing works
Törnwall, M. E. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.05.007 · Cited by 116 · see citing works
Conditions for open-air outdoor culture of Dunaliella salina in southern Spain
García‐González, M., Moreno, J., Cañavate, J. P., Anguís, V., Prieto, A., Manzano, C., Florencio, F. J., & Guerrero, M. G. (2003) · Journal of Applied Phycology · doi:10.1023/a:1023892520443 · Cited by 108 · see citing works
Expression of Foreign Genes in Dunaliella by Electroporation
Sun, Y., Yang, Z., Gao, X.-S., Li, Q., Zhang, Q., & Xu, Z. (2005) · Molecular Biotechnology · doi:10.1385/mb:30:3:185 · Cited by 108 · see citing works
Lers, A., Levy, H., & Zamir, A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)92755-9 · Cited by 107 · see citing works
Massive carotenoid accumulation in Dunaliella bardawil induced by ultraviolet-A radiation
Jahnke, L. S. (1999) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(99)00012-3 · Cited by 104 · see citing works
Brown, A. D., & Borowitzka, L. J. (1979) · Elsevier eBooks · doi:10.1016/b978-0-12-444601-4.50013-8 · Cited by 102 · see citing works
GLYCEROL AS A PHOTOSYNTHETIC PRODUCT IN DUNALIELLA TERTIOLECTA BUTCHER
Craigie, J. S., & McLachlan, J. (1964) · Canadian Journal of Botany · doi:10.1139/b64-068 · Cited by 101 · see citing works
Selective extraction of carotenoids from the microalga Dunaliella salina with retention of viability
Hejazi, M. A., de Lamarliere, C., Rocha, J. M. S., Vermuë, M. H., TRAMPER, J., & Wijffels, R. H. (2002) · Biotechnology and Bioengineering · doi:10.1002/bit.10270 · Cited by 101 · see citing works
Mojaat, M., Pruvost, J., Foucault, A. P., & Legrand, J. (2007) · Biochemical Engineering Journal · doi:10.1016/j.bej.2007.09.009 · Cited by 98 · see citing works
Talbot, P., & de la Noüe, J. (1993) · Water Research · doi:10.1016/0043-1354(93)90206-w · Cited by 93 · see citing works
Experiences and strategies in the recovery of biomass from mass cultures of microalgae
Mohn, F. H. (1980) · Cited by 93 · see citing works
Butcher, R. W. (1959) · Medical Entomology and Zoology · Cited by 93 · see citing works
Foster, S. D., Thomson, D., & Maher, W. A. (2007) · Marine Chemistry · doi:10.1016/j.marchem.2007.11.005 · Cited by 89 · see citing works
Effective cell harvesting of the halotolerant microalga Dunaliella tertiolecta with pH control
Horiuchi, J., Ohba, I., Tada, K., et al. (2003) · Journal of Bioscience and Bioengineering · doi:10.1016/s1389-1723(03)80078-6 · Cited by 87 · see citing works
Ramos, A., Coesel, S., Pimenta-Marques, A., Rodrigues, M., Baumgartner, A., Noronha, J. P., Rauter, A. P., Brenig, B., & Varela, J. C. S. (2008) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-008-1492-4 · Cited by 86 · see citing works
Continuous cultivation of Dunaliella salina in photobioreactor for the production of β-carotene
Zhu, Y., & Jiang, J. (2007) · European Food Research and Technology · doi:10.1007/s00217-007-0789-3 · Cited by 85 · see citing works
Gómez, P. I., Barriga, A. P., Cifuentes, A., & GONZÁLEZ, M. A. (2003) · Biological Research · doi:10.4067/s0716-97602003000200008 · Cited by 85 · see citing works
Shaish, A., Harari, A., Hananshvili, L., Cohen, H., Bitzur, R., Luvish, T., Ulman, E., Golan, M., Ben‐Amotz, A., Gavish, D., et al. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.12.004 · Cited by 83 · see citing works
Holland, J. K., Kemsley, E. K., & Wilson, R. H. (1998) · Journal of the Science of Food and Agriculture · doi:10.1002/(sici)1097-0010(199802)76:2 · Cited by 83 · see citing works
Microalgae mediated photoproduction of β-carotene in aqueous–organic two phase systems
León, R. (2003) · Biomolecular Engineering · doi:10.1016/s1389-0344(03)00048-0 · Cited by 80 · see citing works
Li, J., Xu, N. S., & Su, W. W. (2003) · Biochemical Engineering Journal · doi:10.1016/s1369-703x(02)00135-3 · Cited by 79 · see citing works
Strong Induction of Phytochelatin Synthesis by Zinc in Marine Green Alga, Dunaliella tertiolecta.
