Cited by 184Neurotransmitter Receptor Influence on BehaviorPsychopathy, Forensic Psychiatry, Sexual OffendingNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 270 of the 270 references it cites were found in a registry or an index.

Genetic determinants of aggression and impulsivity in humans

Pavlov, Konstantin A., Chistiakov, Dimitry A., Chekhonin, Vladimir P.·2012·Journal of Applied Genetics

DOI 10.1007/s13353-011-0069-6

Open this paper in CoChat — free account

Abstract

Human aggression/impulsivity-related traits have a complex background that is greatly influenced by genetic and non-genetic factors. The relationship between aggression and anxiety is regulated by highly conserved brain regions including amygdala, which controls neural circuits triggering defensive, aggressive, or avoidant behavioral models. The dysfunction of neural circuits responsible for emotional control was shown to represent an etiological factor of violent behavior. In addition to the amygdala, these circuits also involve the anterior cingulated cortex and regions of the prefrontal cortex. Excessive reactivity in the amygdala coupled with inadequate prefrontal regulation serves to increase the likelihood of aggressive behavior. Developmental alterations in prefrontal-subcortical circuitry as well as neuromodulatory and hormonal abnormality appear to play a role. Imbalance in testosterone/serotonin and testosterone/cortisol ratios (e.g., increased testosterone levels and reduced cortisol levels) increases the propensity toward aggression because of reduced activation of the neural circuitry of impulse control and self-regulation. Serotonin facilitates prefrontal inhibition, and thus insufficient serotonergic activity can enhance aggression. Genetic predisposition to aggression appears to be deeply affected by the polymorphic genetic variants of the serotoninergic system that influences serotonin levels in the central and peripheral nervous system, biological effects of this hormone, and rate of serotonin production, synaptic release and degradation. Among these variants, functional polymorphisms in the monoamine oxidase A (MAOA) and serotonin transporter (5-HTT) may be of particular importance due to the relationship between these polymorphic variants and anatomical changes in the limbic system of aggressive people. Furthermore, functional variants of MAOA and 5-HTT are capable of mediating the influence of environmental factors on aggression-related traits. In this review, we consider genetic determinants of human aggression, with special emphasis on genes involved in serotonin and dopamine metabolism and function.

Integrity signals

Registry

Crossref · 10.1007/s13353-011-0069-6

Cites

270 of 270 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162
Role of genotype in the cycle of violence in maltreated children
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002) · Science · doi:10.1126/science.1072290 · Cited by 4,842
Dopamine receptors: from structure to function
MISSALE, C., NASH, S. R., ROBINSON, S. W., JABER, M., & CARON, M. G. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.189 · Cited by 3,633
International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
Hoyer, D., Clarke, D. E., Fozard, J. R., Hartig, P. R., Martin, G. R., Mylecharane, E. J., Saxena, P. R., & Humphrey, P. P. A. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06783-3 · Cited by 3,025
Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
Spada, A. L., Wilson, E. M., Lubahn, D. B., Harding, A., & Fischbeck, K. (1991) · Nature · doi:10.1038/352077a0 · Cited by 2,801
Mechanisms of Estrogen Action
Nilsson, S. V., Mäkelä, S., Treuter, E., Tujague, M., Thomsen, J. S., Andersson, G., Enmark, E., Pettersson, K., Warner, M. N., & Gustafsson, J.-Α. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.4.1535 · Cited by 2,025
Dysfunction in the neural circuitry of emotion regulation–a possible prelude to violence
Davidson, R. J., Putnam, K. M., & Larson, C. L. (2000) · Science · doi:10.1126/science.289.5479.591 · Cited by 1,894
Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
Brunner, H. G., Nelen, M., Breakefield, X. O., Ropers, H. H., & van Oost, B. A. (1993) · Science · doi:10.1126/science.8211186 · Cited by 1,644
Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform
Walther, D. J., Peter, J., Bashammakh, S., Hörtnagl, H., Voits, M., Fink, H., & Bäder, M. (2003) · Science · doi:10.1126/science.1078197 · Cited by 1,576
Sex Differences in Antisocial Behaviour: Conduct Disorder, Delinquency, and Violence in the Dunedin Longitudinal Study
Moffitt, T. E., Caspi, A., Rutter, M., & Silva, P. A. (2001) · doi:10.1017/cbo9780511490057 · Cited by 1,418

