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Carotenoids in human nutrition and health

Eggersdorfer, Manfred, Wyss, Adrian·2018·Archives of Biochemistry and Biophysics
DOI 10.1016/j.abb.2018.06.001
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Abstract

Carotenoids are naturally occurring pigments found in most fruits and vegetables, plants, algae, and photosynthetic bacteria. Humans cannot synthesize carotenoids and must ingest them in food or via supplementation. Carotenoids have a range of functions in human health. They primarily exert antioxidant effects, but individual carotenoids may also act through other mechanisms; for example, β-carotene has a pro-vitamin A function, while lutein/zeaxanthin constitute macular pigment in the eye. The benefit of lutein in reducing progression of age-related macular eye disease and cataracts is strengthening; an intake recommendation would help to generate awareness in the general population to have an adequate intake of lutein rich foods. There is evidence that carotenoids, in addition to beneficial effects on eye health, also produce improvements in cognitive function and cardiovascular health, and may help to prevent some types of cancer. Despite the evidence for the health benefits of carotenoids, large population-based supplementation studies have produced mixed results for some of the carotenoids. To establish and confirm the health benefits of the different carotenoids more research, including clinical studies, is needed.

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Research works printed but not linked: 75

  1. Rockström, 2016, Acting in the anthropocene: the eat-lancet commission, Lancet, 387, 2364, 10.1016/S0140-6736(16)30681-X · DOI
  2. Johnson, 2012, A possible role for lutein and zeaxanthin in cognitive function in the elderly, Am. J. Clin. Nutr., 96, 10.3945/ajcn.112.034611 · DOI · Paper page
  3. Khoo, 2011, Carotenoids and their isomers: color pigments in fruits and vegetables, Molecules, 16, 1710, 10.3390/molecules16021710 · DOI · Paper page
  4. Zimmer, 2007, Possible influences of lutein and zeaxanthin on the developing retina, Clin. Ophthalmol., 1, 25
  5. Al-Delaimy, 2004, Plasma levels of six carotenoids in nine european countries: report from the european prospective investigation into cancer and nutrition (EPIC), Publ. Health Nutr., 7, 713, 10.1079/PHN2004598 · DOI
  6. Age-Related Eye Disease Study 2 Research Group, 2013, Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial, J. Am. Med. Assoc., 309, 2005, 10.1001/jama.2013.4997 · DOI · Paper page
  7. Walk, 2017, From neuro-pigments to neural efficiency: the relationship between retinal carotenoids and behavioral and neuroelectric indices of cognitive control in childhood, Int. J. Psychophysiol., 118, 1, 10.1016/j.ijpsycho.2017.05.005 · DOI
  8. Grodstein, 2007, A randomized trial of beta carotene supplementation and cognitive function in men: the Physicians' Health Study II, Arch. Intern. Med., 167, 2184, 10.1001/archinte.167.20.2184 · DOI · Paper page
  9. Johnson, 2008, Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women, Nutr. Neurosci., 11, 75, 10.1179/147683008X301450 · DOI · Paper page
  10. Cheng, 2017, Lycopene and tomato and risk of cardiovascular diseases: a systematic review and meta-analysis of epidemiological evidence, Crit. Rev. Food Sci. Nutr., 11, 1, 10.1080/10408398.2017.1362630 · DOI · Paper page
  11. Wan, 2014, Dietary tomato and lycopene impact androgen signaling- and carcinogenesis-related gene expression during early TRAMP prostate carcinogenesis, Canc. Prev. Res., 7, 1228, 10.1158/1940-6207.CAPR-14-0182 · DOI
  12. Köpcke, 2008, Protection from sunburn with beta-Carotene - a meta-analysis, Photochem. Photobiol., 84, 284, 10.1111/j.1751-1097.2007.00253.x · DOI · Paper page
  13. Mínguez-Alarcón, 2012, Dietary intake of antioxidant nutrients is associated with semen quality in young university students, Hum. Reprod., 27, 2807, 10.1093/humrep/des247 · DOI