Hirata, K., Tsujimoto, Y., Namba, T., Ohta, T., Hirayanagi, N., Miyasaka, H., Zenk, M. H., & Miyamoto, K. (2001) · Journal of Bioscience and Bioengineering · doi:10.1016/s1389-1723(01)80193-6 · Cited by 78 · see citing works
Ben‐Amotz, A. (1996) · Journal of Phycology · doi:10.1111/j.0022-3646.1996.00272.x · Cited by 76 · see citing works
Hydroxyl radical scavenging ability of bacterioruberin
Saito, T., Miyabe, Y., Ide, H., et al. (1997) · Radiation Physics and Chemistry · doi:10.1016/s0969-806x(97)00036-4 · Cited by 74 · see citing works
Mojaat, M., Foucault, A. P., Pruvost, J., & Legrand, J. (2007) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2007.11.003 · Cited by 69 · see citing works
An Extreme Source of beta-Carotene.
Aasen, A. J., Eimhjellen, K. E., Liaaen-Jensen, S., et al. (1969) · Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry · doi:10.3891/acta.chem.scand.23-2544 · Cited by 68 · see citing works
Adsorption of Inorganic and Organic Arsenic Compounds by Aluminium-loaded Coral Limestone
Ohki, A., Nakayachigo, K., Naka, K., et al. (1996) · Applied Organometallic Chemistry · doi:10.1002/(sici)1099-0739(199611)10:9 · Cited by 68 · see citing works
Effect of Temperature on Glycerol Retention in the Halotolerant Algae Dunaliella and Asteromonas
Wegmann, K., Ben‐Amotz, A., & Avron, M. (1980) · PLANT PHYSIOLOGY · doi:10.1104/pp.66.6.1196 · Cited by 68 · see citing works
β-Carotene (Provitamin A) Production with Algae
Borowitzka, L. J., & Borowitzka, M. A. (1989) · Springer eBooks · doi:10.1007/978-94-009-1111-6_2 · Cited by 68 · see citing works
Regression of experimental cancer by oral administration of combined α‐tocopherol and β‐carotene
Shklar, G., SCHWARTZ, J. L., Trickier, D., et al. (1989) · Nutrition and Cancer · doi:10.1080/01635588909514032 · Cited by 67 · see citing works
GIBOR, A. (1956) · Biological Bulletin · doi:10.2307/1539013 · Cited by 64 · see citing works
Closed algal photobioreactors: Design considerations for large-scale systems
Borowitzka, M. A. (1996) · Murdoch University Research Portal · Cited by 62 · see citing works
PRODUCTION AND SELECTION OF HIGH β‐CAROTENE MUTANTS OF DUNALIELLA BARDAWIL (CHLOROPHYTA)1
Shaish, A., Ben‐Amotz, A., & Avron, M. (1991) · Journal of Phycology · doi:10.1111/j.0022-3646.1991.00652.x · Cited by 62 · see citing works
Sun, G., Zhang, X., Sui, Z., & Mao, Y. (2008) · Marine Biotechnology · doi:10.1007/s10126-007-9056-7 · Cited by 61 · see citing works
Gómez, P. I., & González, M. A. (2003) · Aquaculture · doi:10.1016/j.aquaculture.2003.11.005 · Cited by 61 · see citing works
Marín, N., Morales, F. J., Lodeiros, C. J., & Tamigneaux, É. (1998) · Journal of Applied Phycology · doi:10.1023/a:1008017928651 · Cited by 58 · see citing works
Ben‐Amotz, A., Gressel, J., & Avron, M. (1987) · Journal of Phycology · doi:10.1111/j.0022-3646.1987.00176.x · Cited by 58 · see citing works
Marine microalgae as a potential source of single cell protein (SCP)
