Towards organ printing: engineering an intra-organ branched vascular tree
Open accessAbstract
IMPORTANCE OF THE FIELD: Effective vascularization of thick three-dimensional engineered tissue constructs is a problem in tissue engineering. As in native organs, a tissue-engineered intra-organ vascular tree must be comprised of a network of hierarchically branched vascular segments. Despite this requirement, current tissue-engineering efforts are still focused predominantly on engineering either large-diameter macrovessels or microvascular networks. AREAS COVERED IN THIS REVIEW: We present the emerging concept of organ printing or robotic additive biofabrication of an intra-organ branched vascular tree, based on the ability of vascular tissue spheroids to undergo self-assembly. WHAT THE READER WILL GAIN: The feasibility and challenges of this robotic biofabrication approach to intra-organ vascularization for tissue engineering based on organ-printing technology using self-assembling vascular tissue spheroids including clinically relevantly vascular cell sources are analyzed. TAKE HOME MESSAGE: It is not possible to engineer 3D thick tissue or organ constructs without effective vascularization. An effective intra-organ vascular system cannot be built by the simple connection of large-diameter vessels and microvessels. Successful engineering of functional human organs suitable for surgical implantation will require concomitant engineering of a 'built in' intra-organ branched vascular system. Organ printing enables biofabrication of human organ constructs with a 'built in' intra-organ branched vascular tree.
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Autologous EPCs can be easily isolated from peripheral blood, lipoaspirate tissue, and bone marrow in sufficient number, holding promising potential for reendothelization of decellularized livers for clinical application.
“This results in the easy isolation of autologous EPCs from peripheral blood, lipoaspirate tissue, and bone marrow in sufficient number, holding promising potential for reendothelization of decellularized livers for clinical application [239].”
From Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities (2024) · cites this paper as [239]
Section 4.3 says large numbers of adipose progenitor cells can be isolated from lipoaspirate and describes their potential for engineering intra-organ vascular trees. But section 4.2 cautions that bone-marrow stem-cell yields are limited, and section 1.4 says reendothelialization of a complete decellularized organ vascular system remains unproven. The paper does not establish easy isolation of sufficient EPCs from all three named sources or their clinical use to reendothelialize decellularized livers; page numbers were not available in our copy. (LLM, conf=0.87)
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Self-citationSystem for the analysis and visualization of large 3D anatomical trees
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Vascular Tissue Engineering and Vascularized 3D Tissue Regeneration
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The Problem with Academic Medicine: Engineering Our Way into and out of the Mess
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The Biological Behavior of Prostate Cancer Cells in 3D Culture Systems
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3D bioprinting of tissues and organs
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25th Anniversary Article: Engineering Hydrogels for Biofabrication
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3D Bioprinting of heterogeneous aortic valve conduits with alginate/gelatin hydrogels
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3D Bioprinting for Organ Regeneration
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3D bioprinting of functional human skin: production and in vivo analysis
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Advances in Regenerative Medicine and Tissue Engineering: Innovation and Transformation of Medicine
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Bioprinting Technology: A Current State-of-the-Art Review
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Scaffolding Biomaterials for 3D Cultivated Meat: Prospects and Challenges
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Organ printing: from bioprinter to organ biofabrication line
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3D Bioprinting of Developmentally Inspired Templates for Whole Bone Organ Engineering
Daly, A. C., Cunniffe, G. M., Sathy, B. N., Jeon, O., Alsberg, E., & Kelly, D. J. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600182 · Cited by 272 · see citing works
Challenges on optimization of 3D-printed bone scaffolds
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3D Bioprinting for Vascularized Tissue Fabrication
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Self-citationControlled Positioning of Cells in Biomaterials—Approaches Towards 3D Tissue Printing
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Self-citationSkin tissue engineering using 3D bioprinting: An evolving research field
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3D bioprinting for cardiovascular regeneration and pharmacology
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Sequential assembly of cell‐laden hydrogel constructs to engineer vascular‐like microchannels
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Three-dimensional printing of biological matters
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Engineering more than a cell: vascularization strategies in tissue engineering
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In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease
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A Plastic Surgery Application in Evolution
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3D-printed vascular networks direct therapeutic angiogenesis in ischaemia
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Vascular Tissue Engineering: Challenges and Requirements for an Ideal Large Scale Blood Vessel
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3D Fabrication of Polymeric Scaffolds for Regenerative Therapy
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3D bioprinting: an emerging technology full of opportunities and challenges
