Vasopressin regulates social recognition in juvenile and adult rats of both sexes, but in sex- and age-specific ways
Open accessAbstract
In adult male rats, vasopressin (AVP) facilitates social recognition via activation of V1a receptors within the lateral septum. Much less is known about how AVP affects social recognition in adult females or in juvenile animals of either sex. We found that administration of the specific V1a receptor antagonist d(CH(2))(5)[Tyr(Me)(2)]AVP into the lateral septum of adult rats impaired, whereas AVP extended, social discrimination in both sexes. In juveniles, however, we detected a sex difference, such that males but not females showed social discrimination. Interestingly, administration of the V1a receptor antagonist to juveniles (either intracerebroventricularly or locally in the lateral septum) did not prevent social discrimination, but instead significantly decreased the investigation of a novel as opposed to a familiar animal in both sexes, with stronger effects in males. V1a receptors were found to be abundantly expressed in the lateral septum with higher binding density in females than in males. These findings demonstrate that activation of V1a receptors in the lateral septum is important for social recognition in both sexes, and that the roles of septal V1a receptors in social recognition change during development.
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V1aR and OTR are abundantly expressed in the lateral septum in juvenile rats.
“V1aR and the OTR are abundantly expressed in this area in juvenile rats (Lukas et al., 2010; Veenema et al., 2012)”
From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Veenema et al., 2012
The Discussion reports abundant septal V1aR binding densities in both male and female juvenile rats. Our copy does not establish abundant OTR expression in the juvenile lateral septum, so it supports only the V1aR part of the claim. The indexed passages provide no page number. (LLM, conf=0.91)
Experimental — accuracy not yet measuredThe injection site was chosen because it is positioned centrally in the region where males and females express high densities of V1aR and OTR binding in the lateral septum and corresponds with previous studies showing that pharmacological manipulations of AVP and OXT systems in the rat lateral septum altered social behavior.
“This injection site was chosen because it is positioned centrally in the region where males and females express high densities of V1aR and OTR binding in the lateral septum (Lukas et al., 2010; Veenema et al., 2012; Figure 1) and because the injection site corresponds with previous studies showing that pharmacological manipulations of AVP and OXT systems in the rat lateral septum altered social”
From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Veenema et al., 2012
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredThe same dose of AVP altered novel cage social play behavior in females, anxiety-related behavior in males, and social recognition in both male and female juvenile rats.
“However, the same dose of AVP altered novel cage social play behavior in females, anxiety-related behavior in males, and social recognition in both male and female juvenile rats (Veenema et al., 2012).”
From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Veenema et al., 2012
The Results (Experiment 3; page not provided) report that the 200 pg AVP dose increased social preference in juvenile females, but not juvenile males. The paper does not report a novel-cage social-play test or an AVP-dose effect on anxiety in male rats; its Discussion mentions anxiety-related behavior only in a separate mouse knockout study. (LLM, conf=0.90)
Experimental — accuracy not yet measuredMale and female rats show very dense V1aR binding in the dorsal and intermediate LS, with females having even denser binding than males.
“Male and female rats show very dense V1aR binding in the dorsal and intermediate LS, with females having even denser binding than males [39,40].”
From Involvement of dopamine, but not norepinephrine, in the sex-specific regulation of juvenile socially rewarding behavior by vasopressin (2018) · cites this paper as [40]
Experiment 4 (Results; page unavailable) reports significantly higher lateral-septum V1aR binding density in females than males. The Discussion describes abundant septal binding in juvenile rats of both sexes. Our copy does not establish the claimed very dense binding specifically in the dorsal and intermediate lateral septum. (LLM, conf=0.86)
Experimental — accuracy not yet measuredDrug concentrations used were shown to be effective in altering social play or other social behaviors in rats.
“These drug concentrations were shown to be effective in altering social play (Veenema et al., 2013) or other social behaviors (Veenema et al., 2012; Dumais et al., 2013b; Lukas et al., 2013) in rats.”
From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Veenema et al., 2012
Drug doses were chosen based on previous microinjection studies in rats inducing changes in behavior.
“Drug doses were chosen based on previous microinjection studies in rats inducing changes in behavior (Veenema et al., 2012(Veenema et al., , 2013;;Bredewold et al., 2015;Stanley et al., 1993;Numan et al., 2010).”
From Vasopressin regulates social play behavior in sex-specific ways through glutamate modulation in the lateral septum (2025) · cites this paper as Veenema et al., 2012
The role of BNST AVP in play behavior may change across age.
“First, the role of BNST AVP in play behavior may change across age, similar to that found for septal AVP in social recognition in juveniles compared to adults (Veenema et al., 2012).”
