Population impact of depression either as a risk factor or consequence of type 2 diabetes in adults: a meta-analysis of longitudinal studies
Abstract
This meta-analysis examined the reciprocal relationship between depression and diabetes mellitus type 2 (T2DM) by conducting a bias adjusted meta-analysis of longitudinal studies using relative and absolute risk estimates. Specifically, the data were reconstructed to compute relative risk (RR), risk difference (RD), and the number needed to be exposed for one additional person to be harmed (NNEH) or benefited (NNEB). The 25 studies selected for review generated 29 datasets of which 15 examined endpoint A (depression as a risk factor for T2DM), and 14 examined endpoint B (T2DM as a risk factor for depression). For both endpoints, there was a small relative risk increase (for both the RR and hazard ratio (HR)) though with significant heterogeneity between studies. This however translated to a non-significant NNEH of 87 (NNEB 161 to ∞ to NNEH 35) and NNEH of 233 (NNEB 28 to ∞ to NNEH 23) for studies examining endpoint A and endpoint B respectively. This study suggests that the magnitude of the relative risk increase for depression as a risk factor or consequence of T2DM is small without significant impact on absolute risk indices. While these risks may be considered in terms of individual patient management, they are unlikely to have an impact on a population perspective.
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From The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness (2019) · cites this paper as [69]
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Depression and anxiety symptoms in type 2 diabetes mellitus: a matter of time?
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- Authors
- Hasan, S. S., Clavarino, A. M., Mamun, A. A., Doi, S. A. R., & Kairuz, T.
- Affiliations
- The University of Queensland (AU)
- Corresponding author
- Hasan, Syed Shahzad
- Venue
- Asian Journal of Psychiatry
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 6
- Issue
- 6
- Pages
- 460-472
- ISSN
- 1876-2018 (ISSN-L)
- OpenAlex
- W2000854523
- Cited by
- 34
- References
- 92
- Citations by year
- 2025: 1 · 2024: 3 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 7 · 2016: 2 · 2015: 1 · 2014: 6 · 2013: 1
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Asian Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- ResearchOnline - JCU (James Cook University) (submittedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- depression, type 2 diabetes, bidirectional relationship, number needed to harm, number needed to benefit, relative risk, absolute risk, population effects
- MeSH terms
- Depression, Depressive Disorder, Diabetes Mellitus, Type 2, Humans, Longitudinal Studies, Risk Factors
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