The role of host molecules in communication with the resident and pathogenic microbiota: A review
Open accessAbstract
The human body harbours around 100 trillion microbial cells within a network of complex ecosytems. There is now a well-established correlation between microbes and health in conditions associated with chronic inflammation, and much research has focused on the microbe-to-human axis of communication. At a molecular level, the particular microbial activities and functions that dictate a “healthy” microbiota remain enigmatic. However, evidence from human and animal studies suggests that the host exercises control over the composition of microbial populations through the tightly regulated production and release of hormones, metabolites, nucleic acids, and immune effectors like cytokines. Many of these molecules are taken up by, or bind directly to, microbial cells, and it has been proposed that extracellular vesicles may help to carry these molecules directly to bacteria for enhanced uptake. Understanding how host control of the microbiota may become dysregulated in disease states will lead to novel ways of treating diseases and symptoms. Here we review the evidence for host regulation of the resident and pathogenic microbiota, with a focus on molecular mechanisms of communication in health and disease, and pinpoint how this knowledge may benefit future therapeutics.
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Microglia are the inherent immune effector cells in the central nervous system.
“Microglia is the inherent immune effector cells in the central nervous system [30, 31].”
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Differential Regulation of β-Defensin Gene Expression duringCryptosporidium parvumInfection
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Critical Role for a Subset of Intestinal Macrophages in Shaping Gut Microbiota in Adult Zebrafish
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Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease
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Dendritic cells: the commanders-in-chief of mucosal immune defenses
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Influences of stress hormones on microbial infections
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Fatty Liver Disease and Gut Microbiota: A Comprehensive Update
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Deterministic Assembly of Complex Bacterial Communities in Guts of Germ-Free Cockroaches
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Insulin-related material in microbes: similarities and differences from mammalian insulins
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Host effects on microbiota community assembly
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Competitive lottery-based assembly of selected clades in the human gut microbiome
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Towards an Integrative Understanding of Diet–Host–Gut Microbiome Interactions
Read, M. N., & Holmes, A. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00538 · Cited by 54 · see citing works
Implication of Gut Microbiota in Diabetes Mellitus and Obesity
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Response to: Comment on “The Gut Microbiome Profile in Obesity: A Systematic Review”
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Pro-inflammatory cytokines can act as intracellular modulators of commensal bacterial virulence
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Impact of Proinflammatory Cytokines on the Virulence of Uropathogenic Escherichia coli
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Flagged first, then by citations
1 of the 121 references couldn’t be matched to a known paper.
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Exploring the Modulatory Effects of Gut Microbiota in Anti-Cancer Therapy
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Potential Application of Living Microorganisms in the Detoxification of Heavy Metals
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The complex, bidirectional role of extracellular vesicles in infection
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First insights into the Aurelia aurita transcriptome response upon manipulation of its microbiome
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Impacts of Delivery Mode and Maternal Factors on Neonatal Oral Microbiota
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- Authors
- White, J. R., Dauros-Singorenko, P., Hong, J., Vanholsbeeck, F., Phillips, A., & Swift, S.
- Affiliations
- University of Auckland (NZ)
- Corresponding author
- White, Joni Renee
- Venue
- Medicine in Microecology
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 4
- Pages
- 100005
- ISSN
- 2590-0978 (ISSN-L)
- OpenAlex
- W3016518751
- Cited by
- 21
- References
- 121
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 6
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Medicine in Microecology (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- ResearchSpace (University of Auckland) (submittedVersion, cc-by-nc-nd)
- Funders
- Health Research Council of New Zealand
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- host-microbe communication, gut microbiota, resident microbiota, pathogenic bacteria, extracellular vesicles, microbial metabolites, cytokines, chronic inflammation, dysbiosis, microbiota-based therapy
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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