Fábregas, J., & Herrero, C. (1985) · Applied Microbiology and Biotechnology · doi:10.1007/bf00938962 · Cited by 58 · see citing works
He, Q., Qiao, D., Bai, L., et al. (2006) · Journal of Plant Physiology · doi:10.1016/j.jplph.2006.04.004 · Cited by 55 · see citing works
THE WAVELENGTH DEPENDENCE OF MASSIVE CAROTENE SYNTHESIS IN DUNALIELLA BARDAWIL (CHLOROPHYCEAE)1
Ben‐Amotz, A., & Avron, M. (1989) · Journal of Phycology · doi:10.1111/j.0022-3646.1989.00175.x · Cited by 54 · see citing works
Gamlieli‐Bonshtein, I., Korin, E., & Cohen, S. (2002) · Biotechnology and Bioengineering · doi:10.1002/bit.10357 · Cited by 54 · see citing works
Tafreshi, A. H., & Shariati, M. (2006) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-006-9145-1 · Cited by 53 · see citing works
Self-citationExposure to Low Irradiances Favors the Synthesis of 9-cis β,β-Carotene in Dunaliella salina (Teod.)
Orset, S., & Young, A. J. (2000) · PLANT PHYSIOLOGY · doi:10.1104/pp.122.2.609 · Cited by 52 · see citing works
Plasma membrane electron transport coupled to Na+ extrusion in the halotolerant alga Dunaliella
Katz, A., & Pick, U. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(01)00157-8 · Cited by 49 · see citing works
Wang, T., Xue, L., Hou, W., et al. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-007-1040-7 · Cited by 49 · see citing works
Production of Lipids Rich in Omega 3 Fatty Acids from the Halotolerant Alga Dunaliella salina
El‐Baky, H. H. A., ., F. K. E. B., & El‐Baroty, G. S. (2003) · Biotechnology(Faisalabad) · doi:10.3923/biotech.2004.102.108 · Cited by 48 · see citing works
Algae removal by fine sand/silt filtration
Naghavi, B., & Malone, R. F. (1986) · Water Research · doi:10.1016/0043-1354(86)90087-4 · Cited by 46 · see citing works
Production of phytoene by herbicide‐treated microalgae Dunaliella bardawil in two‐phase systems
León, R., Vilà, M., Hernánz, D., & Vı́lchez, C. (2005) · Biotechnology and Bioengineering · doi:10.1002/bit.20660 · Cited by 46 · see citing works
Levy, H., Gokhman, I., & Zamir, A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37036-x · Cited by 45 · see citing works
Park, S., Polle, J. E. W., Melis, A., Lee, T., & Jin, E. (2006) · Marine Biotechnology · doi:10.1007/s10126-005-5030-4 · Cited by 45 · see citing works
Sánchez-Estudillo, L., Freile‐Pelegrín, Y., Madrid, R. R., Robledo, D., & Narváez-Zapata, J. A. (2006) · Biotechnology Letters · doi:10.1007/s10529-006-9001-2 · Cited by 45 · see citing works
Growth and carotenogenesis in eight strains ofDunaliella salina Teodoresco from Chile
Cifuentes, A., González, M., Conejeros, M., Dellarossa, V., & Parra, Ó. (1992) · Journal of Applied Phycology · doi:10.1007/bf02442459 · Cited by 44 · see citing works
Su, W. (2003) · Journal of Biotechnology · doi:10.1016/s0168-1656(03)00188-3 · Cited by 44 · see citing works
Use of algae Dunaliella as a protein supplement in bread.