Show all 270 references

Research works printed but not linked: 1

Winqvist R, Lundstrom K, Salminen M, Laatikainen M, Ulmanen I (1991) Mapping of human catechol-O- methyltransferase gene to 22q11.2 and detection of a frequent RFLP with BglI. Cytogenet Cell Genet 58:2051

Sorted by citations

Inhibition and impulsivity: behavioral and neural basis of response control
Bari, A., & Robbins, T. W. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.005 · Cited by 1,921
Emotion regulation and impulsivity in young adults
Schreiber, L. R. N., Grant, J. E., & Odlaug, B. L. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.02.005 · Cited by 274
The neurobiological basis of human aggression: A review on genetic and epigenetic mechanisms
Waltes, R., Chiocchetti, A. G., & Freitag, C. M. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32388 · Cited by 182
Developmental Origins of Chronic Physical Aggression: A Bio-Psycho-Social Model for the Next Generation of Preventive Interventions
Tremblay, R. E., Vitaro, F., & Côté, S. M. (2017) · Annual Review of Psychology · doi:10.1146/annurev-psych-010416-044030 · Cited by 184
Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors
Suri, D., Teixeira, C. M., Cagliostro, M. K. C., Mahadevia, D., & Ansorge, M. S. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.231 · Cited by 167
Monoamine oxidase a gene promoter methylation and transcriptional downregulation in an offender population with antisocial personality disorder
Checknita, D., Maussion, G., Labonté, B., Comai, S., Tremblay, R. E., Vitaro, F., Turecki, N., Bertazzo, A., Gobbi, G., Côté, G., et al. (2014) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.114.144964 · Cited by 112
Detained Male Adolescent Offender’s Emotional, Physical and Sexual Maltreatment Profiles and Their Associations to Psychiatric Disorders and Criminal Behaviors
Aebi, M., Linhart, S., Thun‐Hohenstein, L., Bessler, C., Steinhausen, H., & Plattner, B. (2014) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-014-9961-y · Cited by 102
The developmental origins of chronic physical aggression: biological pathways triggered by early life adversity
Provençal, N., Booij, L., & Tremblay, R. E. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.111401 · Cited by 101
Aggressive behavior in humans: Genes and pathways identified through association studies
Fernàndez‐Castillo, N., & Cormand, B. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32419 · Cited by 87
Gilles de la Tourette Syndrome and Disruptive Behavior Disorders: Prevalence, Associations, and Explanation of the Relationships
Robertson, M. M., Cavanna, A. E., & Eapen, V. (2014) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.13050112 · Cited by 86
Association of Childhood Chronic Physical Aggression with a DNA Methylation Signature in Adult Human T Cells
Provençal, N., Suderman, M. J., Guillemin, C., Vitaro, F., Côté, S. M., Hallett, M., Tremblay, R. E., & Szyf, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089839 · Cited by 85
DNA Methylation Signature of Childhood Chronic Physical Aggression in T Cells of Both Men and Women
Guillemin, C., Provençal, N., Suderman, M. J., Côté, S. M., Vitaro, F., Hallett, M. T., Tremblay, R. E., & Szyf, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086822 · Cited by 84
The Implication of 5-HT Receptor Family Members in Aggression, Depression and Suicide: Similarity and Difference
Popova, N. K., Tsybko, A. S., & Naumenko, V. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158814 · Cited by 87
Potential role of insulin on the pathogenesis of depression
Zou, X. H., Sun, L., Yang, W., Li, B. J., & Cui, R. (2020) · Cell Proliferation · doi:10.1111/cpr.12806 · Cited by 75
Drugs related to monoamine oxidase activity
Fišar, Z. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.02.012 · Cited by 73
Deconstructing violence as a medical syndrome: mapping psychotic, impulsive, and predatory subtypes to malfunctioning brain circuits
Stahl, S. M. (2014) · CNS Spectrums · doi:10.1017/s1092852914000522 · Cited by 56
Polymorphism in the Serotonin Receptor 2a (HTR2A) Gene as Possible Predisposal Factor for Aggressive Traits
Bánlaki, Z., Elek, Z., Nánási, T., Székely, A., Nemoda, Z., Sasvári‐Székely, M., & Rónai, Z. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117792 · Cited by 58