From Sexually dimorphic role for vasopressin in the development of social play (2014) · cites this paper as Veenema et al., 2012
The lateral septum shows denser AVP fibers in males than females and abundant expression of V1aR in male and female juvenile rats.
“To test the hypothesis that the sexually dimorphic effects of ICV injections of V1aR blockade were mediated by the sexually dimorphic projections of the BST and MeA, we specifically targeted the LS, which shows denser AVP fibers in males than in females (De Vries et al., 1981) and abundant expression of V1aR in male and female juvenile rats (Veenema et al., 2012).”
From Sex-specific modulation of juvenile social play by vasopressin (2013) · cites this paper as Veenema et al., 2012
V1aR blockade in the lateral septum made juvenile males and females spend more time investigating a familiar as opposed to a novel conspecific, with effects stronger in males than females.
“V1aR blockade in the LS, for example, made juvenile males as well as females spend more time investigating a familiar as opposed to a novel conspecific, albeit that these effects were significantly stronger in males than in females (Veenema et al., 2012).”
From Sex-specific modulation of juvenile social play by vasopressin (2013) · cites this paper as Veenema et al., 2012
Time of administration and concentrations of drugs were based on previous studies showing behavioral effects in rats.
“Time of administration and concentrations of drugs were based on previous studies showing behavioral effects in rats (Lukas et al., 2011, 2013; Veenema et al., 2012).”
From Sex-specific modulation of juvenile social play by vasopressin (2013) · cites this paper as Veenema et al., 2012
Septal AVP injections extended social recognition in female juvenile rats and in male and female adult rats.
“Using the same concentration and injection procedure, we found previously that septal AVP injections extended social recognition in female juvenile rats and in male and female adult rats (Veenema et al., 2012).”
From Sex-specific modulation of juvenile social play by vasopressin (2013) · cites this paper as Veenema et al., 2012
Septal AVP injections facilitated social recognition in female, but not male, juvenile rats.
“Moreover, whereas in the current study septal AVP injections did not alter social play in either sex, it facilitated social recognition in female, but not male juveniles (Veenema et al., 2012).”
From Sex-specific modulation of juvenile social play by vasopressin (2013) · cites this paper as Veenema et al., 2012
LS-V1AR blockade did not impair social recognition in juvenile rats, but rather induced a preference to investigate familiar over novel conspecifics.
“Surprisingly, LS-V1AR blockade did not impair social recognition in juvenile rats, but rather induced a preference to investigate familiar over novel conspecifics (Veenema et al., 2012).”
From Quantitative mapping reveals age and sex differences in vasopressin, but not oxytocin, immunoreactivity in the rat social behavior neural network (2017) · cites this paper as Veenema et al., 2012
Blockade of the AVP V1A receptor in the LS impaired social recognition in adult rats, while AVP infusions into the LS improved it.
“Here, blockade of the AVP V1A receptor (V1AR) in the LS impaired social recognition in adult rats, while AVP infusions into the LS improved it (Dantzer et al., 1988; Engelmann & Landgraf, 1994; Everts & Koolhaas, 1997; Lukas, Toth, Veenema, & Neumann, 2013; Veenema et al., 2012).”
From Quantitative mapping reveals age and sex differences in vasopressin, but not oxytocin, immunoreactivity in the rat social behavior neural network (2017) · cites this paper as Veenema et al., 2012
In adult male and female rats, administration of AVP in the lateral septum prolonged social recognition, while administration of V1AR antagonists in the lateral septum impaired social recognition.
“administration of AVP in the LS prolonged, while administration of V1AR antagonists in the LS impaired social recognition similarly in adult male and female rats (Veenema et al., 2012)”
From Quantitative mapping reveals age and sex differences in vasopressin, but not oxytocin, immunoreactivity in the rat social behavior neural network (2017) · cites this paper as Veenema et al., 2012
The 3-day recovery period was shown not to affect the display of social behavior.
“The 3-day recovery period matches that used for other procedures applied routinely in our lab (e.g., intracerebral microdialysis) and was shown not to affect the display of social behavior (Beiderbeck et al., 2007; Veenema et al., 2010, 2012; Lukas et al., 2011, 2013).”
From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Veenema et al., 2012
The Experimental procedures section says rats underwent social-discrimination testing two days after cannulation, not after a three-day recovery period. The Social discrimination test and Results sections measure social behavior but do not assess whether a three-day recovery period affects it (pages unavailable in our copy). (LLM, conf=0.76)
Experimental — accuracy not yet measuredAntagonism of V1aRs in several different CNS sites impairs social recognition.
“Antagonism of V1aRs in several different CNS sites impairs social recognition [73; 74]”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [74]
V1aR blockade in the LS impaired social recognition in both male and female adult rats.
