A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis

Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

Pevny, L., Simon, M. C., Robertson, E., Klein, W. H., Tsai, S.-F., D'Agati, V., Orkin, S. H., & Costantini, F. (1991) · Nature · doi:10.1038/349257a0 · Cited by 1,308

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

Geissler, E. N., Ryan, M. A., & Housman, D. E. (1988) · Cell · doi:10.1016/0092-8674(88)90020-7 · Cited by 1,287

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.

Okuda, T., van Deursen, J., Hiebert, S. W., Grosveld, G., & Downing, J. R. (1996) · Cell · doi:10.1016/s0092-8674(00)80986-1 · Cited by 1,856

Tissue-Resident Macrophage Ontogeny and Homeostasis

Ginhoux, F., & Guilliams, M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.024 · Cited by 1,884

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages

Scott, E. W., Simon, M. C., Anastasi, J., & Singh, H. (1994) · Science · doi:10.1126/science.8079170 · Cited by 1,532

An early haematopoietic defect in mice lacking the transcription factor GATA-2

Tsai, F.-Y., Keller, G., Kuo, F. C., Weiss, M., Chen, J., Rosenblatt, M., Alt, F. W., & Orkin, S. H. (1994) · Nature · doi:10.1038/371221a0 · Cited by 1,237

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

Wang, Q., Stacy, T., Binder, M., Marin-Padilla, M., Sharpe, A. H., & Speck, N. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3444 · Cited by 1,178

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

Hoeffel, G., Chen, J., Lavin, Y., Low, D., Almeida, F. F., See, P., Beaudin, A. E., Lum, J., Low, I., Forsberg, E. C., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.03.011 · Cited by 1,135

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

Dickson, M. C., Martin, J. S., Cousins, F. M., Kulkarni, A. B., Karlsson, S., & Akhurst, R. J. (1995) · Development · doi:10.1242/dev.121.6.1845 · Cited by 1,029

Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse

Palis, J., Robertson, S., Kennedy, M., Wall, C., & Keller, G. (1999) · Development · doi:10.1242/dev.126.22.5073 · Cited by 965

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

Shivdasani, R. A., Mayer, E. L., & Orkin, S. H. (1995) · Nature · doi:10.1038/373432a0 · Cited by 938

Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants

Traver, D., Paw, B. H., Poss, K. D., Penberthy, W. T., Lin, S., & Zon, L. I. (2003) · Nature Immunology · doi:10.1038/ni1007 · Cited by 800

The biphasic function of microglia in ischemic stroke

Ma, Y., Wang, J., Wang, Y., & Yang, G.-Y. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.005 · Cited by 655

Transcription Factors, Normal Myeloid Development, and Leukemia

Tenen, D. G., Hromas, R., Licht, J. D., & Zhang, D.-E. (1997) · Blood · doi:10.1182/blood.v90.2.489 · Cited by 735

The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo

Wang, Q., Stacy, T., Miller, J. D., Lewis, A. F., Gu, T.-L., Huang, X., Bushweller, J. H., Bories, J.-C., Alt, F. W., Ryan, G., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81389-6 · Cited by 621

Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells.

Weiss, M. J., Keller, G., & Orkin, S. H. (1994) · Genes & Development · doi:10.1101/gad.8.10.1184 · Cited by 541

Beyond stem cells: self-renewal of differentiated macrophages

Sieweke, M. H., & Allen, J. E. (2013) · Science · doi:10.1126/science.1242974 · Cited by 503

The myb gene family in cell growth, differentiation and apoptosis

Oh, I.-H., & Reddy, E. P. (1999) · Oncogene · doi:10.1038/sj.onc.1202839 · Cited by 498

Developmental origin, functional maintenance and genetic rescue of osteoclasts

Jacome-Galarza, C. E., Percin, G. I., Muller, J. T., Mass, E., Lazarov, T., Eitler, J., Rauner, M., Yadav, V. K., Crozet, L., Bohm, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1105-7 · Cited by 475

Distinct sources of hematopoietic progenitors emerge before HSCs and provide functional blood cells in the mammalian embryo

McGrath, K. E., Frame, J. M., Fegan, K. H., Bowen, J. R., Conway, S. J., Catherman, S. C., Kingsley, P. D., Koniski, A. D., & Palis, J. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.036 · Cited by 433

A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells

Scott, L., Civin, C., Rorth, P., & Friedman, A. (1992) · Blood · doi:10.1182/blood.v80.7.1725.1725 · Cited by 409

Ontogeny of Tissue-Resident Macrophages

Hoeffel, G., & Ginhoux, F. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00486 · Cited by 364

Factors regulating microglia activation

Kierdorf, K., & Prinz, M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00044 · Cited by 360

MicroRNA-Mediated Control of Cell Fate in Megakaryocyte-Erythrocyte Progenitors

Lu, J., Guo, S., Ebert, B. L., Zhang, H., Peng, X., Bosco, J., Pretz, J., Schlanger, R., Wang, J. Y., Mak, R. H., et al. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.03.012 · Cited by 310

Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

Stremmel, C., Schuchert, R., Wagner, F., Thaler, R., Weinberger, T., Pick, R., Mass, E., Ishikawa-Ankerhold, H. C., Margraf, A., Hutter, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02492-2 · Cited by 278

PU.1 Functions in a Cell‐autonomous Manner to Control the Differentiation of Multipotential Lymphoid‐myeloid Progenitors

Scott, E. W., Fisher, R. C., Olson, M. C., Kehrli, E. W., Simon, M. C., & Singh, H. (1997) · Immunity · doi:10.1016/s1074-7613(00)80287-3 · Cited by 270

C/EBP, c-Myb, and PU.1 Cooperate To Regulate the Neutrophil Elastase Promoter

Oelgeschläger, M., Nuchprayoon, I., Lüscher, B., & Friedman, A. D. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4717 · Cited by 229

Human Induced Pluripotent Stem Cell-Derived Macrophages Share Ontogeny with MYB-Independent Tissue-Resident Macrophages

Buchrieser, J., James, W., & Moore, M. D. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.12.020 · Cited by 215

The embryonic origins of erythropoiesis in mammals

Baron, M. H., Isern, J., & Fraser, S. T. (2012) · Blood · doi:10.1182/blood-2012-01-153486 · Cited by 209

Historical origins of transdifferentiation and reprogramming

Graf, T. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.11.012 · Cited by 194

PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation

Olson, M. C., Scott, E. W., Hack, A. A., Su, G. H., Tenen, D. G., Singh, H., & Simon, M. C. (1995) · Immunity · doi:10.1016/1074-7613(95)90060-8 · Cited by 191

Development and homeostasis of “resident” myeloid cells: the case of the microglia

Gomez Perdiguero, E., Schulz, C., & Geissmann, F. (2013) · Glia · doi:10.1002/glia.22393 · Cited by 182

Suppressor screen in Mpl -/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling

Carpinelli, M. R., Hilton, D. J., Metcalf, D., Antonchuk, J. L., Hyland, C. D., Mifsud, S. L., Di Rago, L., Hilton, A. A., Willson, T. A., Roberts, A. W., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401496101 · Cited by 179

Cooperativity in Transcription Factor Binding to the Coactivator CREB-binding Protein (CBP)

Goto, N. K., Zor, T., Martinez-Yamout, M., Dyson, H. J., & Wright, P. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207660200 · Cited by 177

Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish

Xu, J., Zhu, L., He, S., Wu, Y., Jin, W., Yu, T., Qu, J. Y., & Wen, Z. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.08.018 · Cited by 177

Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders

Bauer, D. E., Kamran, S. C., & Orkin, S. H. (2012) · Blood · doi:10.1182/blood-2012-06-292078 · Cited by 177

C/EBP Bypasses Granulocyte Colony-Stimulating Factor Signals to Rapidly Induce PU.1 Gene Expression, Stimulate Granulocytic Differentiation, and Limit Proliferation in 32D cl3 Myeloblasts

Wang, X., Scott, E., Sawyers, C. L., & Friedman, A. D. (1999) · Blood · doi:10.1182/blood.v94.2.560 · Cited by 166

A transcription factor party during blood cell differentiation

Sieweke, M. H., & Graf, T. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80009-9 · Cited by 164

Role of PU.1 in Hematopoiesis

Fisher, R. C., & Scott, E. W. (1998) · STEM CELLS · doi:10.1002/stem.160025 · Cited by 158

Molecular Identity of Hematopoietic Precursor Cells Emerging in the Human Embryo

Labastie, M.-C., Cortés, F., Roméo, P.-H., Dulac, C., & Péault, B. (1998) · Blood · doi:10.1182/blood.v92.10.3624 · Cited by 153

Role of Oncostatin M in hematopoiesis and liver development

Miyajima, A., Kinoshita, T., Tanaka, M., Kamiya, A., Mukouyama, Y., & Hara, T. (2000) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00003-4 · Cited by 153

The Role of C/EBPε in the Terminal Stages of Granulocyte Differentiation

Lekstrom‐Himes, J. A. (2001) · STEM CELLS · doi:10.1634/stemcells.19-2-125 · Cited by 127

Differential Location and Distribution of Hepatic Immune Cells

Freitas-Lopes, M., Mafra, K., David, B., Carvalho-Gontijo, R., & Menezes, G. (2017) · Cells · doi:10.3390/cells6040048 · Cited by 126

Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes.