Oxytocin and vasopressin receptor polymorphisms interact with circulating neuropeptides to predict human emotional reactions to stress.
Moons, W. G., Way, B. M., & Taylor, S. E. (2014) · Emotion · doi:10.1037/a0035503 · Cited by 59
Neurogenetics and Epigenetics in Impulsive Behaviour: Impact on Reward Circuitry
Archer, T., & Blum, K. (2012) · Journal of Genetic Syndromes & Gene Therapy · doi:10.4172/2157-7412.1000115 · Cited by 54
The Great Recession, genetic sensitivity, and maternal harsh parenting
Lee, D., Jeanne Brooks-gunn, B., McLanahan, S., Notterman, D. A., & Garfinkel, I. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312398110 · Cited by 60
Associations of monoamine oxidase A gene first exon methylation with sexual abuse and current depression in women
Checknita, D., Ekström, T. J., Comasco, E., Nilsson, K. W., Tiihonen, J., & Hodgins, S. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1875-3 · Cited by 50
Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species
Rappeneau, V., & Castillo Díaz, F. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105675 · Cited by 51
Genomic approaches to identify hybrids and estimate admixture times in European wildcat populations
Mattucci, F., Galaverni, M., Lyons, L. A., Alves, P. C., Randi, E., Velli, E., Pagani, L., & Caniglia, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-48002-w · Cited by 58
Mechanisms of the placebo effect in pain and psychiatric disorders
Holmes, R. D., Tiwari, A. K., & Kennedy, J. L. (2016) · The Pharmacogenomics Journal · doi:10.1038/tpj.2016.15 · Cited by 49
Predicting substance use in emerging adulthood: A genetically informed study of developmental transactions between impulsivity and family conflict
Elam, K. K., Wang, F. L., Bountress, K. E., Chassin, L., Pandika, D. M., & Lemery‐Chalfant, K. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000249 · Cited by 47
Structural brain abnormalities in aggression and violent behavior
Bannon, S. M., Salis, K. L., & O’Leary, K. D. (2015) · Aggression and Violent Behavior · doi:10.1016/j.avb.2015.09.016 · Cited by 52
Gene-Gene-Environment Interactions of Serotonin Transporter, Monoamine Oxidase A and Childhood Maltreatment Predict Aggressive Behavior in Chinese Adolescents
Zhang, Y., Ming, Q.-S., Yi, J.-Y., Wang, X., Chai, Q.-L., & Yao, S.-Q. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00017 · Cited by 45
Aggression in non‐human vertebrates: Genetic mechanisms and molecular pathways
Freudenberg, F., Gutiérrez, H. C., Post, A. M., Reif, A., & Norton, W. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32358 · Cited by 46
Gene‐set and multivariate genome‐wide association analysis of oppositional defiant behavior subtypes in attention‐deficit/hyperactivity disorder
Aebi, M., van Donkelaar, M. M. J., Poelmans, G., Buitelaar, J. K., Sonuga-Barke, E. J. S., Stringaris, A. K., Faraone, S. V., Franke, B., Steinhausen, H., & van Hulzen, K. J. E. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32346 · Cited by 47
Blunted insula activation reflects increased risk and reward seeking as an interaction of testosterone administration and the MAOA polymorphism
Wagels, L., Votinov, M., Radke, S., Clemens, B., Montag, C., Jung, S., & Habel, U. (2017) · Human Brain Mapping · doi:10.1002/hbm.23685 · Cited by 45
MAOA and MAOB polymorphisms and anger-related traits in suicidal participants and controls
Antypa, N., Giegling, I., Calati, R., Schneider, B., Hartmann, A. M., Friedl, M., Konte, B., Lia, L., Ronchi, D. D., Serretti, A., et al. (2012) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-012-0378-8 · Cited by 47
Psychopharmacology of Persistent Violence and Aggression
Meyer, J. M., Cummings, M. A., Proctor, G. J., & Stahl, S. M. (2016) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2016.07.012 · Cited by 42
Testosterone, Cortisol and Financial Risk-Taking
Herbert, J. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00101 · Cited by 47
Emotional Control, Styles of Coping with Stress and Acceptance of Illness among Patients Suffering from Chronic Somatic Diseases
Janowski, K., Kurpas, D., Kusz, J., Mroczek, B., & Jedynak, T. (2013) · Stress and Health · doi:10.1002/smi.2493 · Cited by 40
The Association Between Peer and Own Aggression is Moderated by the BDNF Val‐Met Polymorphism