“we recently showed that V1aR blockade, using the specific V1aR antagonist d(CH2)5[Tyr(Me)2]AVP), in the LS impaired social recognition in both male and female adult rats (Veenema et al., 2012).”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Veenema et al., 2012
In rodents, the VP system regulates social play in rats in sex-specific ways.
“In rodents, sex-specific regulation of partner preference in prairie voles, social recognition in rats, social play in rats, and aggression in hamsters has been found”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Veenema et al., 2012
In rodents, the VP system regulates social recognition in rats in sex-specific ways.
“In rodents, sex-specific regulation of partner preference in prairie voles, social recognition in rats, social play in rats, and aggression in hamsters has been found”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Veenema et al., 2012
VP plays a stronger role in social recognition in male juvenile rats compared to females.
“VP plays a stronger role in social recognition in male juvenile rats compared to females (Veenema et al., 2012)”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Veenema et al., 2012
V1aR blockade in the LS increased social investigation of a familiar over a novel stimulus rat in both male and female juvenile rats, but with a stronger effect in males.
“we showed that V1aR blockade in the LS increased social investigation of a familiar over a novel stimulus rat in both male and female juvenile rats, but with a stronger effect in males (Veenema et al., 2012).”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Veenema et al., 2012
Bed nucleus of the stria terminalis vasopressin cell ablation impairs social recognition in males, likely through its projection to the lateral septum, and restoration of BNST-LS vasopressin signaling in Magel2-KO mice ameliorated social discrimination deficits.
“For example, BNST AVP cell ablation impairs social recognition in males, likely through its projection to the LS (94, 108, 109), and restoration of BNST-LS AVP signaling in Magel2-KO mice ameliorated social discrimination deficits (110).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [109]
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Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Bielsky, I. F., Hu, S.-B., Szegda, K. L., Westphal, H., & Young, L. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300360 · Cited by 531 · see citing works
de Vries, G. J., & Buijs, R. M. (1983) · Brain Research · doi:10.1016/0006-8993(83)90855-7 · Cited by 524 · cited 2× · see citing works
“The lateral septum receives most of its AVP innervation from the bed nucleus of the stria terminalis (BNST) and the medial amygdala (MeA) (De Vries and Buijs, 1983; Caffé et al., 1987).”
Bielsky, I. F., Hu, S.-B., Ren, X., Terwilliger, E. F., & Young, L. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.031 · Cited by 367 · see citing works
Landgraf, R., Gerstberger, R., Montkowski, A., Probst, J., Wotjak, C., Holsboer, F., & Engelmann, M. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-06-04250.1995 · Cited by 341 · see citing works
De Vries, G. J., Buds, R. M., & Swaab, D. F. (1981) · Brain Research · doi:10.1016/0006-8993(81)90989-6 · Cited by 319 · cited 5× · see citing works
“As AVP fiber density in the lateral septum and AVP mRNA levels in the BNST and MeA are lower in juveniles than in adults (De Vries et al., 1981; Szot and Dorsa, 1993), we also hypothesized that AVP is more important for the regulation of social recognition in adult rats than in juveniles.”
InfluentialSex-specific influences of vasopressin on human social communication
Thompson, R. R., George, K., Walton, J. C., Orr, S. P., & Benson, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600406103 · Cited by 312 · see citing works
Caffé, A. R., van Leeuwen, F. W., & Luiten, P. G. M. (1987) · Journal of Comparative Neurology · doi:10.1002/cne.902610206 · Cited by 286 · see citing works
Brain vasopressin is an important regulator of maternal behavior independent of dams’ trait anxiety
Bosch, O. J., & Neumann, I. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807412105 · Cited by 280 · see citing works
Engelmann, M., Wotjak, C. T., & Landgraf, R. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(95)00053-l · Cited by 274 · see citing works
Septal vasopressin modulates social memory in male rats
Dantzer, R., Koob, G. F., Bluthe´, R.-M., & Le Moal, M. (1988) · Brain Research · doi:10.1016/0006-8993(88)90066-2 · Cited by 262 · see citing works