Finney, K. F., Pomeranz, Y., & Bruinsma, B. L. (1984) · Cereal Chemistry · Cited by 44 · see citing works
Process development and evaluation for algal glycerol production
Chen, B. J., & Chi, C. H. (1981) · Biotechnology and Bioengineering · doi:10.1002/bit.260230608 · Cited by 42 · see citing works
Gómez, P. I., & GONZALEZ, M. A. (2001) · Biological Research · doi:10.4067/s0716-97602001000100012 · Cited by 41 · see citing works
Effect of High-Rate Algal Ponds on Viability of Cryptosporidium parvum Oocysts
Araki, S., Martín-Gómez, S., Bécares, E., et al. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.7.3322-3324.2001 · Cited by 41 · see citing works
Hejazi, M. A., Andrysiewicz, E., TRAMPER, J., & Wijffels, R. H. (2003) · Biotechnology and Bioengineering · doi:10.1002/bit.10791 · Cited by 41 · see citing works
Glycerol production byDunaliella tertiolecta immobilized within Ca-alginate beads
Grizeau, D., & Navarro, J. M. (1986) · Biotechnology Letters · doi:10.1007/bf01030509 · Cited by 40 · see citing works
Inoue, Y., Date, Y., Sakai, T., Shimizu, N., Yoshida, K., Chen, H., Kuroda, K., & Endo, G. (1999) · Applied Organometallic Chemistry · doi:10.1002/(sici)1099-0739(199902)13:2 · Cited by 40 · see citing works
Shariati, M., & Lilley, R. M. (1994) · Plant Cell & Environment · doi:10.1111/j.1365-3040.1994.tb00531.x · Cited by 39 · see citing works
Self-citationAntibiotic substances produced by a marine green alga, Dunaliella primolecta
Chang, T., Ohta, S., Ikegami, N., Miyata, H., KASHIMOTO, T., & Kondo, M. (1993) · Bioresource Technology · doi:10.1016/0960-8524(93)90189-i · Cited by 38 · see citing works
Nitrate, Ammonium, and Phosphate Uptake by the Immobilized Cells of Dunaliella salina
Thakur, A., & Kumar, H. D. (1999) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/s001289900843 · Cited by 36 · see citing works
On the mechanism of osmoregulation in Dunaliella
Ben‐Amotz, A., & Avron, M. (1978) · Cited by 35 · see citing works
Saçan, M. T., & Balcıoğlu, I. A. (2005) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2005.03.017 · Cited by 34 · see citing works
Towards the development of a nuclear transformation system for Dunaliella tertiolecta
Walker, T. L., Becker, D. K., Dale, J. L., et al. (2005) · Journal of Applied Phycology · doi:10.1007/s10811-005-4783-5 · Cited by 33 · see citing works
New Strategy for the cultivation of microalgae using microencapsulation
Joo, M.-G. C. D.-S. (2001) · Journal of Microencapsulation · doi:10.1080/02652040010018065 · Cited by 33 · see citing works
Klausner, A. (1986) · Nature Biotechnology · doi:10.1038/nbt1186-947 · Cited by 33 · see citing works
Santos, C. A., Vieira, A. M., Fernandes, H. L., et al. (2001) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.497 · Cited by 30 · see citing works
Use of the β‐carotene rich alga Dunaliella Bardawil as a source of retinol
Ben‐Amotz, A., Edelstein, S., & Avron, M. (1986) · British Poultry Science · doi:10.1080/00071668608416920 · Cited by 30 · see citing works
Chemoprevention of Lung Cancer Is Proving Difficult and Frustrating, Requiring New Approaches
Omenn, G. S. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.12.959 · Cited by 30 · see citing works
Li, Q., Gao, X.-S., Sun, Y., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.11.144 · Cited by 29 · see citing works
DeLorenzo, M. E., & Serrano, L. (2006) · Journal of Environmental Science and Health Part B · doi:10.1080/03601230600964100 · Cited by 29 · see citing works
Serum vitamins A and E, beta-carotene, and selenium in patients with breast cancer.