Kretschmer, T., Vitaro, F., & Barker, E. D. (2013) · Journal of Research on Adolescence · doi:10.1111/jora.12050 · Cited by 43
Aggression and related stressful life events among Chinese adolescents living in rural areas: A cross-sectional study
Huang, J., Tang, J., Tang, L., Chang, H. J., Ma, Y., Yan, Q., & Yu, Y. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.12.044 · Cited by 38
Treating the violent patient with psychosis or impulsivity utilizing antipsychotic polypharmacy and high-dose monotherapy
Morrissette, D. A., & Stahl, S. M. (2014) · CNS Spectrums · doi:10.1017/s1092852914000388 · Cited by 36
A Strategy to Employ Clitoria ternatea as a Prospective Brain Drug Confronting Monoamine Oxidase (MAO) Against Neurodegenerative Diseases and Depression
Margret, A. A., Begum, T. N., Parthasarathy, S., & Suvaithenamudhan, S. (2015) · Natural Products and Bioprospecting · doi:10.1007/s13659-015-0079-x · Cited by 35
Gene x environment interactions in conduct disorder: Implications for future treatments
Holz, N. E., Zohsel, K., Laucht, M., Banaschewski, T., Hohmann, S., & Brandeis, D. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.017 · Cited by 35
Serotonergic Contributions to Human Brain Aggression Networks
Klasen, M., Wolf, D., Eisner, P. D., Eggermann, T., Zerres, K., Zepf, F. D., Weber, R., & Mathiak, K. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00042 · Cited by 36
Genetic and non-genetic determinants of aggression in combat sports
Gronek, P., Wieliński, D., & Gronek, J. (2014) · Open Life Sciences · doi:10.1515/biol-2015-0002 · Cited by 37
Smoking and psychopathology increasingly associated in recent birth cohorts
Talati, A., WICKRAMARATNE, P. J., Keyes, K. M., Hasin, D. S., LEVIN, F. R., & Weissman, M. M. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2013.08.025 · Cited by 32
Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women
Rodríguez‐Ramos, Á., Moriana, J. A., García‐Torres, F., & Ruiz‐Rubio, M. (2019) · Brain and Behavior · doi:10.1002/brb3.1376 · Cited by 36
Exogenous testosterone and the monoamine-oxidase A polymorphism influence anger, aggression and neural responses to provocation in males
Wagels, L., Votinov, M., Kellermann, T., Konzok, J., Jung, S., Montag, C., Schneider, F. W., Eisert, A., Beyer, C., & Habel, U. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.01.006 · Cited by 32
Luteolin and its antidepressant properties: From mechanism of action to potential therapeutic application
Zhou, J., Wu, Z., & Zhao, P. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.101097 · Cited by 33
Are infants differentially sensitive to parenting? Early maternal care, DRD4 genotype and externalizing behavior during adolescence
Nikitopoulos, J. A., Zohsel, K., Blomeyer, D., Buchmann, A. F., Schmid, B., Jennen-Steinmetz, C., Becker, K., Schmidt, M. H., Esser, G., Brandeis, D., et al. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.08.012 · Cited by 35
Physical and verbal aggressive behavior and COMT genotype: Sensitivity to the environment
Tuvblad, C., Narusyte, J., Comasco, E., Andershed, H., Andershed, A., Colins, O. F., Fanti, K. A., & Nilsson, K. W. (2016) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32430 · Cited by 28
Neural networks underlying trait aggression depend on MAOA gene alleles
Klasen, M., Wolf, D., Eisner, P. D., Habel, U., Repple, J., Vernaleken, I., Schlüter, T., Eggermann, T., Zerres, K., Zepf, F. D., et al. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1528-6 · Cited by 32
How do traditional masculinity ideologies and emotional competence relate to aggression and physical domestic violence in cisgender men?
Logoz, F., Eggenberger, L., Komlenac, N., Schneeberger, M., Ehlert, U., & Walther, A. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1100114 · Cited by 39
Male Inmate Profiles and Their Biological Correlates
Horn, M., Potvin, S., Allaire, J.-F., Côté, G., Gobbi, G., Benkirane, K., Vachon, J., & Dumais, A. (2014) · The Canadian Journal of Psychiatry · doi:10.1177/070674371405900807 · Cited by 28
A spatial discounting test to assess impulsivity in dogs
Brady, K., Hewison, L., Wright, H., Zulch, H. E., Cracknell, N. R., & Mills, D. S. (2018) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2018.01.003 · Cited by 26
Altered Expression of Genes Associated with Major Neurotransmitter Systems in the Reward-Related Brain Regions of Mice with Positive Fighting Experience