  14. Palmer, 2012, The use and interpretation of serum retinol distributions in evaluating the public health impact of vitamin A programmes, Publ. Health Nutr., 15, 1201, 10.1017/S1368980012000560 · DOI
  15. Uchiyama, 2005, β-Cryptoxanthin stimulates cell proliferation and transcriptional activity in osteoblastic MC3T3-E1cells, Int. J. Mol. Med., 15, 675
  16. Sharoni, 2012, The role of lycopene and its derivatives in the regulation of transcription systems: implications for cancer prevention, Am. J. Clin. Nutr., 96, 10.3945/ajcn.112.034645 · DOI
  17. Gurmu, 2014, The potential of orange-fleshed sweet potato to prevent vitamin A deficiency in Africa, Int. J. Vitam. Nutr. Res., 84, 65, 10.1024/0300-9831/a000194 · doi:10.1024/0300-9831/a000194
  18. Barker, 2011, Nutritional manipulation of primate retinas, V: effects of lutein, zeaxanthin, and n-3 fatty acids on retinal sensitivity to blue-light-induced damage, Invest. Ophthalmol. Vis. Sci., 52, 3934, 10.1167/iovs.10-5898 · DOI · Paper page
  19. Tanaka, 2012, Cancer chemoprevention by carotenoids, Molecules, 17, 3202, 10.3390/molecules17033202 · DOI · Paper page
  20. Iwamoto, 2000, Inhibition of low-density lipoprotein oxidation by astaxanthin, J. Atherosclerosis Thromb., 7, 216, 10.5551/jat1994.7.216 · DOI · Paper page
  21. Weber, 2012, The contribution of beta-carotene to vitamin A supply of humans, Mol. Nutr. Food Res., 56, 251, 10.1002/mnfr.201100230 · DOI · Paper page
  22. von Lintig, 2012, Provitamin A metabolism and functions in mammalian biology, Am. J. Clin. Nutr., 96, 10.3945/ajcn.112.034629 · DOI · Paper page
  23. Bernstein, 2016, Lutein, zeaxanthin, and meso-zeaxanthin: the basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease, Prog. Retin. Eye Res., 50, 34, 10.1016/j.preteyeres.2015.10.003 · DOI · Paper page
  24. Bone, 1988, Analysis of the macular pigment by HPLC: retinal distribution and age study, Invest. Ophthalmol. Vis. Sci., 29, 843
  25. Hammond, 2014, A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on photostress recovery, glare disability, and chromatic contrast, Invest. Ophthalmol. Vis. Sci., 55, 8583, 10.1167/iovs.14-15573 · DOI
  26. Yao, 2013, Lutein supplementation improves visual performance in Chinese drivers: 1-year randomized, double-blind, placebo-controlled study, Nutrition, 29, 958, 10.1016/j.nut.2012.10.017 · DOI
  27. Loughman, 2012, The impact of macular pigment augmentation on visual performance using different carotenoid formulations, Invest. Ophthalmol. Vis. Sci., 53, 7871, 10.1167/iovs.12-10690 · DOI
  28. Nolan, 2011, The impact of macular pigment augmentation on visual performance in normal subjects: COMPASS, Vis. Res., 51, 459, 10.1016/j.visres.2010.12.016 · DOI
  29. Richer, 2011, Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function in patients with atrophic age-related macular degeneration: the Zeaxanthin and Visual Function Study (ZVF) FDA IND #78, 973, Optometry, 82, 667, 10.1016/j.optm.2011.08.008 · DOI
  30. Stringham, 2008, Macular pigment and visual performance under glare conditions, Optom. Vis. Sci., 85, 82, 10.1097/OPX.0b013e318162266e · DOI · Paper page
  31. Wenzel, 2006, J. Curran-Celentano J, Macular pigment optical density and photophobia light threshold, Vision Res., 46, 4615, 10.1016/j.visres.2006.09.019 · doi:10.1016/j.visres.2006.09.019
  32. Kvansakul, 2006, Supplementation with the carotenoids lutein or zeaxanthin improves human visual performance, Ophthalmic Physiol. Optic., 26, 362, 10.1111/j.1475-1313.2006.00387.x · DOI
  33. Johnson, 2010, Intake of lutein and zeaxanthin differ with age, sex, and ethnicity, J. Am. Diet Assoc., 110, 1357, 10.1016/j.jada.2010.06.009 · DOI
  34. Nolan, 2016, Enrichment of macular pigment enhances contrast sensitivity in subjects free of retinal disease: central retinal enrichment supplementation trials - report 1, Invest. Ophthalmol. Vis. Sci., 57, 3429, 10.1167/iovs.16-19520 · DOI
  35. Olmedilla, 2003, But not alpha-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot study, Nutrition, 19, 21, 10.1016/S0899-9007(02)00861-4 · DOI · Paper page
  36. Wong, 2014, Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis, Lancet Glob. Health, 2, 10.1016/S2214-109X(13)70145-1 · DOI · Paper page
  37. Liu, 2014, Association between lutein and zeaxanthin status and the risk of cataract: a meta-analysis, Nutrients, 6, 452, 10.3390/nu6010452 · DOI
  38. Age-Related Eye Disease Study 2 (AREDS2) Research Group, 2013, Lutein/zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. 4, JAMA Ophthalmol, 131, 843, 10.1001/jamaophthalmol.2013.4412 · DOI
  39. Biesalski, 2013, Nutrient reference values for bioactives: new approaches needed? A conference report, Eur. J. Nutr., 52, 1, 10.1007/s00394-013-0503-0 · DOI
  40. Semba, 2003, Are lutein and zeaxanthin conditionally essential nutrients for eye health?, Med. Hypotheses, 61, 465, 10.1016/S0306-9877(03)00198-1 · DOI
  41. Ranard, 2017, Dietary guidance for lutein: consideration for intake recommendations is scientifically supported, Eur. J. Nutr., 56, S37, 10.1007/s00394-017-1580-2 · DOI
  42. Keller, 2005, Evidence of increased oxidative damage in subjects with mild cognitive impairment, Neurology, 64, 1152, 10.1212/01.WNL.0000156156.13641.BA · DOI · Paper page
  43. Hammond, 2017, Effects of lutein/zeaxanthin supplementation on the cognitive function of community dwelling older adults: a randomized, double-masked, placebo-controlled trial, Front. Aging Neurosci., 9, 254, 10.3389/fnagi.2017.00254 · DOI
  44. Choi, 2011, Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects, Plant Foods Hum, Nutrition, 66, 363
  45. Miyawaki, 2008, Effects of astaxanthin on human blood rheology, J. Clin. Biochem. Nutr., 43, 69, 10.3164/jcbn.2008048 · DOI
  46. Nakagawa, 2011, Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes, Br. J. Nutr., 105, 1563, 10.1017/S0007114510005398 · DOI
  47. Böhm, 2012, Lycopene and heart health, Mol. Nutr. Food Res., 56, 296, 10.1002/mnfr.201100281 · DOI
  48. Müller, 2016, Lycopene and its antioxidant role in the prevention of cardiovascular diseases-a critical review, Crit. Rev. Food Sci. Nutr., 56, 1868, 10.1080/10408398.2013.801827 · DOI · Paper page
  49. Leermakers, 2016, The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis, Am. J. Clin. Nutr., 103, 481, 10.3945/ajcn.115.120931 · DOI · Paper page
  50. Yamaguchi, 2003, Effect of carotenoid on calcium content and alkaline phosphatase activity in rat femoral tissues in vitro: the unique anabolic effect of β-cryptoxanthin, Biol. Pharm. Bull., 26, 1188, 10.1248/bpb.26.1188 · doi:10.1248/bpb.26.1188
  51. Yamaguchi, 2004, β-Cryptoxanthin stimulates bone formation and inhibits bone resorption in tissue culture in vitro, Mol. Cell. Biochem., 258, 137, 10.1023/B:MCBI.0000012848.50541.19 · DOI
  52. Yamaguchi, 2006, Effect of β-cryptoxanthin on circulating bone metabolic markers: intake of juice (Citrus unshiu) supplemented with β-cryptoxanthin has an effect in menopausal women, J. Health Sci., 52, 758, 10.1248/jhs.52.758 · doi:10.1248/jhs.52.758
  53. Kim, 2016, Relationship between bone mineral density and dietary intake of beta-carotene, vitamin C, zinc and vegetables in postmenopausal Korean women: a cross-sectional study, J. Int. Med. Res., 44, 1103, 10.1177/0300060516662402 · DOI
  54. Warnke, 2011, Dietary constituents reduce lipid accumulation in murine C3H10 T1/2 adipocytes: a novel fluorescent method to quantify fat droplets, Nutr. Metab., 8, 30, 10.1186/1743-7075-8-30 · DOI
  55. Bonet, 2015, Carotenoids and their conversion products in the control of adipocyte function, adiposity and obesity, Arch. Biochem. Biophys., 572, 112, 10.1016/j.abb.2015.02.022 · DOI · Paper page
  56. Amengual, 2011, Beta-carotene reduces body adiposity of mice via BCMO1, PLoS One, 6, 10.1371/journal.pone.0020644 · DOI · Paper page
  57. Canas, 2017, Effects of mixed carotenoids on adipokines and abdominal adiposity in children, a pilot study, J. Clin. Endocrinol. Metab., 102, 1983, 10.1210/jc.2017-00185 · DOI
  58. Clinton, 1996, Cis-trans lycopene isomers, carotenoids, and retinol in the human prostate, Cancer Epidemiol. Biomark. Prev., 5, 823
  59. Zu, 2014, Dietary lycopene, angiogenesis, and prostate cancer: a prospective study in the prostate-specific antigen era, J. Natl. Cancer Inst., 106, 10.1093/jnci/djt430 · DOI · Paper page
  60. Rowles, 2017, Increased dietary and circulating lycopene are associated with reduced prostate cancer risk: a systematic review and meta-analysis, Prostate Cancer Prostatic Dis., 20, 361, 10.1038/pcan.2017.25 · DOI · Paper page
  61. Erhardt, 2011, Plasma levels of vitamin E and carotenoids are decreased in patients with Nonalcoholic Steatohepatitis (NASH), Eur. J. Med. Res., 16, 76, 10.1186/2047-783X-16-2-76 · DOI
  62. Ip, 2014, Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice, Canc. Prev. Res., 7, 1219, 10.1158/1940-6207.CAPR-14-0154 · DOI
  63. Henriksen, 2014, Importance of carotenoids in optimizing eye and brain development, J. Pediatr. Gastroenterol. Nutr., 59, 552, 10.1097/MPG.0000000000000471 · doi:10.1097/mpg.0000000000000471
  64. Hammond, 2008, Possible role for dietary lutein and zeaxanthin in visual development, Nutr. Rev., 66, 695, 10.1111/j.1753-4887.2008.00121.x · DOI
  65. Jackson, 1998, Major carotenoids in mature human milk: longitudinal and diurnal patterns, J. Nutr. Biochem., 9, 2, 10.1016/S0955-2863(97)00132-0 · DOI
  66. Johnson, 1995, Contribution of beta-carotene (BC) from BC enriched formulae to individual and total serum carotenoids in term infants, [abstract] FASEB J, 9, 1869
  67. Bettler, 2010, Serum lutein concentrations in healthy term infants fed human milk or infant formula with lutein, Eur. J. Nutr., 49, 45, 10.1007/s00394-009-0047-5 · DOI
  68. Vishwanathan, 2014, Lutein and preterm infants with decreased concentrations of brain carotenoids, J. Pediatr. Gastroenterol. Nutr., 59, 659, 10.1097/MPG.0000000000000389 · DOI · Paper page
  69. Qiao, 2009, Total and cancer mortality after supplementation with vitamins and minerals: follow-up of the linxian general population nutrition intervention trial, J. Natl. Cancer Inst., 101, 507, 10.1093/jnci/djp037 · DOI · Paper page
  70. Kamangar F, 2006, Lung cancer chemoprevention: a randomized, double-blind trial in Linxian, China, Cancer Epidemiol. Biomark. Prev., 15, 1562, 10.1158/1055-9965.EPI-06-0316 · DOI
  71. Blot, 1993, Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population, J. Natl. Cancer Inst., 85, 1483, 10.1093/jnci/85.18.1483 · DOI · Paper page
  72. Hennekens, 1996, Lack of effect of long-term supplementation with beta-carotene on the incidence of malignant neoplasms and cardiovascular disease, N. Engl. J. Med., 334, 1145, 10.1056/NEJM199605023341801 · DOI · Paper page
  73. Cook, 2000, Effects of beta-carotene supplementation on cancer incidence by baseline characteristics in the Physicians' Health Study (United States), Cancer Causes Control, 11, 617, 10.1023/A:1008995430664 · DOI
  74. Albanes, 1995, Effects of alpha-tocopherol and beta-carotene supplements on cancer incidence in the alpha-tocopherol beta-carotene cancer prevention study, Am. J. Clin. Nutr., 62
  75. Mayne, 1998, Effect of supplemental beta-carotene on plasma concentrations of carotenoids, retinol, and alpha-tocopherol in humans, Am. J. Clin. Nutr., 68, 642, 10.1093/ajcn/68.3.642 · DOI

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Metadata

Authors
Eggersdorfer, M., & Wyss, A.
Venue
Archives of Biochemistry and Biophysics
Publisher
Elsevier BV
Published
2018-08
Volume
652
Pages
18-26
ISSN
0003-9861 (ISSN-L)
DOI
10.1016/j.abb.2018.06.001
OpenAlex
W2807102394
Cited by
945
References
14
FWCI
44.40
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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