Basu, T. K., Hill, G. B., Ng, D., et al. (1989) · Journal of the American College of Nutrition · doi:10.1080/07315724.1989.10720322 · Cited by 28 · see citing works
He, Q., Qiao, D., Zhang, Q., et al. (2004) · Journal of Applied Phycology · doi:10.1023/b:japh.0000047950.76549.ce · Cited by 27 · see citing works
Jiang, G., Lü, Y.-M., Niu, X.-L., et al. (2005) · PubMed · Cited by 24 · see citing works
Li, J., Xue, L., Yan, H., et al. (2007) · Journal of Applied Phycology · doi:10.1007/s10811-007-9197-0 · Cited by 23 · see citing works
Optimal growth of Dunaliella primolecta in axenic conditions to assay herbicides
Montanyá, I. S., Sandín‐España, P., Baudín, J. M. G., et al. (2006) · Chemosphere · doi:10.1016/j.chemosphere.2006.07.019 · Cited by 23 · see citing works
Glycerol Production in the Alga Dunaliella
Ben‐Amotz, A. (1980) · Elsevier eBooks · doi:10.1016/b978-0-12-618980-3.50013-8 · Cited by 23 · see citing works
Cloning and Sequence Analysis of the Gene Encoding (6-4)photolyase from Dunaliella salina
Yi, Y., Cao, Y., Li, Q., et al. (2006) · Biotechnology Letters · doi:10.1007/s10529-005-5716-8 · Cited by 21 · see citing works
Effects ofPhaeodactylum tricornutumandDunaliella tertiolectaExtracts on the Central Nervous System
Villar, R., Laguna, R., Calleja, J., & Cadavid, I. (1992) · Planta Medica · doi:10.1055/s-2006-961501 · Cited by 20 · see citing works
Woutersen, R. A., & van Garderen‐Hoetmer, A. (1988) · Cancer Letters · doi:10.1016/0304-3835(88)90242-x · Cited by 19 · see citing works
Yi, Y., Qiao, D., Bai, L., et al. (2007) · PubMed · Cited by 18 · see citing works
Cultivation of Spirulina (Arthrospira) platensis in Flat Plate Reactors
(1997) · CRC Press eBooks · doi:10.1201/9781482272970-15 · Cited by 18 · see citing works
Effects ofPhaeodactylum tricornutum and Dunaliella tertiolectaExtracts on the Central Nervous System
Laguna, R., Villar, R., Cadavid, I., et al. (1990) · Planta Medica · doi:10.1055/s-2006-960914 · Cited by 17 · see citing works
Biochemical and photosynthetic aspects of energy production
Jawetz, P. (1981) · Energy in Agriculture · doi:10.1016/0167-5826(81)90017-6 · Cited by 16 · see citing works
Influence of areal density on β-carotene production by Dunaliella salina
Grobbelaar, J. U. (1995) · Journal of Applied Phycology · doi:10.1007/bf00003553 · Cited by 16 · see citing works
Characteristics and Dynamics of Pyrolysis Process Microalgae
Jun-mao, T. (2007) · Ranshao kexue yu jishu · Cited by 15 · see citing works
A short flagella mutant of Dunaliella salina (Chlorophyta, Chlorophyceae)
Vismara, R., Verni, F., Barsanti, L. A., et al. (2004) · Micron · doi:10.1016/j.micron.2004.01.001 · Cited by 14 · see citing works
Lei, G., Qiao, D., Bai, L., Xu, H., & Cao, Y. (2007) · Journal of Applied Phycology · doi:10.1007/s10811-007-9175-6 · Cited by 14 · see citing works
Chen, C., Bai, L. H., Qiao, D., et al. (2007) · Molecular Biology Reports · doi:10.1007/s11033-007-9089-z · Cited by 14 · see citing works
