Cited by 126Sleep and Wakefulness ResearchNeuroinflammation and Neurodegeneration MechanismsSleep and Work-Related Fatigue

The DOI matches its Crossref record; 49 of the 55 references it cites were found in a registry or an index.

Involvement of cytokines in slow wave sleep

Open access

Krueger, James M., Clinton, James M., Winters, Bradley D., Zielinski, Mark R., Taishi, Ping, Jewett, Kathryn A., Davis, Christopher J.·2011·Progress in Brain Research

DOI 10.1016/b978-0-444-53839-0.00003-xPMC PMC3645329

Open this paper in CoChat — free account

Abstract

Cytokines such as tumor necrosis factor alpha (TNFα) and interleukin-1 beta (IL1β) play a role in sleep regulation in health and disease. TNFα or IL1β injection enhances non-rapid eye movement sleep. Inhibition of TNFα or IL1β reduces spontaneous sleep. Mice lacking TNFα or IL1β receptors sleep less. In normal humans and in multiple disease states, plasma levels of TNFα covary with EEG slow wave activity (SWA) and sleep propensity. Many of the symptoms induced by sleep loss, for example, sleepiness, fatigue, poor cognition, enhanced sensitivity to pain, are elicited by injection of exogenous TNFα or IL1β. IL1β or TNFα applied unilaterally to the surface of the cortex induces state-dependent enhancement of EEG SWA ipsilaterally, suggesting greater regional sleep intensity. Interventions such as unilateral somatosensory stimulation enhance localized sleep EEG SWA, blood flow, and somatosensory cortical expression of IL1β and TNFα. State oscillations occur within cortical columns. One such state shares properties with whole animal sleep in that it is dependent on prior cellular activity, shows homeostasis, and is induced by TNFα. Extracellular ATP released during neuro- and gliotransmission enhances cytokine release via purine type 2 receptors. An ATP agonist enhances sleep, while ATP antagonists inhibit sleep. Mice lacking the P2X7 receptor have attenuated sleep rebound responses after sleep loss. TNFα and IL1β alter neuron sensitivity by changing neuromodulator/neurotransmitter receptor expression, allowing the neuron to scale its activity to the presynaptic neurons. TNFα's role in synaptic scaling is well characterized. Because the sensitivity of the postsynaptic neuron is changed, the same input will result in a different network output signal and this is a state change. The top-down paradigm of sleep regulation requires intentional action from sleep/wake regulatory brain circuits to initiate whole-organism sleep. This raises unresolved questions as to how such purposeful action might itself be initiated. In the new paradigm, sleep is initiated within networks and local sleep is a direct consequence of prior local cell activity. Whole-organism sleep is a bottom-up, self-organizing, and emergent property of the collective states of networks throughout the brain.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/b978-0-444-53839-0.00003-x

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Two-Process Model of Sleep Regulation
Binder, M. D., Hirokawa, N., & Windhorst, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_6166 · Cited by 3,900
Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804
Synaptic scaling mediated by glial TNF-α
Stellwagen, D., & Malenka, R. C. (2006) · Nature · doi:10.1038/nature04671 · Cited by 1,715
The self-tuning neuron: synaptic scaling of excitatory synapses
Turrigiano, G. G. (2008) · Cell · doi:10.1016/j.cell.2008.10.008 · Cited by 1,533
Sleep and synaptic homeostasis: a hypothesis
Tononi, G., & Cirelli, C. (2003) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2003.09.004 · Cited by 1,217
The P2X7 Receptor: A Key Player in IL-1 Processing and Release
Ferrari, D., Pizzirani, C., Adinolfi, E., Lemoli, R. M., Curti, A., Idzko, M., Panther, E., & Di Virgilio, F. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.3877 · Cited by 1,025
Elevation of Plasma Cytokines in Disorders of Excessive Daytime Sleepiness: Role of Sleep Disturbance and Obesity
Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Kales, A., Tyson, K., & Chrousos, G. P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3950 · Cited by 974
Cortical firing and sleep homeostasis
Vyazovskiy, V. V., Olcese, U., Lazimy, Y. M., Faraguna, U., Esser, S. K., Williams, J. C., Cirelli, C., & Tononi, G. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.024 · Cited by 740
Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation.
Tracey, K. J., He, W., Manogue, K. R., Fong, Y., HESSE, D. G., Nguyen, H. T., Kuo, G. C., Beutler, B., Cotran, R. S., & Cerami, A. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.3.1211 · Cited by 730
Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome
Lähdevirta, J., Maury, C. P. J., Teppo, A., & Repo, H. (1988) · The American Journal of Medicine · doi:10.1016/0002-9343(88)90576-1 · Cited by 717