Смагин, Д. А., Galyamina, A. G., Kovalenko, I. L., & Kudryavtseva, N. N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113644 · Cited by 25
Alterations in grooming activity and syntax in heterozygous SERT and BDNF knockout mice: The utility of behavior-recognition tools to characterize mutant mouse phenotypes
Kyzar, E. J., Pham, M., Roth, A., Cachat, J., Green, J. B. A., Gaikwad, S., & Kalueff, A. V. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.08.004 · Cited by 25
The potential role of myostatin and neurotransmission genes in elite sport performances
Filonzi, L., Franchini, N., Vaghi, M., Chiesa, S., & Marzano, F. N. (2015) · Journal of Biosciences · doi:10.1007/s12038-015-9542-4 · Cited by 26
Aggression in children: unravelling the interplay of genes and environment through (epi)genetics and metabolomics
Boomsma, D. I. (2015) · Journal of pediatric and neonatal individualized medicine · doi:10.7363/040251 · Cited by 22
Heritability of interpack aggression in a wild pedigreed population of North American grey wolves
vonHoldt, B. M., DeCandia, A. L., Heppenheimer, E., Janowitz‐Koch, I., Shi, R., Zhou, H., German, C. A., Brzeski, K. E., Cassidy, K. A., Stahler, D. R., et al. (2020) · Molecular Ecology · doi:10.1111/mec.15349 · Cited by 22
“Previous research has found a clear association between aggression and neurotransmitterrelated genes across taxa (Comai et al., 2012; Pavlov et al., 2012), including domestic dogs (Vage et al.”
Background
Single nucleotide polymorphisms, variable number tandem repeats and allele influence on serotonergic enzyme modulators for aggressive and suicidal behaviors: A review
Xiang, C., Liu, S., Fan, Y., Wang, X., Jia, Y., Li, L., Cong, S., & Han, F. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.03.008 · Cited by 23
Identifying knowledge gaps in understanding the effects of selective serotonin reuptake inhibitors (SSRIs) on fish behaviour
Ferreira, C., Soares, S. C., Kille, P., & Oliveira, M. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.139124 · Cited by 22
COMT and BDNF Gene Variants Help to Predict Alcohol Consumption in Alcohol-dependent Patients
Klimkiewicz, A., Mach, A., Jakubczyk, A., Klimkiewicz, J., Wnorowska, A., Kopera, M., Fudalej, S., Burmeister, M., Brower, K. J., & Wojnar, M. (2016) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000000277 · Cited by 22
Aggressive behavior in cattle is associated with a polymorphism in the MAOA gene promoter
Eusebi, P. G., Sevane, N., Cortés, O., Contreras, E., Cañon, J., & Dunner, S. (2020) · Animal Genetics · doi:10.1111/age.12867 · Cited by 21
Linking Personality to Larval Energy Reserves in Rainbow Trout (Oncorhynchus mykiss)
Andersson, M. Å., & Höglund, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049247 · Cited by 21
Behavioural genetic differences between Chinese and European pigs
Chu, Q., Liang, T., Fu, L., Li, H., & Zhou, B. (2017) · Journal of Genetics · doi:10.1007/s12041-017-0826-3 · Cited by 21
Corrigendum to “Alterations in grooming activity and syntax in heterozygous SERT and BDNF knockout mice: The utility of behavior-recognition tools to characterize mutant mouse phenotypes”
Kyzar, E. J., Pham, M., Roth, A., Cachat, J., Green, J. B. A., Gaikwad, S., & Kalueff, A. V. (2015) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.08.002 · Cited by 19
Serotonergic gene polymorphisms (5-HTTLPR, 5HTR1A, 5HTR2A), and population differences in aggression: traditional (Hadza and Datoga) and industrial (Russians) populations compared
Butovskaya, M., Butovskaya, P. R., Vasilyev, V. A., Sukhodolskaya, J. M., Fekhredtinova, D. I., Карелин, Д. В., Fedenok, J. N., Mabulla, A. Z. P., Рысков, А. П., & Lazebny, O. E. (2018) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-018-0171-0 · Cited by 22
Endophenotypes as a measure of suicidality
Chistiakov, D. A., Kekelidze, Z. I., & Chekhonin, V. P. (2012) · Journal of Applied Genetics · doi:10.1007/s13353-012-0113-1 · Cited by 22
Self-citation
Neurobiología de la agresión y la violencia
Ortega‐Escobar, J., & Alcázar‐Córcoles, M. Á. (2016) · Anuario de Psicología Jurídica · doi:10.1016/j.apj.2016.03.001 · Cited by 40
Serotonin 5-HT2A receptor polymorphisms are associated with irritability and aggression in conduct disorder