Reddy, M. A., Yang, B. S., Yue, X., Barnett, C. J., Ross, I. L., Sweet, M. J., Hume, D. A., & Ostrowski, M. C. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.6.2309 · Cited by 123

Transcriptional regulation of hepatic stellate cells

Mann, J., & Mann, D. A. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.011 · Cited by 119

c-Myb and Core-Binding Factor/PEBP2 Display Functional Synergy but Bind Independently to Adjacent Sites in the T-Cell Receptor δ Enhancer

Hernandez-Munain, C., & Krangel, M. S. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3090 · Cited by 110

Regulation of eosinophil‐specific gene expression by a C/EBP–Ets complex and GATA‐1

McNagny, K. M., Sieweke, M. H., Döderlein, G., Graf, T., & Nerlov, C. (1998) · The EMBO Journal · doi:10.1093/emboj/17.13.3669 · Cited by 108

Core Binding Factor Cannot Synergistically Activate the Myeloperoxidase Proximal Enhancer in Immature Myeloid Cells without c-Myb

Britos-Bray, M., & Friedman, A. D. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5127 · Cited by 94

Transcription factors that regulate growth and differentiation of myeloid cells.

Nagamura-Inoue, T., Tamura, T., & Ozato, K. (2001) · International Reviews of Immunology · doi:10.3109/08830180109056724 · Cited by 94

The ETS family transcription factor PU.1 is necessary for the maintenance of fetal liver hematopoietic stem cells

Kim, H.-G., de Guzman, C. G., Swindle, C. S., Cotta, C. V., Gartland, L., Scott, E. W., & Klug, C. A. (2004) · Blood · doi:10.1182/blood-2002-08-2425 · Cited by 75

The AML1 Transcription Factor Functions to Develop and Maintain Hematogenic Precursor Cells in the Embryonic Aorta–Gonad–Mesonephros Region

Mukouyama, Y.-S., Chiba, N., Hara, T., Okada, H., Ito, Y., Kanamaru, R., Miyajima, A., Satake, M., & Watanabe, T. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9617 · Cited by 81

PU.1 but not ets-2 is essential for macrophage development from embryonic stem cells

Henkel, G., McKercher, Sr., Yamamoto, H., Anderson, K., Oshima, R., & Maki, R. (1996) · Blood · doi:10.1182/blood.v88.8.2917.bloodjournal8882917 · Cited by 76

Nemo-like kinase, a multifaceted cell signaling regulator

Ishitani, T., & Ishitani, S. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2012.09.017 · Cited by 71

Stage-Specific Repression by the EKLF Transcriptional Activator

Chen, X., & Bieker, J. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.23.10416-10424.2004 · Cited by 71

Mechanisms of Transcription in Eosinophils: GATA-1, but not GATA-2, Transactivates the Promoter of the Eosinophil Granule Major Basic Protein Gene

Yamaguchi, Y., Ackerman, S. J., Minegishi, N., Takiguchi, M., Yamamoto, M., & Suda, T. (1998) · Blood · doi:10.1182/blood.v91.9.3447 · Cited by 64

Drosophila abl and genetic redundancy in signal transduction

HOFFMANN, F. (1991) · Trends in Genetics · doi:10.1016/0168-9525(91)90254-f · Cited by 62

GSK3β inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb

Zhou, F., Zhang, L., van Laar, T., van Dam, H., & ten Dijke, P. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-06-0483 · Cited by 55

Inhibitory interaction of c-Myb and GATA-1 via transcriptional co-activator CBP

Takahashi, T., Suwabe, N., Dai, P., Yamamoto, M., Ishii, S., & Nakano, T. (2000) · Oncogene · doi:10.1038/sj.onc.1203228 · Cited by 53

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis

Vanhee, S., De Mulder, K., Van Caeneghem, Y., Verstichel, G., Van Roy, N., Menten, B., Velghe, I., Philippe, J., De Bleser, D., Lambrecht, B. N., et al. (2015) · Haematologica · doi:10.3324/haematol.2014.112144 · Cited by 51

Hematopoietic cells in cultures of the murine embryonic aorta‐gonad‐mesonephros region are induced by c‐Myb

Mukouyama, Y.-S., Chiba, N., Mucenski, M. L., Satake, M., Miyajima, A., Hara, T., & Watanabe, T. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80368-6 · Cited by 49

Granulocytic and monocytic differentiation of CD34hi cells is associated with distinct changes in the expression of the PU.1- regulated molecules, CD64 and macrophage colony-stimulating factor receptor

Olweus, J., Thompson, P., & Lund-Johansen, F. (1996) · Blood · doi:10.1182/blood.v88.10.3741.bloodjournal88103741 · Cited by 47

Targeted disruption of c-myb in the chicken pre B-cell line DT40

Appl, H., & Klempnauer, K.-H. (2002) · Oncogene · doi:10.1038/sj.onc.1205427 · Cited by 21

More on Myb in myelofibrosis: molecular analyses of MYB and EP300 in 55 patients with myeloproliferative disorders

Steensma, D. P., & Pardanani, A. (2006) · Blood · doi:10.1182/blood-2005-09-3646 · Cited by 10

Gene Inactivation in Adult Long-Term Hematopoietic Stem Cells Using Inducible Mouse Models

Gudmundsson, K. O. (2021) · Methods in Molecular Biology · doi:10.1007/978-1-0716-1008-4_13