Show all 55 references

Sorted by citations

Neural Circuitry of Wakefulness and Sleep
Scammell, T. E., Arrigoni, E., & Lipton, J. O. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.014 · Cited by 966
Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome
Möller-Levet, C. S., Archer, S. N., Bucca, G., Laing, E. E., Slak, A., Kabiljo, R., Lo, J. C. Y., Santhi, N., von Schantz, M., Smith, C. P., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217154110 · Cited by 576
Functions and Mechanisms of Sleep
Zielinski, M. R., McKenna, J. T., & McCarley, R. W. (2016) · AIMS neuroscience · doi:10.3934/neuroscience.2016.1.67 · Cited by 392
Self-citation
Neural circuitry engaged by prostaglandins during the sickness syndrome
Saper, C. B., Romanovsky, A. A., & Scammell, T. E. (2012) · Nature Neuroscience · doi:10.1038/nn.3159 · Cited by 285
Crosstalk between the circadian clock circuitry and the immune system
Cermakian, N., Lange, T., Golombek, D., Sarkar, D., Nakao, A., Shibata, S., & Mazzoccoli, G. (2013) · Chronobiology International · doi:10.3109/07420528.2013.782315 · Cited by 279
Slow-wave sleep: From the cell to the clinic
Léger, D., Debellemanière, E., Rabat, A., Bayon, V., Benchenane, K., & Chennaoui, M. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.01.008 · Cited by 284
Impact of anaesthetics and surgery on neurodevelopment: an update
Sanders, R. D., Hassell, J. K., Davidson, A. J., Robertson, N. J., & Ma, D. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet054 · Cited by 219
Circadian and wakefulness-sleep modulation of cognition in humans
Wright, K. P., Lowry, C. A., & LeBourgeois, M. K. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00050 · Cited by 209
Role of the basal ganglia in the control of sleep and wakefulness
Lazarus, M., Chen, J., Urade, Y., & Huang, Z. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.02.001 · Cited by 160
How do the basal ganglia regulate sleep–wake behavior?
Lazarus, M., Huang, Z., Lu, J., Urade, Y., & Chen, J. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.07.001 · Cited by 139
Sleep and Cytokines
Krueger, J. M., Rector, D. M., & Churchill, L. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.03.003 · Cited by 128
Self-citation
Linking Network Activity to Synaptic Plasticity during Sleep: Hypotheses and Recent Data
Puentes-Mestril, C., & Aton, S. J. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00061 · Cited by 130
The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis
Morris, G., Stubbs, B., Köhler, C. A., Walder, K. R., Slyepchenko, A., Berk, M., & Carvalho, A. F. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.03.007 · Cited by 125
Orbitofrontal Gray Matter Relates to Early Morning Awakening: A Neural Correlate of Insomnia Complaints?
Stoffers, D., Moens, S., Benjamins, J. S., van Tol, M., Penninx, B. W. J. H., Veltman, D. J., van der Wee, N. J. A., & Someren, E. J. W. V. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00105 · Cited by 114
Experimental Pain and Opioid Analgesia in Volunteers at High Risk for Obstructive Sleep Apnea
Doufas, A. G., Tian, L., Padrez, K., Suwanprathes, P., Cardell, J., Maecker, H. T., & Panousis, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054807 · Cited by 113
Gating and the Need for Sleep: Dissociable Effects of Adenosine A1 and A2A Receptors
Lazarus, M., Oishi, Y., Bjorness, T. E., & Greene, R. W. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00740 · Cited by 110
Optogenetic stimulation of astrocytes in the posterior hypothalamus increases sleep at night in C57 BL /6J mice
Pelluru, D., Konadhode, R. R., Bhat, N. R., & Shiromani, P. J. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.13074 · Cited by 113
Sleep homeostasis
Porkka‐Heiskanen, T. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.02.010 · Cited by 114
Sleep, vigilance, and thermosensitivity