van Leeuwen, F. W., Caffe, A. R., & Vries, G. J. D. (1985) · Brain Research · doi:10.1016/0006-8993(85)90348-8 · Cited by 248 · see citing works
Engelmann, M., & Landgraf, R. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90022-1 · Cited by 225 · see citing works
Social and individual recognition in rodents: Methodological aspects and neurobiological bases
Gheusi, G., Bluthé, R.-M., Goodall, G., & Dantzer, R. (1994) · Behavioural Processes · doi:10.1016/0376-6357(94)90060-4 · Cited by 206 · see citing works
Lukas, M., Bredewold, R., Neumann, I. D., & Veenema, A. H. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.020 · Cited by 183 · see citing works
Self-citationVeenema, A. H., Beiderbeck, D. I., Lukas, M., & Neumann, I. D. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.03.006 · Cited by 180 · see citing works
Self-citationLandgraf, R., Frank, E., Aldag, J. M., Neumann, I. D., Sharer, C. A., Ren, X., Terwilliger, E. F., Niwa, M., Wigger, A., & Young, L. J. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02750.x · Cited by 164 · see citing works
Endogenous oxytocin is involved in short-term olfactory memory in female rats
Engelmann, M., Ebner, K., Wotjak, C. T., & Landgraf, R. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00084-3 · Cited by 156 · see citing works
Everts, H. G. J., & Koolhaas, J. M. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00004-7 · Cited by 148 · see citing works
Social recognition does not involve vasopressinergic neurotransmission in female rats
Bluthe´, R.-M., & Dantzer, R. (1990) · Brain Research · doi:10.1016/0006-8993(90)91613-l · Cited by 147 · see citing works
Vasopressin 1a receptor knockout mice have a subtle olfactory deficit but normal aggression
Wersinger, S. R., Caldwell, H. K., Martinez, L. A., Gold, P. W., Hu, S.-B., & Young, W. S. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00281.x · Cited by 139 · see citing works
MILLER, M. A., Vician, L. J., Clifton, D. K., & Dorsa, D. M. (1989) · Peptides · doi:10.1016/0196-9781(89)90152-6 · Cited by 126 · see citing works
Lukas, M., Bredewold, R., Landgraf, R., Neumann, I. D., & Veenema, A. H. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.11.007 · Cited by 122 · see citing works
Self-citationLateral septal vasopressin in rats: role in social and object recognition?
Everts, H. G. J., & Koolhaas, J. M. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00269-2 · Cited by 98 · see citing works
Bielsky, I. F., Hu, S.-B., & Young, L. J. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.06.005 · Cited by 91 · see citing works
Szot, P., & Dorsa, D. M. (1993) · Developmental Brain Research · doi:10.1016/0165-3806(93)90136-x · Cited by 65 · see citing works
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- Bielsky IF Hu SB Szegda KL Westphal H Young LJ Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice Neuropsychopharmacology 2004 29 483 493 14647484
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Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520 · see citing works
“We further found that V1aR blockade in the LS of juvenile rats did not impair social recognition in male and female juvenile rats, but rather increased social investigation of the familiar over the novel stimulus rat (Veenema et al., 2012).”
BackgroundMethodInfluentialSelf-citationOxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics
Manning, M., Misicka, A., Olma, A., Bankowski, K., Stoev, S., Chini, B., Durroux, T., Mouillac, B., Corbani, M., & Guillon, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02303.x · Cited by 423 · see citing works
Song, Z., & Albers, H. E. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.10.004 · Cited by 244 · see citing works
Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities
Rigney, N., de Vries, G. J., Petrulis, A., & Young, L. J. (2022) · Endocrinology · doi:10.1210/endocr/bqac111 · Cited by 191 · see citing works
Developmental Perspectives on Oxytocin and Vasopressin
Hammock, E. A. D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.120 · Cited by 177 · see citing works
Sex-specific modulation of juvenile social play by vasopressin
Veenema, A. H., Bredewold, R., & De Vries, G. J. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.002 · Cited by 166 · see citing works
“Time of administration and concentrations of drugs were based on previous studies showing behavioral effects in rats (Lukas et al., 2011, 2013; Veenema et al., 2012).”
