Cited by 21Gut microbiota and healthOral microbiology and periodontitis researchBacterial biofilms and quorum sensing

The role of host molecules in communication with the resident and pathogenic microbiota: A review

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White, Joni Renee, Dauros-Singorenko, Priscila, Hong, Jiwon, Vanholsbeeck, Frédérique, Phillips, Anthony, Swift, Simon·2020·Medicine in Microecology

Abstract

The human body harbours around 100 trillion microbial cells within a network of complex ecosytems. There is now a well-established correlation between microbes and health in conditions associated with chronic inflammation, and much research has focused on the microbe-to-human axis of communication. At a molecular level, the particular microbial activities and functions that dictate a “healthy” microbiota remain enigmatic. However, evidence from human and animal studies suggests that the host exercises control over the composition of microbial populations through the tightly regulated production and release of hormones, metabolites, nucleic acids, and immune effectors like cytokines. Many of these molecules are taken up by, or bind directly to, microbial cells, and it has been proposed that extracellular vesicles may help to carry these molecules directly to bacteria for enhanced uptake. Understanding how host control of the microbiota may become dysregulated in disease states will lead to novel ways of treating diseases and symptoms. Here we review the evidence for host regulation of the resident and pathogenic microbiota, with a focus on molecular mechanisms of communication in health and disease, and pinpoint how this knowledge may benefit future therapeutics.

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Authors
White, J. R., Dauros-Singorenko, P., Hong, J., Vanholsbeeck, F., Phillips, A., & Swift, S.
Affiliations
University of Auckland (NZ)
Corresponding author
White, Joni Renee
Venue
Medicine in Microecology
Publisher
Elsevier BV
Published
2020-06
Volume
4
Pages
100005
ISSN
2590-0978 (ISSN-L)
OpenAlex
W3016518751
Cited by
21
References
121
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 6
FWCI
1.30
Type
journal article
Language
en
Open access
Locations
  • Medicine in Microecology (publishedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • ResearchSpace (University of Auckland) (submittedVersion, cc-by-nc-nd)
Funders
Health Research Council of New Zealand
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords
host-microbe communication, gut microbiota, resident microbiota, pathogenic bacteria, extracellular vesicles, microbial metabolites, cytokines, chronic inflammation, dysbiosis, microbiota-based therapy

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