Romeijn, N., Raymann, R. J. E. M., Møst, E., Te Lindert, B., Van Der Meijden, W. P., Fronczek, R., Gomez-Herrero, G., & Van Someren, E. J. W. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-1042-2 · Cited by 105
ISSLS PRIZE IN CLINICAL SCIENCE 2018: longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode—the good, the bad, and the ugly
Klyne, D. M., Barbe, M. F., van den Hoorn, W., & Hodges, P. W. (2018) · European Spine Journal · doi:10.1007/s00586-018-5490-7 · Cited by 101
Sleep, Slow-Wave Sleep, and Blood Pressure
Javaheri, S., & Redline, S. S. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0289-0 · Cited by 97
Adenosine and Sleep
Lazarus, M., Chen, J., Huang, Z., Urade, Y., & Fredholm, B. B. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_36 · Cited by 100
Investigation of Slow-wave Activity Saturation during Surgical Anesthesia Reveals a Signature of Neural Inertia in Humans
Warnaby, C. E., SLEIGH, J. W., Hight, D., Jbabdi, S., & Tracey, I. (2017) · Anesthesiology · doi:10.1097/aln.0000000000001759 · Cited by 96
Extinction of conditioned fear is better learned and recalled in the morning than in the evening
Pace-Schott, E. F., Spencer, R. M. C., Vijayakumar, S., Ahmed, N. A. K., Verga, P. W., Orr, S. P., Pitman, R. K., & Milad, M. R. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.07.027 · Cited by 87
Neurons containing orexin or melanin concentrating hormone reciprocally regulate wake and sleep
Konadhode, R. R., Pelluru, D., & Shiromani, P. J. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00244 · Cited by 91
Complement activation sustains neuroinflammation and deteriorates adult neurogenesis and spatial memory impairment in rat hippocampus following sleep deprivation
Wadhwa, M., Prabhakar, A., Anand, J. P., Ray, K., Prasad, D. N., Kumar, B., & Panjwani, U. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.08.004 · Cited by 82
Retracted
Neurobiology of sleep (Review)
Falup‐Pecurariu, C., Diaconu, Ș., Ţînţ, D., & Falup‐Pecurariu, O. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.9703 · Cited by 85
Control of Sleep and Wakefulness in Health and Disease
Zeitzer, J. M. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-396971-2.00006-3 · Cited by 68
Slow brain oscillations of sleep, resting state, and vigilance
Van Someren, E. J. W., Van Der Werf, Y. D., Roelfsema, P. R., Mansvelder, H. D., & Lopes da Silva, F. H. (2011) · Progress in Brain Research · doi:10.1016/b978-0-444-53839-0.00001-6 · Cited by 58
Roles of Microglial Phagocytosis and Inflammatory Mediators in the Pathophysiology of Sleep Disorders
Nadjar, A., Wigren, H., & Tremblay, M. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00250 · Cited by 57
Sleep Disturbance and Total Sleep Time in Persons Living with HIV: A Cross-Sectional Study
Faraut, B., Malmartel, A., Ghosn, J., Duracinský, M., Léger, D., Grabar, S., & Viard, J. (2018) · AIDS and Behavior · doi:10.1007/s10461-018-2179-1 · Cited by 55
Interactions between sleep, inflammation, immunity and infections: A narrative review
Feuth, T. (2024) · Immunity Inflammation and Disease · doi:10.1002/iid3.70046 · Cited by 58
Sleep and inflammatory markers in different psychiatric disorders
Krysta, K., Krzystanek, M., Bratek, A., & Krupka-Matuszczyk, I. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-015-1492-3 · Cited by 53
Skin temperature, sleep, and vigilance
Lindert, B. H. W. T., & Someren, E. J. W. V. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63912-7.00021-7 · Cited by 53
Potential Role of Sleep Deficiency in Inducing Immune Dysfunction
Kuna, K., Szewczyk, K., Gabryelska, A., Białasiewicz, P., Ditmer, M., Strzelecki, D., & Sochal, M. (2022) · Biomedicines · doi:10.3390/biomedicines10092159 · Cited by 49
Differential activation of immune factors in neurons and glia contribute to individual differences in resilience/vulnerability to sleep disruption