Lewis, M. A., Weber, D. E., & Stanley, R. S. (1998) · Water Environment Research · doi:10.2175/106143098x123471 · Cited by 13 · see citing works
Moulton, T. P., & Burford, M. A. (1990) · Springer eBooks · doi:10.1007/978-94-009-2049-1_57 · Cited by 12 · see citing works
Moulton, T. P., & Burford, M. A. (1990) · Hydrobiologia · doi:10.1007/bf00040263 · Cited by 12 · see citing works
Effect of Light Intensity on Adaptation ofDunaliellato Very High Salt Concentrations
Ginzburg, M., & Ginzburg, B. Z. (1993) · Journal of Experimental Botany · doi:10.1093/jxb/44.10.1561 · Cited by 10 · see citing works
OBSERVATIONS ON THE GROWTH OF DUNALIELLA EUCHLORA IN CULTURE
McLachlan, J., & Yentsch, C. S. (1959) · Biological Bulletin · doi:10.2307/1538955 · Cited by 10 · see citing works
Wei, L., Cao, Y., Bai, L., et al. (2006) · Journal of Applied Phycology · doi:10.1007/s10811-006-9116-9 · Cited by 9 · see citing works
The Production of Hydrocarbons from Photoautotrophic Growth of Dunaliella salina 1650
Park, D.-H., Ruy, H.-W., Lee, K., et al. (1998) · Humana Press eBooks · doi:10.1007/978-1-4612-1814-2_68 · Cited by 9 · see citing works
Hatanaka, Y., Kudo, T., Miyataka, M., Kobayashi, O., HIGASHIHARA, M., & Hiyama, K. (1999) · Journal of Bioscience and Bioengineering · doi:10.1016/s1389-1723(00)80010-9 · Cited by 9 · see citing works
Immobilized Microbe Bioreactors for Waste Water Treatment
Portier, R. J., & Miller, G. P. (1991) · Waste Management & Research The Journal for a Sustainable Circular Economy · doi:10.1177/0734242x9100900163 · Cited by 9 · see citing works
Isolation and characterization of Dunaliella salina from Thailand
Powtongsook, S., Kittakoop, P., Menasveta, P., et al. (1995) · Journal of Applied Phycology · doi:10.1007/bf00003554 · Cited by 8 · see citing works
Li, J., Dongjing, Q., Liu, L., et al. (2007) · Zhongguo shengwu gongcheng zazhi · Cited by 8 · see citing works
Cloning and characterization of the 14-3-3 protein gene from the halotolerant alga Dunaliella salina
Wang, T., Xue, L., Ji, X., et al. (2007) · Molecular Biology Reports · doi:10.1007/s11033-007-9168-1 · Cited by 7 · see citing works
Lyukevich, A. A., Mouradyan, E. A., & Los, D. A. (2003) · Russian Journal of Plant Physiology · doi:10.1023/a:1024764522062 · Cited by 5 · see citing works
Technical Note: Toxicity Tests of Typical Mutagenic Phenols on Dunaliella salina
Chen, J., Jiang, J., & Qing-sheng, L. I. N. (2007) · Transactions of the ASABE · doi:10.13031/2013.22657 · Cited by 5 · see citing works
4554390 Method for harvesting algae
(1986) · Biotechnology Advances · doi:10.1016/0734-9750(86)90670-1 · Cited by 5 · see citing works
The production of hydrocarbons from photoautotrophic growth ofDunaliella salina 1650
Park, D.-H., Ruy, H.-W., Lee, K., et al. (1998) · Applied Biochemistry and Biotechnology · doi:10.1007/bf02920185 · Cited by 5 · see citing works
[Transformation of Dunaliella salina by using glass beads--a novel transformation method].