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Bioprinting of a functional vascularized mouse thyroid gland construct
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Self-citationBiomaterials for Bioprinting Microvasculature
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3D Printing for Tissue Engineering
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Solid Organ Bioprinting: Strategies to Achieve Organ Function
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Strategies for organ level tissue engineering
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Bioengineering Outlook on Cultivated Meat Production
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Three-dimensional Printing in Developing Countries
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Self-citationProspects for 3D bioprinting of organoids
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Techniques and assays for the study of angiogenesis
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Additive Manufacturing of Vascular Grafts and Vascularized Tissue Constructs
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The Application of Cell Sheet Engineering in the Vascularization of Tissue Regeneration
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In Situ Organ-Specific Vascularization in Tissue Engineering
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A Hybrid Bioprinting Approach for Scale-Up Tissue Fabrication
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Determinants of Microvascular Network Topologies in Implanted Neovasculatures
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Emulating Host-Microbiome Ecosystem of Human Gastrointestinal Tract in Vitro
Park, G.-S., Park, M. H., Shin, W., Zhao, C., Sheikh, S., Oh, S. J., & Kim, H. J. (2017) · Stem Cell Reviews and Reports · doi:10.1007/s12015-017-9739-z · Cited by 69 · see citing works
Three dimensional bioprinting technology: Applications in pharmaceutical and biomedical area
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A Facile Method to Fabricate Hydrogels with Microchannel-Like Porosity for Tissue Engineering
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Bioprinting a Synthetic Smectic Clay for Orthopedic Applications
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Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
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Current challenges in three-dimensional bioprinting heart tissues for cardiac surgery
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Self-citationSynthesis and High-Throughput Processing of Polymeric Hydrogels for 3D Cell Culture
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Bioprinting Technologies and Bioinks for Vascular Model Establishment
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Modeling fusion of cellular aggregates in biofabrication using phase field theories
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Self-citationBioprinting of glioma stem cells improves their endotheliogenic potential
Wang, X., Li, X., Dai, X., Zhang, X., Zhang, J., Xu, T., & Lan, Q. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.08.006 · Cited by 57 · see citing works
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Cartilage and bone tissue engineering using adipose stromal/stem cells spheroids as building blocks
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Advances in Skin Tissue Engineering and Regenerative Medicine
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Engineering a vascularized collagen-β-tricalcium phosphate graft using an electrochemical approach
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Bioengineered tissue solutions for repair, correction and reconstruction in cardiovascular surgery
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Bioprinting and Tissue Engineering: Recent Advances and Future Perspectives
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Photosynthetic Microorganisms for the Oxygenation of Advanced 3D Bioprinted Tissues
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Self-citation3D biofabrication for soft tissue and cartilage engineering
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The environmental prospects of cultured meat in China
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Self-citationThe fusion of tissue spheroids attached to pre-stretched electrospun polyurethane scaffolds
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Self-citation5.14 Biofabrication in Tissue Engineering ☆
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In situ 3D bioprinting: a promising technique in advanced biofabrication strategies
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Scalable Biofabrication of Tissue Spheroids for Organ Printing
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Self-citation3D Printing of Organs for Transplantation: Where Are We and Where Are We Heading?
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- Authors
- Visconti, R. P., Kasyanov, V., Gentile, C., Zhang, J., Markwald, R. R., & Mironov, V.
- Affiliations
- Medical University of South Carolina (US)
- Riga Stradiņš University (LV)
- Corresponding author
- Mironov, Vladimir
- Venue
- Expert Opinion on Biological Therapy
- Publisher
- Informa Healthcare
- Published
- 2010-02-04
- Volume
- 10
- Issue
- 3
- Pages
- 409-420
- ISSN
- 1471-2598 (ISSN-L)
- 1744-7682
- PMC
- PMC4580374
- OpenAlex
- W2052215721
- Cited by
- 224
- References
- 105
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 11 · 2022: 15 · 2021: 19 · 2020: 12 · 2019: 12 · 2018: 20 · 2017: 25 · 2016: 19 · 2015: 15 · 2014: 18 · 2013: 19 · 2012: 12
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Expert Opinion on Biological Therapy (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- publication.editionName
- Funders
- National Institutes of Health (5p20rr016461-11, 1c06rr015455-01a1, 1c06rr018823-01)
- National Center for Research Resources (RR16434-08, P20RR016434, P20RR021949, 2 P20 RR16461-05A1, C06 RR-015455, C06 RR-018823, P 20 RR-016461)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Automotive Engineering › Additive Manufacturing and 3D Printing Technologies
- Keywords
- organ printing, self-assembly, 3D tissue constructs, organ engineering, microvascular networks
- MeSH terms
- Animals, Blood Vessels, Feasibility Studies, Humans, Robotics, Tissue Engineering
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