Nedic Erjavec, G., Tudor, L., Nikolac Perkovic, M., Podobnik, J., Dodig Curkovic, K., Curkovic, M., Svob Strac, D., Cusek, M., Bortolato, M., & Pivac, N. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110542 · Cited by 18
Gene–Environment Interactions in the Etiology of Human Violence
Laucht, M., Brandeis, D., & Zohsel, K. (2013) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2013_260 · Cited by 18
Depressive Symptoms among Middle-Aged Women—Understanding the Cause
Cybulska, A. M., Szkup, M., Schneider-Matyka, D., Skonieczna‐Żydecka, K., Kaczmarczyk, M., Jurczak, A., Wieder-Huszla, S., Karakiewicz, B., & Grochans, E. (2020) · Brain Sciences · doi:10.3390/brainsci11010026 · Cited by 19
Impulsivity in patients with panic disorder-agoraphobia: The role of cyclothymia
Carlo, A. D., Benvenuti, M., Toni, C., Dell’Osso, L., & Perugi, G. (2013) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2013.05.003 · Cited by 18
A meta-analytic evaluation of the endophenotype hypothesis: Effects of measurement paradigm in the psychiatric genetics of impulsivity.
Jonas, K. G., & Markon, K. E. (2014) · Journal of Abnormal Psychology · doi:10.1037/a0037094 · Cited by 21
Paraphilic Sexual Offenders Do Not Differ from Control Subjects with Respect to Dopamine- and Serotonin-Related Genetic Polymorphisms
Jakubczyk, A., Krasowska, A., Bugaj, M., Kopera, M., Klimkiewicz, A., Łoczewska, A., Michalska, A., Majewska, A., Szejko, N., Podgórska, A., et al. (2016) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2016.11.309 · Cited by 17
Monoamine and neuroendocrine gene-sets associate with frustration-based aggression in a gender-specific manner
van Donkelaar, M. M. J., Hoogman, M., Shumskaya, E., Buitelaar, J. K., Bralten, J., & Franke, B. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.11.016 · Cited by 19
Val158Met COMT polymorphism and risk of aggression in alcohol dependence
Soyka, M., Zill, P., Koller, G., Samochowiec, A., Grzywacz, A., & Preuss, U. W. (2013) · Addiction Biology · doi:10.1111/adb.12098 · Cited by 18
Association of Polymorphisms of Serotonin Transporter (5HTTLPR) and 5-HT2C Receptor Genes with Criminal Behavior in Russian Criminal Offenders
Toshchakova, V. A., Bakhtiari, Y., Kulikov, A. V., Gusev, S. I., Трофимова, М. В., Fedorenko, O. Y., Викторовна, М. Е., Popova, N. K., Bokhan, N. A., Hovens, J. E. J. M., et al. (2017) · Neuropsychobiology · doi:10.1159/000487484 · Cited by 16
Effect of mental construals on cooperative and competitive conflict management styles
Mukherjee, K., & Upadhyay, D. (2018) · International Journal of Conflict Management · doi:10.1108/ijcma-11-2017-0136 · Cited by 19
Melatonin pretreatment alleviates blast-induced oxidative stress in the hypothalamic-pituitary-gonadal axis by activating the Nrf2/HO-1 signaling pathway
Zhang, Y., Cong, P., Tong, C., Jin, H., Liu, Y., & Hou, M. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119722 · Cited by 16
Self-reported impulsivity is negatively correlated with amygdalar volumes in cocaine dependence
Mei, S., Xu, J., Carroll, K. M., & Potenza, M. N. (2015) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2015.07.013 · Cited by 16
Feeding motivation as a personality trait in Nile tilapia (Oreochromis niloticus): role of serotonergic neurotransmission
Silva, P. I. M., Martins, C. I. M., Höglund, E., Gjøen, H. M., & Øyvind Øverli, A. (2014) · Fish Physiology and Biochemistry · doi:10.1007/s10695-014-9947-2 · Cited by 16
Managing dingoes on Fraser Island: culling, conflict, and an alternative
O’Neill, A. J., Cairns, K. M., Kaplan, G., & Healy, E. (2016) · Pacific Conservation Biology · doi:10.1071/pc16026 · Cited by 16
Early-life adversity-induced long-term epigenetic programming associated with early onset of chronic physical aggression: Studies in humans and animals
Chistiakov, D. A., & Chekhonin, V. P. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1322714 · Cited by 16
Self-citation
Associations of age, sex, sexual abuse, and genotype with monoamine oxidase a gene methylation
Checknita, D., Tiihonen, J., Hodgins, S., & Nilsson, K. W. (2021) · Journal of Neural Transmission · doi:10.1007/s00702-021-02403-2 · Cited by 14
RGS2 drives male aggression in mice via the serotonergic system