Dissel, S., Seugnet, L., Thimgan, M. S., Silverman, N. S., Angadi, V., Thacher, P. V., Burnham, M. M., & Shaw, P. J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.09.019 · Cited by 50
Impact of traumatic brain injury on sleep structure, electrocorticographic activity and transcriptome in mice
Sabir, M., Gaudreault, P.-O., Freyburger, M., Massart, R., Blanchet-Cohen, A., Jaber, M., Gosselin, N., & Mongrain, V. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.12.023 · Cited by 47
Sleep as a translationally-relevant endpoint in studies of autism spectrum disorder (ASD)
Missig, G., McDougle, C. J., & Carlezon, W. A. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0409-5 · Cited by 49
Enzymolysis peptides from Mauremys mutica plastron improve the disorder of neurotransmitter system and facilitate sleep-promoting in the PCPA-induced insomnia mice
Lv, Y.-B., Zhou, Q., Yan, J., Luo, L. F., & Zhang, J. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114047 · Cited by 44
The Putative Role of Neuroinflammation in the Interaction between Traumatic Brain Injuries, Sleep, Pain and Other Neuropsychiatric Outcomes: A State-of-the-Art Review
Babiloni, A. H., Baril, A., Charlebois‐Plante, C., Jodoin, M., Sanchez, E., Baets, L. D., Arbour, C., Lavigne, G. J., Gosselin, N., & Beaumont, L. D. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12051793 · Cited by 47
Relationship between systemic inflammation and recovery over 12 months after an acute episode of low back pain
Klyne, D. M., Barbe, M. F., & Hodges, P. W. (2021) · The Spine Journal · doi:10.1016/j.spinee.2021.09.006 · Cited by 42
The stress of losing sleep: Sex-specific neurobiological outcomes
Wright, C. J., Milosavljevic, S., & Pocivavsek, A. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100543 · Cited by 47
The Interplay Between Neuroinfections, the Immune System and Neurological Disorders: A Focus on Africa
Ngarka, L., Fodjo, J. N. S., Aly, E., Masocha, W., & NJAMNSHI, A. K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.803475 · Cited by 46
Sleep and brain infections
Tesoriero, C., Gallo, F. D., & Bentivoglio, M. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.07.002 · Cited by 41
Cytokine Polymorphisms are Associated with Poor Sleep Maintenance in Adults Living with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome
Lee, K. A., Gay, C., Pullinger, C. R., Koenig, M. D., Zak, R., & Aouizerat, B. E. (2014) · SLEEP · doi:10.5665/sleep.3474 · Cited by 39
Prostaglandin D2 is crucial for seizure suppression and postictal sleep
Kaushik, M. K., Aritake, K., Kamauchi, S., Hayaishi, O., Huang, Z., Lazarus, M., & Urade, Y. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.12.002 · Cited by 40
Anxiety and depression in rheumatologic diseases: the relevance of diagnosis and management
Torta, R., Pennazio, F., & Ieraci, V. (2014) · Reumatismo · doi:10.4081/reumatismo.2014.769 · Cited by 40
Sleep quality and COVID-19 outcomes: the evidence-based lessons in the framework of predictive, preventive and personalised (3P) medicine
Richter, K., Kellner, S., Hillemacher, T., & Golubnitschaja, O. (2021) · The EPMA Journal · doi:10.1007/s13167-021-00245-2 · Cited by 37
Selective contributions of neuronal and astroglial interleukin-1 receptor 1 to the regulation of sleep
Ingiosi, A. M., Raymond, R. M., Pavlova, M. N., & Opp, M. R. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.03.014 · Cited by 39
Circadian rhythm and sleep-wake systems share the dynamic extracellular synaptic milieu
Cooper, J. M., Halter, K. A., & Prosser, R. A. (2018) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2018.04.001 · Cited by 38
Chronic intermittent hypoxia decreases pain sensitivity and increases the expression of HIF1α and opioid receptors in experimental rats
Wu, J., Li, P., Wu, X., & Chen, W.-M. (2014) · Sleep And Breathing · doi:10.1007/s11325-014-1047-0 · Cited by 37
Sleep and cytokines
Davis, C. J., & Krueger, J. M. (2012) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2012.06.006 · Cited by 36
Self-citation
Genetic Dissection of Sleep Homeostasis
Mang, G. M., & Franken, P. (2013) · Current topics in behavioral neurosciences · doi:10.1007/7854_2013_270 · Cited by 37
The Underlying Mechanisms of Sleep Deprivation Exacerbating Neuropathic Pain
Zhu, M., & Huang, H. (2023) · Nature and Science of Sleep · doi:10.2147/nss.s414174 · Cited by 39
Sleep fragmentation and sepsis differentially impact blood–brain barrier integrity and transport of tumor necrosis factor-α in aging
Opp, M. R., George, A. M., Ringgold, K. M., Hansen, K. M., Bullock, K. M., & Banks, W. A. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.07.023 · Cited by 32
Role of astrocytes in sleep deprivation: accomplices, resisters, or bystanders?
Que, M., Li, Y., Wang, X., Zhan, G., Luo, X., & Zhou, Z. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1188306 · Cited by 35
Behavioral Sleep-Wake Homeostasis and EEG Delta Power Are Decoupled By Chronic Sleep Restriction in the Rat
Stephenson, R., Caron, A. M., & Famina, S. (2015) · SLEEP · doi:10.5665/sleep.4656 · Cited by 30
Cytotoxic chemotherapy increases sleep and sleep fragmentation in non-tumor-bearing mice
Borniger, J. C., Gaudier‐Diaz, M. M., Zhang, N., Nelson, R. J., & DeVries, A. C. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.11.001 · Cited by 28
Impact of chronic rhinosinusitis on sleep: a controlled clinical study
Alt, J. A., Ramakrishnan, V. R., Platt, M. P., Schlosser, R. J., Storck, T., & Soler, Z. M. (2019) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22212 · Cited by 28
Microglial TNFα orchestrates protein phosphorylation in the cortex during the sleep period and controls homeostatic sleep
Pinto, M. J., Cottin, L., Dingli, F., Laigle, V., Ribeiro, L. F., Triller, A., Henderson, F. J., Loew, D., Fabre, V., & Bessis, A. (2022) · The EMBO Journal · doi:10.15252/embj.2022111485 · Cited by 24
Electrophysiological signatures of acute systemic lipopolysaccharide-induced inflammation: potential implications for delirium science
Sultan, Z. W., Jaeckel, E. R., Krause, B. M., Grady, S. M., Murphy, C. A., Sanders, R. D., & Banks, M. I. (2021) · British Journal of Anaesthesia · doi:10.1016/j.bja.2020.12.040 · Cited by 28
Short-term sleep deprivation in mice induces B cell migration to the brain compartment
Korin, B., Avraham, S., Azulay‐Debby, H., Farfara, D., Hakim, F., & Rolls, A. (2019) · SLEEP · doi:10.1093/sleep/zsz222 · Cited by 28
From Physiology to Pathology of Cortico-Thalamo-Cortical Oscillations: Astroglia as a Target for Further Research
Gobbo, D., Scheller, A., & Kirchhoff, F. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.661408 · Cited by 25
The Leptomeninges Produce Prostaglandin D2 Involved in Sleep Regulation in Mice
Chérasse, Y., Aritake, K., Oishi, Y., Kaushik, M. K., Korkutata, M., & Urade, Y. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00357 · Cited by 24
Pannexins Are Potential New Players in the Regulation of Cerebral Homeostasis during Sleep-Wake Cycle
Shestopalov, V. I. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00210 · Cited by 24
An insight of sleep disorders in Africa
Aragón-Arreola, J. F., Moreno-Villegas, C. A., Armienta-Rojas, D. A., & la Herrán-Arita, A. K. D. (2016) · eNeurologicalSci · doi:10.1016/j.ensci.2016.02.006 · Cited by 23
Zebrafish as a Tool in the Study of Sleep and Memory-related Disorders
Bonan, C. D., & Altenhofen, S. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210712141041 · Cited by 23
Emerging Roles of Microglia in Neuro-vascular Unit: Implications of Microglia-Neurons Interactions
Ding, Z., Guo, S., Luo, L., Zheng, Y., Gan, S., Kang, X., Wu, X., & Zhu, S. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.706025 · Cited by 23
Sleeping Sickness Disrupts the Sleep-Regulating Adenosine System
Rijo‐Ferreira, F., Bjorness, T. E., Cox, K. H., Sonneborn, A., Greene, R. W., & Takahashi, J. S. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1046-20.2020 · Cited by 19
Association of Innate Immune Single-Nucleotide Polymorphisms with the Electroencephalogram During Desflurane General Anaesthesia
Mulholland, C. V., Somogyi, A. A., Barratt, D. T., Coller, J. K., Hutchinson, M. R., Jacobson, G. M., Cursons, R. T. M., & Sleigh, J. W. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0201-7 · Cited by 18
Serum Levels of TNF-α Are Increased in Patients with Rotator Cuff Tear and Sleep Disturbance
Cho, C., Kim, D. H., Baek, E.-H., & Kim, D. (2021) · Diagnostics · doi:10.3390/diagnostics11122215 · Cited by 17
Sleep and the ICU
Wang, J. (2013) · The Open Critical Care Medicine Journal · doi:10.2174/1874828701306010080 · Cited by 16
Wrist actigraphic approach in primary, secondary and tertiary care based on the principles of predictive, preventive and personalised (3P) medicine
Acker, J. G., Golubnitschaja, O., Büttner‐Teleagă, A., & Richter, K. (2021) · The EPMA Journal · doi:10.1007/s13167-021-00250-5 · Cited by 15
Time Course of Blood and Brain Cytokine/Chemokine Levels Following Adolescent Alcohol Exposure and Withdrawal in Rats
Sánchez-Alavez, M., Nguyen, W., Mori, S., Wills, D. N., Otero, D. C., Aguirre, C., Singh, M., Ehlers, C. L., & Conti, B. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14209 · Cited by 14
Neurobiology of REM Sleep, NREM Sleep Homeostasis, and Gamma Band Oscillations
McKenna, J. T., Zielinski, M. R., & McCarley, R. W. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6578-6_5 · Cited by 15
Self-citation
Depressive Disorders And Pain: A Joint Model Of Diagnosis And Treatment
Torta, R. (2013) · Journal of Pain & Relief · doi:10.4172/2167-0846.1000s2-003 · Cited by 13
P2X7 receptor-activated microglia in cortex is critical for sleep disorder under neuropathic pain
Li, T., Gao, Y., He, M., Gui, Z., Zhao, B., Cao, Y., Chen, T., Zhu, J., Wang, J., Zhong, Q., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1095718 · Cited by 14
Exposure to Workplace Bullying, Distress, and Insomnia: The Moderating Role of the miR-146a Genotype
Rajalingam, D., Jacobsen, D. P., Nielsen, M. B., Einarsen, S. V., & Gjerstad, J. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01204 · Cited by 13
How genetically engineered systems are helping to define, and in some cases redefine, the neurobiological basis of sleep and wake
Fuller, P. M., Yamanaka, A., & Lazarus, M. (2015) · Temperature · doi:10.1080/23328940.2015.1075095 · Cited by 12
Association between sleep quality and inflammatory complement components in collegiate males
Manzar, M. D., Rajput, M. M., Zannat, W., Hameed, U. A., Al-Jarrah, M. D., Spence, D. W., Pandi-Perumal, S. R., BaHammam, A. S., & Hussain, M. E. (2015) · Sleep And Breathing · doi:10.1007/s11325-015-1249-0 · Cited by 11
Sleep- and time of day-linked RNA transcript expression in wild-type and IL1 receptor accessory protein-null mice
Oles, V., Koh, K. M. S., Dykstra-Aiello, C., Savenkova, M. I., Gibbons, C. M., Nguyen, J., Karatsoreos, I. N., Panchenko, A., & Krueger, J. M. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00839.2019 · Cited by 10
Self-citation
Acute sleep loss increases CNS health biomarkers and compromises the ability to stay awake in a sex-and weight-specific manner
van Egmond, L. T., Bukhari, S. H., Benedet, A. L., Ashton, N. J., Meth, E. M. S., Boukas, A., Engström, J., Ilemosoglou, M., Blennow, K., Zetterberg, H., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02146-y · Cited by 11
Prostaglandin D2in the regulation of sleep
Urade, Y., & Lazarus, M. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139649469.010 · Cited by 10
Mediating role of obstructive sleep apnea in altering slow-wave activity and elevating Alzheimer’s disease risk: Pilot study from a northern Taiwan cohort
Tsai, C.-Y., Su, C.-L., Huang, H.-T., Lin, H.-W., Lin, J., Hei, N.-H., Cheng, W.-H., Chen, Y.-L., Majumdar, A., Kang, J., et al. (2024) · Sleep Health · doi:10.1016/j.sleh.2024.08.012 · Cited by 9
Obstructive sleep apnea as an independent predictor of postoperative delirium and pain: protocol for an observational study of a surgical cohort
Strutz, P., Tzeng, W. S., Arrington, B., Kronzer, V. L., McKinnon, S., Abdallah, A. B., Haroutounian, S., & Avidan, M. S. (2018) · F1000Research · doi:10.12688/f1000research.14061.2 · Cited by 8
Microglia in the pathogenesis of depression, insomnia and their comorbidity
Liu, F., Guo, D., Gao, T., Diao, M., & Han, Y. (2023) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2023.100030 · Cited by 8
Non-pharmacological interventions for improving sleep in people living with HIV: a systematic narrative review
Meng, J., Zheng, C., Wang, H., Valimaki, M. A., & Wang, M. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1017896 · Cited by 8
Sleep-inducing effect of substance P-cholera toxin A subunit in mice
Zielinski, M. R., & Gerashchenko, D. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.08.066 · Cited by 8
Self-citation
A [11C]PBR28 PET study on the associations between sleep health and microglial density
Balter, L. J. T., Malmros, J., Stenkrona, P., Varrone, A., Forsberg, A., Gustavsson, E., Mouyobo, C. E., Kalpouzos, G., & Papenberg, G. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03613-1 · Cited by 7
Maternal tiredness and cytokine concentrations in mid-pregnancy
Kaartinen, M., Karlsson, L., Paavonen, E. J., Polo‐Kantola, P., Pelto, J., Nousiainen, N., Scheinin, N. M., Maksimow, M., Salmi, M., & Karlsson, H. (2019) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2019.109843 · Cited by 7
Postoperative Cognitive Trajectories in Adults
Sanders, R. D., & Avidan, M. S. (2013) · Anesthesiology · doi:10.1097/aln.0b013e3182838b67 · Cited by 7
Objective and Subjective Sleep in Rheumatoid Arthritis and Severe Seasonal Allergy: Preliminary Assessments of the Role of Sickness, Central and Peripheral Inflammation
Tamm, S., Lensmar, C., Andréasson, A., Axelsson, J., Morén, A. F., Grünewald, J., Gyllfors, P., Karshikoff, B., Kosek, E., Lampa, J., et al. (2021) · Nature and Science of Sleep · doi:10.2147/nss.s297702 · Cited by 6
Contribution of transcriptional and translational mechanisms to the recovery aspect of sleep regulation
Rachalski, A., Freyburger, M., & Mongrain, V. (2014) · Annals of Medicine · doi:10.3109/07853890.2013.866439 · Cited by 6
Neurochemistry and Pharmacology of Sleep
Torterolo, P., Monti, J. M., & Vanini, G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816430-3.00004-x · Cited by 6
Research advances in children's sleep and vitamin D levels
Zhu, L., & Yao, D. (2025) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2448076.038 · Cited by 5
Neuroimaging of sleep disorders
Nofzinger, E. A., Maquet, P., & Thorpy, M. J. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139088268.025 · Cited by 5
Adenosinergic Regulation of Sleep–Wake Behavior in the Basal Ganglia
Lazarus, M., & Urade, Y. (2015) · Current topics in neurotoxicity · doi:10.1007/978-3-319-20273-0_15 · Cited by 4
Adaptation and survival: hypotheses about the neural mechanisms of unihemispheric sleep
Mascetti, G. G. (2020) · Laterality Asymmetries of Body Brain and Cognition · doi:10.1080/1357650x.2020.1828446 · Cited by 6
Genetic Mechanisms Underlying SleepPreprint
Toda, H., Shi, M., Williams, J. A., & Sehgal, A. (2018) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2018.83.037705 · Cited by 3
Deep sleep helps the heart to heal
Rowe, R. K. (2024) · Nature · doi:10.1038/d41586-024-03394-2 · Cited by 2

Authors: Krueger, J. M., Clinton, J. M., Winters, B. D., Zielinski, M. R., Taishi, P., Jewett, K. A., & Davis, C. J.
Affiliations: Washington State University Spokane (US)
Corresponding author: Krueger, James M.
ORCID: Winters, Bradley D.
Jewett, Kathryn A.
Davis, Christopher J.
Venue: Progress in Brain Research
Publisher: Elsevier
Published: 2011
Volume: 193
Pages: 39-47
ISSN: 0079-6123 (ISSN-L)
DOI: 10.1016/b978-0-444-53839-0.00003-x
PMC: PMC3645329
OpenAlex: W3779999
Cited by: 126
References: 55
Citations by year: 2026: 5 · 2025: 9 · 2024: 3 · 2023: 7 · 2022: 9 · 2021: 13 · 2020: 4 · 2019: 10 · 2018: 11 · 2017: 9 · 2016: 3 · 2015: 11 · 2014: 6 · 2013: 17 · 2012: 6
FWCI: 21.11
Type: book chapter
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in brain research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: W. M. Keck Foundation
National Institutes of Health
National Institute of Neurological Disorders and Stroke (NS-31453, NS-25378, R01NS031453, R01NS025378)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-36520, R01HD036520)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: cytokines, slow-wave sleep, TNF-α, IL-1β, sleep regulation, EEG slow-wave activity, sleep deprivation, P2X7 receptor, extracellular ATP, synaptic scaling, somatosensory cortex, sleep homeostasis, sleep initiation, neuroinflammation
MeSH terms: Animals, Brain, Humans, Sleep, Tumor Necrosis Factor-alpha, Signal Transduction, Cytokines, Interleukin-1beta, Receptors, Purinergic P2Y1, Receptors, Purinergic P2X7

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Involvement of cytokines in slow wave sleep

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks