Social recognition does not involve vasopressinergic neurotransmission in female rats
Abstract
Social recognition is the ability to recognize a previously investigated conspecific. This phenomenon has been shown to be modulated by androgen-dependent vasopressinergic transmission in intact but not in castrated male rats. The dependence of social recognition on vasopressinergic transmission was studied in female rats. In comparison to intact males, females showed less persistence in investigating juvenile conspecifics and held social memories for longer intervals. Social recognition was enhanced by peripheral injections of vasopressin (6 micrograms/kg) in both sexes. However, in contrast to what had been observed in males, social recognition in females was insensitive to the blocking effects of a vasopressor antagonist of vasopressin, dPTyr(Me)AVP (30 micrograms/kg, s.c.). These results suggest that social recognition is not mediated by vasopressinergic transmission in female rats.
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Early studies suggested that female and castrated male rats hold social memories for longer time than intact males.
“Additionally, early studies suggested that female and castrated male rats hold social memories for longer time than intact males [21, 31].”
From Effects of sex and gonadectomy on social investigation and social recognition in mice (2015) · cites this paper as [31]
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- Authors
- Bluthe´, R.-M., & Dantzer, R.
- Affiliations
- Inserm (FR)
- Corresponding author
- Dantzer, Robert
- ORCID
- Dantzer, Robert
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1990-12
- Volume
- 535
- Issue
- 2
- Pages
- 301-304
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2074024629
- Cited by
- 147
- References
- 2
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 7 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 3 · 2013: 5 · 2012: 4
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- social recognition, vasopressin, female rats, social memory, androgen dependence, vasopressin receptor antagonists, sex differences
- MeSH terms
- Animals, Arginine Vasopressin, Female, Male, Memory, Synaptic Transmission, Orchiectomy, Rats, Inbred Strains, Sex Factors, Social Behavior, Vasopressins, Rats
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