Mark, M. D., Wollenweber, P., Gesk, A., Kösters, K., Batzke, K., Janoschka, C., Maejima, T., Han, J., Deneris, E. S., & Herlitze, S. (2019) · Communications Biology · doi:10.1038/s42003-019-0622-0 · Cited by 14
Physical predictors, behavioural/emotional attributes and neurochemical determinants of dominant behaviour
Chichinadze, K., Chichinadze, N., Gachechiladze, L., Lazarashvili, A., & Nikolaishvili, M. (2014) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12091 · Cited by 15
The effect of age on discrimination learning and self-control in a marshmallow test for pigs
Krause, A., Kreiser, M., Puppe, B., Tuchscherer, A., & Düpjan, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-97770-x · Cited by 16
Psychopathic Genes: A Multi-level Adaptive Dynamic Modelling Approach
Augustinus, F., Hendrikse, S. C. F., & Jan Treur, A. (2025) · Lecture notes in networks and systems · doi:10.1007/978-3-031-94770-4_38 · Cited by 12
Effects of an early experience of reward through maternal contact or its denial on the dopaminergic system of the rat brain
Raftogianni, A., Stamatakis, A., Diamantopoulou, A., Kollia, A.-M., & Stylianopoulou, F. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.03.035 · Cited by 12
Serotonin and Dopamine Candidate Gene Variants and Alcohol- and Non-Alcohol-Related Aggression
Preuss, U. W., Koller, G., Samochowiec, A., Zill, P., Samochowiec, J., Kucharska–Mazur, J., Wong, J., & Soyka, M. (2015) · Alcohol and Alcoholism · doi:10.1093/alcalc/agv057 · Cited by 11
Aggressive behavior: Genetic and physiological mechanisms
Kudryavtseva, N. N., Markel, А. L., & Orlov, Y. L. (2015) · Russian Journal of Genetics Applied Research · doi:10.1134/s2079059715040085 · Cited by 11
Maoa and Maob polymorphisms and personality traits in suicide attempters and healthy controls: a preliminary study
Balestri, M., Calati, R., Serretti, A., Hartmann, A. M., Konte, B., Friedl, M., Giegling, I., & Rujescu, D. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.01.020 · Cited by 12
Effect of Direct-fed Microbials, Bacillus subtilis, on Production Performance, Serotonin Concentrations and Behavioral Parameters in a Selected Dominant Strain of White Leghorn Hens
Hu, J., Chen, H., & Cheng, H. W. (2018) · International Journal of Poultry Science · doi:10.3923/ijps.2018.106.115 · Cited by 10
Genetic and Genomic Basis of Aggressive Behavior
Novoselskaya-Dragovich, A. Y., & Borinskaya, S. A. (2019) · Russian Journal of Genetics · doi:10.1134/s1022795419090059 · Cited by 12
On the Potential Role of the Neural Crest Cells in Integrating Pigmentation Into Behavioral and Physiological Syndromes
San‐Jose, L. M., & Roulin, A. (2020) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2020.00278 · Cited by 10
The development of the serotonergic and dopaminergic systems during chicken mid-late embryogenesis
Huang, X., Kuang, S., Applegate, T. J., Lin, T.-L., & Cheng, H. W. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110472 · Cited by 9
Genetic Susceptibility of Impulse Control and Related Behavior in Parkinson's Disease
Kim, Y. E., & Jeon, B. S. (2014) · Journal of Parkinson s Disease · doi:10.3233/jpd-130292 · Cited by 9
Homicidal ideation and psychiatric comorbidities in the inpatient adolescents aged 12–17
Sun, C.-F., Mansuri, Z., Trivedi, C. G., Vadukapuram, R., & Reddy, A. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.933524 · Cited by 9
Genetic polymorphisms in the serotonin, dopamine and opioid pathways influence social attention in rhesus macaques (Macaca mulatta)
Howarth, E., Szott, I. D., Witham, C. L., Wilding, C. S., & Bethell, E. (2023) · PLoS ONE · doi:10.1371/journal.pone.0288108 · Cited by 9
Self‐regulatory failure and the perpetration of adolescent dating violence: Examining an alcohol use by gene explanation
Foshee, V. A., Benefield, T., Puvanesarajah, S., Reyes, H. L. M., Haberstick, B. C., Smolen, A., Ennett, S. T., & Suchindran, C. (2014) · Aggressive Behavior · doi:10.1002/ab.21550 · Cited by 9
Should High Dose or Very Long-Term Antipsychotic Monotherapy Be Considered Before Antipsychotic Polypharmacy?
Stahl, S. M., & Morrissette, D. A. (2012) · Springer eBooks · doi:10.1007/978-94-007-5805-6_5 · Cited by 8
Impulsivity and Metacognition in a Psychiatric Population.
Turiaco, F., Bruno, A., Mento, C., Cedro, C., Pandolfo, G., & Muscatello, M. R. A. (2022) · PubMed Central · doi:10.36131/cnfioritieditore20220203 · Cited by 9