Feng, S., Jia, Y., Liu, H., et al. (2007) · PubMed · Cited by 3 · see citing works
Mild method of pre-concentration of Dunaliella salina from culture medium
Fernandes, H. L., Veloso, V., Gouveia, L., et al. (1997) · Biotechnology Techniques · doi:10.1023/a:1018486721741 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Khan, M. I., Shin, J. H., & Kim, J. D. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0879-x · Cited by 2,082 · see citing works
Markou, G., & Nerantzis, E. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.07.011 · Cited by 815 · see citing works
Fabris, M., Abbriano, R. M., Pernice, M., Sutherland, D. L., Commault, A. S., Hall, C. C., Labeeuw, L., McCauley, J. I., Kuzhiuparambil, U., Ray, P., et al. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00279 · Cited by 382 · see citing works
Industrial potential of carotenoid pigments from microalgae: Current trends and future prospects
Ambati, R. R., Gogisetty, D., Aswathanarayana, R. G., Ravi, S., Bikkina, P. N., Bo, L., & Yuepeng, S. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1432561 · Cited by 372 · see citing works
Sustainable approaches for algae utilisation in bioenergy production
Chia, S. R., Ong, H. C., Chew, K. W., Show, P. L., Phang, S.-M., Ling, T. C., Nagarajan, D., Lee, D.-J., & Chang, J.-S. (2018) · Renewable Energy · doi:10.1016/j.renene.2017.04.001 · Cited by 333 · see citing works
Effects of shear stress on microalgae- A Review
Wang, C., & Lan, C. Q. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.03.001 · Cited by 269 · see citing works
Microalgae Encapsulation Systems for Food, Pharmaceutical and Cosmetics Applications
Vieira, M. V., Pastrana, L. M., & Fuciños, P. (2020) · Marine Drugs · doi:10.3390/md18120644 · Cited by 205 · see citing works
Srinivasan, R., Mageswari, A., Subramanian, P., Suganthi, C., Chaitanyakumar, A., Aswini, V., & Gothandam, K. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-25417-5 · Cited by 96 · see citing works
Shekh, A., Sharma, A., Schenk, P. M., Kumar, G., & Mudliar, S. (2022) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.6902 · Cited by 90 · see citing works
Silva, M. R. O. B. D., Moura, Y. A. S., Converti, A., Porto, A. L. F., Viana Marques, D. D. A., & Bezerra, R. P. (2021) · Algal Research · doi:10.1016/j.algal.2021.102396 · Cited by 52 · see citing works
Antioxidant Production in Dunaliella
Roy, U. K., Nielsen, B. V., & Milledge, J. J. (2021) · Applied Sciences · doi:10.3390/app11093959 · Cited by 51 · see citing works
Microalgae as a source of carotenoids in foods, obstacles and solutions
Mostafa, H. S., & Hashem, M. M. (2025) · Phytochemistry Reviews · doi:10.1007/s11101-024-10039-9 · Cited by 36 · see citing works
- Authors
- Hosseini Tafreshi, A., & Shariati, M.
- Affiliations
- University of Isfahan (IR)
- ORCID
- Shariati, M.
- Venue
- Journal of Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-07
- Volume
- 107
- Issue
- 1
- Pages
- 14-35
- ISSN
- 1364-5072 (ISSN-L)
- 1365-2672
- OpenAlex
- W1981194760
- Cited by
- 343
- References
- 179
- Citations by year
- 2026: 20 · 2025: 20 · 2024: 18 · 2023: 30 · 2022: 26 · 2021: 34 · 2020: 26 · 2019: 27 · 2018: 26 · 2017: 13 · 2016: 28 · 2015: 25 · 2014: 8 · 2013: 18 · 2012: 12
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Keywords
- Dunaliella salina, microalgal biotechnology, β-carotene production, carotenoid accumulation, glycerol production, lipid accumulation, protein expression, wastewater treatment, strain selection, culture conditions, downstream processing
- MeSH terms
- Chlorophyta, Animals, Biotechnology, Culture Media, Hydrogen-Ion Concentration, Light, Plant Extracts, Temperature, Waste Disposal, Fluid, Water Purification, beta Carotene, Biofuels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review