BackgroundMethodInfluentialSelf-citationNeurobiology of the lateral septum: regulation of social behavior
Menon, R., Süß, T., Oliveira, V. E. D. M., Neumann, I. D., & Bludau, A. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.10.010 · Cited by 158 · see citing works
Bredewold, R., Smith, C. J. W., Dumais, K. M., & Veenema, A. H. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00216 · Cited by 157 · see citing works
Self-citationVeenema, A. H. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.002 · Cited by 157 · see citing works
Self-citationBredewold, R., & Veenema, A. H. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.02.011 · Cited by 144 · see citing works
Self-citationSmith, C. J. W., Poehlmann, M. L., Li, S., Ratnaseelan, A. M., Bredewold, R., & Veenema, A. H. (2017) · Brain Structure and Function · doi:10.1007/s00429-016-1260-7 · Cited by 143 · see citing works
Self-citationLukas, M., & Neumann, I. D. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.08.011 · Cited by 136 · see citing works
Ramos, L., Hicks, C., Kevin, R., Caminer, A., Narlawar, R., Kassiou, M., & McGregor, I. S. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.125 · Cited by 128 · see citing works
Filial responses as predisposed and learned preferences: Early attachment in chicks and babies
Giorgio, E. D., Loveland, J. L., Mayer, U., Salva, O. R., Versace, E., & Vallortígara, G. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.09.018 · Cited by 116 · see citing works
Neuronal Responses to Conspecifics in the Ventral CA1
Rao, R. P., von Heimendahl, M., Bahr, V., & Brecht, M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.081 · Cited by 85 · see citing works
Mayer, U., Salva, O. R., & Vallortígara, G. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.09.031 · Cited by 80 · see citing works
DiBenedictis, B. T., Nussbaum, E. R., Cheung, H. K., & Veenema, A. H. (2017) · Journal of Comparative Neurology · doi:10.1002/cne.24216 · Cited by 74 · see citing works
“Here, blockade of the AVP V1A receptor (V1AR) in the LS impaired social recognition in adult rats, while AVP infusions into the LS improved it (Dantzer et al., 1988; Engelmann & Landgraf, 1994; Everts & Koolhaas, 1997; Lukas, Toth, Veenema, & Neumann, 2013; Veenema et al., 2012).”
BackgroundInfluentialSelf-citationDumais, K. M., Alonso, A. G., Immormino, M. A., Bredewold, R., & Veenema, A. H. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.11.007 · Cited by 72 · see citing works
Self-citationSocial Novelty Investigation in the Juvenile Rat: Modulation by the μ‐Opioid System
Smith, C. J. W., Wilkins, K. B., Mogavero, J. N., & Veenema, A. H. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12301 · Cited by 72 · see citing works
Self-citationNeuro-Immune Mechanisms Regulating Social Behavior: Dopamine as Mediator?
Kopec, A. M., Smith, C. J. W., & Bilbo, S. D. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.02.005 · Cited by 68 · see citing works
Rubin, L. H., Carter, C. S., Bishop, J. R., Pournajafi‐Nazarloo, H., Harris, M. S. H., Hill, S. K., Reilly, J. L., & Sweeney, J. A. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.01.019 · Cited by 65 · see citing works
Bredewold, R., Schiavo, J. K., van der Hart, M., Verreij, M., & Veenema, A. H. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.052 · Cited by 64 · see citing works
Self-citationRigney, N., Whylings, J., Mieda, M., de Vries, G. J., & Petrulis, A. (2019) · eNeuro · doi:10.1523/eneuro.0415-18.2019 · Cited by 63 · see citing works
“, 2004) and social recognition and active social behaviors in rats (Dantzer et al., 1988; Veenema et al., 2012).”
BackgroundLukas, M., & Neumann, I. D. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.03.013 · Cited by 63 · see citing works
Modulation of social behavior by distinct vasopressin sources
Rigney, N., Vries, G. J. D., & Petrulis, A. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1127792 · Cited by 61 · see citing works
Smith, C. J. W., DiBenedictis, B. T., & Veenema, A. H. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.02.001 · Cited by 59 · see citing works
Self-citationHodges, T. E., Baumbach, J. L., Marcolin, M. L., Bredewold, R., Veenema, A. H., & McCormick, C. M. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.07.032 · Cited by 56 · see citing works
Self-citationKompier, N. F., Keysers, C., Gazzola, V., Lucassen, P. J., & Krugers, H. J. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00143 · Cited by 53 · see citing works
Sexually dimorphic role for vasopressin in the development of social play
Paul, M. J., Terranova, J. I., Probst, C. K., Murray, E. K., Ismail, N. I., & de Vries, G. J. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00058 · Cited by 51 · see citing works
“First, the role of BNST AVP in play behavior may change across age, similar to that found for septal AVP in social recognition in juveniles compared to adults (Veenema et al., 2012).”
ResultSong, Z., Larkin, T. E., Malley, M. O., & Albers, H. E. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.02.004 · Cited by 47 · see citing works
Rigney, N., Beaumont, R., & Petrulis, A. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104715 · Cited by 47 · see citing works
Lee, W., Hiura, L. C., Yang, E., Denney, K. A., Ophir, A. G., & Curley, J. P. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.06.015 · Cited by 46 · see citing works
Sexual dimorphism of oxytocin and vasopressin in social cognition and behavior
Lu, Q., Lai, J., Du, Y., Huang, T., Prukpitikul, P., Xu, Y., & Hu, S. (2019) · Psychology Research and Behavior Management · doi:10.2147/prbm.s192951 · Cited by 45 · see citing works
Septal oxytocin administration impairs peer affiliation via V1a receptors in female meadow voles
Anacker, A. M. J., Christensen, J. D., LaFlamme, E. M., Grunberg, D. M., & Beery, A. K. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.02.025 · Cited by 44 · see citing works
Grundwald, N. J., Benítez, D. P., & Brunton, P. J. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12343 · Cited by 44 · see citing works
Dannenhoffer, C. A., Kim, E. U., Saalfield, J., Werner, D. F., Varlinskaya, E. I., & SPEAR, L. P. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5003-8 · Cited by 43 · see citing works
Rigney, N., Whylings, J., de Vries, G. J., & Petrulis, A. (2021) · Neuroendocrinology · doi:10.1159/000509421 · Cited by 42 · see citing works
Neuroendocrine underpinning of social recognition in males and females
Aspesi, D., & Choleris, E. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13070 · Cited by 41 · see citing works
Qiao, X., Yan, Y., Wu, R., Tai, F., Hao, P., Cao, Y., & Wang, J. (2014) · Journal of Comparative Physiology A · doi:10.1007/s00359-013-0870-2 · Cited by 40 · see citing works
Oxytocin and MDMA (‘Ecstasy’) enhance social reward in rats
Ramos, L., Hicks, C., Caminer, A., Goodwin, J., & McGregor, I. S. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3899-9 · Cited by 40 · see citing works
Gemmel, M., Lacalle, S. D., Mort, S. C., Hill, L. A., Charlier, T. D., & Pawluski, J. L. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.10.009 · Cited by 39 · see citing works
Neural mechanisms of female sexual behavior in the rat; comparison with male ejaculatory control
Veening, J. G., Coolen, L. M., & Gerrits, P. O. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.025 · Cited by 38 · see citing works
Fodor, A., Kovács, K., Balázsfi, D., Klausz, B., Pintér, O., Demeter, K., Daviu, N., Rabasa, C., Rotllant, D., Nadal, R. A., et al. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.02.041 · Cited by 38 · see citing works
Whylings, J., Rigney, N., Peters, N. V., de Vries, G. J., & Petrulis, A. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.09.015 · Cited by 37 · see citing works
The role of vasopressin in olfactory and visual processing
Wacker, D. W., & Ludwig, M. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2867-1 · Cited by 36 · see citing works
Frank Beach award winner: Neuroendocrinology of group living
Beery, A. K. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.11.002 · Cited by 36 · see citing works
Smith, C. J. W., Wilkins, K. B., Li, S. J., Tulimieri, M. T., & Veenema, A. H. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.12.017 · Cited by 33 · see citing works
Self-citationAtypical Social Development in Vasopressin-Deficient Brattleboro Rats
Paul, M. J., Peters, N. V., Holder, M. K., Kim, A. M., Whylings, J., Terranova, J. I., & Vries, G. J. D. (2016) · eNeuro · doi:10.1523/eneuro.0150-15.2016 · Cited by 32 · see citing works
Bredewold, R., Nascimento, N. F., Ro, G. S., Cieslewski, S. E., Reppucci, C. J., & Veenema, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0100-2 · Cited by 31 · see citing works
Self-citationCharacterization of the intergenerational impact of in utero and postnatal oxycodone exposure
Odegaard, K. E., Schaal, V. L., Clark, A. R., Koul, S., Gowen, A. M., Sankarasubramanian, J., Xiao, P., Guda, C., Lisco, S. J., Yelamanchili, S. V., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01012-z · Cited by 31 · see citing works
Kozlova, E. V., Valdez, M. C., Denys, M. E., Bishay, A. E., Krum, J. M., Rabbani, K. M., Carrillo, V., Gonzalez, G. M., Lampel, G., Tran, J. D., et al. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-03163-4 · Cited by 31 · see citing works
Rigney, N., Zbib, A., de Vries, G. J., & Petrulis, A. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13083 · Cited by 29 · see citing works
Sagoshi, S., Maejima, S., Morishita, M., Takenawa, S., Otubo, A., Takanami, K., Sakamoto, T., Sakamoto, H., Tsukahara, S., & Ogawa, S. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.04.047 · Cited by 28 · see citing works
Early life manipulations of vasopressin-family peptides alter vocal learning
Baran, N. M., Carouso-Peck, S., Kim, T. H., Goldstein, M. H., & Adkins–Regan, E. (2017) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2017.1114 · Cited by 28 · see citing works
Kinley, B. L., Kyne, R. F., Lawton‐Stone, T. S., Walker, D. M., & Paul, M. J. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15520 · Cited by 27 · see citing works
Baran, N. M., Sklar, N. C., & Adkins–Regan, E. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.10.005 · Cited by 27 · see citing works
Karlsson, S. A., Studer, E., Kettunen, P., & Westberg, L. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00041 · Cited by 26 · see citing works
Holman, P. J., Ellis, L. A., Morgan, E., & Weinberg, J. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.08.004 · Cited by 26 · see citing works
Hodges, T. E., Eltahir, A. M., Patel, S. D., Bredewold, R., Veenema, A. H., & McCormick, C. M. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.104579 · Cited by 26 · see citing works
Self-citationHolman, P. J., Raineki, C., Chao, A., Grewal, R., Haghighat, S., Fung, C., Morgan, E., Ellis, L. A., Yu, W. K., & Weinberg, J. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105146 · Cited by 25 · see citing works
Hicks, C., Ramos, L., Reekie, T. A., Narlawar, R., Kassiou, M., & McGregor, I. S. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3902-5 · Cited by 23 · see citing works
Perkins, A. E., Doremus‐Fitzwater, T. L., Spencer, R. L., Varlinskaya, E. I., Conti, M. M., Bishop, C., & Deak, T. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.01.012 · Cited by 23 · see citing works
Vasopressin Proves Essential: Vasopressin and the Modulation of Sensory Processing in Mammals
Bester‐Meredith, J. K., Fancher, A. P., & Mammarella, G. E. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00005 · Cited by 23 · see citing works
Hodges, T. E., Louth, E. L., Bailey, C. D. C., & McCormick, C. M. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1789-8 · Cited by 22 · see citing works
Perkins, A. E., Varlinskaya, E. I., & Deak, T. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.08.001 · Cited by 22 · see citing works
Morais, L. H., Golubeva, A. V., Casey, S., Scott, K. A., Costa, A. P., Moloney, G. M., Dinan, T. G., & Cryan, J. F. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01040-3 · Cited by 22 · see citing works
Graf, A., Murray, S. H., Eltahir, A., Patel, S., Hansson, A. C., Spanagel, R., & McCormick, C. M. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114180 · Cited by 21 · see citing works
Inhaled vasopressin increases sociability and reduces body temperature and heart rate in rats
Ramos, L., Hicks, C., Caminer, A., & McGregor, I. S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.04.013 · Cited by 21 · see citing works
Schatz, K. C., Kyne, R. F., Parmeter, S. L., & Paul, M. J. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.08.015 · Cited by 21 · see citing works
DiBenedictis, B. T., Cheung, H. K., Nussbaum, E. R., & Veenema, A. H. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104462 · Cited by 20 · see citing works
Self-citationOxytocin and vasopressin increase male-directed threats and vocalizations in female macaques
Jiang, Y., & Platt, M. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-36332-0 · Cited by 19 · see citing works
Sex Differences in Social Cognition
Paletta, P., Bass, N., Aspesi, D., & Choleris, E. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_325 · Cited by 19 · see citing works
Hiura, L. C., & Ophir, A. G. (2018) · Integrative Zoology · doi:10.1111/1749-4877.12338 · Cited by 18 · see citing works
Vasopressin eliminates the expression of familiar odor bias in neonatal female mice through V1aR
Hammock, E. A. D., Law, C. S., & Levitt, P. R. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.12.006 · Cited by 18 · see citing works
Neural correlates of winning and losing fights in poison frog tadpoles
Fischer, E. K., Alvarez, H., Lagerstrom, K. M., McKinney, J. E., Petrillo, R., Ellis, G., & O’Connell, L. A. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.112973 · Cited by 18 · see citing works
Borie, A. M., Theofanopoulou, C., & Andari, E. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819973-2.00009-5 · Cited by 18 · see citing works
Baran, N. M., Tomaszycki, M. L., & Adkins–Regan, E. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00058 · Cited by 17 · see citing works
Extrahippocampal Contributions to Social Memory: The Role of Septal Nuclei
Shivakumar, A. B., Mehak, S. F., Jijimon, F., & Gangadharan, G. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.04.018 · Cited by 17 · see citing works
Do animal models hold value in Autism spectrum disorder (ASD) drug discovery?
Chadman, K. K., Fernandes, S., DiLiberto, E., & Feingold, R. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2019.1621285 · Cited by 17 · see citing works
Finger release sequence for fastball and curveball pitches.
Stevenson, J. M. (1985) · PubMed · Cited by 16 · see citing works
Sensitive Periods, Vasotocin-Family Peptides, and the Evolution and Development of Social Behavior
Baran, N. M. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00189 · Cited by 15 · see citing works
McCormick, C. M. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2021_245 · Cited by 14 · see citing works
Bredewold, R., Washington, C., & Veenema, A. H. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-024-01987-z · Cited by 13 · see citing works
“Drug doses were chosen based on previous microinjection studies in rats inducing changes in behavior [27, 29, 41 – 43].”
Self-citationHolman, P. J., Baglot, S. L., Morgan, E., & Weinberg, J. (2019) · Developmental Psychobiology · doi:10.1002/dev.21842 · Cited by 13 · see citing works
Development of social recognition ability in female rats: Effect of pubertal ovarian hormones
Yoest, K. E., Henry, M. G., Velisek, H. A., & Veenema, A. H. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105347 · Cited by 13 · see citing works
Self-citationRigney, N., Vries, G. J. D., & Petrulis, A. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105407 · Cited by 13 · see citing works
Vasopressin as Possible Treatment Option in Autism Spectrum Disorder
László, K., Vörös, D., Correia, P., Fazekas, C. L., Török, B., Plangár, I., & Zelena, D. (2023) · Biomedicines · doi:10.3390/biomedicines11102603 · Cited by 13 · see citing works
Vielle, C., Montanari, C., Pelloux, Y., & Baunez, C. (2021) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2021.2260 · Cited by 13 · see citing works
Mate Selection, Sexual Orientation, and Pair Bonding
Balthazart, J., & Young, L. J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00048-x · Cited by 12 · see citing works
Trujillo-Villarreal, L. A., Cárdenas‐Tueme, M., Maldonado‐Ruiz, R., Reséndez‐Pérez, D., & Camacho‐Morales, A. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15141 · Cited by 12 · see citing works
Schatz, K. C., Martin, C. D., Ishiwari, K., George, A. M., Richards, J. B., & Paul, M. J. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.04.004 · Cited by 12 · see citing works
Charlton, P. E., Schatz, K. C., Burke, K., Paul, M. J., & Dent, M. L. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222096 · Cited by 11 · see citing works
Dumais, K. M., & Veenema, A. H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802114-9.00011-1 · Cited by 11 · see citing works
Self-citationLee, J., Reppucci, C. J., Bowden, S. M., Huez, E. D. M., Bredewold, R., & Veenema, A. H. (2021) · Hormones and Behavior · doi:10.1016/j.yhbeh.2024.105563 · Cited by 10 · see citing works
Self-citationAmygdala AVPR1A mediates susceptibility to chronic social isolation in female mice
François, M., Vranich, K. A., Delgado, I. C., Lafond, A., Lopatinsky, N. R., Davis, T., Lewis, E. M., Kuromaru, M., Hassouna, R., Williams, B. L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64742-y · Cited by 10 · see citing works
Penta, P. T., Villarreal, S., Rameas, C. I., Collins, E. C., Towner, T. T., Varlinskaya, E. I., & Werner, D. F. (2024) · Alcohol · doi:10.1016/j.alcohol.2024.10.001 · Cited by 9 · see citing works
Wang, J., Jin, S., Fu, W., Liang, Y., Yang, Y., & Xu, X. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112843 · Cited by 9 · see citing works
Schatz, K. C., Brown, L. M., Barrett, A., Roth, L. C., Grinevich, V., & Paul, M. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-44776-1 · Cited by 9 · see citing works
Fu, P., Liu, C.-P., Liu, C.-Y., Zhang, Y.-C.-F., Xu, J.-P., Mao, R.-T., Ding, X., Li, F., Zhang, Y.-L., Yang, H., et al. (2025) · Research · doi:10.34133/research.0701 · Cited by 7 · see citing works
Socha, J., Grochecki, P., Smaga, I., Jastrzębska, J., Wronikowska‐Denysiuk, O., Marszałek‐Grabska, M., Słowik, T., Kotlinski, R., Filip, M., Lübec, G., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021041 · Cited by 7 · see citing works
- Authors
- Veenema, A. H., Bredewold, R., & De Vries, G. J.
- Affiliations
- Boston College (US)
- Corresponding author
- Veenema, A.H.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 61
- Issue
- 1
- Pages
- 50-56
- ISSN
- 0018-506X (ISSN-L)
- PMC
- PMC3264802
- OpenAlex
- W1978497905
- Cited by
- 129
- References
- 27
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 5 · 2021: 15 · 2020: 6 · 2019: 16 · 2018: 12 · 2017: 8 · 2016: 11 · 2015: 12 · 2014: 7 · 2013: 5 · 2012: 3
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH047538)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- vasopressin, V1a receptor, social recognition, social discrimination, lateral septum, young rats, sex differences, age differences, V1a receptor antagonist, social behavior development
- MeSH terms
- Age Factors, Animals, Arginine Vasopressin, Female, Male, Septal Nuclei, Sex Factors, Social Behavior, Rats, Wistar, Receptors, Vasopressin, Recognition, Psychology, Rats, Antidiuretic Hormone Receptor Antagonists
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