Authors: Pavlov, K. A., Chistiakov, D. A., & Chekhonin, V. P.
Affiliations: Pirogov Russian National Research Medical University (RU)
Corresponding author: Chistiakov, Dimitry A.
ORCID: Chistiakov, Dimitry A.
Chekhonin, Vladimir P.
Venue: Journal of Applied Genetics
Publisher: Springer Science and Business Media LLC
Published: 2011-10-13
Volume: 53
Issue: 1
Pages: 61-82
ISSN: 1234-1983 (ISSN-L)
2190-3883
DOI: 10.1007/s13353-011-0069-6
OpenAlex: W2055506273
Cited by: 184
References: 270
Citations by year: 2026: 6 · 2025: 8 · 2024: 11 · 2023: 12 · 2022: 16 · 2021: 9 · 2020: 13 · 2019: 13 · 2018: 12 · 2017: 14 · 2016: 12 · 2015: 16 · 2014: 23 · 2013: 9 · 2012: 10
FWCI: 1.28
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Applied Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: aggression, impulsivity, genetic susceptibility, serotonin, dopamine, monoamine oxidase A, serotonin transporter, 5-HTT polymorphism, amygdala, prefrontal cortex, anterior cingulate cortex, testosterone, cortisol, limbic system, violent behavior, gene-environment interaction, emotion regulation
MeSH terms: Aggression, Dopamine, Genetic Markers, Humans, Impulsive Behavior, Monoamine Oxidase, Receptors, Estrogen, Serotonin, Sex Factors, Stress, Physiological, Testosterone, Genetic Predisposition to Disease, Membrane Transport Proteins, Genetic Determinism, Serotonin Plasma Membrane Transport Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Genetic determinants of aggression and impulsivity in humans

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks